Review
Biochemistry & Molecular Biology
Lola Llobat, Olivia Gourbault
Summary: Osteosarcoma is a rare but highly deadly cancer, especially among children and adolescents. The discovery of miRNAs holds potential for earlier diagnosis, prognosis prediction, and development of new therapies for various types of tumors, including OS. The number of clinical trials involving miRNAs as prognostic and diagnostic biomarkers, as well as therapeutic targets, is likely to increase in the near future.
Article
Urology & Nephrology
Jiasian Teh, Ellen O'Connor, Jasamine Coles-Black, Nathan Lawrentschuk
Summary: The COVID-19 pandemic has disrupted thousands of clinical trials globally, prompting the need for new strategies in urologic oncology. The long-term impact on this field and the understanding of unmet needs remain uncertain.
WORLD JOURNAL OF UROLOGY
(2021)
Review
Chemistry, Multidisciplinary
Wei Wang, Zhuyifan Ye, Hanlu Gao, Defang Ouyang
Summary: Computational pharmaceutics, integrating big data, artificial intelligence, and multi-scale modeling techniques, offers great potential to shift the paradigm of drug delivery. It provides multi-scale lenses for pharmaceutical scientists, revealing detailed information across various stages of pharmaceutical research.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Neurosciences
Sauson Soldozy, Kathleen M. Mulligan, David X. Zheng, Melissa A. Levoska, Christopher R. Cullison, Turki Elarjani, Daniel G. Eichberg, Leonel E. Ampie, Ashish H. Shah, Kaan Yagmurlu, Mark E. Shaffrey, Jeffrey F. Scott, Ricardo J. Komotar
Summary: Current evidence for oncolytic virotherapy treatment of melanoma is mostly limited to T-VEC, with a lack of data specifically regarding brain tumor metastasis. Despite promising findings, further investigation is needed.
Review
Biochemistry & Molecular Biology
Achille Aveta, Simone Cilio, Roberto Contieri, Gianluca Spena, Luigi Napolitano, Celeste Manfredi, Antonio Franco, Fabio Crocerossa, Clara Cerrato, Matteo Ferro, Francesco Del Giudice, Paolo Verze, Francesco Lasorsa, Andrea Salonia, Rajesh Nair, Jochen Walz, Giuseppe Lucarelli, Savio Domenico Pandolfo
Summary: Through a systematic review of scientific databases, it has been found that urinary miRNAs (umiRNAs) have potential applications in the detection, prognosis, and therapy of genitourinary cancers. In bladder cancer and urothelial carcinoma, several umiRNAs have been identified as potential non-invasive molecular biomarkers. In prostate cancer and renal cell carcinoma, umiRNAs may serve as therapeutic targets or prognostic markers. These findings suggest that umiRNAs could play an important role in the diagnosis, prognosis, and therapy of urological cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Gregoire Robert, Jean-Christophe Bernhard, Gregoire Capon, Eric Alezra, Vincent Estrade, Peggy Blanc, Franck Bladou, Henri Bensadoun
Summary: The SARS-CoV-2 pandemic had a significant impact on urological surgery in France, with non-oncological surgeries being more affected than oncological ones. Delaying appropriate care increases the risk on survival impact.
Review
Cell Biology
Yiping Mao, Mengting Zhang, Lanfeng Wang, Yukang Lu, Xinyi Hu, Zhiping Chen
Summary: Small extracellular vesicles (sEVs) are tiny vesicles secreted by cells that transport cargo, including microRNAs, between cells. MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in various biological processes, including tumorigenesis. Recent studies have shown that miRNAs encapsulated in sEVs have significant implications in the diagnosis and treatment of urological tumors, particularly in prostate cancer, clear cell renal cell carcinoma, and bladder cancer. These sEV-enclosed miRNAs have the potential to serve as biomarkers and therapeutic targets, and can be detected and analyzed in biological fluids such as urine, plasma, and serum.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Wence Zhou, Shi Dong, Zhou Chen, Xin Li, Wenkai Jiang
Summary: Acute pancreatitis is a common abdominal emergency with increasing incidence. Severe cases can lead to systemic inflammatory response and multiple organ dysfunction, resulting in higher hospitalization rates and mortality. MicroRNAs (miRNAs) have been found to play a significant role in gene expression regulation and the development of acute pancreatitis, potentially offering insights for diagnosis and treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Mahdi Rafiyan, Mohammad Hassan Jafari Najaf Abadi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Mahboubeh Mousavi, Hamed Mirzaei
Summary: MiRNAs play critical roles in regulating gene expression in both normal and cancer cells. Lysophosphatidic acid (LPA) signaling can induce overexpression of miRNAs, whose functional roles remain to be fully clarified. RNA-based treatments hold great promise in personalized medicine.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Antonio Russo, Lorena Incorvaia, Ettore Capoluongo, Pierosandro Tagliaferri, Antonio Galvano, Marzia Del Re, Umberto Malapelle, Rita Chiari, Pierfranco Conte, Romano Danesi, Matteo Fassan, Roberto Ferrara, Maurizio Genuardi, Paola Ghiorzo, Stefania Gori, Fiorella Guadagni, Antonio Marchetti, Paolo Marchetti, Massimo Midiri, Nicola Normanno, Francesco Passiglia, Carmine Pinto, Nicola Silvestris, Giovanni Tallini, Simona Vatrano, Bruno Vincenzi, Saverio Cinieri, Giordano Beretta
Summary: The development of innovative technologies and advances in genetics and genomics have provided new opportunities for personalized treatment in oncology. However, this approach is challenging and requires collaboration among different specialists to ensure access and economic sustainability of required genomic tests. This position paper by Italian scientific societies critically discusses the technologies, criteria for patient selection, sample selection and analysis, and regulatory and pharmaco-economic issues.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Menghua Wang, Zhongyu Jian, Xiaoshuai Gao, Chi Yuan, Xi Jin, Hong Li, Kunjie Wang
Summary: Using Mendelian randomization (MR), the study found that educational attainment (EA) may have causal effects on certain urological and reproductive health outcomes, such as increasing the risk of prostate cancer and decreasing the risk of kidney stones and cystitis. However, no causal effects were observed for bladder cancer, kidney cancer, testicular cancer, benign prostatic hyperplasia, and erectile dysfunction.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Oncology
Katarzyna Szklener, Marek Mazurek, Malgorzata Wieteska, Monika Waclawska, Mateusz Bilski, Slawomir Mandziuk
Summary: This article discusses the therapeutic targets and novel targeted therapies for glioblastoma, as well as the treatment efficacy of various antitumor drugs and their impact on patients.
Review
Oncology
Haicun Wang, Xin Gao, Shaobo Yu, Weina Wang, Guanglin Liu, Xingming Jiang, Dongsheng Sun
Summary: circRNAs have gained significant research attention in recent years due to their differential expression in various human tumors and their ability to regulate oncogene and tumor suppressor gene expression. They also have specific regulatory roles in promoting or inhibiting the progression of malignant biological behaviors in tumor cells. Moreover, circRNAs can regulate not only other genes expression, but also their parental gene expression, thereby influencing tumor development. This review summarizes the molecular mechanisms of circRNAs in regulating parental gene expression and their biological roles in tumorigenesis and development, providing new insights for the clinical application of circRNAs in tumor-targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jianguo Xu, Zhi Li, Yumei Li, Yusheng Lu, Jie Wang
Summary: This work presents a single-stranded degradable modular grafting probe for analyzing microRNA-21. The exonuclease activity of phi29 polymerase helps reduce background noise, achieving a detection limit of 0.26 fM and showing potential in biochemical analysis.
CHEMICAL COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Tetiana Pozniak, Dzmitry Shcharbin, Maria Bryszewska
Summary: Circulating microRNAs serve as sensitive biomarkers for diagnosing and treating various diseases, playing a significant role in monitoring diseases and evaluating treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alexandre B. Godoi, Amanda M. do Canto, Amanda Donatti, Douglas C. Rosa, Danielle C. F. Bruno, Marina K. Alvim, Clarissa L. Yasuda, Lucas G. Martins, Melissa Quintero, Ljubica Tasic, Fernando Cendes, Iscia Lopes-Cendes
Summary: In this study, changes in plasma metabolites were investigated as disease biomarkers in patients with mesial temporal lobe epilepsy (MTLE). The metabolomics data provided insights into the mechanisms underlying MTLE and response to antiseizure medication (ASM). Plasma metabolites were found to be associated with cell-energy metabolism, inflammatory processes, and the modulation of neurotransmitter release and activity in MTLE. These findings suggest that plasma metabolites may serve as potential biomarkers for MTLE, aiding in treatment decision-making.
Letter
Urology & Nephrology
Tomas Bernardo Costa Moretti, Leonardo Oliveira Reis
INTERNATIONAL BRAZ J UROL
(2022)
Article
Oncology
Diana Taheri, Fatemeh Jahanshahi, Alireza Khajavi, Fatemeh Kafi, Alireza Pouramini, Reza M. Farsani, Yasamin Alizadeh, Maryam Akbarzadeh, Leonardo O. Reis, Fatemeh Khatami, Seyed Mohammad Kazem Aghamir
Summary: Our study aims to evaluate the impact of the COVID-19 pandemic on the number of uro-oncological surgeries and assess the staging and grading based on pathological results. The results showed that among urinary tract cancers, the staging of bladder cancer and TURBT were mainly affected by the COVID-19 pandemic with higher stages compared to the non-COVID period.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Immunology
Mehrsa Jalalizadeh, Cristiane F. Giacomelli, Patricia A. F. Leme, Keini Buosi, Luciana S. B. Dal Col, Franciele A. Dionato, Cristiane L. Maia, Reza Yadollahvandmiandoab, Adilson P. Domingues-Junior, Leonardo O. Reis
Summary: The BATTLE trial revealed that recently infected SARS-CoV-2 patients can benefit from receiving BCG, with minimal adverse effects. Two strains of the vaccine were used in the study, and their clinical outcomes were compared. The results showed that there was no significant difference between the Russian and Brazilian strains in terms of symptom progression, lesion-size or type in COVID-19 convalescent patients.
Editorial Material
Urology & Nephrology
Diego Moreira Capibaribe, Natalia Dalsenter Avilez, Carlos Alberto Ricetto Sacomani, Alexandre Sa Pinto da Nobrega Lucena, Leonardo Oliveira Reis
Summary: This study aims to demonstrate a total transabdominal robotic approach for treating recalcitrant vesicourethral anastomotic stenosis. The results showed that robot-assisted surgery successfully removed residual prostate and bladder neck, and reconstructed the vesicourethral anastomosis, potentially improving continence function. This method has significant clinical implications.
INTERNATIONAL BRAZ J UROL
(2023)
Editorial Material
Urology & Nephrology
Wilmar Azal Neto, Lukas Costa de Salles, Bruno di Domenico, Ricardo Miyaoka, Leonardo O. Reis
INTERNATIONAL BRAZ J UROL
(2023)
Review
Oncology
Tomas B. C. Moretti, Luis A. Magna, Leonardo O. Reis
Summary: A new method called reverse systematic review (RSR) was used to compare the evidence of open (RRP), laparoscopic (LRP), and robotic (RARP) radical prostatectomy (RP). The study found that RARP was the most common surgical approach and was predominantly performed in North America and Asia. The analysis also identified potential biases related to the higher volume of surgeries in RARP centers.
CLINICAL GENITOURINARY CANCER
(2023)
Review
Urology & Nephrology
Tomas Bernardo Costa Moretti, Luis Alberto Magna, Leonardo Oliveira Reis
Summary: The RSR method was applied to compare oncological outcomes of radical prostatectomy techniques (RRP, LRP, and RARP), showing that minimally invasive surgeries (LRP and RARP) have better results in terms of PSMs and long-term BCRs.
JOURNAL OF ENDOUROLOGY
(2023)
Review
Urology & Nephrology
Tomas B. C. Moretti, Luis A. Magna, Leonardo O. Reis
Summary: This study applied a new evidence-gathering methodology called reverse systematic review (RSR) to analyze the influence of different continence classification criteria on urinary continence rates among open retropubic radical prostatectomy (RRP), laparoscopic RP (LRP), and robot-assisted RP (RARP). The results showed that the "No pad" criterion was the most commonly used and had the least impact on the results, making it the fairest option for future comparisons.
Article
Statistics & Probability
Julio C. S. Vasconcelos, Thiago da Costa Travassos, Edwin M. M. Ortega, Gauss M. Cordeiro, Leonardo Oliveira Reis
Summary: In recent years, several statistical models, including semiparametric regression, have been proposed. Linear regression is not practical for statistical modeling in medicine when there is a nonlinear relationship between explanatory variables and the response variable. Another common situation is when the response variable does not have a unimodal shape. In this study, a semiparametric heteroskedastic regression based on an extension of the normal distribution is proposed to analyze the cost of prostate cancer surgery. The model considers predictor variables, including different treatment groups and other relevant variables, with a nonlinear effect on the cost.
JOURNAL OF APPLIED STATISTICS
(2023)
Editorial Material
Urology & Nephrology
Cristiano Mendes Gomes, Leonardo O. Reis
INTERNATIONAL BRAZ J UROL
(2023)
Article
Urology & Nephrology
Danilo L. Andrade, Mehrsa Jalalizadeh, Ana Clara C. Salustiano, Leonardo O. Reis
Summary: This study aimed to investigate the effects of Nitazoxanide (NTZ), Rapamycin, and Thalidomide on bladder cancer (BC) histopathology and expression of PD-L1 and CTLA4. It was found that adding NTZ to BCG increased PD-L1 expression, while Rapamycin and Thalidomide decreased both PD-L1 and CTLA4 expression.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Abdolreza Mohammadi, Leonardo Oliveira Reis, Alireza Khajavi, Leila Zareian Baghdadabad, Seyed Mohammad Kazem Aghamir
Summary: This study aimed to evaluate the impact of the skin-to-stone distance (SSD) in the supine and prone positions on the outcome of shockwave lithotripsy (SWL) of kidney stones. The results showed that prone position SWL in obese patients had a higher stone-free rate compared to the supine position, with similar safety and pain scores. In addition, SSD measured by ultrasound was more accurate than CT measurement, suggesting a need to define SSD using ultrasound probe in SWL.
Article
Multidisciplinary Sciences
Dalila Andrade Pereira, Danillo Andrade Pereira, Pamela da Silva Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Leonardo Oliveira Reis, Fernando Ferreira Costa, Fabio Henrique Silva
Summary: Hydroxyurea treatment is not effective for priapism associated with sickle cell disease (SCD). Excess plasma hemoglobin and reactive oxygen species in SCD may react with nitric oxide (NO) before it binds to guanylyl cyclases (GCs) in the smooth muscle of the corpus cavernosum, preventing the restoration of baseline NO/cGMP levels. Furthermore, downregulation of endothelial NO synthase in the penis may impair the pharmacological action of hydroxyurea at the endothelial level in SCD mice. Therefore, alternative therapeutic approaches for priapism in SCD that are not hindered by high plasma hemoglobin and reactive oxygen species levels need to be explored.
Review
Urology & Nephrology
Carla Manzoni Salgado, Herney Andres Garcia-Perdomo, Leonardo O. Reis
Summary: The purpose of this study was to evaluate the use of new antiandrogens alone or in combination with ADT in advanced castration-resistant prostate cancer patients. A systematic review of literature identified three studies with similar results in terms of PSA response, radiological progression-free survival, and testosterone levels. However, due to the heterogeneity of the studies, it is still unclear whether suspending ADT during the use of new antiandrogens has a statistical benefit.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
