Article
Multidisciplinary Sciences
Avishai Halev, Beatriz Martinez-Lopez, Maria Clavijo, Carlos Gonzalez-Crespo, Jeonghoon Kim, Chao Huang, Seth Krantz, Rebecca Robbins, Xin Liu
Summary: In this study, a machine learning model is proposed to predict infection in swine production systems on a daily basis, allowing for early warning and preventive strategies. The model demonstrates good ability to predict infection in two swine production systems.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Yin Wang, Wannarat Yim-im, Elizabeth Porter, Nanyan Lu, Joe Anderson, Lance Noll, Ying Fang, Jianqiang Zhang, Jianfa Bai
Summary: PRRS is still one of the most economically devastating diseases in the swine population in the USA, but the high mutation rate of the PRRSV genome makes it difficult to develop an accurate diagnostic assay. Current real-time PCR systems struggle to differentiate vaccine strains from field strains, while Luminex xTAG technology allows for detection of more molecular targets.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Infectious Diseases
Brent Pepin, Todd Williams, Dale Polson, Phillip Gauger, Scott Dee
Summary: Composting preprocessed swine carcasses is a safe and feasible option for mass disposal of infected carcasses, reducing pathogen levels and environmental contamination risks under adverse weather conditions.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Review
Immunology
Jesus Hernandez, Yanli Li, Enric Mateu
Summary: Dendritic cells in pigs consist of three types, with different pathogens having the ability to infect these cells, especially Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Research has shown that some dendritic cells are refractory to PRRSV infection, while others may have different responses depending on the type of PRRSV involved.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Kai Zheng, Liang Zhu, Yiwei Ding, Xixi Zhang, Ning Chen, Gang Liu, Qiushui He
Summary: The study revealed significant changes in serum pro-inflammatory and anti-inflammatory cytokines in pediatric patients with pneumococcal meningitis. IL-10 levels were significantly higher, while IL-12p40, IL-17A, and IL-1 beta levels were significantly lower in patients compared to healthy controls. Additionally, there was a negative correlation between blood neutrophil percentages and IL-10 concentrations, and lower levels of IL-12p40 and CXCL-1 were observed in patients with sepsis.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Agriculture, Dairy & Animal Science
Haofei Song, Jima Quan, Chang Li, Wan Liang, Lan Zhang, Shuangshuang Wang, Hongyu Lu, Keli Yang, Danna Zhou, Peng Li, Yongxiang Tian
Summary: In this study, we found that overexpression of the SLAMF1 gene significantly inhibited PRRSV replication and reduced the levels of key signaling pathways and inflammatory factors. On the other hand, knockdown of the SLAMF1 gene enhanced PRRSV replication and the levels of key signaling pathways and inflammatory factors.
Article
Immunology
Ines Ruedas-Torres, Jaime Gomez-Laguna, Jose Maria Sanchez-Carvajal, Fernanda Larenas-Munoz, Inmaculada Barranco, Francisco Jose Pallares, Librado Carrasco, Irene Magdalena Rodriguez-Gomez
Summary: This study aimed to evaluate the expressions of TFs and cytokines during early infection with different virulent PRRSV-1 strains. The results showed upregulation of TFs T-bet, EOMES, and FOXP3, along with an increase in IFN-gamma, suggesting a stronger polarization to Th1 cells and Tregs in virulent PRRSV-1-infected animals, warranting further studies on their biological functionality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Dandan Jiang, Maojuan He, Chao Sui, Xiangju Wu, Yue Hu, Xiaoyan Cong, Juntong Li, Yijun Du, Jing Qi
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped positive-stranded RNA virus that causes significant economic losses to the pig industry worldwide. In this study, it was shown that the nonstructural protein 11 (Nsp11) of PRRSV inhibits the ISGylation of cellular proteins by its endoribonuclease activity, leading to decreased expression of ISG15. Additionally, Nsp11 induces the degradation of ISG15 through the autophagy-lysosome system, thus antagonizing the antiviral response of ISG15 and promoting PRRSV replication.
VETERINARY MICROBIOLOGY
(2023)
Article
Immunology
Wenchang Li, Fangqian Chen, Han Gao, Zhuoqing Xu, Yu Zhou, Shenjie Wang, Zeping Lv, Yuchen Zhang, Zifeng Xu, Jianting Huo, Jingkun Zhao, Yaping Zong, Wenqing Feng, Xiaohui Shen, Zhiyuan Wu, Aiguo Lu
Summary: This study compared the concentrations of various cytokines in the peripheral blood of healthy controls and colorectal cancer (CRC) patients at different stages. The results showed that advanced CRC patients had increased concentrations of multiple cytokines compared to healthy controls and early-stage patients. These differential upregulations were mainly observed in CRC patients with distant metastasis and were related to the size of the primary tumor.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Wenxian Chen, Weijun Wang, Xinyan Wang, Zhaoyao Li, Keke Wu, Xiaowen Li, Yuwan Li, Lin Yi, Mingqiu Zhao, Hongxing Ding, Shuangqi Fan, Jinding Chen
Summary: This paper summarizes various nucleic acid detection methods for vesicular disease pathogens in swine, including traditional RT-PCR and real-time RT-PCR methods, as well as recent developments in isothermal amplification methods and luminex technology. Additionally, the CRISPR-Cas diagnostic system is introduced as an emerging nucleic acid detection technology.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Matteo Tonni, Claudia Romeo, Nicoletta Formenti, Maria Beatrice Boniotti, Flavia Guarneri, Livio Colosio, Simone Andreoni, Federico Scali, Giovanni Loris Alborali
Summary: The efficacy and reliability of a monitoring plan for PRRS based on PF sampling in Italian swine production system were assessed. The two methods agreed in discriminating between herds with stable and unstable PRRSV circulation, but showed slight discrepancy in classifying high- and low-prevalence herds within unstable herds.
Article
Veterinary Sciences
Qianru Zhang, Chenchen Cui, Siyu Zhang, Xiaohong Deng, Xuehui Cai, Gang Wang
Summary: The variants of PRRSV strains make it difficult to control PRRS. Tylvalosin tartrate has been used to control PRRSV infection and improve the swine herd's status during PRRSV vaccination.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Qian Dong, Joan K. Lunney, Kyu-Sang Lim, Yet Nguyen, Andrew S. Hess, Hamid Beiki, Raymond R. R. Rowland, Kristen Walker, James M. Reecy, Christopher K. Tuggle, Jack C. M. Dekkers
Summary: The study reveals that different PRRSV isolates can induce different immune responses in tonsils of infected pigs at 42 days post infection, with pigs having higher viral levels showing larger immune cell enrichments. However, effects associated with viral levels and genotypes may not be significant after accounting for differences in cell composition.
BMC VETERINARY RESEARCH
(2021)
Article
Virology
Zhenbang Zhu, Yuqian Xu, Lulu Chen, Meng Zhang, Xiangdong Li
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) causes economic losses in the swine industry. Current vaccines are not effective against PRRSV and specific treatments for infected herds are not available. In this study, bergamottin was found to inhibit PRRSV replication by activating IRF3 and NF-κB signaling, which increased the expression of proinflammatory cytokines and interferon to inhibit viral replication. Bergamottin also reduced the expression of non-structural proteins, interrupting replication and transcription complex formation and viral dsRNA synthesis, ultimately restraining PRRSV replication. This study identified bergamottin as a potential antiviral agent against PRRSV in vitro.
Article
Infectious Diseases
Benjamin D. Anderson, Myagmarsukh Yondon, Emily S. Bailey, Ege K. Duman, Ryan A. Simmons, Annette G. Greer, Gregory C. Gray
Summary: This study implemented a non-invasive bioaerosol sampling strategy in a swine farm in the United States to detect economically important swine pathogens. The results showed that the bioaerosol surveillance strategy was feasible and able to quickly generate data for dissemination to farm stakeholders.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Review
Immunology
Crystal L. Loving, Fernando A. Osorio, Michael P. Murtaugh, Federico A. Zuckermann
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2015)
Article
Virology
Basavaraj Binjawadagi, Yashavanth Shaan Lakshmanappa, Zhu Longchao, Santosh Dhakal, Jagadish Hiremath, Kang Ouyang, Duan-Liang Shyu, Jesus Arcos, Shang Pengcheng, Aaron Gilbertie, Federico Zuckermann, Jordi B. Torrelles, Daral Jackwood, Ying Fang, Gourapura J. Renukaradhya
ARCHIVES OF VIROLOGY
(2016)
Article
Education, Scientific Disciplines
Jonathan H. Foreman, Dawn E. Morin, Thomas K. Graves, Mark A. Mitchell, Federico A. Zuckermann, Herbert E. Whiteley
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2017)
Article
Virology
Wei-Yu Chen, William M. Schniztlein, Gabriela Calzada-Nova, Federico A. Zuckermann
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Gabriela Calzada-Nova, William M. Schnitzlein, Robert J. Husmann, Federico A. Zuckermann
JOURNAL OF VIROLOGY
(2011)
Article
Multidisciplinary Sciences
Debra J. Thomas, Robert J. Husmann, Mauricio Villamar, Timothy R. Winship, Rachael H. Buck, Federico A. Zuckermann
Article
Immunology
Jennifer A. Landolfi, Michele Miller, Carol Maddox, Federico Zuckermann, Jennifer N. Langan, Karen A. Terio
Article
Immunology
Gabriela Calzada-Nova, William Schnitzlein, Robert Husmann, Federico A. Zuckermann
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2010)
Article
Immunology
Gabriela Calzada-Nova, Robert J. Husmann, William M. Schnitzlein, Federico A. Zuckermann
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2012)
Article
Virology
Yijun Du, Federico A. Zuckermann, Dongwan Yoo
Article
Virology
Rajeshwari Parida, In-Soo Choi, Daniel A. Peterson, Asit K. Pattnaik, William Laegreid, Federico A. Zuckermann, Fernando A. Osorio
Article
Virology
David Benfield, Joan K. Lunney, Michael Murtaugh, Eric Nelson, Fernando Osorio, Roman Pogranichniy, Sheela Ramamoorthy, Raymond R. R. Rowland, Jeffrey J. Zimmerman, Federico A. Zuckermann
Article
Immunology
Federico A. Zuckermann, Robert Husmann, WeiYu Chen, Patrick Roady, Janice Pfeiff, Kyle R. Leistikow, Megan Duersteler, Sona Son, Michael R. King, Nathan R. Augspurger
Summary: This study found that providing pigs with a Bacillus-based direct-fed microbial can reduce bacterial colonization in the lungs, eliminate or reduce the presence of the virus, and alleviate lung pathology. Additionally, the DFM also has a systemic modulating effect on innate immunity, enabling it to fight respiratory infections.
INFECTION AND IMMUNITY
(2022)
Article
Immunology
Raquel Portugal, Lynnette C. Goatley, Robert Husmann, Federico A. Zuckermann, Linda K. Dixon
EMERGING MICROBES & INFECTIONS
(2020)