Review
Cell Biology
Jia-Min B. Pang, David J. Byrne, Alice R. T. Bergin, Franco Caramia, Sherene Loi, Kylie L. Gorringe, Stephen B. Fox
Summary: In recent years, molecular findings have been incorporated into routine diagnostic practice of anatomical pathology, revolutionizing the field. Spatial transcriptomics, a group of technologies that provide transcriptome-wide expression profiling while preserving spatial origin of the data, allows analysis of highly specific areas within a tissue section and correlation of expression data with morphology, tissue type, and location relative to other structures. Some spatial transcriptomics methods are now compatible with formalin-fixed paraffin-embedded tissue (FFPE), potentially leading to their incorporation in routine anatomical pathology practice.
Article
Immunology
Weizhuo Wang, Xi Zhang, Silin Jiang, Peng Xu, Kang Chen, Kai Li, Fei Wang, Xiang Le, Ke Zhang
Summary: This study aimed to construct a prognostic model based on differential gene expression between muscular and non-muscular invasive bladder cancer (BCa), and to investigate the prognosis of BCa patients. BCa patient data from GEO and TCGA databases were analyzed, and single-cell sequencing and microarray data were used to validate the differential gene expression. The prognostic model showed accuracy and validity, and S100A9 may be a better prognostic marker and therapeutic target for BCa.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Francesca Sanguedolce, Beppe Calo, Vito Mancini, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Stefano Ascani, Giuseppe Carrieri, Luigi Cormio
Summary: The biological features and prognostic/predictive role of variant histology (VH) in non-muscle invasive bladder cancer (NMIBC) were examined through a systematic literature search, revealing conflicting findings due to the rarity of these forms and heterogeneity in study populations. The presence of VH should be considered when counseling NMIBC patients for potential disease upgrade to high-risk tumors and aggressive treatment.
Review
Oncology
Adam S. Feldman, Girish S. Kulkarni, Trinity J. Bivalacqua, Peter C. Black, Scott Delacroix, Seth P. Lerner, Ashish M. Kamat, Wassim Kassouf
Summary: Trimodal therapy has become an accepted alternative to radical cystectomy for the treatment of muscle invasive bladder cancer. Urologists play a critical role in patient selection, surgical resection, surveillance, and management of recurrences. Multiple factors, both patient-related and tumor-related, influence the choice between trimodal therapy and radical cystectomy. Collaboration among urology, radiation oncology, and medical oncology is essential for successful treatment. Salvage cystectomy should be considered for patients with adverse features after trimodal therapy. Understanding surgical considerations is crucial for urologists managing patients through trimodal therapy.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Veterinary Sciences
Emily Jones, Solomon Woldeyohannes, Fernanda Castillo-Alcala, Brandon N. Lillie, Mee-Ja M. Sula, Helen Owen, John Alawneh, Rachel Allavena
Summary: The study aimed to develop a probability-based tool to influence the agreement between test pathologists. The results showed significant differences in the interpretation of bladder slides among pathologists. This study provides a starting point for standardizing pathologist agreement in veterinary pathology using probability-based tools.
VETERINARY SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Jillian Marie Walker, Padraic O'Malley, Mei He
Summary: Muscle invasive bladder cancer (MIBC) is a subtype of bladder cancer with a high risk of metastasis and death. Current diagnostic methods include urologic evaluation, CT scan, urinalysis, and cystoscopy. However, these invasive procedures carry risks and potential health concerns. Exosomes, as a novel source of biomarkers, show promise in addressing some of the limitations of urine cytology. This review provides an overview of MIBC, current urine cytology methods, the role of exosomes, and their potential as a diagnostic tool.
Article
Immunology
Raquel Benitez, Katherine Yu, Marina Sirota, Nuria Malats, Silvia Pineda
Summary: This study analyzed the tumor-infiltrating B and T cell repertoire in the tumor microenvironment of MIBC and found differences among different MIBC subtypes. The Basal/Squamous-like and Stroma-rich subtypes showed higher infiltration and were associated with better survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Camilla De Carlo, Marina Valeri, Devin Nicole Corbitt, Miriam Cieri, Piergiuseppe Colombo
Summary: This review summarizes the recent evidence on prognostic and predictive tissue biomarkers in non-muscle invasive bladder cancer (NMIBC), highlighting the importance of histological features and molecular events in predicting recurrence and progression. The review also emphasizes the potential of immunohistochemical evaluation as a cost-effective tool for clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Hualin Chen, Wenjie Yang, Xiaoqiang Xue, Yingjie Li, Zhaoheng Jin, Zhigang Ji
Summary: Neoadjuvant immunotherapy and chemoimmunotherapy have been found to be effective and safe in the treatment of muscle-invasive bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qi Zhang, Yezhen Tan, Jianye Zhang, Yue Shi, Jie Qi, Daojia Zou, Weimin Ci
Summary: Pyroptosis plays a significant role in muscle invasive bladder cancer (MIBC) and offers new opportunities for its treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Arighno Das, Jason E. Cohen, Oliver S. Ko, Brian J. Jordan, Alexander P. Glaser, Gregory B. Auffenberg, Joshua J. Meeks
Summary: The creation and distribution of individual surgeon scorecards improved detrusor muscle sampling during transurethral resection, leading to a decreased risk of disease recurrence in patients with nonmuscle invasive bladder cancer.
JOURNAL OF UROLOGY
(2021)
Article
Pathology
Mary K. Klassen-Fischer, Ann M. Nelson, Ronald C. Neafie, Fides A. Neafie, Aaron Auerbach, Thomas P. Baker, Allen P. Burke, Anandita A. Datta, Teri J. Franks, Iren Horkayne-Szakaly, Ernest E. Lack, Michael R. Lewin-Smith, Alejandro Luina Contreras, Rubina H. Mattu, Walter L. Rush, Paul C. Shick, Yang Zhang, Francisco J. Rentas, Joel T. Moncur
Summary: This study examined the histopathologic features of measles in commonly infected tissues during different phases of the disease. It was found that measles caused acute and chronic histopathologic changes, with specific features helping pathologists to diagnose the disease.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Ceana Nezhat, Kaitlin McGrail, Maria Hincapie
Summary: This study demonstrates the importance of microsurgical techniques in minimally invasive surgery through surgical cases. The proper application of these techniques can improve patient outcomes and preserve reproductive organs and fertility potential.
FERTILITY AND STERILITY
(2023)
Review
Medicine, General & Internal
Valentina Angerilli, Francesca Galuppini, Fabio Pagni, Nicola Fusco, Umberto Malapelle, Matteo Fassan
Summary: The current practice of pathology is influenced by the increasing complexity of modern medicine, especially precision oncology, as well as major technological advancements. In the era of next-generation technologies, pathologists are responsible for integrating and interpreting morphologic and molecular information, delivering critical answers to diagnostic, prognostic, and predictive queries, and playing a prominent role in molecular tumor boards.
Article
Multidisciplinary Sciences
Won Sik Ham, Jee Soo Park, Won Sik Jang, Young Deuk Choi, Jongchan Kim
Summary: The study suggests a correlation between larger prostate volume and worse recurrence and progression-free survival in non-muscle invasive bladder cancer.
SCIENTIFIC REPORTS
(2021)
