Article
Biology
Irene Man, Damien Georges, Maxime Bonjour, Iacopo Baussano, Belinda Nicolau
Summary: Local cervical cancer epidemiological data are often missing, so we developed the Footprinting framework to approximate missing data and made context-specific impact projections for cervical cancer prevention measures in India. Two patterns of cervical cancer incidence were identified, and missing data on incidence and HPV prevalence were approximated based on available data within each cluster. This framework assists public health decisions on cervical cancer prevention not only in India but also in other countries.
Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Review
Biochemistry & Molecular Biology
Yi Liu, Hejing Liu, Bo Sheng, Shuya Pan, Zhi-wei Wang, Xueqiong Zhu
Summary: This review describes the incidence and development of HPV-negative cervical cancer, pointing out the differences in diagnosis, age, stage, and prognosis between HPV-negative and HPV-positive cervical cancer. Furthermore, the significant role and functions of lncRNAs in HPV-negative cervical cancer are clarified.
Article
Oncology
Brhanu Teka, Muluken Gizaw, Ededia Firdawoke, Adamu Addissie, Tesfamichael Awoke Sisay, Carola Schreckenberger, Anna Sophie Skof, Sarah Thies, Adane Mihret, Eva Johanna Kantelhardt, Tamrat Abebe, Andreas M. Kaufmann
Summary: This study compared the performance and adequacy of three HPV genotyping assays on samples from rural women in south-central Ethiopia. The three evaluated assays showed similar analytical performance in the detection of hr-HPV infections and moderate or better concordance in HPV genotyping.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Maria Hortlund, Tine van Mol, Frederik Van de Pol, Johannes Bogers, Joakim Dillner
Summary: HPV-based cervical screening is a globally recommended health policy, with sensitivity and specificity varying for different HPV types at different viral loads. Testing for HPV16 and 18 at low viral load significantly increases sensitivity for cervical cancer, while testing for HPV types 31, 33, 45, and 52 also improves prediction sensitivity. However, for some HPV types, detection of low viral load does not further increase sensitivity.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Maria Kyrgiou, Anna-Barbara Moscicki
Summary: The microbiome in the female reproductive tract plays a crucial role in maintaining health and homeostasis. Imbalances in the genital tract microbiome and specific bacteria and cytokines may contribute to the development of HPV infection and cervical intra-epithelial neoplasia, leading to cervical cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marianna Martinelli, Chiara Giubbi, Laura Saderi, Rosario Musumeci, Federica Perdoni, Biagio Eugenio Leone, Robert Fruscio, Fabio Landoni, Andrea Piana, Giovanni Sotgiu, Clementina Elvezia Cocuzza
Summary: HPV genotyping and viral load may serve as potential diagnostic biomarkers for high-grade cervical lesions. This study evaluated a new HPV test and found that the distribution of HR-HPV genotypes and viral copy numbers differed between women with high- and low-grade cervical lesions. These findings suggest that HPV genotyping and normalized viral load may help identify women at increased risk of cervical lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Uraiwan Khomphaiboonkij, Nattapong Sreamsukcharoenchai, Supakorn Pitakkarnkul, Kristsanamon Rittiluechai, Siriwan Tangjitgamol
Summary: Knowledge about cervical cancer screening and HPV is important for women's awareness and adherence to the screening program. This study found that only 26.9% of women had good knowledge about cervical cancer screening, and similarly, only 20.1% of women who had heard about HPV had good knowledge about it. Providing information about these topics could improve women's knowledge and increase their participation in screening procedures.
Review
Oncology
Shuang Zhao, Liuye Huang, Partha Basu, Efren Javier Domingo, Wisit Supakarapongkul, Woo Yin Ling, Dwiana Ocviyanti, Remila Rezhake, Youlin Qiao, Eng Hseon Tay, Fanghui Zhao
Summary: Multiple barriers hinder the implementation of cervical cancer screening in ASEAN countries, including inequity, lack of service availability, knowledge deficit, and insufficient funding. Only a few countries have initiated population-based screening programs with low participation rates. Tailored solutions and improved health education are crucial in promoting cervical cancer prevention efforts.
Article
Virology
Vijayalakshmi Ramshankar, Soundharya Ravindran, Komathi Arun, Kanchana Albert, Sakthi Lalitha Sri, Lalitha Ramasubramanian, Banumathy Satyaseelan
Summary: Cervical cancer can be eliminated by 2030 through a global strategy that includes HPV vaccination for young girls, screening for women aged 30-69, and treatment for women with precancerous lesions. However, implementing these strategies in countries like India poses challenges. A study using Cobas 4800 HPV test in a community screening program in South India found a high prevalence of high-risk HPV in younger women (30-40 years old) and a second peak in women aged 46-50.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi Yuan, Xushan Cai, Fangrong Shen, Feng Ma
Summary: HPV infection is closely linked to cervical cancer, with the post-infection microenvironment (PIM) playing a crucial role in viral persistence and malignant progression. Targeting the PIM may be a potential strategy to enhance therapeutic outcomes for cervical cancer.
Article
Oncology
Smita Joshi, Richard Muwonge, Vinay Kulkarni, Mahesh Mandolkar, Eric Lucas, Sanjay Pujari, Rengaswamy Sankaranarayanan, Partha Basu
Summary: This study provides updated incidence rates of cervical intraepithelial neoplasia (CIN) among women living with HIV (WHIV), and examines disease outcomes and HPV status among women treated for CIN. The study found that women who cleared HPV infection had a significantly increased risk of incident CIN 2 or worse lesions, while those with persistent HPV infection had an even higher risk of such lesions. The study also highlights the importance of long-term surveillance and the possibility of extending screening intervals among HPV negative women.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Public, Environmental & Occupational Health
Mohan Narasimhamurthy, Santhosh Upadhyaya Kafle
Summary: Nepal has a high burden of cervical cancer due to limited screening programs. Despite efforts by the Ministry of Health and Population and international collaborations, the current prevention and treatment methods are inadequate to meet WHO's goals. This article provides an overview of Nepal's efforts to address the growing burden of cervical cancer and discusses potential challenges and solutions.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T. Goodman, Nancy A. Hessol, Beatriz Grinsztejn, Ana P. Ortiz, Fanghui Zhao, Erna M. Kojic, Rupert Kaul, Isabelle Heard, Imran O. Morhason-Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M. Palefsky, Luana L. S. Rodrigues, Racheal S. Dube Mandishora, Reshmie A. Ramautarsing, Silvia Franceschi, Sheela Godbole, Fernanda K. Tso, Lynette J. Menezes, Chunqing Lin, Gary M. Clifford
Summary: Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections may persist longer, or occur later in life, in the anus than cervix. This has important implications for using cervical screening results to direct anal cancer prevention.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Infectious Diseases
Cindy Simoens, Tarik Gheit, Ruediger Ridder, Ivana Gorbaslieva, Dana Holzinger, Eric Lucas, Susanne Rehm, Peter Vermeulen, Martin Lammens, Olivier M. Vanderveken, Rekha Vijay Kumar, Nitin Gangane, Alessandro Caniglia, Fausto Maffini, Maria Belen Lloveras Rubio, Devasena Anantharaman, Susanna Chiocca, Paul Brennan, Madhavan Radhakrishna Pillai, Rengaswamy Sankaranarayanan, Johannes Bogers, Michael Pawlita, Massimo Tommasino, Marc Arbyn
Summary: This study analyzed the accuracy of three testing strategies for diagnosing HPV-induced oropharyngeal cancer. Single hrHPV DNA PCR and p16(INK4a) IHC showed high sensitivity, but low specificity, while combined testing had higher sensitivity and specificity.
BMC INFECTIOUS DISEASES
(2022)
Article
Virology
Assunta Venuti, Maria Carmen Romero-Medina, Giusi Melita, Maria Grazia Ceraolo, Rosario Nicola Brancaccio, Cecilia Sirand, Valerio Taverniti, Renske Steenbergen, Tarik Gheit, Massimo Tommasino, Lori Frappier
Summary: Lyon IARC PyV is a recently discovered polyomavirus that shares structural similarities with known oncogenic pyroviruses in animals and humans. This study shows that LIPyV is capable of promoting cellular transformation in primary human cells, indicating a possible oncogenic role in domestic animals and/or humans. The study also highlights a novel mechanism of gene expression activation involving the accumulation of the Sp1 transcription factor.
JOURNAL OF VIROLOGY
(2022)
Article
Oncology
Martina Taborelli, Federica Toffolutti, Ettore Bidoli, Luigino Dal Maso, Stefania Del Zotto, Elena Clagnan, Michele Gobbato, Diego Serraino, Silvia Franceschi
Summary: This study described the practice of PSA testing in Friuli Venezia Giulia, Italy over a period of more than 20 years. Population-based data from regional administrative health-related databases were used. The number of PSA tests steadily increased over time but decreased in recent years. The biopsy rate also showed a similar pattern, with an initial increase followed by a decrease.
Article
Oncology
Tarik Gheit, Richard Muwonge, Eric Lucas, Luisa Galati, Devasena Anantharaman, Sandrine McKay-Chopin, Sylla G. Malvi, Kasturi Jayant, Smita Joshi, Pulikkottil O. Esmy, M. Radhakrishna Pillai, Partha Basu, Rengaswamy Sankaranarayanan, Massimo Tommasino
Summary: This study compared the prevalence of oral HPV infections in women vaccinated with different doses of HPV vaccine and found that three doses of the vaccine were more effective in preventing oral HPV infection compared to a single dose.
Article
Public, Environmental & Occupational Health
Jean-Marc Kutz, Pia Rausche, Tarik Gheit, Dewi Ismajani Puradiredja, Daniela Fusco
Summary: This review synthesizes the factors influencing the successful implementation of HPV vaccination programs in sub-Saharan Africa in order to improve roll-out and coverage. The review provides an overview and contextualizes the barriers and facilitators of HPV vaccination implementation in 12 countries in sub-Saharan Africa. Lessons learned from past experiences of HPV vaccination in sub-Saharan Africa can contribute to more effective national HPV vaccination programs targeted at eliminating cervical cancer and implementing the WHO triple intervention strategy.
Article
Dermatology
Manuelle Viguier, Corine Perals, Beatrice Poirier, Maxime Battistella, Francois Aubin, Herve Bachelez, Jean-Luc Pretet, Tarik Gheit, Massimo Tommasino, Antoine Touze, Marie-Lise Gougeon, Nicolas Fazilleau
Summary: Lichen planus (LP) is a chronic inflammatory disease characterized by CD8(+) T-cell infiltrate, and HPV16-specific CD8(+) T-cells are involved in different clinical forms of LP. Lichen sclerosus et atrophicus (LSA) has a different immune response, with oligoclonal TCRVss6(+) CTL repertoire.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Virology
Luana Lorena Silva Rodrigues, Jose Henrique Pilotto, Katrini Guidolini Martinelli, Alcina F. Nicol, Vanessa Salete De Paula, Tarik Gheit, Nathalia Silva Carlos Oliveira, Carlos Silva-de-Jesus, Vikrant V. Sahasrabuddhe, Diane M. Da Silva, W. Martin Kast, Justin Hardick, Charlotte A. Gaydos, Mariza Goncalves Morgado
Summary: The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajos region, Amazon, Brazil. The overall prevalence of anal HPV infection was high, especially in HIV-infected women. The concordance analysis showed moderate to fair agreement between anal and genital HPV and non-HPV STIs.
Article
Oncology
Gary M. Clifford, Iacopo Baussano, Danielle A. M. Heideman, Sangay Tshering, Tashi Choden, Fulvio Lazzarato, Vanessa Tenet, Silvia Franceschi, Teresa M. Darragh, Tashi Tobgay, Ugyen Tshomo
Summary: The REACH-Bhutan study aimed to evaluate the feasibility and clinical performance of a community-based screening program for cervical cancer in rural Bhutan using self-collected samples for high-risk human papillomavirus (HR-HPV) testing. The results showed that screening with self-collection of samples and HR-HPV testing can effectively detect women with high-grade squamous intraepithelial lesions or worse (hHSIL+).
Article
Microbiology
Amina Gihbid, Amal El Amrani, Fatima Zahra Mouh, Tarik Gheit, Mustapha Benhessou, Mariam Amrani, Sandrine McKay-Chopin, Selma Mohamed Brahim, Souha Sahraoui, Abdelouaheb Bennani, Mohammed El Mzibri, Meriem Khyatti
Summary: Breast cancer is the most common cancer in women worldwide, accounting for a significant percentage of new cancer cases and deaths. A study in Morocco explored the presence of viral DNA in breast cancer tissues and found a high prevalence of Epstein-Barr virus (EBV), suggesting its potential role in breast cancer development and progression.
Article
Immunology
Walid A. Al-Soneidar, Sam Harper, Francois Coutlee, Tarik Gheit, Massimo Tommasino, Belinda Nicolau
Summary: This study investigated the prevalence of alpha (α), beta (β), and gamma (γ) human papillomaviruses (HPVs) among head and neck cancer (HNC) cases and controls, and their relationship with sociodemographic, behavioral, and oral health factors. The findings showed that the prevalence of α- and γ-HPV was associated with sexual activity, smoking, and drinking habits, while the prevalence of β-HPV was not. Tumor samples mainly included α-HPV, with HPV-16 being the most common genotype.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Nilanjana Chatterjee, Farhin Sultana, Rituparna Roy, Samyadipta Dey, Sukanya Naskar, Aniruddha Dam, Anup K. Bhowmick, Rakiba Begum, Shyam S. Mandal, Ranajit K. Mandal, Jayanta Chakrabarti, Chinmay K. Panda, Massimo Tommasino, Tarik Gheit, Sankhadeep Dutta
Summary: This study investigated the prevalence of novel-HPV 223 and 225 in oral mucosa and keratinized skin epithelium. HPV 223 was found to be present only in the oral mucosal epithelium, while HPV 225 was found in both oral mucosa and skin epithelium.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Taja Lozar, Aysenur Keske, Racheal S. Dube Mandishora, Qiqi Yu, Adam Bailey, Jin Xu, Massimo Tommasino, Stephanie M. Mcgregor, Paul F. Lambert, Tarik Gheit, Megan B. Fitzpatrick
Summary: This study is the first to report the association between p16-negative vulvar squamous intraepithelial lesions and detection of beta-HPVs. These findings expand possible etiologic mechanisms that may contribute to p16-negative lesions of the vulva.
Article
Oncology
Abbas Karimi, Tohid Jafari-Koshki, Mojtaba Zehtabi, Farzaneh Kargar, Tarik Gheit
Summary: Liquid biopsy using HPV ctDNA can predict the rate of relapse or recurrence after treatment, with post-treatment measurement being more effective than baseline assessment. HPV ctDNA could be used as a surrogate or incorporated with other methods for detecting residual disease.
