Review
Biochemistry & Molecular Biology
Yongdong Su, Andrew L. Hong
Summary: Renal medullary carcinoma (RMC) is a rare renal malignancy that primarily occurs in adolescents and young adults of African ancestry. This aggressive cancer is driven by the loss of the tumor suppressor SMARCB1, and limited knowledge of RMC biology has hindered treatment options. However, significant advances have been made in understanding the genomics and therapeutic targets of RMC in the past 5 years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Xuejiao Wei, Yue Hou, Mengtuan Long, Lili Jiang, Yujun Du
Summary: Renal fibrosis is a common precursor to chronic kidney disease, and metabolic reprogramming is closely related to renal fibrosis. Targeted therapies for specific metabolic pathways are expected to be the next generation of treatments for renal fibrosis.
Review
Oncology
Yien Xiang, Ge Zheng, Jianfeng Zhong, Jiyao Sheng, Hanjiao Qin
Summary: This article summarizes the established methods and applications of in vivo and in vitro RCC drug resistance models, aiming to improve understanding of resistance mechanisms, increase treatment efficacy, and provide a theoretical basis for the development and application of new drugs.
FRONTIERS IN ONCOLOGY
(2022)
Correction
Pathology
Kiril Trpkov, Sean R. Williamson, Anthony J. Gill, Adebowale J. Adeniran, Abbas Agaimy, Reza Alaghehbandan, Mahul B. Amin, Pedram Argani, Ying-Bei Chen, Liang Cheng, Jonathan I. Epstein, John C. Cheville, Eva Comperat, Isabela Werneck da Cunha, Jennifer B. Gordetsky, Sounak Gupta, Huiying He, Michelle S. Hirsch, Peter A. Humphrey, Payal Kapur, Fumiyoshi Kojima, Jose I. Lopez, Fiona Maclean, Cristina Magi-Galluzzi, Jesse K. McKenney, Rohit Mehra, Santosh Menon, George J. Netto, Christopher G. Przybycin, Priya Rao, Qiu Rao, Victor E. Reuter, Rola M. Saleeb, Rajal B. Shah, Steven C. Smith, Satish Tickoo, Maria S. Tretiakova, Lawrence True, Virginie Verkarre, Sara E. Wobker, Ming Zhou, Ondrej Hes
Summary: A correction to this paper has been published at https://doi.org/10.1038/s41379-021-00775-0.
Review
Immunology
Hongzhao Fan, Jia Liu, Jiajia Sun, Guiwen Feng, Jinfeng Li
Summary: Renal ischemia-reperfusion injury (IRI) is a significant challenge in clinical practice, particularly in surgeries like renal transplantation. This review focuses on the role of B cells in the pathogenesis of IRI and discusses possible B cell targets for therapeutic intervention.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Yiqin Wang, Qiong Wen, Luhua Jin, Wei Chen
Summary: Digital imaging and advanced microscopy are crucial in the diagnosis of kidney diseases. AI-assisted technology has shown great potential in providing precise assessments and relieving burdens for renal pathologists. The development of AI methods through interdisciplinary collaboration holds promise for renal pathology diagnoses. The rapid growth of AI-based technology in nephrology is evident from numerous publications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Daniel Vogele, Stefan A. Schmidt, Daniel Gnutzmann, Wolfgang M. Thaiss, Thomas J. Ettrich, Marko Kornmann, Meinrad Beer, Markus S. Juchems
Summary: Gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) is a heterogeneous and complex group of tumors that are often difficult to classify due to their heterogeneity and varying locations. Standard radiological methods, including ultrasound, CT, MRI, and PET/CT, are available for localization and staging of NEN. Nuclear medical imaging methods with somatostatin analogs are superior in detection, especially in gastrointestinal NEN, while CT and MRI have high detection rates and have been further improved by developments such as diffusion-weighted imaging. PET/CT with somatostatin analogs should be used as the subsequent method.
Review
Pharmacology & Pharmacy
Yurong Liu, Mingchun Jiang, Yue Li, Peng Chen, Xiaoyu Chen
Summary: ELABELA (ELA), also known as Toddler or Apela, is a novel endogenous ligand of the angiotensin receptor AT1-related receptor protein (APJ). It plays important roles in embryonic development, blood circulation regulation, and maintaining body fluid homeostasis. ELA is closely related to the occurrence and development of kidney-related diseases, providing new targets and directions for clinical treatment of kidney diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Veterinary Sciences
Emmanouela P. Apostolopoulou, Ioannis Vlemmas, Dimitra Pardali, Katerina K. Adamama-Moraitou, Theofilos Poutahidis, Paraskevi L. Papadopoulou, Georgia D. Brellou
Summary: This study presents a rare case of primary renal lymphoma in a dog, emphasizing its rarity in veterinary literature and the importance of diagnosis and classification.
VETERINARY SCIENCES
(2021)
Review
Immunology
Rui Rui, Liqun Zhou, Shiming He
Summary: This review provides a comprehensive summary of the advancements in exosome research in the context of renal cell carcinoma, emphasizing the importance of exosomes as tumor markers and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cassandra Millet-Boureima, Stephanie He, Thi Bich Uyen Le, Chiara Gamberi
Summary: RCC and ADPKD share similarities in tumor cell growth, cyst formation, and angiogenesis, with involvement of pathways like PI3K/AKT/mTOR and Ras/Raf/ERK. Hypoxia triggers HIF-alpha activation, potentially involving primary cilia and altered cell metabolism in disease progression. Drosophila model shows potential for accelerating disease mechanism understanding and drug screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Badr Khbouz, Shiyang Gu, Tiago Pinto Coelho, Francois Lallemand, Francois Jouret
Summary: Ionizing irradiation is widely used as a fundamental therapeutic treatment. Acute kidney injury (AKI) is a global public health problem with high morbidity and mortality. Renal ischemia/reperfusion (I/R) is the main cause of AKI. Renal ischemic preconditioning (IPC) can protect against ischemic damage by activating defense pathways involved in oxidative stress, angiogenesis, and inflammation. Safe irradiation modalities, including timing, dosage, and fractionation, need to be determined before applying this technique in patients.
BIOENGINEERING-BASEL
(2023)
Article
Pathology
Khaleel Al-Obaidy, Julia A. Bridge, Liang Cheng, Janos Sumegi, Victor E. Reuter, Ryma Benayed, Meera Hameed, Sean R. Williamson, Ondrej Hes, Fatimah Alruwaii, Jeremy P. Segal, Pankhuri Wanjari, Muhammad T. Idrees, Mehdi Nassiri, John N. Eble, David J. Grignon
Summary: Thyroid-like follicular renal cell carcinoma is a rare kidney tumor with distinct histological features, positive immunohistochemical markers, and molecular alterations involving EWSR1-PATZ1 fusion gene. No evidence of recurrence or metastasis was found in the cohort of patients during the follow-up period. The identification of EWSR1-PATZ1 fusion provides the first distinct molecular abnormality in thyroid-like follicular renal cell carcinomas.
Letter
Hematology
Tzu-Fei Wang, Ranjeeta Mallick, Marc Carrier, Philip S. Wells
Summary: This study aimed to evaluate the efficacy and safety of apixaban thromboprophylaxis according to renal function in cancer patients. The results showed that patients with a creatinine clearance (CrCl) less than 60 mL/min did not have a higher risk of thrombotic or bleeding complications compared to those with a CrCl greater than or equal to 60 mL/min.
THROMBOSIS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Kexin Lin, Xiaorui Kong, Xufeng Tao, Xiaohan Zhai, Linlin Lv, Deshi Dong, Shilei Yang, Yanna Zhu
Summary: This article reviews the traditional research methods of renal transporter-mediated drug-drug interactions (DDIs) and updates the recent progress in the development of methods. Through the sorting work conducted in this paper, it will be convenient for researchers at different learning stages to choose the best method for their own research based on their own subject's situation when they are going to study DDIs mediated by renal transporters.
Article
Pathology
Kimmo Kartasalo, Peter Strom, Pekka Ruusuvuori, Hemamali Samaratunga, Brett Delahunt, Toyonori Tsuzuki, Martin Eklund, Lars Egevad
Summary: This study developed an artificial intelligence algorithm based on deep neural networks for detecting perineural invasion (PNI) in prostate biopsies. By digitizing and annotating a large number of biopsy samples, the algorithm achieved high accuracy in PNI detection, potentially providing valuable assistance to pathologists.
Article
Biochemical Research Methods
Philippe Weitz, Yinxi Wang, Kimmo Kartasalo, Lars Egevad, Johan Lindberg, Henrik Gronberg, Martin Eklund, Mattias Rantalainen
Summary: This study proposes a new approach to predict gene expression profiles based on the morphological features of tumors. By using convolutional neural networks, gene expression profiles were successfully predicted from hematoxylin and eosin-stained images, offering a cost-effective solution for large-scale research studies and molecular diagnostics.
Article
Urology & Nephrology
William John Yaxley, James Mackean, Devang J. Desai, Gail Tsang, Judi Dixon, Hemamali Samaratunga, Brett Delahunt, Lars Egevad, Robert A. Gardiner, John William Yaxley
Summary: This study examines the long-term oncological outcomes and urological morbidity of low-dose-rate prostate brachytherapy (LDRBT) monotherapy for men with low and intermediate-risk prostate cancer. The results show excellent prostate cancer-specific survival (PCSS) and low risk of post-implantation urethral stricture and urinary incontinence (UI) with LDRBT.
Article
Multidisciplinary Sciences
Bojing Liu, Yinxi Wang, Philippe Weitz, Johan Lindberg, Johan Hartman, Wanzhong Wang, Lars Egevad, Henrik Gronberg, Martin Eklund, Mattias Rantalainen
Summary: This study suggests that deep learning can detect potential prostate cancer in benign prostate biopsies, reducing false negatives and indicating men who could benefit from rebiopsies.
Editorial Material
Urology & Nephrology
Kenneth A. Iczkowski, Mariel Molina, Lars Egevad, David G. Bostwick, Geert J. L. H. van Leenders, Francisco G. La Rosa, Theodorus van der Kwast, Daniel M. Berney, Andrew J. Evans, Thomas M. Wheeler, Katia R. M. Leite, Hemamali Samaratunga, John Srigley, Murali Varma, Toyonori Tsuzuki, Marshall Scott Lucia, Elward David Crawford, Richard G. Harris, Philip Stricker, Nathan Lawrentschuk, Henry H. Woo, Neil E. Fleshner, Neal D. Shore, John Yaxley, Ola Bratt, Peter Wiklund, Matthew Roberts, Liang Cheng, Brett Delahunt
Article
Pathology
Rachel N. Flach, Lars Egevad, Martin Eklund, Theodorus H. van der Kwast, Brett Delahunt, Hemamali Samaratunga, Britt B. M. Suelmann, Peter-Paul M. Willemse, Richard P. Meijer, Paul J. van Diest
Summary: This study investigated the effect of e-learning on the interobserver variability of prostate cancer grading using the ISUP Education web platform. The results showed that e-learning reduced variability in PCa grading, making it a cost-effective method for standardisation of pathology.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Letter
Pathology
Hemamal Samaratunga, Tony Gianduzzo, Joanna Perry-Keene, Lars Egevad, Brett Delahunt
Article
Cell Biology
Lars Egevad, Brett Delahunt, Kenneth A. Iczkowski, Theo van der Kwast, Geert J. L. H. van Leenders, Katia R. M. Leite, Chin-Chen Pan, Hemamali Samaratunga, Toyonori Tsuzuki, Nita Mulliqi, Xiaoyi Ji, Henrik Olsson, Masi Valkonen, Pekka Ruusuvuori, Martin Eklund, Kimmo Kartasalo
Summary: There is evidence that cribriform morphology is associated with a worse prognosis for prostatic adenocarcinoma. This study aimed to investigate the reproducibility of cribriform cancer diagnosis in prostate needle biopsies. A panel of nine prostate pathology experts independently reviewed 304 digitised biopsies and achieved a 2/3 consensus diagnosis of cribriform and noncribriform cancer in 90% of the cases. Strict diagnostic criteria were used to identify cribriform patterns and generate a set of consensus cases for standardization.
Article
Medicine, General & Internal
M. Alvaro Berbis, David S. McClintock, Andrey Bychkov, Jeroen Van der Laak, Liron Pantanowitz, Jochen K. Lennerz, Jerome Y. Cheng, Brett Delahunt, Lars Egevad, Catarina Eloy, Alton B. Farris III, Filippo Fraggetta, Raimundo Garcia del Moral, Douglas J. Hartman, Markus D. Herrmann, Eva Hollemans, Kenneth A. Iczkowski, Aly Karsan, Mark Kriegsmann, Mohamed E. Salama, John H. Sinard, J. Mark Tuthill, Bethany Williams, Cesar Casado-Sanchez, Victor Sanchez-Turrion, Antonio Luna, Jose Aneiros-Fernandez, Jeanne Shen
Summary: AI is expected to be routinely and impactfully used in pathology practice by 2030, according to experts in the field. This consensus study highlights the anticipated short-to-mid-term impact of AI and raises important practical, ethical, and legal challenges that need to be addressed prior to its clinical implementation.
Article
Oncology
Naveen S. Vasudev, Ghislaine Scelo, Kate I. Glennon, Michelle Wilson, Louis Letourneau, Robert Eveleigh, Nazanin Nourbehesht, Madeleine Arseneault, Antoine Paccard, Lars Egevad, Juris Viksna, Edgars Celms, Sharon M. Jackson, Behnoush Abedi-Ardekani, Anne Y. Warren, Peter J. Selby, Sebastian Trainor, Michael Kimuli, Jon Cartledge, Naeem Soomro, Adebanji Adeyoju, Poulam M. Patel, Magdalena B. Wozniak, Ivana Holcatova, Antonin Brisuda, Vladimir Janout, Estelle Chanudet, David Zaridze, Anush Moukeria, Oxana Shangina, Lenka Foretova, Marie Navratilova, Dana Mates, Viorel Jinga, Ljiljana Bogdanovic, Bozidar Kovacevic, Anne Cambon-Thomsen, Guillaume Bourque, Alvis Brazma, Jorg Tost, Paul Brennan, Mark Lathrop, Yasser Riazalhosseini, Rosamonde E. Banks
Summary: Targeted gene sequencing can help in risk prediction and adjuvant treatment decisions for patients with resected localized ccRCC. Mutations in the VHL gene have a significant impact on patient outcomes, independent of other gene mutations. Genomic characterization can personalize treatment discussions and inform future adjuvant trial design.
CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Pathology
Murali Varma, Brett Delahunt, Liang Cheng, Runjan Chetty, Eva Comperat, Vikram Deshpande, Lars Egevad, Theodorus H. van der Kwast, Antonio Lopez-Beltran, W. Glenn McCluggage
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Letter
Pathology
Hemamali Samaratunga, Lars Egevad, Brett Delahunt
Review
Pathology
Murali Varma, Laura C. Collins, Runjan Chetty, Dipti M. Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D. Guzman-Arocho, Adam Jones, Miranda Pring, W. Glenn Mccluggage
Summary: This paper highlights the importance of macroscopic examination and tissue sampling in histopathology reporting and discusses potential solutions and challenges. It emphasizes the need for adequate guidance and supervision in macroscopic examination and highlights the importance of clinical context, specimen fixation, macroscopic descriptions, and tissue sampling.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Urology & Nephrology
Joel Andersson, Thorgerdur Palsdottir, Anna Lantz, Markus Aly, Henrik Gronberg, Lars Egevad, Martin Eklund, Tobias Nordstrom
Summary: The study found that for men with PSA >= 3 ng/ml, a suspicious DRE indicates a more than threefold higher risk of significant prostate cancer. DRE as a variable adds significant precision to the Stockholm3 prediction model.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Letter
Pathology
Hemamali Samaratunga, Brett Delahunt, John W. Yaxley, Shulammite Johannsen, Lars Egevad
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
