Article
Public, Environmental & Occupational Health
Colleen L. Lau, Deborah J. Mills, Helen Mayfield, Narayan Gyawali, Brian J. Johnson, Hongen Lu, Kasim Allel, Philip N. Britton, Weiping Ling, Tina Moghaddam, Luis Furuya-Kanamori
Summary: A Bayesian network model was developed to assess the risk-benefit analysis of Japanese encephalitis (JE) vaccine in travelers. The interactive digital tool estimates the risks of JE infection and severe health outcomes based on travelers' characteristics and itinerary, facilitating decision-making between clinicians and travelers.
JOURNAL OF TRAVEL MEDICINE
(2023)
Review
Immunology
Anar Andani, Pierre van Damme, Eveline M. Bunge, Fernanda Salgado, Rosa C. van Hoorn, Bernard Hoet
Summary: This study examined the impact and effectiveness of one-dose and two-dose universal vaccination (UV) programs against Hepatitis A virus (HAV) in children. The results showed that both strategies led to a significant reduction in the incidence of hepatitis A and demonstrated good vaccine effectiveness and antibody persistence. However, there is limited evidence for the long-term immune response and the need for booster doses in one-dose UV programs.
Article
Immunology
Serim Min, Sun-Hong Kwon, Yeon-Woo Lee, Jung-Min Lee, Eun Jin Bae, Eui-Kyung Lee
Summary: In South Korea, the ready-to-use hexavalent vaccine offers advantages over the current pentavalent vaccine scheme, including a cost reduction of KRW 47,155 (USD36.22) per infant and a lower infection rate. It can save time and reduce the number of vaccination sessions. The ready-to-use hexavalent vaccine has the potential to improve convenience for infants, parents, and medical professionals while reducing the societal costs of vaccination.
Article
Virology
Ozgur M. Koc, Eva van Oorschot, Lloyd Brandts, Astrid Oude Lashof
Summary: This study evaluated the optimal timing of primary three-dose hepatitis B vaccination and postvaccination serologic testing (PVST) among a large group of healthy naive adults in the Netherlands. The results showed that PVST should be obtained 1-2 months after the last vaccination, and a delayed PVST was the main factor for lower seroprotection rates after the primary vaccination schedule. Furthermore, the hepatitis B vaccination allows flexibility for the second and third dose without restarting the vaccination series or confirmation of immune response.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Richard M. Mihigo, Joseph C. Okeibunor, Fahmy Karmal, Helena O'Malley, Natasha Godinho, Linda Okero, Alain N. Poy, Ouma Onyango, Niamh Fitzgerald
Summary: While progress has been made in immunization in African countries, it has stagnated in recent years. The lack of immunization coverage and outbreaks of vaccine-preventable diseases highlight existing challenges. A study in 2022 explores the impact of political will on the immunization agenda and the importance of fulfilling immunization commitments in a post-COVID world.
Article
Public, Environmental & Occupational Health
Oluwafemi Balogun, Ashley Brown, Kristina M. Angelo, Natasha S. Hochberg, Elizabeth D. Barnett, Laura Ambra Nicolini, Hilmir Asgeirsson, Martin P. Grobusch, Karin Leder, Fernando Salvador, Lin Chen, Silvia Odolini, Marta Diaz-Menendez, Federico Gobbi, Bradley A. Connor, Michael Libman, Davidson H. Hamer
Summary: Non-immune international travelers are at risk of acquiring hepatitis A, even when traveling to low-endemicity destinations. Providing pre-departure hepatitis A vaccine to susceptible travelers is crucial to reducing travel-associated hepatitis A.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Immunology
Dasha Shamarina, Martina Sluga-O'Callaghan, George Kassianos, Alen Marijam, Vaidehi Dave, Eric Davenport, Anar Andani, Desmond Curran, Pavitra Dewda, Robert Steffen
Summary: Despite hepatitis A and hepatitis B outbreaks in Europe, not all European countries have implemented vaccinations for at-risk adults. An online survey among healthcare professionals in Germany, Spain, and the United Kingdom found that most professionals were familiar with national vaccination recommendations and followed them when advising or prescribing vaccines. Non-disclosure of risk factors by patients and lack of patient motivation or knowledge about the disease were the main barriers to recommending or administering vaccines.
Article
Microbiology
Nariman Kareem, Khaled Al-Salahat, Faris G. Bakri, Yaser Rayyan, Azmi Mahafzah, Malik Sallam
Summary: The study investigated the prevalence of HAV IgG in Jordan and found that sero-prevalence increased with age, with the estimated age at mid-population immunity being between 21 and 30 years. Individuals residing outside the Central region of Jordan had a significantly higher HAV sero-prevalence.
Article
Infectious Diseases
Marianna Riekkinen, Sari H. Pakkanen, Veronik Hutse, Inge Roukaerts, Jukka Ollgren, Helena Kayhty, Christian Herzog, Lars Rombo, Anu Kantele
Summary: This study examined the influence of coadministration of HepA and PCV13 on safety and immunogenicity. The results showed that coadministration of PCV13 significantly impaired antibody responses to HepA, but did not impact the response to PCV13. Overall, there were no major safety concerns.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Vincenza Gianfredi, Antonietta Filia, Maria Cristina Rota, Roberto Croci, Lorenzo Bellini, Anna Odone, Carlo Signorelli
Summary: Ensuring timely access to affordable vaccines is a global public health priority, as highlighted during the COVID-19 pandemic. Effective vaccine procurement strategies are essential to achieve this goal. Research in this area needs to clarify key concepts, describe main procurement methods, and identify future perspectives.
Article
Immunology
Chao Wang, Ninghua Huang, Qing-Bin Lu, Steven Black, Xiaofeng Liang, Fuqiang Cui
Summary: The study found that after the implementation of the vaccine administration law in China, the number of adverse event reaction (AEFI) reports related to HepB vaccine significantly increased, with the majority being common reactions and rare reactions mainly being anaphylactic reactions. Children receiving multiple vaccines were more likely to experience fever, anaphylaxis, and febrile convulsions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Elizabeth A. Donckels, Luke Cunniff, Nina Regenold, Kaitlyn Esselman, Erik Muther, Alexandra Bhatti, Amanda L. Eiden
Summary: The COVID-19 pandemic has brought attention to the use of immunization information systems (IIS) for recording and consolidating immunization records to generate comprehensive patient immunization histories. The operationalization of IIS in the United States is decentralized, resulting in wide variations in policies and functionalities of over 60 different IIS. A targeted literature review was conducted to assess the impact of IIS policies and functionalities, with provider-based patient reminder/recall, IIS-based centralized reminder/recall, and clinical decision support being the most commonly evaluated components.
Article
Public, Environmental & Occupational Health
Mingming Shu, Dandan Zhang, Rui Ma, Tianchi Yang, Xingqiang Pan
Summary: This study evaluates the long-term efficacy of the 2-dose varicella vaccine in China and analyzes its influencing factors. The overall efficacy of the vaccine compared to no vaccine is 90.31% and the incremental efficacy compared to the 1-dose vaccine is 64.71%. The age of the second dose and the interval between 2 doses are both associated with efficacy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Immunology
Christopher L. D. McMillan, Paul R. Young, Daniel Watterson, Keith J. Chappell
Summary: Current influenza virus vaccines mainly induce antibodies against the highly variable head domain of the hemagglutinin protein, but these antibodies are often strain-specific, resulting in limited cross-protection. Therefore, the annual update of vaccine formulations to counteract the challenge of influenza virus evolution is crucial.
Article
Immunology
Tianli Lin, Xiaojing Chi, Xiuying Liu, Shengnan Pan, Wenfang Chen, Huarui Duan, Xinhui Zhang, Wei Yang
Summary: This study designed and produced recombinant E1E2 antigens for genotypes 1a/1b/2a/3a/6a, which were found to elicit a pangenotypic antibody response and showed higher and more uniform neutralizing antibody titer and T cell response when formulated as a pentavalent antigen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Matthew Jalink, Joanne M. Langley
Summary: There is substantial variation in qualifications for RSV prevention with palivizumab among Canadian provinces and territories, and none of them strictly adhere to the guidelines set by the Canadian Paediatric Society. The differences in subnational policies may be due to factors such as resource availability, interpretation of efficacy evidence, epidemiological variations, local pressures, or advocacy efforts.
PAEDIATRICS & CHILD HEALTH
(2021)
Review
Immunology
Melissa K. Andrew, Shelly A. McNeil
Summary: In Canada, public health efforts for influenza prevention are multi-pronged and include vaccination programs and surveillance. Recommendations are made nationally by NACI, but vaccination programs vary by province/territory.
Article
Geriatrics & Gerontology
Desmond Curran, Joon H. Kim, Sean Matthews, Christophe Dessart, Myron J. Levin, Lidia Oostvogels, Megan E. Riley, Kenneth E. Schmader, Anthony L. Cunningham, Shelly A. McNeil, Anne E. Schuind, Melissa K. Andrew
Summary: Frail participants, including frail older adults, had a high efficacy of recombinant zoster vaccine against herpes zoster, with a reduced risk of adverse events as frailty increased.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Melissa K. Andrew, Sarah MacDonald, Judith Godin, Janet E. McElhaney, Jason LeBlanc, Todd F. Hatchette, William Bowie, Kevin Katz, Allison McGeer, Makeda Semret, Shelly A. McNeil
Summary: This study investigated the persistent functional change in older adults admitted to hospital with influenza and other acute respiratory illness (ARI). It found that higher baseline frailty was associated with increased odds of experiencing functional decline, catastrophic disability, and death, with similar risks observed for influenza and other ARI admissions.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Immunology
Ashleigh McGirr, Tara Bourgoin, Michael Wortzman, Brad Millson, Shelly A. McNeil
Summary: This study evaluated the second-dose completion of RZV in Canada, finding high but suboptimal completion rates, indicating the need for further research to understand the factors influencing second dose timing and completion in order to improve series completion.
Article
Public, Environmental & Occupational Health
Kieran J. Moore, David Greencorn, Nadine Smith, Joanne M. Langley, Ketan Kulkarni
Summary: This study found that mechanical complications of CVCs are common and significant in the pediatric population, with the highest risk seen in non-tunneled lines. The authors suggest that CVC-associated mechanical complications should be routinely reported as a patient safety outcome.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Immunology
Blanche Oguti, Asad Ali, Nick Andrews, Daan Barug, Duc Anh Dang, Scott A. Halperin, Ha Thi Thu Hoang, Beth Holder, Beate Kampmann, Abdul M. Kazi, Joanne M. Langley, Elke Leuridan, Naomi Madavan, Kirsten Maertens, Herberth Maldonado, Elizabeth Miller, Flor M. Munoz-Rivas, Saad B. Omer, Andrew J. Pollard, Thomas F. Rice, Nynke Rots, Maria E. Sundaram, Nasamon Wanlapakorn, Merryn Voysey
Summary: This study aimed to calculate the half-lives of passively acquired diphtheria, tetanus, and pertussis antibodies in infants. The decay rates of maternal antibodies were found to vary for different antigens but were not significantly influenced by demographic or vaccine characteristics.
Article
Biotechnology & Applied Microbiology
Jeanna Parsons Leigh, Donna Halperin, Sara J. Mizen, Emily A. FitzGerald, Stephana Julia Moss, Kirsten M. Fiest, Antonia Di Castri, Henry T. Stelfox, Scott Halperin
Summary: This study explored the influence of media and information on individuals' intentions to vaccinate against COVID-19 and found that while many people intended to vaccinate, concerns and hesitancy still exist. Confidence, complacency, and convenience are key factors influencing vaccination intentions.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Pediatrics
Jennifer B. Frazer, Dafydd A. Davies, Joanne M. Langley
Summary: This report presents a case of a newborn with a Staphylococcus aureus infection of a branchial cleft anomaly (BCA) and reviews the characteristics and frequency of infection of this congenital anomaly over 18 years at our center. It is found that 6% of patients presented as neonates and 42% of BCAs became infected.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Terra A. Manca, Manish Sadarangani, Scott A. Halperin, Joanne M. Langley, Elisabeth McClymont, Shannon E. MacDonald, Karina A. Top
Summary: Exclusion of pregnant and breastfeeding women from COVID-19 vaccine trials has led to knowledge gaps, vaccine hesitancy, and misinformation. Inclusion of these populations in trials should be prioritized and regulatory authorities can play a crucial role.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Khaled Alsager, Nirma Khatri Vadlamudi, Taj Jadavji, Julie A. Bettinger, Cora Constantinescu, Wendry Vaudry, Ben Tan, Laura Sauve, Manish Sadarangani, Scott A. Halperin, Karina A. Top
Summary: This study characterized Kawasaki disease cases reported to the Canadian Immunization Monitoring Program ACTive (IMPACT) between 2013 and 2018. Cases primarily occurred within 0-42 days following vaccination and showed temporal association with diphtheria-tetanus acellular pertussis and pneumococcal conjugate vaccines. Echocardiogram results indicated abnormality in about half of the cases.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Public, Environmental & Occupational Health
David J. Greencorn, Stefan Kuhle, Lingyun Ye, Kieran J. Moore, Ketan P. Kulkarni, Joanne M. Langley
Summary: Risk factors for mechanical complications in children with PICCs have been identified, which can improve best practices for PICC insertion and care.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Zourab Bebia, Osvaldo Reyes, Robert Jeanfreau, Anu Kantele, Ruth Graciela De Leon, Marta Garcia Sanchez, Peyman Banooni, Glenn J. Gardener, Jose Luis Bartha Rasero, Maria Begona Encinas Pardilla, Joanne M. Langley, Claudio Maanon Di Leo, Elisabeth Botelho-Nevers, Jim Buttery, Helene Laurichesse, Shabir A. Madhi, Adrian Martin Garcia, Thorsten Stanley, Tiphaine Barjat, Rebecca Griffith, Maria Mercedes Castrejon-Alba, Magali de Heusch, Ilse Dieussaert, Melanie Hercor, Patricia Lese, Hui Qian, Antonella N. Tullio, Ouzama Henry
Summary: Maternal vaccination with RSVPreF3 during late pregnancy has an acceptable safety risk profile and induces robust RSV-specific immune responses with successful antibody transfer to newborns.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Janet A. Englund, Rachel A. Cohen, Veronique Bianco, Joseph B. Domachowske, Joanne M. Langley, Shabir A. Madhi, Khalequ Zaman, Agustin Bueso, Ana Ceballos, Luis Cousin, Sanjay Gandhi, Olivier Gruselle, Lisa Jose, Nicola P. Klein, Anthonet Koen, Thanyawee Puthanakit, Meng Shi, Peter Silas, Auchara Tangsathapornpong, Jamaree Teeratakulpisarn, Timo Vesikari, Gerco Haars, Amanda Leach, Sonia K. Stoszek, Ilse Dieussaert
Summary: Respiratory syncytial virus (RSV) causes respiratory illnesses ranging from common cold to moderate and severe lung disease. Symptoms and methods used to identify/track RSV disease are not always the same in different settings. Three definitions of RSV disease were compared with the World Health Organization (WHO) recommendation in 2015. A universal definition of RSV disease and severity is needed for effective treatment and prevention measures.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)