Article
Public, Environmental & Occupational Health
Renata Zelic, Francesca Giunchi, Jonna Fridfeldt, Jessica Carlsson, Sabina Davidsson, Luca Lianas, Cecilia Mascia, Daniela Zugna, Luca Molinaro, Per Henrik Vincent, Gianluigi Zanetti, Ove Andren, Lorenzo Richiardi, Olof Akre, Michelangelo Fiorentino, Andreas Pettersson
Summary: The International Society of Urological Pathology (ISUP) revised the Gleason system in 2005 and 2014, resulting in improved prediction of prostate cancer death. The inclusion of cribriform patterns as Gleason 4, as well as the presence of comedonecrosis, HGPIN, and higher percentage of cores with cancer, further enhance the discrimination of prostate cancer death.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Pathology
Chantal Atallah, Ants Toi, Theodorus H. van der Kwast
Summary: Several modifications have been made to the Gleason grading system, including the definition and reporting of GP5, with the addition of sub-patterns over time. The presence of GP5 indicates an unfavorable prognosis, but there is a lack of data on the prognostic impact of individual GP5 sub-patterns.
Article
Oncology
Keiichiro Mori, Vidit Sharma, Eva M. Comperat, Shun Sato, Ekaterina Laukhtina, Victor M. Schuettfort, Benjamin Pradere, Mehdi Kardoust Parizi, Pierre I. Karakiewicz, Shin Egawa, Derya Tilki, Stephen A. Boorjian, Shahrokh F. Shariat
Summary: This study assessed prognostic differences in PC patients with GG 4 treated with RP and found considerable heterogeneity within GG 4, suggesting that primary and secondary Gleason patterns should be considered for stratifying high-risk PC patients after RP.
Article
Cell Biology
Neslisah Seyrek, Eva Hollemans, Susanne Osanto, Rob C. M. Pelger, Henk G. van der Poel, Elise Bekers, Chris H. Bangma, John Rietbergen, Monique J. Roobol, Ivo G. Schoots, Geert J. L. H. van Leenders
Summary: This study showed that in GG2 prostate cancer patients, the GP4 percentage was related to the presence of IC/IDC and TP5, with IC/IDC being an independent predictor for BCRFS while GP4 percentage and TP5 were not.
Article
Oncology
Bumjin Lim, Wonchul Lee, Yoon Soo Kyung, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
Summary: A Gleason grade of 5 and bone metastasis lesion count >= 4 were found to be significantly associated with CRPC-free survival and overall survival in patients with metastatic hormone-sensitive prostate cancer (mHSPC). Gleason grade 5 is a new prognostic indicator for mHSPC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Pathology
Yalei Chen, Ian M. Loveless, Tiffany Nakai, Rehnuma Newaz, Firas F. Abdollah, Craig G. Rogers, Oudai Hassan, Dhananjay Chitale, Kanika Arora, Sean R. Williamson, Nilesh S. Gupta, Benjamin A. Rybicki, Sudha M. Sadasivan, Albert M. Levin
Summary: The use of artificial intelligence in assessing the percentage of Gleason pattern 4 (%GP4) improves the accuracy and reproducibility of prostate cancer grade group (GG) 2 and 3 tumor classification. This study trained a convolutional neural network (CNN) model to identify and quantify GP3 and GP4 areas and estimate %GP4. The CNN-predicted %GP4 was found to be significantly associated with biochemical recurrence (BCR) risk in intermediate-risk GG 2 and 3 tumors.
Article
Urology & Nephrology
Liang G. Qu, Modher Al-Shawi, Tess Howard, Nathan Papa, Cedric Poyet, Brian Kelly, A. J. Matthew Egan, Nathan Lawrentschuk, Damien Bolton, Gregory S. Jack
Summary: This study suggests that transperineal (TP) prostate biopsies may provide more accurate Gleason grading compared to transrectal (TR) biopsies in MRI-naive patients. TP approach also resulted in less upgrading for lesions in the anterior and apical prostate compared to TR.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Review
Urology & Nephrology
Satoru Taguchi, Teppei Morikawa, Junji Shibahara, Hiroshi Fukuhara
Summary: The Gleason score and Gleason grade grouping play important roles in predicting the prognosis of prostate cancer patients, but the concept of tertiary Gleason pattern, its definition, and its application in clinical practice still require further clarification.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaojing He, Hui Xiong, Haiping Zhang, Xinjie Liu, Jun Zhou, Dajing Guo
Summary: Multiparametric magnetic resonance imaging (mpMRI) texture analysis (TA) is valuable in predicting new Gleason Grade Group (GGG). Certain TA parameters show significant differences among GGG groups, and ADC-energy and T2-energy are independent predictors of GGG trend.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Urology & Nephrology
David Dearnaley, Clare L. L. Griffin, Pedro Silva, Anna Wilkins, Christine Stuttle, Isabel Syndikus, Shama Hassan, Julia Pugh, Clare Cruickshank, Emma Hall, Catherine M. M. Corbishley
Summary: This study compared the Gleason Grade Group (GGG) classification based on central pathology review with previous local pathology assessment, and investigated the difference between using overall and worst GGG. The results showed that central pathology-derived GGG better stratified patients in terms of biochemical/clinical failure (BCF) and distant metastases (DM) outcomes. Both overall and worst GS should be used to derive GGG.
Article
Urology & Nephrology
Margaretha A. van der Slot, Neslisah Seyrek, Charlotte F. Kweldam, Michael A. den Bakker, Martijn B. Busstra, Melanie Gan, Sjoerd Klaver, John B. W. Rietbergen, Geert J. L. H. van Leenders
Summary: Age, clinical stage T3, percentage Gleason pattern 4, and presence of PI-RADS 5 lesions are independent predictors for upgrading in men with biopsy GG2 without CR/IDC, allowing for improved clinical decision-making on surveillance eligibility in intermediate-risk prostate cancer patients.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Pediatrics
Andre Miguel Miranda, Pedro Bem, Andre Araujo, Conceicao Brito, Joana Nunes, Ana Filipa Geraldo
Summary: This study found a high prevalence of torcular pseudomass in the fetal population and it showed a natural tendency to involute, even in utero.
PEDIATRIC RADIOLOGY
(2022)
Article
Veterinary Sciences
Marcha Badenhorst, Phebe de Heus, Angelika Auer, Birthe Tegtmeyer, Alexander Stang, Katharina Dimmel, Alexander Tichy, Jakub Kubacki, Claudia Bachofen, Eike Steinmann, Jessika M. Cavalleri
Summary: The prevalence of EqPV-H antibodies and DNA is high in Austrian horses, but active infection does not lead to hepatitis. Older horses are at higher risk for active EqPV-H infection, and Austrian EqPV-H variants are closely related to global sequences.
EQUINE VETERINARY JOURNAL
(2022)
Article
Oncology
Xuanhan Hu, Jia Miao, Jiaqing Huang, Lin Qian, Dahong Zhang, Haibin Wei
Summary: This study focuses on the link between active surveillance and Gleason score upgrade in prostate cancer patients, and its impact on prognosis based on risk stratification. The findings suggest that active surveillance duration is only associated with Gleason score upgrade in low-risk patients, while high Gleason score at diagnosis is a strong predictor of upgrade for favorable and unfavorable intermediate-risk patients. Long-term surveillance only significantly affects the prognosis of unfavorable intermediate-risk patients. Active surveillance is recommended for low-risk and favorable intermediate-risk patients until a Gleason score of 8 is reached, but may not be suitable for some unfavorable intermediate-risk patients.
Article
Urology & Nephrology
Mike Wenzel, Christoph Wurnschimmel, Francesco Chierigo, Keiichiro Mori, Zhe Tian, Carlo Terrone, Shahrokh F. Shariat, Fred Saad, Derya Tilki, Markus Graefen, Philipp Mandel, Frederik C. Roos, Felix K. H. Chun, Pierre I. Karakiewicz
Summary: There are significant differences in cancer-specific death rates according to Gleason pattern (4 + 5 vs 5 + 4 vs 5 + 5) in patients with biopsy GG 5 prostate cancer treated with radical prostatectomy (RP) or external beam radiation therapy (EBRT). The highest death rate was observed in patients with a Gleason pattern score of 5 + 5, followed by Gleason 5 + 4 and then Gleason 4 + 5. These differences were observed in both RP and EBRT treatment subgroups.
EUROPEAN UROLOGY FOCUS
(2022)