Journal
VACCINE
Volume 28, Issue 23, Pages 3963-3971Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.03.046
Keywords
Replication-competent adenovirus; HIV envelope; Vaccine
Categories
Funding
- National Institutes of Health, National Cancer Institute
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An HIV Env immunogen capable of eliciting broad immunity is critical for a successful vaccine. We constructed and characterized adenovirus 5 host range mutant (Ad5hr) recombinants encoding HIVSF162 gp160 (subtype B) and HIVTV1 gp160 (subtype C). Immunization of mice with one or both induced cellular immunity to subtype B and C peptides by ELISpot, and antibody responses with high binding titers to HIV Env of subtypes A, B, C. and E. Notably, Ad5hr-HIVTV1 gp160 induced better cellular immunity than Ad5hr-HIVSF162 gp160, either alone or following co-administration. Thus, the TV1 Env recombinant alone may be sufficient for eliciting immune responses against both subtype B and C envelopes. Further studies of Ad5hr-HIVTV1 gp160 in rhesus macaques will evaluate the suitability of this insert for a future phase I clinical trial using a replication-competent Ad4 vector. Published by Elsevier Ltd.
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