Review
Biochemistry & Molecular Biology
Ruben Moreira, Ana D. Martins, Marco G. Alves, Maria de Lourdes Pereira, Pedro F. Oliveira
Summary: Low testosterone levels are a major cause of male infertility, and endocrine-disrupting chemicals such as chromium (Cr) can affect testicular steroidogenesis and male fertility. In particular, Cr(III) picolinate (CrPic(3)) has been found to inhibit enzymes involved in steroidogenesis and impact reactive oxygen species (ROS) levels, testosterone levels, and sperm motility and count. However, further research is needed to fully understand the effects of CrPic(3) on male fertility and ensure its safety for use by men.
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Petr Slama, Shubhadeep Roychoudhury
Summary: Inflammation and oxidative stress are core causatives of male infertility, with a close connection between the two. Inflammation leads to elevated levels of proinflammatory mediators in the male reproductive tract, while oxidative stress causes oxidative damage to reproductive cells and intracellular components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qiyao Li, Qiqi Zhu, Fuhong Tian, Jingjing Li, Lei Shi, Yang Yu, Yang Zhu, Huitao Li, Yiyan Wang, Ren-Shan Ge, Xiaoheng Li
Summary: Testicular dysgenesis syndrome in male neonates, characterized by cryptorchidism and hypospadias, can be caused by in utero phthalate exposure. The study explores the mechanism of DEHP-mediated effects and the therapeutic potential of taxifolin, and finds that taxifolin can rescue DEHP-induced alterations by regulating oxidative balance and SIRT1/PGC1 alpha levels.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Arana-Hidalgo Dana, Silva-Palacios Alejandro
Summary: SFN acts as a versatile nutraceutical agent by regulating cellular stress responses and modulating ER stress through the Nrf2-mediated antioxidant pathway, thus maintaining cellular homeostasis balance.
Review
Biochemistry & Molecular Biology
Elizabeth Monageng, Ugochukwu Offor, Ndivhuho Beauty Takalani, Kutullo Mohlala, Chinyerum Sylvia Opuwari
Summary: Leydig cells are vital for reproductive health and oxidative stress can cause dysfunction of these cells, leading to male infertility. Medicinal plants have shown potential in improving Leydig cell function and are being considered as alternative treatments for male infertility. This review provides an overview of the impact of oxidative stress on Leydig cells and the effects of various medicinal plant extracts on these cells, including Aspalathus linearis, Camellia sinensis, and Moringa oleifera.
Article
Environmental Sciences
Xueyun Li, Lili Tian, Xinyi Oiao, Lei Ye, Hong Wang, Mengyun Wang, Jianmin Sang, Fuhong Tian, Ren-Shan Ge, Yiyan Wang
Summary: Citrinin, a mycotoxin found in fruits, is toxic to the kidneys, liver, and embryos. This study revealed that citrinin inhibits Leydig cell development in prepubertal male rats, resulting in decreased testosterone levels, increased serum LH and FSH levels, and apoptosis of Leydig cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biology
Muhammad Umar Ijaz, Ayesha Rauf, Shama Mustafa, Hussain Ahmed, Asma Ashraf, Khalid Al-Ghanim, Satyanarayana Swamy Mruthinti, S. Mahboob
Summary: The study found that Pachypodol effectively alleviated PFOS-induced testicular toxicity, showing good antioxidant activity and improving biochemical markers, hormonal levels, and histopathological profiles.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Andrology
Shokoufeh Yahyavy, Armita Valizadeh, Ghasem Saki, Layasadat Khorsandi
Summary: DEHP induces toxic effects on TM3 cells, including decreased cell viability, reduced testosterone level, increased apoptosis, and oxidative stress. However, treatment with TAU can mitigate these negative impacts induced by DEHP.
Article
Biochemistry & Molecular Biology
Evan Paul Tracy, Michaela Dukes, Gabrielle Rowe, Jason E. Beare, Rajeev Nair, Amanda Jo LeBlanc
Summary: This study aimed to investigate the mechanisms underlying the restorative effects of adipose stromal vascular fraction (SVF) on vasodilation in aging-induced coronary microvascular disease (CMD). The results showed that SVF can attenuate chronic accumulation of reactive oxygen species (ROS) and enhance antioxidant gene and protein expression in coronary arterioles, thus restoring flow- and beta 1-adrenergic receptor (beta 1ADR)-mediated vasodilation. The study also identified a novel mechanism involving the impact of ROS on beta 1ADR trafficking.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Yuxuan Lin, Wenqi Xu, Zhengguo Chen, Jianan Zhai, Qi Zhu, Zhifang Guo, Ningning Wang, Cong Zhang, Haoyuan Deng, Shaopeng Wang, Guang Yang
Summary: Di-ethylhexyl phthalate (DEHP) is widely used as a plasticizer in various products. It has been found to have toxic effects on the testicles, causing testicular damage through oxidative stress, ferroptosis, interference with the hypothalamic-pituitary-gonadal axis, and testosterone level. Recent studies have identified protective agents that can repair this type of testicular damage, suggesting new directions for future research on the health effects and molecular mechanisms of DEHP.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pharmacology & Pharmacy
Dongxue Ma, Pengfei Han, Mingji Song, Hongfu Zhang, Wei Shen, Guian Huang, Minghui Zhao, Qingyuan Sun, Yong Zhao, Lingjiang Min
Summary: Beta-carotene is a powerful antioxidant that can improve oocyte quality and enhance spermatogenesis. It also increases the expression of important genes and proteins for spermatogenesis and enhances testicular antioxidant capacity. Beta-carotene shows potential for improving fertility in infertile couples affected by failed gametogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fan Qi, Jianwei Li, Xiufang Hong, Zhiyi Jia, Binyan Wu, Fucheng Lin, Yan Liang
Summary: Breeding crops with enhanced immunity is an effective strategy, but the cpr5 mutant, which shows enhanced pathogen resistance, has retarded growth. Excessive accumulation of reactive oxygen species (ROS) was found in the cpr5 mutant, and the mutation of RBOHD did not suppress it. APX1 overexpression removed excessive ROS and restored the growth phenotype of cpr5 without reducing pathogen resistance. These findings provide a basis for using CPR5 in breeding disease-resistant crops through effective oxidative stress management via APX1 expression.
Article
Environmental Sciences
Umar M. Bello, Mary-Cathrine Madekurozwa, Hermanus B. Groenewald, Augustine Arukwe, Tom A. Aire
Summary: This study investigated the effects of DBP exposure on the testes of adult male quails. The results showed that high doses of DBP led to significant decreases in seminiferous tubular diameter and epithelial height, as well as structural changes in the Leydig cells. These findings suggest that DBP exposure may impair the reproductive system of adult birds.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Dichao Hu, Lili Tian, Xueyun Li, Yirui Chen, Zheqing Xu, Ren-shan Ge, Yiyan Wang
Summary: This study found that Tetramethyl bisphenol A (TMBPA) inhibits the activity of Leydig cell steroidogenic enzymes and induces ferroptosis, thereby inhibiting testosterone synthesis in late puberty.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Fernanda C. R. Dias, Sergio L. P. Matta, Michelle B. Soares, Elizabeth L. Oliveira, Fabiana C. S. A. Melo, Nivaldo A. Parizotto, Angelica O. Gomes, Marcos L. M. Gomes
Summary: This study evaluated the structural and organizational aspects of the testicles in mice with homozygous and heterozygous offspring related to the Foxn1 gene, and described its implications on spermatogenesis. The results indicate the importance of the Foxn1 gene in Leydig cell function, leading to lower sperm production.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
