Article
Pathology
Gozde Kir, Gozde Ecem Cecikoglu, Cumhur Selcuk Topal, Muhammet Huseyin Sorkun, Meftun Culpan, Ferhat Yakup Suceken, Hakan Karaca, Asif Yildirim
Summary: According to the 2022 WHO/ISUP classification, noninvasive carcinomas are categorized based on the highest grade observed in pathology samples. This study examined the prognosis of low-grade papillary urothelial carcinoma (LGUC), high-grade papillary urothelial carcinoma (HGUC), and mixed-grade papillary urothelial carcinoma (MGUC). The results demonstrated that histologic grade, invasion of the lamina propria, and the presence of carcinoma in situ were independent prognostic factors for recurrence-free survival and disease-specific survival. There were also significant differences in disease-specific survival between NMI MGUC and NMI LGUC, as well as between NMI MGUC and NMI HGUC, suggesting the clinical importance of MGUC.
Article
Surgery
Kai Huang, Lara Appiah, Ankita Mishra, Sanjay P. Bagaria, M. Emmanuel Gabriel, Subhasis Misra
Summary: IPC, considered to have a better prognosis than IDC, showed similar 5-year overall survival in a large nationwide study. Although IPC presented in older postmenopausal women, black Americans, and those with government insurance, it had larger tumor size, lower grade, earlier stage, less node-positive disease, higher hormone positivity, and lower human epidermal growth factor receptor 2 amplification compared to IDC.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Pathology
Andres Matoso, Vamsi Parimi, Jonathan I. Epstein
Summary: This study retrospectively reviewed 16 cases of noninvasive low-grade papillary urothelial carcinoma with degenerative atypia, which showed difficulties in grading due to significant nuclear pleomorphism. Most cases had no disease progression, with one case recurring after 20 months.
Article
Medicine, General & Internal
Kelly K. Bree, Yong Shan, Patrick J. Hensley, Niyati Lobo, Chengrui Hu, Douglas S. Tyler, Karim Chamie, Ashish M. Kamat, Stephen B. Williams
Summary: This population-based study found that surveillance testing rates increased over time among patients with low-risk non-muscle-invasive bladder cancer (NMIBC), despite low rates of disease recurrence and progression. The annual cost of care also increased, particularly among patients with recurrent disease.
Article
Pathology
Tiansheng Wang, Xinrong Liu, Wentao Yu, Lin Gao, Wenzhi Deng, Qiongzhi He, Feifei Liao, Ling Chu
Summary: In this study, the genomic characteristics of four cases of TL-LGNPPA were reported, shedding light on the clinical pathological features of this tumor. It was found that 41 mutations and two copy number variations were present, but no typical driver mutations were identified. Additionally, no microsatellite instability and HLA loss of heterozygosity were found. This study is the first to reveal the genetic underpinnings of this rare tumor.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Xiaodan Chen, Haiyan Ge, Junjie Yang, Bin Huang, Hongsheng Liu
Summary: This study reports a case of collision tumor between primary malignant melanoma of the bladder and high-grade non-invasive urothelial papillary carcinoma. Immunohistochemical analysis revealed different marker expressions between the two tumors, and no transitional regions were observed. This pathology is associated with a high risk of recurrence and metastasis and has a poor prognosis.
Article
Oncology
Minsun Jung, Cheol Lee, Dohyun Han, Kwangsoo Kim, Sunah Yang, Ilias P. Nikas, Kyung Chul Moon, Hyeyoon Kim, Min Ji Song, Bohyun Kim, Hyebin Lee, Han Suk Ryu
Summary: Proteomic analysis revealed distinct 'NU-like' and 'PUC-like' signatures in IUP, with SERPINH1, PKP2, and PYGB identified as potential diagnostic biomarkers. Immunohistochemical validation confirmed PYGB as a specific biomarker to distinguish between IUP and PUC with inverted growth, suggesting its promising role in routine practice for IUP diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Daniel H. Russell, Jonathan Epstein
Summary: This study investigates intraductal carcinoma of the prostate (IDC-P) with ductal morphology and proposes a similar naming approach as IDC-P with acinar morphology. The authors recommend reporting and treating IDC-P with ductal morphology in a manner analogous to IDC-P with acinar morphology. Additionally, they suggest modifying the diagnostic criteria of IDC-P to include lesions with papillary fronds or cribriform morphology lined by cytologically atypical pseudostratified epithelium.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Cell Biology
Changwen Zhai, Huan Wang, Shimin Li, Dehui Wang
Summary: This study evaluated the clinicopathological and molecular characteristics of five cases of Low-grade Papillary Schneiderian Carcinoma (LGPSC) in the sinonasal tract, confirming it as a new aggressive carcinoma with metastatic potential. Further research is needed to fully understand its behavior and characteristics.
Article
Pathology
Yuqing Cheng, Mingzhan Du, Xiaoli Zhou, Lingchuan Guo, Kequn Xu, Jin Huang, Qin Huang
Summary: The study found that high-grade papillary EGC tumors are larger in size, have a higher risk of lymphovascular invasion and lymph node metastasis. Low-grade papillary EGC tumors are more likely to be elevated in a macroscopic examination, but do not exhibit lymphovascular invasion or lymph node metastasis, similar to tubular EGC.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Pathology
Peter P. Chen, Preetha Ramalingam, Isabel Alvarado-Cabrero, Elizabeth D. Euscher, Priyadharsini Nagarajan, Barrett C. Lawson, Anais Malpica
Summary: Vulvar high-grade neuroendocrine carcinomas (HGNECs) are rare and aggressive tumors that can be subclassified into MCC, SCNEC, and large cell neuroendocrine carcinomas. Specific biomarkers aid in distinguishing between these subtypes.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ivonne A. Montes-Mojarro, Saki Hassas, Sina Staehle, Philip Sander, Niklas Harland, Lina Maria Serna-Higuita, Irina Bonzheim, Hans Boesmueller, Arnulf Stenzl, Falko Fend
Summary: This study aims to develop a multiparametric classification to distinguish low-grade and high-grade urothelial tumors by analyzing immunohistochemical stains and pathogenic mutations. Analysis of clinical and histological data revealed that PUN-LMP and LG-PUC belong to one cluster, while HG-PUC belongs to another cluster, providing guidance for clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Satya Dutta, Biswajit Dey, Vandana Raphael, Yookarin Khonglah, Jaya Mishra, Evarisalin Marbaniang, Pranjal Kalita, Stephen Sailo
Summary: According to the findings, patients with larger initial tumor sizes and tumor multiplicity at presentation had an increased tumor recurrence rate.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Oncology
Haoyue Hu, Lang Long, Xue Fan, Jun He
Summary: Low-grade thyroid-like nasopharyngeal papillary adenocarcinoma is a rare tumor with good prognosis after complete surgical resection.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2022)
Article
Endocrinology & Metabolism
Stephen Halada, Julia A. Baran, Andrew J. Bauer, Julio C. Ricarte-Filho, Amber Isaza, Tasleema Patel, Aime T. Franco, Sogol Mostoufi-Moab, N. Scott Adzick, Ken Kazahaya, Tricia R. Bhatti, Zubair Baloch, Lea F. Surrey
Summary: This study retrospectively reviewed the clinical and histological features of pediatric cases with follicular patterned thyroid nodules with nuclear features of papillary thyroid carcinoma (PTC), focusing on the invasive encapsulated follicular variant of PTC (Ienc-fvPTC) and infiltrative fvPTC (inf-fvPTC) subtypes. The study found that pediatric NIFTP and fvPTC subtypes demonstrate alignment between clinical and histological risk stratification, with indolent behavior in Ienc-fvPTC and invasive features in inf-fvPTC tumors.
Review
Urology & Nephrology
Theo van der Kwast, Fredrik Liedberg, Peter C. Black, Ashish Kamat, Bas W. G. van Rhijn, Ferran Algaba, David M. Berman, Arndt Hartmann, Antonio Lopez-Beltran, Hemamali Samaratunga, Murali Varma, Liang Cheng
Summary: This article explores the requirements for an optimal grading system for non-muscle-invasive bladder cancer through expert opinion. It suggests splitting the WHO 2004 high-grade category into WHO 1973 grade 2 and 3 subsets, providing more detailed histological criteria. These changes may lead to better treatment decisions for patients with bladder cancer.
EUROPEAN UROLOGY FOCUS
(2022)
Letter
Urology & Nephrology
Theo van der Kwast, Bas Van Rhijn, Ashish Kamat, Liang Cheng
EUROPEAN UROLOGY FOCUS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominik Deniffel, Gerard M. Healy, Xin Dong, Sangeet Ghai, Emmanuel Salinas-Miranda, Neil Fleshner, Robert Hamilton, Girish Kulkarni, Ants Toi, Theodorus van der Kwast, Alexandre Zlotta, Antonio Finelli, Nathan Perlis, Masoom A. Haider
Summary: Comparing MRI-based risk models with PSAd-based strategy can effectively reduce unnecessary prostate biopsies. In a risk-averse scenario, the PSAd strategy can guide biopsy decisions better than MRI-based risk models.
Article
Oncology
James R. Hawley, Stanley Zhou, Christopher Arlidge, Giacomo Grillo, Ken J. Kron, Rupert Hugh-White, Theodorus H. van der Kwast, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Mathieu Lupien
Summary: Prostate cancer is a heterogeneous disease with genome instability, impacting noncoding genome organization. While higher-order genome organization remains consistent, changes in chromatin interactions can lead to aberrant gene regulation, often mediated by structural variants in primary prostate cancer.
Article
Oncology
Renu Jeyapala, Shivani Kamdar, Ekaterina Olkhov-Mitsel, Alexandre Zlotta, Neil Fleshner, Tapio Visakorpi, Theodorus van der Kwast, Bharati Bapat
Summary: This study validates the prognostic ability of IDC/C and CAPRA-S in predicting biochemical recurrence (BCR) in prostate cancer (PCa) patients. The combined assessment of IDC/C and CAPRA-S improves the predictive accuracy of BCR and helps identify patients at different risk levels.
CLINICAL GENITOURINARY CANCER
(2022)
Article
Endocrinology & Metabolism
Christopher Ma, Michelle Downes, Rahi Jain, Marc Ientilucci, Neil Fleshner, Nathan Perlis, Theodorus van der Kwast
Summary: The presence of adverse histopathological features, such as cribriform pattern and intraductal carcinoma, is more common in GG2 prostate cancers with metastatic disease compared to those without metastatic disease. This emphasizes the importance of these features as contra-indicators for deferred treatment in GG2 prostate cancer patients.
Review
Dermatology
Shifaa Al Qa'qa', Raj Tiwari, Theodorus van der Kwast
Summary: Background: Extramammary Paget disease (EMPD) is an uncommon disease affecting older men and women. We present a case of an 85-year-old patient with recurrent erythematous plaque lesions involving the penis and known to have urothelial carcinoma (UC) in situ of the bladder. The histopathologic examination revealed Paget cell proliferation within the surface squamous epithelium. A literature review showed that EMPD associated with UC often requires surgical treatment, but recurrence and death of the disease are more common in cases with invasive UC.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Article
Pathology
Yanhong Yu, Katherine Lajkosz, Antonio Finelli, Neil Fleshner, Theodorus H. van der Kwast, Michelle R. Downes
Summary: This study analyzed the impact of cribriform pattern 4 (CC) and intraductal carcinoma (IDC) on risk scores in prostate cancer and found that incorporating CC/IDC into the scores can improve patient classification and prognostic evaluation.
Article
Pathology
Rachel N. Flach, Lars Egevad, Martin Eklund, Theodorus H. van der Kwast, Brett Delahunt, Hemamali Samaratunga, Britt B. M. Suelmann, Peter-Paul M. Willemse, Richard P. Meijer, Paul J. van Diest
Summary: This study investigated the effect of e-learning on the interobserver variability of prostate cancer grading using the ISUP Education web platform. The results showed that e-learning reduced variability in PCa grading, making it a cost-effective method for standardisation of pathology.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Pathology
Hemamali Samaratunga, Lars Egevad, Michelle Thunders, Kenneth A. Iczskowski, Theodorus van der Kwast, Glen Kristiansen, Chin-Chen Pan, Katia R. M. Leite, Andrew Evans, David Clouston, Diane N. Kenwright, Peter B. Bethwaite, Greg Malone, Simon Wood, John W. Yaxley, Brett Delahunt
Summary: The classification of malignant tumors is influenced by immunohistochemical and molecular genetic findings. Renal oncocytoma, a benign tumor, can occasionally exhibit malignant behavior as a variant called hybrid oncocytic chromophobe tumor. Two new entities, low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) with varying nuclear pleomorphism, have been proposed. The diagnosis of these apparently benign tumors is based on morphological, immunohistochemical features, and mutations in the mTOR pathway. However, the importance and specificity of these tumors are still debatable.
Editorial Material
Pathology
Murali Varma, Brett Delahunt, Liang Cheng, Runjan Chetty, Eva Comperat, Vikram Deshpande, Lars Egevad, Theodorus H. van der Kwast, Antonio Lopez-Beltran, W. Glenn McCluggage
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Neil E. Fleshner, Rashid K. Sayyid, Aaron R. Hansen, Joseph L. K. Chin, Ricardo Fernandes, Eric Winquist, Theodorus van der Kwast, Joan Sweet, Katherine Lajkosz, Miran Kenk, Karen Hersey, Rosette Veloso, Doron Berlin, Jaime O. Herrera-Caceres, Srikala Sridhar, Madeleine Moussa, Antonio Finelli, Robert J. Hamilton, Girish S. Kulkarni, Alexandre R. Zlotta, Anthony M. Joshua
Summary: The addition of neoadjuvant cabazitaxel to abiraterone acetate/leuprolide acetate prior to radical prostatectomy did not improve pathologic complete response or minimal residual disease in localized, high-risk prostate cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Vincent Francis Castillo, Mehdi Masoomian, Kiril Trpkov, Michelle Downes, Fadi Brimo, Theodorus van Der Kwast, George M. Yousef, Abraam Zakhary, Fabio Rotondo, Gina Saad, Vy-nhan Nguyen, Wondwossen Kidanewold, Catherine Streutker, Corwyn Rowsell, Malek Hamdani, Rola M. Saleeb
Summary: This study evaluated the prognostic significance of ABCC2 expression in PRCC and found that ABCC2 IHC brush-border expression is associated with higher gene expression and predicts worse survival outcomes.
Review
Pathology
Murali Varma, Laura C. Collins, Runjan Chetty, Dipti M. Karamchandani, Karen Talia, John Dormer, Monika Vyas, Brendan Conn, Yaileen D. Guzman-Arocho, Adam Jones, Miranda Pring, W. Glenn Mccluggage
Summary: This paper highlights the importance of macroscopic examination and tissue sampling in histopathology reporting and discusses potential solutions and challenges. It emphasizes the need for adequate guidance and supervision in macroscopic examination and highlights the importance of clinical context, specimen fixation, macroscopic descriptions, and tissue sampling.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Cell Biology
Murali Varma, Eva Comperat, Theodorus van der Kwast
Summary: The grading of urothelial carcinoma varies globally, with different guidelines recommending different reporting methods. Some experts propose novel grading systems for urothelial carcinoma. This article discusses the arguments for and against splitting urothelial carcinomas into different grade categories.
