Article
Obstetrics & Gynecology
Eran Ashwal, Howard Berger, Liran Hiersch, Eugene W. Yoon, Arthur Zaltz, Baiju Shah, Ilana Halperin, Jon Barrett, Nir Melamed
Summary: This study found that gestational diabetes mellitus is less likely to be associated with accelerated fetal growth in twin pregnancies compared to singleton pregnancies. The results suggest the need for individualized diagnostic criteria and blood glucose targets for women diagnosed with gestational diabetes mellitus in twin pregnancies.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
V O'Dwyer, N. M. Russell, B. McDonnell, L. Sharkey, C. Mulcahy, M. F. Higgins
Summary: This study investigated specific ultrasound measurements in the third trimester and measures of glycaemic control to predict fetal macrosomia in babies born to women with pre-gestational diabetes. Results showed that abdominal circumference at 36 weeks was the most predictive of macrosomia, and a combined model of HbA1c, abdominal circumference, and anterior abdominal wall thickness was the best antenatal predictor of macrosomia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
M. K. Kiefer, M. M. Finneran, C. A. Ware, P. Foy, S. F. Thung, S. G. Gabbe, M. B. Landon, W. A. Grobman, K. K. Venkatesh
Summary: The FMF fetal growth chart demonstrated the best predictive performance for LGA at birth compared to the Hadlock and NICHD race/ethnicity-specific growth charts in pregnant individuals with pregestational diabetes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miira M. M. Klemetti, Sruthi Alahari, Martin Post, Isabella Caniggia
Summary: Disturbances in lipid metabolism are common in diabetes. This study compared the placental sphingolipid metabolism in type 1 and type 2 diabetic pregnancies and non-diabetic controls. The results showed that placental ceramide levels were lower in diabetic pregnancies, but higher in cases of preeclampsia and poor glycemic control. Sphingosine kinases (SPHK) and sphingoid-1-phosphates (S1P) were elevated in diabetic pregnancies, especially in cases of fetal macrosomia.
Article
Obstetrics & Gynecology
Tracy M. Tomlinson, Alexandra M. Johnson, Alexandra M. Edwards, Gilad A. Gross, Dorothea J. Mostello
Summary: The study assessed the validity of a fetal overgrowth index for predicting risk in women with diabetes in pregnancy and found strong performance in an external cohort.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Kartik K. Venkatesh, Xiaoning Huang, Natalie A. Cameron, Lucia C. Petito, Joshua Joseph, Mark B. Landon, William A. Grobman, Sadiya S. Khan
Summary: This study compared trends in pregestational and gestational diabetes in rural and urban areas in the USA and found that pregnant women in rural areas face unique challenges that contribute to disparities in adverse pregnancy outcomes. The frequency of diabetes increased in both rural and urban areas from 2011 to 2019, with rural areas having a higher risk. These findings have implications for delivering equitable diabetes care in pregnancy in rural US communities.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Endocrinology & Metabolism
E. Paige Isabey, Christy L. Pylypjuk
Summary: In our study, measuring AWT at 36 weeks did not accurately predict the risk of shoulder dystocia or emergency Caesarean section in pregnant women with type 2 diabetes.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Multidisciplinary Sciences
David Salcedo-Tacuma, Leonardo Bonilla, Maria Cristina Geney Montes, Jorge Ernesto Nino Gonzalez, Sandra Milena Sanchez Gutierrez, Miguel Chirivi, G. Andres Contreras
Summary: In this study, RNA-seq was used to analyze the transcriptomic profile of adipose tissues in patients with gestational diabetes. The results revealed differences based on anatomical location and provided whole-transcriptome data for further exploration of unique gene expression patterns in gestational diabetes patients.
Article
Endocrinology & Metabolism
Meng-Nan Yang, Rong Huang, Xin Liu, Ya-Jie Xu, Wen-Juan Wang, Hua He, Guang-Hui Zhang, Tao Zheng, Fang Fang, Jian-Gao Fan, Fei Li, Jun Zhang, Jiong Li, Fengxiu Ouyang, Zhong-Cheng Luo
Summary: This study found that FGF19 is not associated with glucose homeostasis in newborns of GDM mothers. However, cord plasma FGF19 concentrations were positively correlated with birth weight and length in females, suggesting a sex-dimorphic role of FGF19 in fetal growth. Further studies are needed to validate these findings and explore the underlying mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Pawel Jan Stanirowski, Agata Majewska, Michal Lipa, Dorota Bomba-Opon, Miroslaw Wielgos
Summary: Ultrasound-derived measurements of fetal soft tissue, heart, liver and umbilical cord are significantly increased in women with gestational diabetes treated with insulin and type 1 diabetes mellitus. In addition to standard biometric measurements, parameters such as abdominal fat mass may be useful in the management of diabetes-complicated pregnancies.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Medicine, Research & Experimental
Duaa Ahmed Elhag, Souhaila Al Khodor
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. They have been found to be involved in the pathogenesis of gestational diabetes mellitus (GDM), and their aberrant expression in the placenta and/or maternal blood suggests their potential as biomarkers for early diagnosis and prognosis. Additionally, miRNAs have been shown to modulate key signaling pathways involved in glucose homeostasis, insulin sensitivity, and inflammation, providing insights into the pathophysiology of GDM. This review summarizes the current knowledge on the dynamics of miRNA in pregnancy, their role in GDM, and their potential as diagnostic and therapeutic targets.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Wonjin Kim, Soo Kyung Park, Yoo Lee Kim
Summary: The study found that there is a higher risk of fetal abdominal obesity (FAO) in older and/or obese women with gestational diabetes mellitus (GDM), while no significant change was observed in young and nonobese women with GDM. FAO detected at the time of GDM diagnosis may persist until delivery, emphasizing the importance of early diagnosis and treatment to prevent near term FAO in high-risk older and/or obese women.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Obstetrics & Gynecology
Yuting Zhang, Linying Chen, Lijing Zhang, Yudan Wu, Li Li
Summary: This study aimed to analyze and predict the risk of macrosomia in pregnant women with gestational diabetes mellitus. The results showed that fasting plasma glucose, gestational weight gain, ultrasound fetal weight gain, and amniotic fluid index were important predictors of macrosomia. The predictive model combining all variables had a high accuracy in predicting macrosomia.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Atalay Ekin, Baris Sever
Summary: The study evaluated the changes in fetal intracranial structures in pregnant women with pregestational DM and GDM. It found that maternal hyperglycemia was significantly associated with an increase in the widths of fetal PLV, CSP, and CM, as well as a decrease in fetal TCD.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Rong Huang, Mark Kibschull, Laurent Briollais, Zdenka Pausova, Kellie Murphy, John Kingdom, Stephen Lye, Zhong-Cheng Luo
Summary: The study found that fetal sex affects the concentration of myostatin in cord blood, with higher levels in male fetuses. Gestational diabetes does not affect the concentration of myostatin in cord blood. The study also revealed a strong correlation between myostatin and testosterone levels in male fetuses.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tricia M. Peters, Michael V. Holmes, J. Brent Richards, Tom Palmer, Vincenzo Forgetta, Cecilia M. Lindgren, Folkert W. Asselbergs, Christopher P. Nelson, Nilesh J. Samani, Mark I. McCarthy, Anubha Mahajan, George Davey Smith, Mark Woodward, Linda M. O'Keeffe, Sanne A. E. Peters
Summary: The study found that genetic risk of type 2 diabetes affects the odds of coronary heart disease (CHD) similarly in both women and men, indicating no sex differential in the causal effect of diabetes on CHD risk. This suggests that prevention and management of type 2 diabetes for CHD risk reduction should be prioritized equally in both sexes.
Article
Nutrition & Dietetics
Briar L. McKenzie, Katie Harris, Sanne A. E. Peters, Jacqui Webster, Mark Woodward
Summary: This study using data from UK Biobank found that high carbohydrate intake increases the risk of death, while higher protein intake reduces the risk. Moderate intake of energy and protein can lower the risk of cardiovascular disease, and moderate energy intake can reduce the risk of dementia. Sex differences were identified, and targeting combinations of macronutrients in dietary policy and interventions may provide the greatest benefits.
BRITISH JOURNAL OF NUTRITION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sanne A. E. Peters, Jolanda Kluin
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Lena Tschiderer, Lisa Seekircher, Setor K. Kunutsor, Sanne A. E. Peters, Linda M. O'Keeffe, Peter Willeit
Summary: This study systematically reviewed the association between breastfeeding and maternal risk of cardiovascular disease (CVD) outcomes. The findings suggest that breastfeeding is associated with a reduced risk of CVD outcomes in mothers. The association is consistent across different age groups, follow-up durations, parity, adjustment levels, study quality, and geographical regions.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Ana-Catarina Pinho-Gomes, Amy Vassallo, Cheryl Carcel, Sanne Peters, Mark Woodward
Summary: The study found that gender equality had a more significant impact on men's life expectancy than on women's in EU member states, especially in the domains of health, money, and knowledge. With the increase in gender equality, men experienced a faster growth in life expectancy, resulting in a narrowing of the gender gap in life expectancy.
Editorial Material
Cardiac & Cardiovascular Systems
Sanne A. E. Peters, Mark Woodward
Review
Nursing
Tina G. A. Oostrom, Patricia Cullen, Sanne A. E. Peters
Summary: This study aimed to assess the health impacts of the COVID-19 pandemic on children and adolescents. The results showed that the pandemic had various effects on the health of young people, particularly in terms of mental health conditions, declines in presentations to pediatric emergency departments, and decreases in vaccination rates. Currently, there is limited understanding of protective factors for young people's health and wellbeing, as well as how to mitigate the impacts of the pandemic.
JOURNAL OF CHILD HEALTH CARE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Sanne A. E. Peters
Article
Urology & Nephrology
Rob C. M. van Kruijsdijk, Robin W. M. Vernooij, Michiel L. Bots, Sanne A. E. Peters, Jannick A. N. Dorresteijn, Frank L. J. Visseren, Peter J. Blankestijn, Thomas P. A. Debray
Summary: This study developed a treatment effect prediction model to determine which patients would benefit most from haemodiafiltration compared with haemodialysis in terms of all-cause mortality, using readily available patient and disease characteristics.
CLINICAL KIDNEY JOURNAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Lena Tschiderer, Peter Willeit, Sanne A. E. Peters
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Lena Tschiderer, Sanne A. E. Peters, Peter Willeit
Article
Medicine, General & Internal
Sanne A. E. Peters, Mark Woodward
Summary: Sex and gender are fundamental to health and wellbeing, yet many research studies fail to consider their differences. This article presents a roadmap for conducting sex- and gender-disaggregated health research, including exploring differences, explaining underlying mechanisms, and translating implications to policy and practice. Methodological considerations and practical examples are provided, with a focus on cardiovascular disease. The article stresses the importance of sex and gender research and calls for further disaggregation of identities and intersectionality in future studies.
Editorial Material
Cardiac & Cardiovascular Systems
Sanne A. E. Peters
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Sanne A. E. Peters, Yvonne T. van der Schouw, Anniek C. van Westing, Tammy Y. N. Tong, Peter Willeit, Lisa Seekircher, Conchi Moreno-Iribas, Jose Maria Huerta, Marta Crous-Bou, Martin Soderholm, Matthias B. Schulze, Cecilia Johansson, Sara Sjalander, Alicia K. Heath, Alessandra Macciotta, Christina C. Dahm, Daniel B. Ibsen, Valeria Pala, Lene Mellemkjaer, Stephen Burgess, Angela Wood, Rudolf Kaaks, Verena Katzke, Pilar Amiano, Miguel Rodriguez-Barranco, Gunnar Engstrom, Elisabete Weiderpass, Anne Tjonneland, Jytte Halkjaer, Salvatore Panico, John Danesh, Adam Butterworth, N. Charlotte Onland-Moret
Summary: Early menopause is associated with a higher risk of stroke, but the relationships with stroke subtypes are inconsistent. However, genetically proxied age at menopause is not significantly associated with stroke risk, suggesting no causal relationship.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Peripheral Vascular Disease
Sophie C. de Ruiter, A. Floriaan Schmidt, Diederick E. Grobbee, Hester M. den Ruijter, Sanne A. E. Peters
Summary: Hypertension is a key risk factor for cardiovascular disease, with stronger associations found in women compared to men. However, it is unclear if these differences are due to actual differential effects or confounding factors. The use of Mendelian randomisation (MR) and cis-MR can help uncover causality in sex differences and improve clinical practice.
JOURNAL OF HUMAN HYPERTENSION
(2023)