Article
Multidisciplinary Sciences
Jae Hoon Chung, Jae Yong Jeong, Ji Youl Lee, Was Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong I. L. Seo, Hyun Moo Lee, Seong Soo Jeon
Summary: After radical prostatectomy, the nadir PSA value and time to nadir are associated with biochemical recurrence (BCR), with a high PSA nadir value and short TTN predicting the risk of BCR.
Article
Oncology
Nicholas W. Eyrich, John T. Wei, Yashar S. Niknafs, Javed Siddiqui, Chad Ellimoottil, Simpa S. Salami, Ganesh S. Palapattu, Rohit Mehra, Lakshmi P. Kunju, Scott A. Tomlins, Arul M. Chinnaiyan, Todd M. Morgan, Jeffrey J. Tosoian
Summary: This study aimed to evaluate the association between urinary MyProstateScore (MPS) and pathologic grade group in men diagnosed with GG1 prostate cancer. The results showed that MPS was significantly associated with the cancer grade at surgery, with a higher discriminative ability compared to models based on PSA and PSAD.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Oncology
Derya Tilki, Felix Preisser, Reinhard Thamm, Raisa S. Pompe, Felix K. -H. Chun, Markus Graefen, Alessandra Siegmann, Dirk Boehmer, Volker Budach, Thomas Wiegel
Summary: This study compares the long-term oncologic outcomes of patients with biochemical recurrence after prostatectomy, who were treated with salvage radiotherapy or no radiotherapy. The results show that salvage radiotherapy reduces the risk of metastasis and death in these patients.
Article
Andrology
Alessandro Sciarra, Martina Maggi, Arianna Del Proposto, Fabio Massimo Magliocca, Antonio Ciardi, Valeria Panebianco, Ettore De Berardinis, Stefano Salciccia, Giovanni Battista Di Pierro, Alessandro Gentilucci, Alex M. Kasman, Benjamin Chung, Matteo Ferro, Ottavio de Cobelli, Francesco Del Giudice, Gian Maria Busetto, Michele Gallucci, Marco Frisenda
Summary: The study found that perineural invasion in prostate cancer patients is closely correlated with unfavorable pathological parameters and may help stratify intermediate risk cases for the risk of biochemical progression.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Pathology
Jingci Chen, Liju Zong, Pengyan Wang, Yilin Liu, Hongkai Zhang, Xiaoyan Chang, Zhaohui Lu, Wencai Li, Yihui Ma, Shuangni Yu, Jie Chen
Summary: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare and have low metastatic potential. Tumor size, lymphovascular invasion, and Ki-67 index are independent predictors of relapse. A Peking Union Medical College Hospital-SPN risk model was proposed to guide patient counseling and showed higher sensitivity compared to the American Joint Committee on Cancer tumor staging system.
Article
Multidisciplinary Sciences
Jaehun Jung, Gi Hwan Bae, Jae Heon Kim, Jaehong Kim
Summary: This study aimed to evaluate the clinical impact of robot-assisted radical prostatectomy (RARP) on health outcomes in Korean patients with prostate cancer (PCa). The study found that RARP had a higher risk of overall mortality within 3 and 12 months compared to radical prostatectomy (RP). The RARP group in hospitals with the largest PCa surgery volume had higher mortality rates and more surgical complications than the total RARP patients. The study suggests that RARP may not be superior to RP, possibly due to increased robotic surgery in the elderly.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Donglin Sun, Ao Lin, Zhun Sun, Shuqi Yang, Yuexin Sun, Anning Chen, Guojun Qian, Zhonghua Ji, Li Wang
Summary: This study aimed to identify independent prognosis-associated factors of bone-metastatic prostate cancer and developed nomograms for prognostic evaluation. Results showed that radical prostatectomy and chemotherapy were strongly associated with the prognosis of bone-metastatic prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Kenneth J. Pienta, Michael A. Gorin, Steven P. Rowe, Peter R. Carroll, Frederic Pouliot, Stephan Probst, Lawrence Saperstein, Mark A. Preston, Ajjai S. Alva, Akash Patnaik, Jeremy C. Durack, Nancy Stambler, Tess Lin, Jessica Jensen, Vivien Wong, Barry A. Siegel, Michael J. Morris
Summary: The study aimed to evaluate the diagnostic performance of F-18-DCFPyL positron emission tomography/computerized tomography in detecting metastatic sites of prostate cancer. The results showed high specificity and positive predictive value, but moderate sensitivity.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Steven B. Goldenthal, Melissa A. Reimers, Udit Singhal, Mark Farha, Rohit Mehra, Morand Piert, Jeffrey J. Tosoian, Parth K. Modi, Nicole Curci, James Peabody, Eduardo Kleer, David C. Smith, Todd M. Morgan
Summary: This study reports five cases of peritoneal carcinomatosis following robotic-assisted radical prostatectomy (RARP), which occurred relatively late and may be related to the preoperative pathological stage. The use of next-generation imaging modalities, such as PSMA PET, can help identify metastases. Further research and classification are needed to improve the understanding and management of this atypical presentation.
Article
Urology & Nephrology
Jack R. Andrews, Mohamed E. Ahmed, Vidit Sharma, Cameron Britton, Bradley Stish, Ryan Phillips, A. Tuba Kendi, Vidhu B. Joshi, Akshay Sood, Mathew K. Tollefson, Stephen A. Boorjian, R. Jeffery Karnes, Eugene D. Kwon
Summary: This study characterizes the outcomes of metastasis-directed therapy without concurrent androgen deprivation therapy in patients with solitary metastatic lesions in prostate cancer. The results demonstrate that this approach can delay the initiation of systemic therapy and call for further prospective studies in patients with solitary recurrent prostate cancer metastases.
JOURNAL OF UROLOGY
(2022)
Article
Oncology
Tarek Al-Hammouri, Ricardo Almeida-Magana, Rachel Lawrence, Tom Duffy, Laura White, Edwina Burke, Sakunthala Kudahetti, Justin Collins, Prabhakar Rajan, Daniel Berney, Rhian Gabe, Greg Shaw, Yong-Jie Lu
Summary: This study aims to evaluate the feasibility of using CTC analysis to predict post-RP treatment failure in localized high-risk prostate cancer. A total of 294 patients diagnosed with unfavourable intermediate to high and very high-risk localized PCa will be recruited. Blood samples will be collected before and 3 months after the surgery for CTC analysis to predict treatment failure.
Article
Urology & Nephrology
Bruce J. Trock, Yuezhou Jing, Brent Mabey, Zaina Sangale, Lauren Lenz, Nora Haney, Igor Vidal, Stephanie A. Glavaris, Gunes Guner, Onur Ertunc, Ibrahim Kulac, Javier A. Baena Del Valle, Tracy Jones, Misop Han, Alan W. Partin, Todd Cohen, Steven Stone, Angelo M. De Marzo
Summary: The study showed that cell-cycle progression was independently associated with metastasis-free survival in prostate cancer patients, particularly those receiving salvage radiotherapy, while phosphatase and tensin homolog had weaker correlation with metastasis after adjustment for post-surgical risk assessment.
JOURNAL OF UROLOGY
(2022)
Article
Medicine, Research & Experimental
Mohammad Alyamani, Patrick Michael, Daniel Hettel, Lewis Thomas, Scott D. Lundy, Mike Berk, Mona Patel, Jianbo Li, Hooman Rashidi, Jesse K. McKenney, Eric A. Klein, Nima Sharifi
Summary: This study reveals that some men have enriched levels of testosterone (T) in the prostate region, which is associated with higher rates of prostate cancer recurrence. These findings suggest that the role of local androgen delivery in prostate cancer has been underestimated.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Lara Franziska Stolzenbach, Sophie Knipper, Philipp Mandel, Luigi Ascalone, Marina Deuker, Zhe Tian, Hans Heinzer, Derya Tilki, Tobias Maurer, Markus Graefen, Pierre Karakiewicz, Thomas Steuber
Summary: In this study, the impact of lymph-node involvement on oncological outcomes in patients with pathologically organ-confined prostate cancer after radical prostatectomy was investigated. Patients with pathologically organ-confined but lymph node-positive cancer showed favorable outcomes, but presence of 3 or more positive lymph nodes predicted higher rates of biochemical recurrence and metastatic progression, suggesting consideration of adjuvant treatment in these cases.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hanan Zahed, Jerome Laufer, Martin LeBlanc, Steven Tisseverasinghe, Tamim Niazi, Stephan Probst
Summary: Port-site metastasis is a rare complication following minimally invasive oncologic surgery for prostate cancer. In this case, a patient developed biochemical recurrence despite treatment, but no evidence of disease was found on CT and bone scan. F-18-DCFPyL PET/CT revealed a solitary focus of intense uptake in the right rectus abdominis muscle, confirming the presence of a port-site metastasis through histopathologic evaluation.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Urology & Nephrology
Martin Baunacke, Christer Groeben, Angelika Borkowetz, Annemarie Uhlig, Marianne Leitsmann, Bjoern Volkmer, Christian Thomas, Johannes Huber
Summary: The study presented the development and current state of sphincter and penile prosthesis implantation in Germany. Since 2012/2013, there has been a stagnation in the number of cases of penile and sphincter prosthesis implantations, suggesting a possible undersupply.
Article
Urology & Nephrology
Martin Baunacke, Maria-Luisa Schmidt, Christer Groeben, Angelika Borkowetz, Christian Thomas, Rainer Koch, Falk Hoffmann, Felix K. H. Chun, Lothar Weissbach, Johannes Huber
Summary: The study found that in Germany, a significant percentage of patients with post-prostatectomy urinary incontinence and erectile dysfunction did not receive effective treatment, leading to a significant decrease in quality of life.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Luka Flegar, Bjoern Buerk, Rick Proschmann, Stefan Propping, Christer Groeben, Martin Baunacke, Roman Herout, Johannes Huber, Christian Thomas, Angelika Borkowetz
Summary: This study presents the initial experience of treating patients with unilateral low-risk prostate cancer using vascular-targeted photodynamic therapy (VTP). The short-term functional and oncological outcomes of VTP were compared to those of patients undergoing radical prostatectomy (RP). The results showed that VTP had promising outcomes with lower complication rates compared to RP in a real-world setting. However, the recurrence and progression after VTP still need to be carefully discussed with patients who choose this treatment option.
EUROPEAN UROLOGY FOCUS
(2022)
Editorial Material
Oncology
Christer Groeben, Rainer Koch, Klaus Kraywinkel, Nina Buttmann-Schweiger, Martin Baunacke, Angelika Borkowetz, Christian Thomas, Johannes Huber
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Urology & Nephrology
Elena Nikitin, Johannes Huber, Christian Thomas, Juliane Putz
Summary: This report describes a rare case of symptomatic nephroptosis following kidney transplant, presenting with intermittent symptomatic hydronephrosis and elevated creatinine levels. Diagnostic procedures were described along with successful minimally-invasive treatment, making it the first report of its kind without complications of perfusion.
UROLOGIA INTERNATIONALIS
(2021)
Article
Urology & Nephrology
Martin Baunacke, Isabel Leuchtweis, Albert Kaufmann, Marcel Schmidt, Christer Groeben, Angelika Borkowetz, Nicole Eisenmenger, Christian Thomas, Johannes Huber
Summary: The utilization of urodynamic studies in Germany decreased overall from 2013 to 2018, with a more significant decrease in hospital settings compared to outpatient settings. Urodynamic studies decreased in urology and gynaecology departments, but increased in paediatrics.
UROLOGIA INTERNATIONALIS
(2022)
Article
Oncology
Anja K. Koether, Bjoern Buedenbender, Britta Gruene, Sonja Holbach, Johannes Huber, Nicolas von Landenberg, Julia Lenk, Thomas Martini, Maurice S. Michel, Maximilian C. Kriegmair, Georg W. Alpers
Summary: This study examines the role of personality and anxiety in preference-sensitive decisions for bladder cancer patients. It finds that personality traits and anxiety affect treatment preferences and patients' motivation to be involved in decision making.
Article
Urology & Nephrology
Cem Aksoy, Andreas Ihrig, Philipp Reimold, Georgi Tosev, Ruth Himmelsbach, Jessica Jesser, Guven Babayigit, Johannes Huber
Summary: Public awareness of testicular cancer is low among German medical students. Improving knowledge about the disease may increase the chance of early detection.
UROLOGIA INTERNATIONALIS
(2022)
Article
Urology & Nephrology
Luka Flegar, Smita George Thoduka, Andreas H. Mahnken, Jens Figiel, Hendrik Heers, Cem Aksoy, Nicole Eisenmenger, Christer Groeben, Johannes Huber, Aristeidis Zacharis
Summary: The aim of the study was to investigate trends of FT for in-patient treatment of renal RCC in the USA and Germany. The share of FT increased in both countries from 2006 to 2019. The number of RFAs and cryotherapies also showed an increasing trend in both countries.
UROLOGIA INTERNATIONALIS
(2023)
Review
Urology & Nephrology
Hendrik Heers, Marius Cristian Butea-Bocu, Christer Groeben, Johannes Huber, Bernd Wullich, Peter J. Goebell, Christian Fiebig
Summary: Currently, combination therapies are predominantly used for the systemic treatment of prostate cancer. Many considerations need to be taken into account in older and comorbid patients to avoid toxicities and achieve successful therapy and good quality of life. Geriatric screening, assessment, and treatment improvement are recommended for patients over 70 years old who have comorbidities. Fit patients can be treated similarly to non-geriatric patients, while vulnerable and frail patients require special care to minimize toxicities. Individualized concepts, including aspects of palliative care and patient needs, should be established when deciding on further treatment.
Article
Urology & Nephrology
Andreas Ihrig, Pascal Marino Pernt, Stefanie Zschaebitz, Johannes Huber, Hans-Christoph Friederich, Till J. J. Bugaj, Imad Maatouk
Summary: This study aimed to provide further data on domain-specific cognitive impairments in metastatic prostate cancer (mPC) patients with androgen deprivation therapy (ADT) and new hormonal agents. The results showed that patients treated with ADT scored significantly lower on neurocognitive tests and had a higher prevalence of neurocognitive deficits.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Till Johannes Bugaj, Imad Maatouk, Tobias Hanslmeier, Stefanie Zschaebitz, Johannes Huber, Charlotte Flock, Hans-Christoph Friederich, Andreas Ihrig
Summary: The purpose of this study was to explore the characteristics of treatment decision-making preferences, general self-efficacy, and fear of progression among couples coping with advanced prostate cancer. The study found that more than half of the patients and spouses preferred active involvement in decision-making, and spouses had higher levels of fear of progression.
WORLD JOURNAL OF UROLOGY
(2023)
Letter
Urology & Nephrology
Andreas Ihrig, Pascal Marino Pernt, Stefanie Zschaebitz, Johannes Huber, Hans-Christoph Friederich, Till J. Bugaj, Imad Maatouk
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Roman Herout, Martin Baunacke, Luka Flegar, Angelika Borkowetz, Alina Reicherz, Rainer Koch, Klaus Kraywinkel, Christian Thomas, Christer Groeben, Johannes Huber
Summary: This study reported contemporary epidemiology and treatment trends of upper tract urothelial carcinoma (UTUC) in Germany over a 14-year period. The incidence rate showed a non-significant increase, while survival rates were relatively low. Diagnostic and therapeutic procedures for UTUC have increased, and minimally invasive nephroureterectomy is now the predominant surgical approach.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Luka Flegar, Aristeidis Zacharis, Cem Aksoy, Hendrik Heers, Marcus Derigs, Nicole Eisenmenger, Angelika Borkowetz, Christer Groeben, Johannes Huber
Summary: Focal therapy (FT) is an alternative approach for prostate cancer treatment in selected patients. In Germany, the development of FT followed the Gartner hype cycle, with high-intensity focused ultrasound (HIFU) being the most commonly performed FT. However, newer FT modalities such as Vascular-Targeted Photodynamic Therapy (VTP-TOOKAD) and Transurethral Ultrasound Ablation (TULSA) are becoming increasingly popular.
WORLD JOURNAL OF UROLOGY
(2022)
