Journal
VACCINE
Volume 27, Issue 51, Pages 7173-7177Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2009.09.032
Keywords
Rabies; Vaccine; Immune globulin
Categories
Funding
- Zach Jones Memorial Foundation
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Administration of rabies vaccine or rabies immune globulin (RIG) during symptomatic rabies is ineffective, and there are concerns about the phenomenon of early death reported in animals that develop rabies after receipt of rabies vaccine or immune globulin. Survival analyses of the original animal data confirm these findings in two species, whereas analyses of human case reports and the Milwaukee Protocol registry suggest lower risk of early death in humans. There may be a deleterious interaction of rabies vaccine and RIG with bat rabies in humans. Animal studies of bat rabies virus with bat-origin vaccines and RIG are urgently needed. (C) 2009 Elsevier Ltd. All rights reserved.
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