Article
Biology
Joseph Newman, David J. Rowlands, Tobias J. Tuthill
Summary: This study compared the characteristics of recombinant assembly and disassembly pentamers of picornavirus, specifically FMDV. Assembly pentamers sedimented faster and had higher reactivity with anti-VP4 antibodies compared to the disassembly pentamers. However, the reactivity with other antibodies was similar between the two pentamers, suggesting that major antigenic features may be preserved between assembly pentamers containing VP4 and disassembly pentamers lacking VP4.
Article
Veterinary Sciences
Jidong Li, Jianlin Wang, Yanan Guo, Zhenxing Gong, Xuepeng Cai
Summary: This study constructed a recombinant goat pox virus (rGPV) capable of expressing the F gene of PPRV and the P12A3C gene of FMDV as a live vector vaccine. The rGPV induced high levels of specific antibodies against GPV, PPRV and FMDV, providing a reference for the development of a vaccine with multiple uses.
BMC VETERINARY RESEARCH
(2023)
Article
Microbiology
Zhidong Zhang, Ryan Waters, Yanmin Li
Summary: Foot-and-mouth disease virus (FMDV) infection causes epithelial cell lesions and muscle-associated lesions in cloven-hoofed animals, leading to high mortality. Current knowledge about the non-epithelial tropism of FMDV remains limited.
VETERINARY MICROBIOLOGY
(2021)
Article
Virology
Jonathan Arzt, Ian H. Fish, Miranda R. Bertram, George R. Smoliga, Ethan J. Hartwig, Steven J. Pauszek, Lauren Holinka-Patterson, Fayna C. Diaz-San Segundo, Tatjana Sitt, Elizabeth Rieder, Carolina Stenfeldt
Summary: Research showed that cattle can be simultaneously infected with two different serotypes of foot-and-mouth disease virus (FMDV), with different outcomes depending on the timing of exposure to the viruses. Dominant interserotypic recombinant FMDVs were discovered in upper respiratory tract samples of superinfected animals, indicating the potential role of persistently infected FMDV carriers in generating novel viral strains.
JOURNAL OF VIROLOGY
(2021)
Article
Infectious Diseases
Carolina Stenfeldt, Miranda R. Bertram, Haillie C. Meek, Ethan J. Hartwig, George R. Smoliga, Megan C. Niederwerder, Diego G. Diel, Scott A. Dee, Jonathan Arzt
Summary: The study investigated the infectivity of foot-and-mouth disease virus (FMDV) in commercial pig feed and feed ingredients, determining the minimum infectious dose required for pigs to develop the disease. The results indicated that FMDV can remain infectious in pig feed ingredients for durations compatible with transoceanic transport, with variations in feeding conditions and virus strains affecting the probability of infection. This information can be used to model the risk of FMDV incursions and regulate feed importation to minimize the risk of unintentional importation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Virology
Mo Zhou, Muhammad Abid, Shinuo Cao, Shanyuan Zhu
Summary: Pseudorabies virus (PRV) is a pathogen causing pseudorabies, belonging to the alpha herpesvirus subfamily with a genome encoding approximately 70 proteins. PRV has non-essential regions for replication, making it suitable for genetic modification. It can be used as a vaccine vector to stimulate the immune system and provide long-lasting immunity lasting more than 4 months.
Article
Pharmacology & Pharmacy
Tatsuya Nishi, Katsuhiko Fukai, Kentaro Masujin, Rie Kawaguchi, Mitsutaka Ikezawa, Manabu Yamada, Nozomi Nakajima, Takashi Komeno, Yousuke Furuta, Hiromi Sugihara, Chie Kurosaki, Kenichi Sakamoto, Kazuki Morioka
Summary: This study found that the pyrazinecarboxamide derivative T-1105 has strong antiviral activity against foot-and-mouth disease virus (FMDV) and can effectively control the spread of FMDV in pigs.
ANTIVIRAL RESEARCH
(2022)
Article
Immunology
Kay Childs, Yongjie Harvey, Ryan Waters, Timothy Woma, Ginette Wilsden, Hualu Sun, Peng Sun, Julian Seago
Summary: Foot-and-mouth disease is a highly contagious viral disease of livestock that has a severe economic impact on the agriculture industry in many regions. Current vaccines are not effective against the contemporary strains of the disease, particularly in East Africa. Researchers have identified stable strains of the virus and developed a quadrivalent vaccine that generates high neutralizing antibody titers and provides good cross-protection against regional strains.
Article
Immunology
Ben Jackson, Yongjie Harvey, Eva Perez-Martin, Ginette Wilsden, Nicholas Juleff, Bryan Charleston, Julian Seago
Summary: Foot-and-mouth disease (FMD) is a global burden on the livestock industry, with vaccination being the most effective control strategy in endemic regions. However, challenges such as the instability of FMDV and the emergence of new strains exist in the development of efficient vaccines. Currently, vaccines in East Africa are comprised of relatively historic strains with unknown stabilities.
Article
Biotechnology & Applied Microbiology
Zhixun Zhao, Caiyun Huang, Xueliang Zhu, Zheng Qi, Yimei Cao, Pinghua Li, Huifang Bao, Pu Sun, Xingwen Bai, Yuanfang Fu, Kun Li, Jing Zhang, Xueqing Ma, Jian Wang, Hong Yuan, Dong Li, Zaixin Liu, Qiang Zhang, Zengjun Lu
Summary: In this study, a dual live vector vaccine against Foot-and-mouth disease (FMD) and Peste des petits ruminant disease (PPR) was constructed using the MVA-GFP recombinant virus skeleton. The recombinant virus successfully expressed the target proteins and the empty capsid of FMDV. This study laid the foundation for the successful construction of a live vector vaccine against FMD and PPR.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Immunology
Junyong Guan, Shichong Han, Jin'en Wu, Yun Zhang, Manyuan Bai, Sahibzada Waheed Abdullah, Shiqi Sun, Huichen Guo
Summary: Ribosomal protein L13 (RPL13) is involved in the antiviral immune response against foot-and-mouth disease virus (FMDV), inhibiting viral replication by inducing the activation of NF-kappa B and IFN-beta genes. The interaction between FMDV 3C(pro) protease and RPL13 reduces the expression of RPL13, thereby counteracting its antiviral activity. This study provides new insights into cellular antiviral defenses and virus-antagonizing mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Wei Liu, Junjun Shao, Guanglei Zhang, Yanyan Chang, Sudan Ge, Yue Sun, Zhan Gao, Huiyun Chang
Summary: A multi-epitope-based indirect chemiluminescence immunoassay (ME-CLIA) was developed to specifically detect antibodies against FMDV serotype O in swine sera, showing high diagnostic sensitivity and excellent diagnostic specificity, suitable for evaluating multiple-epitope recombinant vaccine as a matching detection method.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yun-Jung Hwang, Kyung-Kwan Lee, Jong-Won Kim, Kwang-Hyo Chung, Sang-Jick Kim, Wan-Soo Yun, Chang-Soo Lee
Summary: The study introduces an optical and electrochemical dual-modal approach for the specific detection of foot-and-mouth disease virus serotypes O and A, offering high sensitivity and accuracy.
Article
Biochemistry & Molecular Biology
Tingting Ren, Haotai Chen, Xinsheng Liu, Yanxue Wang, Aixia Fan, Linlin Qi, Li Pan, Wenlong Bai, Yongguang Zhang, Yuefeng Sun
Summary: The ID1 protein promotes the degradation of FOXO1, suppresses interferon production, and inhibits HDAC4, ultimately suppressing the replication of FDMV and potentially other viruses.
Article
Biotechnology & Applied Microbiology
Ernesto Garay, Diego Fontana, Lautaro Leschiutta, Ricardo Kratje, Claudio Prieto
Summary: Chimeric virus-like particles were generated by identifying suitable regions in rabies glycoprotein to expose a major antigenic site of foot-and-mouth disease virus (FMDV), demonstrating a novel heterologous display platform concept. The study successfully identified appropriate insertion sites for heterologous sequences without affecting proper folding of the protein, leading to exposed foreign antigens recognized by antibodies. This work provides a foundation for the development of a heterologous antigen display platform based on rabies VLPs.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)