Review
Endocrinology & Metabolism
Xianlu Zhang, Gejun Zhang, Jianfeng Wang, Yanli Wang
Summary: Androgen deprivation therapy (ADT) is commonly used to treat prostate cancer, with luteinizing hormone-releasing hormone (LHRH) agonist being the preferred medication option. However, the long-term side effects of ADT have raised concerns, leading to a reevaluation of the role of medication and surgery in prostate cancer treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
H. E. Flay, C. B. Reed, B. Kuhn-Sherlock, C. V. C. Phyn, C. R. Burke, S. Meier, I. J. Clarke
Summary: Previous research has found that Holstein-Friesian dairy heifers with positive genetic merit for fertility traits reach puberty earlier than those with negative genetic merit. This study investigated the functionality of the hypothalamus-pituitary-gonadal (HPG) axis in peripubertal heifers with divergent genetic merit, finding that the earlier onset of puberty in positive heifers is associated with earlier activation of the HPG axis.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Article
Biochemistry & Molecular Biology
Juan Morote, Adriana Aguilar, Jacques Planas, Enrique Trilla
Summary: Castrate resistant prostate cancer (CRPC) refers to the continued progression of prostate cancer in an environment with very low serum testosterone concentration. The current definition is outdated and needs to be updated with more accurate imaging modalities and biochemical measurements to assess clinical progression and the castration environment.
Article
Reproductive Biology
Xi Luo, Bo Deng, Lei Li, Rui Ma, Xuancheng Mai, Ze Wu
Summary: This study aimed to evaluate the impact of luteinizing hormone levels on in vitro fertilization outcomes. The study found that luteinizing hormone levels were positively correlated with clinical pregnancy and live birth rates in the agonist regimen, but not in the antagonist regimen, except for women in the nonadvanced age group or those with excessively suppressed levels.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Benjamin E. Onderdonk, Paige L. Dorn, Carlos Martinez, Fauzia Arif, Denise Cloutier, Tatjana Antic, Daniel W. Golden, Theodore Karrison, Sean P. Pitroda, Russell Z. Szmulewitz, Stanley L. Liauw
Summary: The study compared oral ADT with standard ADT in the treatment of PCa undergoing RT, showing that oral ADT may improve 6-month QOL and have a similar impact on androgen-responsive gene expression.
Article
Medicine, General & Internal
Rihwa Choi, Aerin Kwon, Youngju Oh, Sang Gon Lee, Eun Hee Lee
Summary: The study investigated laboratory data for GnRH stimulation testing in Korean children and found that the time points of 45 minutes and 60 minutes after stimulation showed the best performance in identifying pubertal responses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Anat Hershko Klement, Raoul Orvieto, Efrat Esh Broder, Judith Frei, Amy Solnica, Orit Zandman, Hananel Holzer, Jigal Haas
Summary: This study found that LH concentrations post-GnRHa trigger differ based on the antagonist-agonist intervals, but the achieved follicle/mature oocyte ratio was not affected.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Chemistry, Multidisciplinary
Lindsay E. Calderon, Carrie A. Black, Joseph D. Rollins, Brittany Overbay, Semekidus Shiferawe, Andrew Elliott, Sara Reitz, Shu Liu, Junling Li, Chin K. Ng, Margaret W. Ndinguri
Summary: Current radionuclides Re-186/188 and Tc-99m are widely used for cancer detection and diagnosis. New advancements in modalities and targeting strategies of radiopharmaceuticals aim to enhance imagery and detection of smaller cancer cell colonies while reducing false-positive diagnoses. Designs like Re-Acdien-LHRH and Re-Acdien-peg-LHRH show enhanced cellular uptake and potential for selective targeting of breast cancers expressing the LHRH receptor.
Article
Biology
Fumiya Sugino, Keita Nakane, Makoto Kawase, Shota Ueda, Masayuki Tomioka, Yasumichi Takeuchi, Risa Tomioka-Inagawa, Toyohiro Yamada, Sanae Namiki, Naotaka Kumada, Shinichi Takeuchi, Kota Kawase, Daiki Kato, Manabu Takai, Koji Iinuma, Yuki Tobisawa, Takuya Koie
Summary: This study evaluates the efficacy and safety of neoadjuvant LHRH antagonist and UFT therapy followed by RARP in patients with high-risk PCa. The results suggest that combining these treatments may improve oncological outcomes in this patient population.
Article
Cardiac & Cardiovascular Systems
Hao-Lin Ren, Ruiping Cai, Ruize Xue, Yaoxia Zhang, Qian Xu, Xianyang Zhang, RenZhi Cai, Wei Sha, Andrew V. V. Schally, Ming-Sheng Zhou
Summary: GHRH-A MR409 has been shown to effectively attenuate vascular calcification and heart valve calcification in diabetic mice, while protecting against endothelial dysfunction and vascular injury. This may be achieved through upregulation of anti-calcifying protein Klotho and reduction in vascular reactive oxygen species (ROS) generation, as well as the expression of redox sensitive osteogenic genes Runx2 and ALP. GHRH-A could represent a new pharmacological strategy for the treatment of vascular calcification and diabetes-associated cardiovascular complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Lucas Oliveira e Silva, NatAlia P. Folchini, Rodrigo L. O. R. Alves, Guilherme Madureira, Carlos E. C. Consentini, JEssica C. L. Motta, Milo C. Wiltbank, Roberto Sartori
Summary: This study aimed to determine the effect of circulating progesterone concentrations produced by a corpus luteum or released by an intravaginal progesterone implant on GnRH-induced LH release, ovulatory response, and subsequent CL development. Rating: 7/10.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Oncology
Nicola J. Nasser, Kai Sun, Karen M. Scanlon, Mark V. Mishra, Jason K. Molitoris
Summary: Administering docetaxel during the testosterone flare associated with LHRH initiation in patients with metastatic hormone-sensitive prostate cancer (MHSPC) can lead to improved clinical outcomes.
Review
Chemistry, Physical
Tommaso Capezzuoli, Margherita Rossi, Francesco La Torre, Silvia Vannuccini, Felice Petraglia
Summary: In the past, surgery was the primary approach for treating endometriosis. However, with the development of imaging technologies, medical treatment has become the preferred approach. Hormonal drugs, particularly progestins, are highly effective in reducing pain associated with endometriosis. The long-term treatment, though, comes with high costs to women's health.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
K. KARKIN, G. GURLEN
Summary: The study suggests that COVID-19 may increase serum LH levels and decrease TT levels in patients. Patients with COVID-19 pneumonia may experience a greater decline in serum TT levels compared to those without pneumonia.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Urology & Nephrology
Peter A. Elliott, George A. Abdelsayed, Patrick S. Kilday, Brian J. Kim, Jeff M. Slezak, Gary W. Chien
WORLD JOURNAL OF UROLOGY
(2018)
Article
Medical Informatics
Leslie S. Wilson, Traci M. Blonquist, Fangxin Hong, Barbara Halpenny, Seth Wolpin, Peter Chang, Christopher P. Filson, Viraj A. Master, Martin G. Sanda, Gary W. Chien, Randy A. Jones, Tracey L. Krupski, Donna L. Berry
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2019)
Article
Oncology
Jeff M. Slezak, Stephen K. Van Den Eeden, Kimberly L. Cannavale, Gary W. Chien, Steven J. Jacobsen, Chun R. Chao
Article
Oncology
Donna L. Berry, Fangxin Hong, Traci M. Blonquist, Barbara Halpenny, Niya Xiong, Christopher P. Filson, Viraj A. Master, Martin G. Sanda, Peter Chang, Gary W. Chien, Randy A. Jones, Tracey L. Krupski, Seth Wolpin, Leslie Wilson, Julia H. Hayes, Quoc-Dien Trinh, Mitchell Sokoloff
Summary: The study found that the use of the Personal Patient Profile-Prostate decision support tool can reduce decisional regret among Black men with prostate cancer. Additionally, Black men, men with hormonal symptoms, and men with bowel symptoms reported higher levels of decision regret.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
Michael C. Chen, Patrick S. Kilday, Peter A. Elliott, Daniel Artenstein, Jeff Slezak, Steven J. Jacobsen, Gary W. Chien
Summary: NADT prior to RALP does not significantly affect urinary or bowel function outcomes for up to 24 months postoperatively, but results in worse hormonal scores. The NADT group shows worse sexual function outcomes within 2 years after surgery, although there is no significant difference when nerve sparing is taken into account.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Oncology
Chun R. Chao, Jeff Slezak, Kimberly Siegmund, Kimberly Cannavale, Yu-Hsiang Shu, Gary W. Chien, Xu-Feng Chen, Feng Shi, Nan Song, Stephen K. Van Den Eeden, Jiaoti Huang
Summary: This study identified methylation markers associated with metastasis in localized prostate cancer, but adding the methylation score to clinical risk prediction did not significantly improve the predictive accuracy. The identified methylation markers may provide insight into the role of these genetic regions in metastasis development.
Article
Health Policy & Services
Stephen M. Wertheimer, Jerad A. Harris, J. Craig Collins, Nancy H. Spiegel, Gary W. Chien
Summary: By reviewing data of KPSC physicians, we found differences between internally trained physicians and those trained elsewhere. In terms of retention, leadership, physician relations, member appraisal, and board certification, KPSC-trained physicians outperformed non-KPSC-trained physicians.
HUMAN RESOURCES FOR HEALTH
(2023)
Meeting Abstract
Urology & Nephrology
Reza Goharderakhshan, Nikhil Crain, Drew Clausen, Dennis Walsh, Gary Chien, Ronald Loo
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Daniel Artenstein, Tyler Kern, Michael C. Chen, Joanie J. Chung, Steven J. Jacobsen, Gary W. Chien
Summary: The study found low rates of inappropriate imaging for low risk prostate cancer patients, with no change in trend after the publication of Choosing Wisely guidelines. Higher prostate specific antigen levels and White ethnicity were predictors for ordering unnecessary imaging.
Meeting Abstract
Oncology
Kim Cannavale, Jeff Slezak, Yu-Hsiang Shu, Gary W. Chien, XuFeng Chen, Feng Shi, Kim Siegmund, Stephen Van den Eeden, Jiaoti Huang, Chun R. Chao
Meeting Abstract
Oncology
Chun R. Chao, Yu-Hsiang Shu, Jeff Slezak, Kimberly L. Cannavale, Gary Chien, Stephen Van den Eeden
Meeting Abstract
Urology & Nephrology
Daniel Artenstein, Tyler Kern, Aaron Krug, Joanie Chung, Steven Jacobsen, Gary Chien
JOURNAL OF UROLOGY
(2020)
Meeting Abstract
Urology & Nephrology
Donna L. Berry, Fangxin Hong, Traci Blonquist, Barbara Halpenny, Niya Xiong, Christopher P. Filson, Viraj A. Master, Martin G. Sanda, Peter Chang, Gary Chien, Randy Jones, Tracey Krupski, Seth Wolpin, Leslie Wilson, Julia Hayes, Quoc-Dien Trinh, Mitch Sokoloff
JOURNAL OF UROLOGY
(2020)
Article
Urology & Nephrology
Donna L. Berry, Fangxin Hong, Barbara Halpenny, Martin G. Sanda, Viraj A. Master, Christopher P. Filson, Peter Chang, Gary W. Chien, Meghan Underhill, Erica Fox, Justin McReynolds, Seth Wolpin
Article
Urology & Nephrology
Pooya Banapour, Kian Asanad, Ramzi Jabaji, Daniel Artenstein, Gary Chien, Samuel Asanad, Indu Sehgal, Yekaterina Bakhta
UROLOGY CASE REPORTS
(2018)