Article
Infectious Diseases
Yuying Fu, Lishan Zhang, Huanhuan Song, Junyan Liao, Li Lin, Wenjia Jiang, Xiaoyun Wu, Guibin Wang
Summary: This study investigates the role of lysine acetylation and succinylation in the antibiotic resistance mechanism of Edwardsiella tarda. The results demonstrate that these post-translational modifications play important roles in bacterial antibiotic resistance and are enriched in various metabolic pathways. The findings provide insights into the mechanism of antibiotic resistance and may aid future research on the pathogenesis of this bacterium.
Article
Multidisciplinary Sciences
Jernej Pusnik, Werner O. Monzon-Posadas, Jasmin Zorn, Kathrin Peters, Maximilian Baum, Hannah Proksch, Celina Beta Schlueter, Galit Alter, Tanja Menting, Hendrik Streeck
Summary: According to the research data, receiving two doses of mRNA vaccine along with a booster dose, recovering from a breakthrough infection, or both, provides better B cell immunity. Individuals who received three doses of the vaccine and experienced breakthrough infections with the omicron variant showed a particularly strong B cell response. Additional antigen exposure did not significantly affect the T cell response after two doses of the vaccine. Individuals with hybrid immunity exhibited better correlated adaptive immune responses.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyan Wu, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: In this study, researchers investigated the protective immune responses induced by an inactivated Edwardsiella tarda vaccine in flounder. The results showed that the vaccine significantly increased the proportions of CD4+ T and CD8+ T lymphocytes, as well as IgM+ B lymphocytes, in the vaccinated group. The vaccine also upregulated the expression of immune-related genes and increased the levels of immune enzymes. Moreover, the vaccine conferred a relative percent survival (RPS) of 54.76%, and reduced the bacterial load in the spleen and head kidney of the vaccinated fish. These findings demonstrate the strong protective efficacy of the vaccine against E. tarda infection in flounder.
MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Wojciech Witkowski, Sarah Gerlo, Evelien De Smet, Magdalena Wejda, Delphine Acar, Steven Callens, Stefan Heytens, Elizaveta Padalko, Hanne Vercruysse, Piet Cools, Linos Vandekerckhove
Summary: This study analyzed the humoral response to the BNT162b2 vaccine among nursing home residents and staff. The results showed significantly decreased serum antibody levels and neutralization titers among nursing home residents, with a high proportion of non-responders. Additionally, a significant decrease in antibody titers was observed three months post-vaccination in COVID-19-naive nursing home residents. Flow cytometry and interferon gamma secretion analyses indicated that antibody non-responders also failed to mount cellular responses. This study highlights the need for additional measures and continued monitoring in the population of frail elderly individuals.
Article
Medicine, General & Internal
Natalia Syrimi, Flora Sourri, Maria-Christina Giannakopoulou, Dimitrios Karamanis, Asterios Pantousas, Persefoni Georgota, Eleni Rokka, Zoe Vladeni, Euaggelia Tsiantoula, Evangelia Soukara, Nikoletta Lavda, Dimitrios Gkaragkanis, Aikaterini Zisaki, Panagiotis Vakalidis, Vasiliki Goula, Evdokia Loupou, Leonidas Palaiodimos, Dimitrios Hatzigeorgiou
Summary: In this study, the trajectory of humoral and cellular immunity after nine months of primary vaccination with the BNT162b2 mRNA vaccine among 189 healthcare workers was investigated. Correlations between immunity parameters and common variables and comorbidities were also examined. The study found a significant drop in antibodies over time, with age and smoking status affecting the rise of antibodies. T-cell activation was not demonstrated in more than half of the participants at nine months. Female gender and antibody levels at four months predicted the detection of cellular immunity at nine months post-vaccination. This study contributes to our understanding of the immune response to the BNT162b2 mRNA vaccine and its associated factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Fisheries
Hee Jae Choi, Ji-Hoon Lee, Da Yeon Choi, Ji Hee Kim, Jin Man Cho, Hyuk Chu Kwon, Yue Jai Kang
Summary: This study evaluated the effects of betaine-supplemented feed on the growth and immunity of olive flounders. The results showed that betaine can promote growth and enhance immunity against bacterial infections in fish, potentially providing an alternative to conventional antibiotics in aquaculture.
JOURNAL OF FISH DISEASES
(2022)
Article
Immunology
Junfei Wei, Venkatesh L. Hegde, Ananta V. Yanamandra, Madison P. O'Hara, Brian Keegan, Kathryn M. Jones, Ulrich Strych, Maria Elena Bottazzi, Bin Zhan, K. Jagannadha Sastry, Peter J. Hotez
Summary: Trichuriasis is a neglected tropical disease affecting the poorest populations. Researchers are developing a vaccine composed of Tm-WAP49 protein to be delivered through intranasal immunization. Preliminary results in a mouse model showed high levels of antibody response and significant reduction in worm burden. The addition of adjuvants further improved the vaccine efficacy, inducing robust cellular responses and long-term T cell memory.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Gian Luca Salvagno, Laura Pighi, Brandon M. M. Henry, Myriam Valentini, Beatrice Tonin, Damiano Bragantini, Gianluca Gianfilippi, Simone De Nitto, Mario Plebani, Giuseppe Lippi
Summary: This study investigated the feasibility and clinical value of using a novel, automated and high-throughput SARS-CoV-2 Interferon Gamma Release Assay (IGRA), combined with total anti-SARS-CoV-2 antibodies assessment, for evaluating the immune response after bivalent BNT162b2 vaccination. The results showed that the bivalent BNT162b2 vaccine booster enhances humoral and cellular immunity against SARS-CoV-2, especially in recipients with lower baseline biological protection.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Immunology
Rie Chida, Kazuki Iio, Haruki Kaizuka, Yuji Hirai, Yu Ishida, Gaku Yamanaka
Summary: This article reports a case of a 12-year-old boy with symptoms of chronic diarrhea, abdominal pain, and weight loss, who was suspected to have inflammatory bowel disease but was ruled out by endoscopy and tissue biopsy.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Muhammad S. Khan, Eun Kim, Quentin Le Hingrat, Adam Kleinman, Alessandro Ferrari, Jose C. Sammartino, Elena Percivalle, Cuiling Xu, Shaohua Huang, Thomas W. Kenniston, Irene Cassaniti, Fausto Baldanti, Ivona Pandrea, Andrea Gambotto, Cristian Apetrei
Summary: This study evaluated the immunogenicity and efficacy of an adjuvanted tetravalent S1 subunit protein COVID-19 vaccine candidate. The vaccine candidate induced both cellular and humoral immune responses, including neutralizing and cross-reactive antibodies and spike-specific T cell responses. Importantly, the vaccine candidate showed potential protection against emerging variants.
Article
Entomology
Bo Qin, Shichao Yu, Qiming Chen, Li Hua Jin
Summary: Autophagy is an essential cellular process that regulates development and stress responses. However, its role in innate immunity is not well understood. In this study, we demonstrated that Atg2, an autophagy-related protein, plays an important role in controlling innate immunity in Drosophila melanogaster. Inhibiting Atg2 led to the formation of melanotic nodules, disrupted phagocytosis, altered the expression of AMP-encoding genes, and impaired the ability to resist bacterial infections.
Article
Fisheries
Jiayu Liu, Rui Shao, Yawen Lan, Xinmeng Liao, Jinjin Zhang, Kangsen Mai, Qinghui Ai, Min Wan
Summary: The study demonstrates that vitamin D-3 enhances immune responses in fish, leading to lower mortality and reduced bacterial load in infected fish. Additionally, VD3 supplementation promotes bactericidal activity and modulates immune cell responses, highlighting its potential as a defense mechanism against pathogen infection in fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Immunology
Barbara Poniedzialek, Ewelina Hallmann, Dominika Sikora, Karol Szymanski, Katarzyna Kondratiuk, Jakub Zurawski, Piotr Rzymski, Lidia Brydak
Summary: Evidence suggests that vaccination against seasonal influenza can enhance innate immune responses to COVID-19 and reduce disease severity. This study aimed to compare humoral responses to SARS-CoV-2 in non-hospitalized, COVID-19 unvaccinated patients and mild COVID-19 convalescent patients who were and were not vaccinated against influenza. The results showed that influenza-vaccinated patients had higher levels of antibodies against nucleocapsid and receptor binding domain compared to non-vaccinated patients.
Article
Immunology
Cristina Venegas-Vargas, Lucas P. Taylor, Dennis L. Foss, Traci K. Godbee, Ryan Philip, Meggan Bandrick
Summary: This study evaluated immune responses to different PCV2 vaccines in pigs and found that the trivalent chimeric vaccine induced robust cell-mediated immunity and protective efficacy following either a single dose or splitting the dose into two administrations.
Article
Fisheries
Yilong Wang, Hang Xu, Boguang Sun
Summary: In this study, a lysosomal cysteine protease CsCatH was identified from half-smooth tongue sole. CsCatH and CsCatB were upregulated upon infection by E. tarda, a severe fish pathogen. Knockdown of CsCatH and CsCatB increased the replication of E. tarda and mitigated E. tarda-induced apoptosis in tongue sole tissues. These findings reveal the importance of CsCatH and CsCatB in the anti-bacterial immunity of tongue sole.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Tingting Wang, Jie Feng, Liying Zhou, Ting Zhao, Huilan Zhang, Hao Shen, Li Xu, Li Sun, Jianhua Wu, Hongjian Li, Luhai Yu
Summary: This study aimed to assess the effect of genetic polymorphisms in CYP2C19*2 and *3 and clinical and demographic factors on major adverse cardiovascular events (MACE) in Kazak patients following percutaneous coronary intervention (PCI). The results showed that CYP2C19*2 carriers and poor metabolizers were significantly associated with MACE.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Economics
Zhibin Hu, Guangdong Wu, Yilong Han, Yanliang Niu
Summary: This study constructs China's High-Speed Rail (HSR) network using complex network theory and spatial analysis technique. It employs a stochastic actor-oriented model (SAOM) to examine the effects of network structure, attribute-based similarity, and exogenous control variables on the generation of China's HSR network. The findings highlight the role of 3-cycles in the formation of China's HSR network and the influence of GDP similarity and geographical proximity on its evolution, providing insights for urban regional development and HSR planning policies.
SOCIO-ECONOMIC PLANNING SCIENCES
(2023)
Article
Materials Science, Ceramics
Bobo Yang, Shiliang Mei, Yuxuan Zhu, Dan Yang, Haiyang He, Rongrong Hu, Yang Li, Jun Zou, Ruiqian Guo
Summary: This study successfully prepared high-quality perovskite quantum dots embedded in borosilicate glass with the introduction of alkaline earth metals, which improved their stability and luminescence performance, showing promising potential applications in the backlit display field.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ming Yang, Yu-ting Liu, Ya-chun Han, Wei Zhang, Hao Zhang, Shikun Yang
Summary: This study aims to evaluate the regulatory mechanism between P66Shc and ferroptosis in cisplatin-induced acute kidney injury (CP-AKI). The results showed that the mitochondrial translocation of P66Shc could result in mitochondrial injury and lipid peroxide accumulation, ultimately leading to ferroptosis and aggravated CP-induced AKI.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Psychology, Multidisciplinary
Bo Peng, Jiwu Liao, Yang Li, Guangbo Jia, Jihui Yang, Zhiwei Wu, Jian Zhang, Yingjia Yang, Xinxin Luo, Yao Wang, Yingli Zhang, Jiyang Pan
Summary: This study aimed to investigate the differences in personality traits, defensive styles, and borderline symptoms among first-episode youth patients with depression and self-injury. The results showed that patients with depression and self-injury had higher levels of psychoticism and intermediate defense styles. The frequency of self-injury was negatively correlated with mature defense styles and positively correlated with depressive symptoms and borderline symptoms. Psychoticism and depressive symptoms were identified as independent risk factors for predicting non-suicidal self-injury in patients with depression.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Energy & Fuels
Di Zhao, Qiang Wu, Yifan Zeng, Juan Zhang, Aoshuang Mei, Xiaohui Zhang, Shuai Gao, Hanyuan Wang, Honglei Liu, Yong Zhang, Shuai Qi, Xu Jia
Summary: Chifeng is a concentrated mining area for non-ferrous metal minerals and a key prevention and control area for heavy-duty enterprises, necessitating an effective ecological and human health risk assessment of heavy metal(loid)s. The study found that the concentrations of Cd, Pb, and As in some soil samples exceeded the environmental quality standards, posing potential ecological and health risks.
INTERNATIONAL JOURNAL OF COAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Jie Yang, Chen Tu, Lianzhen Li, Ruijie Li, Yudong Feng, Yongming Luo
Summary: Anthropogenic micro(nano)plastics (MNPs) contaminate global terrestrial ecosystems. Plants can uptake and transport MNPs, leading to adverse effects on plant morphology and physiology. MNPs can further transfer through the food chain, posing a potential risk to human health.
CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Jessica Pihl, Thomas M. M. Clausen, Jiarong Zhou, Nishta Krishnan, Maj S. S. Orum-Madsen, Tobias Gustavsson, Robert Dagil, Mads Daugaard, Swati Choudhary, Camilla Foged, Jeffrey D. D. Esko, Liangfang Zhang, Ronnie H. H. Fang, Ali Salanti
Summary: Malaria-infected erythrocytes and oncofetal CS have distinct tropism and can potentially be used for cancer targeting. Researchers have developed a drug delivery platform using erythrocyte membrane-coated nanoparticles that mimic malaria-infected erythrocytes and specifically target and kill melanoma cells. This biomimetic approach shows potential as a broadly targeted cancer therapy.
Article
Chemistry, Physical
Xiao Dong, Shoujie Li, Chang Zhu, Jianing Mao, Gangfeng Wu, Guihua Li, Guanghui Feng, Aohui Chen, Yiheng Wei, Xiaohu Liu, Jiangjiang Wang, Yanfang Song, Wei Chen, Wei Wei
Summary: Efficient C2+ production from CO2 electrocatalytic reduction is achieved using serial Ag and Cu hollow-fiber penetration electrodes, with a partial current density of 1.8 A cm-2 and a faradaic efficiency of 90.5%. The unique penetration effect induced by hierarchical micro/nanostructured hollow fiber configurations and the regulated electronic structures by chloride ion adsorption are responsible for the superior activity. This work provides a facile tactic and encouraging headway in designing efficient CO2 electrocatalytic reduction systems for high-value C2+ chemicals.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Biochemistry & Molecular Biology
Yunxiao Yang, Enzehua Xie, Yuhua Liu, Zhan Peng, Cuntao Yu, Kun Hua, Xiubin Yang
Summary: The study found that patients with Marfan syndrome (MFS) have elevated blood calcium levels and dyslipidemia. Increased calcium concentration is associated with promoted vascular smooth muscle cell (VSMC) phenotype switching in MFS. SERCA may become a novel therapeutic target for suppressing aneurysm progression in MFS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Entomology
Shanshan Gao, Shuang Xue, Tian Gao, Ruixue Lu, Xinyi Zhang, Yonglei Zhang, Kunpeng Zhang, Ruimin Li
Summary: TcZelda plays a crucial role in the development and metamorphosis of insects. Knocking down TcZelda leads to increased mortality rate in adults and may be involved in wing development, reproductive system, and pheromone synthesis.
BULLETIN OF ENTOMOLOGICAL RESEARCH
(2023)
Article
Engineering, Environmental
Chaoliang Zheng, Jiameng Feng, Zhicheng Wei, Da Zhang, Jianling Li
Summary: In this study, Eu was used to modify Li1.2Mn0.54Co0.13Ni0.13O2 for lithium-rich cathode, significantly improving its redox activity and structural stability. The doping of Eu resulted in the formation of Eu2O3 modified layer at the interface and heterogenous structure of rock-salt phase, effectively preventing structural degradation during long-term cycling. Ex-situ methods were used to analyze charge compensation mechanism, phase structure transition pattern, anion behavior, and CEI evolution. This simple modification method provides guidance for enhancing the performance of lithium-rich cathode materials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Critical Care Medicine
Fengyun Wang, Yiming Li, Bingqing Wang, Jianguo Li, Zhiyong Peng
Summary: This study conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and efficacy of mesenchymal stromal cells (MSC) in acute respiratory distress syndrome (ARDS). The results showed that MSC treatment was as safe as standard treatment and could reduce the mortality rate of ARDS. However, more high-quality and large-scale clinical trials are needed to further confirm these findings.
Article
Geriatrics & Gerontology
Pinhao Li, Yan Wang, Hui Li, Baoli Cheng, Shuijing Wu, Hui Ye, Daqing Ma, Xiangming Fang
Summary: By analyzing with a deep learning model, this study aimed to develop and validate predictive models for postoperative infections in elderly patients. The deep learning model including risk factors relevant to baseline clinical characteristics and surgery showed higher accuracy in predicting postoperative infections compared to the conventional model. Further studies are needed to assess the potential of using this model to guide clinical practice and improve surgical outcomes in elderly patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Letter
Materials Science, Multidisciplinary
Akshar Varma, Xiaoyu Zhang, Brian Lejeune, Laura Cebada Almagro, Rafael P. del Real, Pilar Marin, Ogheneyunume Fitchorova, Laura H. Lewis, Ravi Sundaram
Summary: In this study, machine learning was used to analyze the complex electromagnetic responses of arrangements of amorphous ferromagnetic microwires, demonstrating the potential of these materials for use in tags for secure article surveillance systems.
MRS COMMUNICATIONS
(2023)
