Article
Optics
Nadezhda Ignatova, Tatiana Ivanova, Artem Antonyan, Ivan Budruev, Olga Streltsova, Vadim Elagin, Vladislav Kamensky
Summary: PDI is considered an effective method for preventing postoperative complications of urolithiasis. This study demonstrates the application of PDI in dealing with drug-resistant bacterial strains associated with renal calculi and selecting optimal exposure modes for different bacteria. Antibiotic-resistant bacteria were predominant in urinary tract infection samples, and exposure modes with maximal bactericidal activity were chosen for certain bacterial strains.
Article
Geriatrics & Gerontology
Jie Gu, Ping Song, Xiong Chen, Zhiming Yang, Xiaobo Zhang, Yao Bai
Summary: This study compared the bacterial spectrum and antibiotic susceptibility of uropathogens in older and younger patients with urinary stones. The results showed that the main pathogens in the older group with urinary tract infection were Escherichia coli and Klebsiella pneumoniae, while in the younger group, they were Escherichia coli and Enterococcus faecalis. In addition, the prevalence of Klebsiella pneumoniae and Enterococcus faecium was significantly higher in the older group. The proportion of males was higher in the older group. For antibiotic susceptibility, Escherichia coli and Klebsiella pneumoniae showed high sensitivity to piperacillin/tazobactam, imipenem, and amikacin, but high resistance to penicillin, tetracycline, and vancomycin. Enterococcus faecalis and Enterococcus faecium showed high sensitivity to gentamicin and vancomycin. Uropathogens isolated from younger patients were more susceptible to antimicrobials than those from older patients.
Article
Microbiology
Kanika Bhargava, Gopal Nath, Amit Bhargava, Ritu Kumari, G. K. Aseri, Neelam Jain
Summary: Urinary tract infection (UTI) is a common infectious disease that affects men and women. This study investigated the prevalence and antibiotic susceptibility of uropathogens isolated from UTI patients in the eastern part of Northern India. The findings revealed a high prevalence of multidrug-resistant (MDR) pathogens, emphasizing the importance of proper management and antibiotic policy based on the local susceptibility patterns.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yanfang Feng, Caroline Coradi Tonon, Shoaib Ashraf, Tayyaba Hasan
Summary: Combination therapy of PDT and antibiotics shows promising potential in overcoming the limitations of antibiotic treatment and PDT, exerting increased disinfection efficacy on multidrug-resistant bacterial pathogens.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Zhongyuan Guo, Jiarong Zhou, Yiyan Yu, Nishta Krishnan, Ilkoo Noh, Audrey Ting Zhu, Raina M. Borum, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: Researchers have explored the use of nanoparticulate strategies for more effective antigen delivery to the immune system. They formulated nanotoxoids against staphylococcal alpha-hemolysin and embedded them into a DNA-based hydrogel with immunostimulatory CpG motifs to improve immunogenicity. The resulting nanoparticle-hydrogel composite enhances vaccine delivery and stimulates immune responses, providing protection against methicillin-resistant Staphylococcus aureus infections.
ADVANCED MATERIALS
(2023)
Article
Infectious Diseases
Naveed Ahmed, Hira Khalid, Mariam Mushtaq, Sakeenabi Basha, Ali A. Rabaan, Mohammed Garout, Muhammad A. Halwani, Abbas Al Mutair, Saad Alhumaid, Zainab Al Alawi, Chan Yean Yean
Summary: This study investigated the prevalence of bacterial infection and antimicrobial resistance in UTI patients in a Tertiary Care Hospital in Lahore, Pakistan. Methicillin-resistant Staphylococcus aureus (MRSA) was found to have a prevalence of 16.93% and showed high resistance to several antibiotics.
Article
Immunology
Huan-Cheng Lai, Shih-Ni Chang, Hsiao-Chuan Lin, Yu-Lung Hsu, Hsiu-Mei Wei, Chin-Chi Kuo, Kao-Pin Hwang, Hsiu-Yin Chiang
Summary: This study found an association between urine pH and specific uropathogens in pediatric patients, with the prevalence of P. mirabilis increasing significantly across higher pH categories. Age and urine pH are both associated with certain causative uropathogens in UTIs. Future studies should further investigate the role of urine pH in predicting uropathogens and UTI.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Arthika Manoharan, Samantha Ognenovska, Denis Paino, Greg Whiteley, Trevor Glasbey, Frederik H. Kriel, Jessica Farrell, Kate H. Moore, Jim Manos, Theerthankar Das
Summary: NAC is a non-toxic, antibiofilm agent in vitro and can prevent cell invasion and IBC formation by uropathogens, providing a potentially novel and efficacious treatment for UTIs. When combined with an antibiotic, it may disrupt bacterial biofilms and eliminate residual bacteria.
Article
Chemistry, Multidisciplinary
Zhigang Yu, Emily C. A. Goodall, Ian R. R. Henderson, Jianhua Guo
Summary: This study reveals that plasmid-free bacterial cells exhibit filamentation and asymmetrical cell division under exposure to sub-inhibitory concentrations of antibiotics, while plasmid-bearing cells do not show such morphological changes. Higher expression of sulA is observed in plasmid-free cells. The benefits of plasmid carriage include less DNA damage, stronger efflux pump activities, and higher antibiotic tolerance.
Review
Medical Laboratory Technology
Aref Shariati, Milad Noei, Zahra Chegini
Summary: The combination of low-dose ciprofloxacin and bacteriophages can effectively manage bacterial infections with high antibiotic resistance by increasing phage production and reducing bacterial counts. This combination therapy also exerts selection pressures that decrease phage and antibiotic resistance. Additionally, it shows promising results in reducing bacterial counts in biofilm communities and managing Pseudomonas aeruginosa infections in mouse models.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Tesfa Addis, Yonas Mekonnen, Zeleke Ayenew, Surafel Fentaw, Habtamu Biazin
Summary: Urinary tract infections (UTIs) are a major cause of morbidity in the general population, with Gram-negative organisms being the most common causes. The study found high resistance levels to commonly used antibiotics among the cultured isolates.
Review
Infectious Diseases
Jinzhou Ye, Xinhai Chen
Summary: Infections caused by antibiotic-resistant bacteria are a major global health challenge. This review compiles the most promising strategies currently under development to tackle antibiotic resistance, including the discovery of novel antibiotics, improvement of existing antibiotics, and the development of alternatives to conventional antibiotics. Clinical or preclinical studies show the great potential of these treatments against antibiotic-resistant bacteria, with some products expected to become commercially available soon.
Review
Microbiology
Lavoisier Akoolo, Sandra C. Rocha, Nikhat Parveen
Summary: Various protozoan pathogens can cause multiple human diseases, and co-infections may lead to synergistic or antagonistic pathogenic effects that affect host immune responses and disease severity. Understanding the immunological changes caused by protozoan infections can help prevent and treat co-infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Stephany Navarro, Ethan Sherman, Jane A. Colmer-Hamood, Thomas Nelius, Matthew Myntti, Abdul N. Hamood
Summary: This study demonstrates the effectiveness of a novel biofilm preventative agent coating in inhibiting biofilm formation by both Gram-negative and Gram-positive uropathogens on urinary catheters.
Article
Chemistry, Multidisciplinary
Rui Zhang, Xiaoyang Liang, Jia Wang, Bingran Yu, Yang Li, Fu-Jian Xu
Summary: Due to the widespread use of antibiotics, drug-resistant pathogens have become a significant global health problem. In this study, a supramolecular hydrogel based on pseudopolyrotaxanes aggregation was developed for antibiotic delivery. The hydrogel could be obtained under mild conditions and could encapsulate antibiotics. The hydrogel exhibited reversible changes in crosslink density, controlled antibiotic release, and demonstrated good antimicrobial efficiency against different types of bacteria, making it potentially useful for biomedical applications.
CHEMISTRY-AN ASIAN JOURNAL
(2022)