Article
Oncology
P. Travis Courtney, Rishi Deka, Nikhil Kotha, Daniel R. Cherry, Mia A. Salans, Tyler J. Nelson, Abhishek Kumar, Elaine Luterstein, Anthony T. Yip, Vinit Nalawade, J. Kellogg Parsons, A. Karim Kader, Tyler F. Stewart, Brent S. Rose
Summary: Outcomes were similar for African American and White men treated for low-intermediate-risk prostate cancer with active surveillance in the Veterans Affairs Health System.
Article
Oncology
Laura C. Kidd, Matthew Loecher, Nahrin Ahmed, Joseph Terzian, Jun Song, Adam C. Reese
Summary: Active surveillance outcomes in minority patients, particularly African American men, showed relatively high rates of progression to definitive treatment. Cessation of active surveillance most commonly occurred due to grade reclassification at the time of confirmatory biopsy in African American men. These findings highlight the importance of confirmatory biopsy and strict compliance with surveillance protocols in ensuring timely detection of disease reclassification in this population.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Edmund M. Qiao, Julie A. Lynch, Kyung M. Lee, Nikhil Kotha, Vinit Nalawade, Rohith S. Voora, Alexander S. Qian, Tyler J. Nelson, Kosj Yamoah, Isla P. Garraway, Tyler F. Stewart, J. Kellogg Parsons, Brent S. Rose
Summary: PSA screening is associated with reduced risk of high PSA levels, high Gleason score, metastatic disease, and prostate cancer-specific mortality in young African American men. However, the retrospective design of this study limits the precise estimation of screening effects, and prospective studies are needed to validate these findings.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Joshua Pincus, Jacob W. Greenberg, Caleb Natale, Christopher R. Koller, Stephanie Miller, Jonathan L. Silberstein, L. Spencer Krane
Summary: Active surveillance is a safe treatment option for low and very low risk prostate cancer, regardless of race.
Article
Medicine, General & Internal
Tyler J. Nelson, Juan Javier-DesLoges, Rishi Deka, P. Travis Courtney, Vinit Nalawade, Loren Mell, James Murphy, J. Kellogg Parsons, Brent S. Rose
Summary: The study suggests that PSAV is significantly associated with grade progression in low-risk prostate cancer patients managed with active surveillance, with optimal PSAV thresholds being lower in African American patients compared to non-Hispanic White patients.
Article
Biochemistry & Molecular Biology
Anindita Ravindran, Danthasinghe Waduge Badrajee Piyarathna, Jie Gohlke, Vasanta Putluri, Tanu Soni, Stacy Lloyd, Patricia Castro, Subramaniam Pennathur, Jeffrey A. Jones, Michael Ittmann, Nagireddy Putluri, George Michailidis, Thekkelnaycke M. Rajendiran, Arun Sreekumar
Summary: African-American men are more likely to die of prostate cancer than European American men. This study reveals the association between lipid metabolic pathway alterations and prostate cancer disparities, as well as specific lipid changes associated with early biochemical recurrence.
Article
Urology & Nephrology
Kevin Shee, Janet E. Cowan, Ashwin Balakrishnan, Domenique Escobar, Kevin Chang, Samuel L. Washington, Hao G. Nguyen, Katsuto Shinohara, Matthew R. Cooperberg, Peter R. Carroll
Summary: Although the American Urological Association and European Association of Urology do not use the very low-risk (VLR) subcategory for low-risk prostate cancer (PCa), the National Comprehensive Cancer Network (NCCN) still maintains this classification. However, a study found that the NCCN VLR criteria are less applicable in the era of imaging-targeted prostate biopsies, and the Cancer of the Prostate Risk Assessment (CAPRA) score may be a better tool for risk stratification in men on active surveillance. The study suggests that the VLR criteria should be reevaluated for its relevance in the modern era.
Article
Oncology
Andrew M. Fang, Luke A. Shumaker, Kimberly D. Martin, Jamaal C. Jackson, Richard E. Fan, Ghazal Khajir, Hiten D. Patel, Nachiketh Soodana-Prakash, Srinivas Vourganti, Christopher P. Filson, Geoffrey A. Sonn, Preston C. Sprenkle, Gopal N. Gupta, Sanoj Punnen, Soroush Rais-Bahrami
Summary: Elevated PSA density, older age, and a biopsy-naive status are associated with clinically significant prostate cancer (CSPCa) in men with PI-RADS 3 lesions, while a prior negative biopsy is negatively associated. A predictive model can prevent unnecessary biopsies for PI-RADS 3 lesions while missing only a few cases of CSPCa.
Article
Medicine, General & Internal
Margaret S. Pichardo, Tsion Zewdu Minas, Catherine M. Pichardo, Maeve Bailey-Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Brid M. Ryan, Christopher A. Loffredo, Stefan Ambs
Summary: This study found that African American men living in deprived neighborhoods have a higher risk of prostate cancer and related mortality, potentially due to their systemic immune function and inflammation levels.
Article
Oncology
Shivanshu Awasthi, Anders Berglund, Julieta Abraham-Miranda, Robert J. Rounbehler, Kevin Kensler, Amparo Serna, Adriana Vidal, Sungyong You, Michael R. Freeman, Elai Davicioni, Yang Liu, R. Jeffrey Karnes, Eric A. Klein, Robert B. Den, Bruce J. Trock, Joshua D. Campbell, David J. Einstein, Raavi Gupta, Steven Balk, Priti Lal, Jong Y. Park, John L. Cleveland, Timothy R. Rebbeck, Stephen J. Freedland, Kosj Yamoah
Summary: Prostate tumors in African American men exhibit a unique immune profile with significant enrichment in proinflammatory immune pathways. The tumor microenvironment of African American men shows higher immune content compared to European American men, as well as lower DNA damage repair and increased genomic radiosensitivity. Overexpression of proinflammatory genes in African American men, such as IFITM3, is associated with higher risk of biochemical recurrence and poorer outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Peter S. Kirk, Kehao Zhu, Yingye Zheng, Lisa F. Newcomb, Jeannette M. Schenk, James D. Brooks, Peter R. Carroll, Atreya Dash, William J. Ellis, Christopher P. Filson, Martin E. Gleave, Michael Liss, Frances Martin, Jesse K. McKenney, Todd M. Morgan, Peter S. Nelson, Ian M. Thompson, Andrew A. Wagner, Daniel W. Lin, John L. Gore
Summary: This study found that approximately 1 in 10 men undergoing active surveillance for prostate cancer choose to be treated within 4 years of diagnosis, even if their cancer remains stable. Quality of life and marital status may play important roles in these treatment decisions.
Article
Biology
Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G. Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Schaeffer, Felix Y. Feng, Brandon Mahal, Paul L. Nguyen, Robert B. Den, Mark D. Greenberger, Randy Bradley, Justin M. Watson, Matthew Beamer, Lambros Stamatakis, Darrell J. Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A. Deane, Dimple Chakravarty, Kamlesh K. Yadav, Kosj Yamoah, Sujit S. Nair, Ashutosh K. Tewari
Summary: Racial disparities in prostate cancer were investigated in a multi-institutional retrospective analysis of African-American and European-American men who underwent radical prostatectomy. Differences were found in gene expression with African-American men showing higher expression of inflammation genes and lower expression of mismatch repair genes.
COMMUNICATIONS BIOLOGY
(2021)
Review
Oncology
Julieta Abraham-Miranda, Shivanshu Awasthi, Kosj Yamoah
Summary: Health disparities between American men of African and European descent can be attributed to various factors such as socioeconomic status, healthcare access, lifestyle, ancestry, and molecular aberrations. Clinical trials and research studies on prostate cancer are predominantly enrolling European descent men, potentially overlooking existing disparities between races. With advancements in immunotherapies, exploring immunological differences between ethnicities is crucial for developing innovative therapeutic approaches for prostate cancer globally.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Endocrinology & Metabolism
Steven S. Coughlin, Marlo Vernon, Zachary Klaassen, Martha S. Tingen, Jorge E. Cortes
Summary: Recent studies show that many African American men lack knowledge about prostate cancer and early detection. This lack of knowledge is particularly prevalent among older, less-educated, lower-income, unmarried men, as well as those without regular healthcare or insurance. Culturally appropriate educational efforts are needed to inform African American men about these issues.
Article
Oncology
Maeve Kiely, Ginger L. Milne, Tsion Z. Minas, Tiffany H. Dorsey, Wei Tang, Cheryl J. Smith, Francine Baker, Christopher A. Loffredo, Clayton Yates, Michael B. Cook, Stefan Ambs
Summary: In this study, we found that high levels of TXB2 were associated with prostate cancer and poor outcomes in African American men, indicating a potential role of upregulated TXA2 synthesis in promoting disease progression and metastasis. Our findings suggest a potential benefit of aspirin in preventing lethal prostate cancer through inhibition of TXA2 synthesis, especially in high-risk populations like African American men.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Psychiatry
Michelle L. Pennington, Kelly R. Ylitalo, Beth A. Lanning, Sara L. Dolan, Suzy B. Gulliver
Summary: Compared to non-firefighters, firefighters are more likely to die by firearm suicide, less likely to be diagnosed with depression, but more likely to be diagnosed with post-traumatic stress disorder. A higher percentage of firefighter decedents had relationship or physical health problems prior to death, while a lower percentage had a history of suicide thoughts/attempts.
PSYCHIATRY RESEARCH
(2021)
Article
Sport Sciences
Leslie W. Oglesby, Andrew R. Gallucci, Christopher Wynveen, Kelly Ylitalo, Nicholas Benson
Summary: The study explored the correlation between spiritual well-being and burnout in collegiate athletic trainers. The research found that existential well-being is a protective factor against burnout.
JOURNAL OF ATHLETIC TRAINING
(2021)
Article
Geriatrics & Gerontology
Jenna M. Napoleone, Robert M. Boudreau, Brittney S. Lange-Maia, Samar R. El Khoudary, Kelly R. Ylitalo, Andrea M. Kriska, Carrie A. Karvonen-Gutierrez, Elsa S. Strotmeyer
Summary: This study found that midlife metabolic syndrome groups were associated with poor physical performance in early old age multiethnic women, suggesting that managing midlife metabolic function may improve physical performance later in life.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Environmental Sciences
Megan E. McClendon, M. Renee Umstattd Meyer, Tyler Prochnow, Kelly R. Ylitalo, Andrew R. Meyer, Christina N. Bridges Hamilton, Joseph R. Sharkey
Summary: This study examined perceptions and activities of Mexican-heritage fathers, finding that fathers tend to engage in more activities with sons than daughters. The role of fathers in child physical activity is crucial yet often lacking in specific involvement.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biology
Kathleen E. Adair, Rodney G. Bowden, LesLee K. Funderburk, Jeffrey S. Forsse, Kelly R. Ylitalo
Summary: The study used NHANES data to analyze the association between metabolic phenotypes and renal function, finding that the MUN phenotype had the greatest association with poor renal function, while the MHO phenotype may be due to a transient state caused by renal hyperfiltration. Further research is needed to investigate the association between dyslipidemia and CKD.
Article
Biology
Kathleen E. Adair, Kelly R. Ylitalo, Jeffrey S. Forsse, LesLee K. Funderburk, Rodney G. Bowden
Summary: Metabolic syndrome (MetS) is associated with decreased renal function and chronic kidney disease (CKD). Through analyzing sixteen metabolic constellations, this study found that MetS has varying effects on renal function, indicating a need for further research to understand the relationship between different MetS iterations and renal function.
Article
Public, Environmental & Occupational Health
Kelley Pettee Gabriel, Carrie A. Karvonen-Gutierrez, Alicia B. Colvin, Kelly R. Ylitalo, Kara M. Whitaker, Brittney S. Lange-Maia, Alexander R. Lucas, Sheila A. Dugan, Carol Derby, Jane A. Cauley, Barbara Sternfeld
Summary: The study found that engaging in moderate to vigorous intensity physical activity is associated with better physical performance outcomes in older women, with differences in impact observed among different racial/ethnic groups. The results underscore the importance of MVPA on physical performance outcomes in older women and suggest the need for further research on the complex associations between physical (in)activity and physical performance outcomes by race/ethnicity.
PREVENTIVE MEDICINE REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Jordan Smith, Kelly R. Ylitalo
Summary: Only one-third of adults in the United States received physical activity recommendations, with those who received them more likely to have functional limitations. Recommendations for physical activity for those with limitations appeared to increase during middle age, peak for adults aged 65-75 years, but declined substantially for adults >= 75 years.
PREVENTIVE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Kelly R. Ylitalo, Carrie A. Karvonen-Gutierrez, Minsuk Oh, Barbara Sternfeld, James Stamey, Kelley Pettee Gabriel
Summary: This study quantified physical activity estimates with and without adjustments for perceived exertion and found that the differences were associated with individual-level characteristics. For most participants, absolute intensity-based estimates closely approximated perceived intensity-adjusted estimates over time, indicating the feasibility of using traditional scoring techniques in cohort studies of mid-life and older adult women.
PREVENTIVE MEDICINE REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Bradley M. Appelhans, Kelley Pettee Gabriel, Brittney S. Lange-Maia, Kelly Karavolos, Kelly R. Ylitalo, Carrie A. Karvonen-Gutierrez, Howard M. Kravitz, Imke Janssen
Summary: This study examined the association between employment status during mid-life and older adulthood and physical function impairment, and found that women with lower levels of employment were more likely to experience severe impairment in physical function.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Wade M. Sanders, Sioban D. Harlow, Kelly R. Ylitalo, Brittney S. Lange-Maia, Aleda M. Leis, Daniel S. McConnell, Carrie A. Karvonen-Gutierrez
Summary: Cardiometabolic factors and inflammation are significantly associated with peripheral neuropathy (PN), independent of diabetes and obesity. C-reactive protein (CRP) mediates the relationship between obesity and MetS with PN.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gerontology
Brittney S. Lange-Maia, Samar R. El Khoudary, Carolyn J. Crandall, Yanyu Zhang, Carrie A. Karvonen-Gutierrez, Kelley Pettee Gabriel, Bradley M. Appelhans, Elsa S. Strotmeyer, Kelly R. Ylitalo, Kelly Karavolos, Howard M. Kravitz, Sheila A. Dugan, Imke Janssen
Summary: The study found that physical function before menopause is associated with cardiovascular disease risk, with women who have substantial limitations having a higher risk compared to those with no limitations.
JOURNAL OF AGING AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Kelly R. Ylitalo, Jordan Smith, Wendy Cox, Raejone Lucas, Brock Niceler, M. Renee Umstattd Meyer
Summary: Physical activity improves quality of life and prevents chronic disease, but many adults are inactive. This study explores the role of self-regulation strategies in exercise prescription programs. The results show that the frequency of self-regulation strategies changed significantly over time. Among participants in the exercise prescription program, higher self-regulation strategy scores were associated with increased physical activity at follow-up. Leveraging self-regulation strategy training in clinical settings can provide a personalized and multicomponent approach to promoting physical activity among underserved patients with chronic disease.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Minsuk Oh, Kelly R. R. Ylitalo
Summary: The study examined the joint associations of diabetes and physical activity with falls. The results showed that leisure-time physical activity may reduce the likelihood of falls in adults with and without diabetes.
AMERICAN JOURNAL OF HEALTH PROMOTION
(2023)
Article
Gerontology
Kelly R. Ylitalo, Carrie A. Karvonen-Gutierrez, Barbara Sternfeld, Kelley Pettee Gabriel
Summary: Women with low PA-low PF and high PA-low PF are more likely to fall, while worsening PF over time increases fall risk, although increasing PA does not. This highlights the importance of physical activity engagement in reducing fall risk.
JOURNAL OF AGING AND HEALTH
(2021)
