Journal
VACCINE
Volume 28, Issue 1, Pages 120-131Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.09.095
Keywords
HPV; Cervical cancer; Vaccine designing; DNA vaccine; Clinical informatics
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HPV vaccines available in the market are not effective against different strains of papillomavirus, therefore, there is a need to develop a new prophylactic DNA vaccine which can work against different strains of HPVs and may lead to protection of cervical cancer against new pandemic viruses We designed a potential prophylactic DNA vaccine by using all the consensus epitopic sequences of HPVs L2 capsid protein and performed in silica cloning of multiepitopic antigenic DNA sequence in pVAX-1 vector Immunogenicity of vaccine has been enhanced by techniques like codon optimization, engineering CpG motifs, introducing promoters and co-injection with plasmids expressing immune-stimulatory molecules (C) 2009 Elsevier Ltd All rights reserved
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