Article
Infectious Diseases
Haijin Liu, Jianxia Tian, Kejia Lu, Yangyang Li, Zhao Guan, Xuhong Cao, Xiaoqin Li, Zhengwu Chang, Xinglong Wang, Xiao Sa, Zengqi Yang
Summary: This research identified chicken interferon-stimulated gene 12-2 as a potential adjuvant that can attenuate the virulence of Newcastle disease virus and increase the immunogenicity of the vaccine strain. It may contribute to the development of efficient poultry vaccines.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Immunology
Anthony C. Ike, Chukwuebuka M. Ononugbo, Okechukwu J. Obi, Chisom J. Onu, Chinasa V. Olovo, Sophia O. Muo, Okoro S. Chukwu, Eleazar E. Reward, Odinakachukwu P. Omeke
Summary: Infectious bronchitis (IB) and Newcastle disease (ND) remain major threats to the poultry industry worldwide. Despite numerous vaccines developed against these viruses, rapid genetic variations pose a challenge to effective control. Various strategies, such as combining live attenuated and inactivated vaccines, developing IB/ND vaccines, and using DNA vaccines and transgenic plant vaccines, are being utilized to address this issue. Increasing understanding of immunological mechanisms in birds is crucial for successful disease control and global food security.
Article
Microbiology
Rui Yang, Shubo Zhang, Yue Yu, Xinya Hong, Dan Wang, Yanlong Jiang, Wentao Yang, Haibin Huang, Chunwei Shi, Yan Zeng, Nan Wang, Xin Cao, Jianzhong Wang, Chunfeng Wang
Summary: The study demonstrates that bacterium-like particles (BLPs) can induce effective immune responses in chickens, which enhances protection against Newcastle disease virus (NDV).
VETERINARY MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fang Huang, Chuanjing Dai, Youni Zhang, Yuqi Zhao, Yigang Wang, Guoqing Ru
Summary: This article discusses the biological properties of NDV, the antitumor molecular mechanisms of oncolytic NDV, and its application in tumor therapy. Additionally, new insights are presented on the challenges that NDV will face and suggestions for increasing NDV's therapeutic efficacy in cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Fiona Ingrao, Victoria Duchatel, Isabel Fernandez Rodil, Mieke Steensels, Eveline Verleysen, Jan Mast, Benedicte Lambrecht
Summary: Recombinant Newcastle disease viruses (rNDV) have been used as bivalent vectors for vaccination against multiple economically important avian pathogens. NDV-vectored vaccines expressing the immunogenic H5 hemagglutinin (rNDV-H5) are considered attractive candidates to protect poultry from both highly pathogenic avian influenza (HPAI) and Newcastle disease (ND). The study compared a rNDV-H5 vaccine and its parental NDV LaSota strain in terms of their structural and functional characteristics, as well as their recognition by the innate immune sensors.Structural analysis of the rNDV-H5 demonstrated a decreased number of fusion (F) and a higher number of hemagglutinin-neuraminidase (HN) glycoproteins compared to NDV LaSota.
Article
Immunology
Hesham A. Sultan, Wael K. Elfeil, Ahmed A. Nour, Laila Tantawy, Elsayed G. Kamel, Emad M. Eed, Ahmad El Askary, Shaimaa Talaat
Summary: Class II genotype VII Newcastle disease viruses (NDV) are prevalent in the Middle East and Asia despite extensive vaccination efforts. This study evaluated the protective efficacy of three different commercial vaccine regimes against challenge with a virulent NDV genotype VII strain. The results indicate that using closely genotype-matched vaccines provides higher protection against challenge compared to using non-matched or non-genotype-matched vaccines. Regular updating of vaccine seeds with closely related isolates is crucial for enhancing protection levels.
Article
Multidisciplinary Sciences
D. G. Roy, K. Geoffroy, M. Marguerie, S. T. Khan, N. T. Martin, J. Kmiecik, D. Bobbala, A. S. Aitken, C. T. de Souza, K. B. Stephenson, B. D. Lichty, R. C. Auer, D. F. Stojdl, J. C. Bell, M-C Bourgeois-Daigneault
Summary: Vaccination with oncolytic viruses co-administered with tumour antigenic peptides is as efficient as antigen-engineered oncolytic viruses, providing a potential alternative for personalized anti-cancer vaccines targeting patient-specific mutations.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jianzhong Wang, Qiguan Lan, Xianchun Zong, Guangmei Zhu, Rui Yang, Guilian Yang, Yanlong Jiang, Wentao Yang, Haibin Huang, Chunwei Shi, Yan Zeng, Nan Wang, Xin Cao, Chunfeng Wang
Summary: An effective mucosal subunit vaccine based on bacterium-like particles (BLPs) was developed, which provided up to 90% protection against genotype VII Newcastle disease virus (NDV) infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Genetics & Heredity
Juanjuan Huang, Tingting Zheng, Ying Liang, Ying Qin, Xing Wu, Xiaohui Fan
Summary: When tumor cells are infected by the Newcastle disease virus (NDV), the lysis of tumor cell by natural killer (NK) cells is enhanced. Transcriptome analysis of NK cells stimulated by NDV-infected hepatocellular carcinoma (HCC) cells identified 1568 differentially expressed genes (DEGs), including 1389 upregulated and 179 downregulated genes. Functional analysis revealed enrichment of DEGs in immune system, signal transmission, cell growth, cell death, and cancer pathways. Increased expression of 9 IFN family genes in NK cells upon NDV infection suggests their potential as prognosis markers for patients with HCC.
Article
Immunology
Qilong Qiao, Mingzhen Song, Congcong Song, Yihang Zhang, Xiangdong Wang, Qing Huang, Baiyu Wang, Panpan Yang, Shiyi Zhao, Yongtao Li, Zeng Wang, Jun Zhao
Summary: Newcastle disease virus (NDV) and infectious bursal disease virus (IBDV) are two of the most economically damaging viruses in the global poultry industry. A genetically matched chimeric NDV LaSota vaccine strain expressing IBDV VP2 gene has been successfully developed, providing full protection against both genotype VII NDV and IBDV.
Article
Gastroenterology & Hepatology
Wen-Qiang He, Guan Nan Guo, Chenxi Li
Summary: The study demonstrates that the hepatitis B vaccine has been highly effective in preventing HBV infection since its inclusion in the infant immunization schedule in the US in 1991. For participants who received three or more doses of the vaccine, it also showed a reduction in all-cause mortality and cancer-related mortality.
Article
Chemistry, Multidisciplinary
Tong Guo, Xiuli Liu, Zhikun Zhang, Yiqun Luo, Tong Li, Lan Li, Huixue Wang, Yong Huang, Jian He, Qiaoying Chen, Yongxiang Zhao, Lu Gan, Liping Zhong
Summary: The study on using matrix metalloproteinase to enhance oncolytic virus (NDV-MMP8) spread in tumors showed that in vitro and in vivo experiments, NDV-MMP8 can effectively degrade extracellular matrix, promote virus spread, and reduce tumor growth.
CHINESE CHEMICAL LETTERS
(2021)
Review
Veterinary Sciences
Qian Mao, Shengming Ma, Philip Luke Schrickel, Pengwei Zhao, Jingya Wang, Yuhua Zhang, Shuangyu Li, Chengbao Wang
Summary: The review summarizes the latest research on Newcastle disease virus, including history, molecular structure, infection mechanism, and various detection strategies; it analyzes the performance of different detection methods, and also discusses the limitations of currently available strategies.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Alessandro Manenti, Niccolo Solfanelli, Paolo Cantaloni, Livia Mazzini, Margherita Leonardi, Linda Benincasa, Giulia Piccini, Serena Marchi, Martina Boncioli, Chiara Spertilli Raffaelli, Danilo Tacconi, Giada Mattiuzzo, Otfried Kistner, Emanuele Montomoli, Claudia Maria Trombetta
Summary: This study aimed to evaluate a possible approach to performing Monkeypox and vaccinia live-virus microneutralization assays. The results confirmed the presence and cross-reactivity of antibodies elicited by vaccinia-based vaccines, which were able to neutralize the Monkeypox virus in the presence of an external source of complement.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Veterinary Sciences
Zenglei Hu, Xiaozheng He, Jing Deng, Jiao Hu, Xiufan Liu
Summary: Newcastle disease is a highly economically damaging infectious disease affecting poultry, causing severe tissue damage in multiple systems. Progress has been made in preventing morbidity and mortality caused by the virus. However, the virus is still endemic in some regions, impacting the livelihoods of people dependent on poultry for food.
VETERINARY RESEARCH
(2022)
