Journal
VACCINE
Volume 28, Issue 27, Pages 4340-4347Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.04.062
Keywords
BCG; Mycobacterium tuberculosis; Newborns; HBHA; Prime-boost
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Funding
- European Commission [LSHP-CT-2005-018736]
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Heterologous prime-boost regimens are a valuable strategy to improve the generation of effector-memory T cell responses against intracellular pathogens. In this study we show that newborn mice vaccinated with bacillus Calmette-Guerin (BCG) and boosted with heparin-binding haemagglutinin (HBHA) had enhanced protective immunity against intranasal or aerosol Mycobacterium tuberculosis challenge over non-boosted mice, as evidenced by a considerable reduction of mycobacterial load in spleen and lung. The route of HBHA delivery had a differential impact on cytokine and antibody production in BCG-primed mice. The prime-boost regimen induced not only HBHA-specific IFN-gamma, but also other cytokines, such as IL-12 and TGF-beta, which may be associated with the generation of lung Th1 effector-memory lymphocytes, responsible for the enhanced protection against M. tuberculosis challenge. (C) 2010 Elsevier Ltd. All rights reserved.
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