Article
Multidisciplinary Sciences
Dan Zhu, Weiyu Chen, Yuchen Pan, Tingcui Li, Ming Cui, Baoxia Chen
Summary: The study found that maternal age and parity have an impact on cardiac diastolic function, with older pregnant women having a higher probability of impaired diastolic function. Additionally, impaired diastolic function is significantly correlated with the occurrence rate of pre-eclampsia in mid-gestation.
SCIENTIFIC REPORTS
(2021)
Article
Acoustics
V Giorgione, K. Melchiorre, J. O'Driscoll, A. Khalil, R. Sharma, B. Thilaganathan
Summary: Objective: This study aims to evaluate the changes in maternal cardiac morphology and diastolic function in twin pregnancies with and without hypertensive disorders.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ilona Jaszczuk, Izabela Winkler, Dorota Koczkodaj, Maciej Skrzypczak, Agata Filip
Summary: This review article analyzes the role of C19MC miRNA in the development of pre-eclampsia and summarizes the current research data. The results indicate that C19MC miRNAs are significantly upregulated in placental tissue of pre-eclampsia patients and can be detected in high levels in the blood. Among them, miR-525-5p shows low expression in the plasma of the first trimester. By identifying these miRNAs, it may be possible to predict the development of pre-eclampsia before the onset of clinical symptoms, thereby avoiding serious complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Shun-Fu Piao, Juan Cong, Rong Li, Guang-Hui Song, Yong Li, Lin Xu
Summary: This study analyzed the changes in myocardial work properties and their correlation with cardiovascular and clinical indices in pre-eclampsia (PE) pregnancy. It found that global myocardial work index, constructive work, and wasted work significantly increased in PE cases, while work efficiency decreased. The changes in myocardial work were associated with hypertension grades and poor prognosis in PE.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Acoustics
J. Gutierrez Henares, R. Gutierrez Henares, H. Perry, A. Khalil, B. Thilaganathan
Summary: Objective non-invasive assessment of maternal cardiovascular potential and kinetic energy using PKR and SMII may help distinguish pregnancies affected by specific placental disorders and those exhibiting healthy cardiovascular adaptation to pregnancy. Women with HDP and/or SGA have distinctive PKR and SMII profiles, reflecting low kinetic energy in pregnancies with SGA and high potential energy in pregnancies affected by HDP. Non-invasive assessment of potential and kinetic cardiovascular energy demonstrates high-flow and low-resistance adaptation in uncomplicated pregnancies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Immunology
Chiara Agostinis, Alessandro Mangogna, Andrea Balduit, Azin Aghamajidi, Giuseppe Ricci, Uday Kishore, Roberta Bulla
Summary: COVID-19 is characterized by multiple organ failure due to virus-induced injury, accompanied by inflammatory reactions and prothrombotic coagulopathy; pregnant women contracting SARS-CoV-2 infection are more vulnerable to developing pre-eclampsia (PE); C inhibitors targeting C3 or MASP-2 offer promising options for treating both COVID-19 and consequent PE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Viktoria Bitsadze, Sylvie Bouvier, Jamilya Khizroeva, Eva Cochery-Nouvellon, Eric Mercier, Antonia Perez-Martin, Alexander Makatsariya, Jean-Christophe Gris
Summary: This study found that ADAMTS13 activity, antibodies, and antigen levels in newly pregnant women with obstetric antiphospholipid syndrome (oAPS) are associated with the occurrence of pre-eclampsia (PEcl). These markers serve as significant risk factors for PEcl and its subgroups, exhibiting acceptable discrimination power in predicting clinical events. ADAMTS13 may help identify pregnant women with oAPS who do not require escalated treatment strategies to prevent PEcl.
THROMBOSIS RESEARCH
(2021)
Article
Obstetrics & Gynecology
Anna Aulitzky, Julia Lanbach, Sophie Falkensteiner, Sarah Maier, Hanno Ulmer, Bettina Toth, Beata Seeber
Summary: This retrospective cohort study investigates the relationship between outlier high values of HCG following embryo transfer and pregnancy complications, specifically pre-eclampsia. The study finds that women with the highest HCG concentrations have a lower incidence of pre-eclampsia. This is the first known report linking high first-measured HCG after SET to an adverse pregnancy outcome.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Acoustics
E. Gibbone, A. Wright, R. Vallenas Campos, A. Sanchez Sierra, K. H. Nicolaides, M. Charakida
Summary: The study examined the impact of various factors on maternal cardiovascular indices during 19-23 weeks' gestation, finding that peripheral vascular resistance was the only index significantly affected by the subsequent development of PE, while other indices showed weak correlations with PE. Although maternal cardiovascular indices provide insights into the pathophysiology of PE, they are not useful for predicting PE.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Transplantation
Luca Valsecchi, Alessandro Galdini, Daniela Gabellini, Giacomo Dell'Antonio, Silvia Galbiati, Andrea Fanecco, Ilaria Vigano', Maddalena Smid, Rosa Bernardi, Silvia Maestroni, Hans J. Baelde, Gianpaolo Zerbini
Summary: Pre-eclampsia leads to inhibition of vascular endothelial growth factor (VEGF), which may cause an increase in VEGF synthesis in the kidney, leading to renal dysfunction. This non-canonical VEGF inhibition mechanism is possibly involved in podocyturia and the development of pre-eclampsia.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Sara Hallum, Saima Basit, Mads Kamper-Jorgensen, Thomas S. G. Sehested, Heather A. Boyd
Summary: Pre-eclampsia increases women's risk of cardiovascular disease, especially within a decade after delivery and for women aged 30-39 years. A history of pre-eclampsia can be used to identify women at increased risk of cardiovascular disease, and targeted interventions should be initiated soon after delivery.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Acoustics
V. Giorgione, J. O'Driscoll, C. M. Coutinho, C. Di Fabrizio, R. Sharma, A. Khalil, B. Thilaganathan
Summary: This study compared echocardiographic findings before and after delivery in women with HDP, and found that hemodynamic changes related to delivery did not significantly influence TTE indices. Suboptimal echocardiographic findings in HDP patients may be due to chronic pregnancy cardiovascular load changes or pre-existing maternal cardiovascular impairment.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Nutrition & Dietetics
Huifeng Shi, Yuanhui Jiang, Pengbo Yuan, Lian Chen, Xiaoli Gong, Yike Yang, Yuanyuan Wang, Hai Jiang, You Li, Mengxing Sun, Yangyu Zhao, Yuan Wei
Summary: This study revealed a non-linear association between vitamin E concentrations in the first trimester and gestational vitamin E change with pre-eclampsia. The findings showed that vitamin E concentrations below 7.3 mg/L and gestational decrease were associated with increased risk of pre-eclampsia.
FRONTIERS IN NUTRITION
(2022)
Review
Obstetrics & Gynecology
K. E. Eddy, J. P. Vogel, R. Zahroh, M. A. Bohren
Summary: This qualitative evidence synthesis identified key factors influencing the underutilization of MgSO4 for the prevention and treatment of pre-eclampsia and eclampsia, with themes such as provider competence, health system capability, and knowledge translation. Mapping facilitators and barriers within the COM-B behavior change theory framework highlighted the complex interplay between physical and psychological capability, social and physical opportunity, and motivation. The findings from this review can guide policy and guideline development to improve the appropriate use of MgSO4 in clinical care worldwide.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Health Care Sciences & Services
Oana Balint, Cristina Secosan, Laurentiu Pirtea
Summary: This study found a positive correlation between CA-125 levels and the severity of hypertensive disorders of pregnancy. CA-125 can be used as a marker to evaluate the severity and manage high-risk patients. Further research is needed to improve the accuracy of the results and determine the optimal measurement time.
Article
Obstetrics & Gynecology
Herbert Valensise, Daniele Farsetti, Ilaria Pisani, Grazia Maria Tiralongo, Giulia Gagliardi, Damiano Lo Presti, Gian Paolo Novelli, Barbara Vasapollo
Summary: The study aimed to evaluate the relationship between cardiovascular health and cardiac function during early pregnancy and the development of complications in chronic hypertensive patients. The results showed that patients with complications had abnormal cardiac indices in early pregnancy, including heart rate, cardiac output, vascular resistance, and left ventricular morphology. In addition, diastolic and systolic function were also affected. These findings suggest that early assessment of cardiovascular parameters during early pregnancy can help predict the development of complications in hypertensive patients.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Daniele Farsetti, Francesca Pometti, Grazia Maria Tiralongo, Damiano Lo Presti, Ilaria Pisani, Giulia Gagliardi, Barbara Vasapollo, Gian Paolo Novelli, Herbert Valensise
Summary: The study found that using QUV and maternal hemodynamics examination can accurately distinguish between SGA and FGR, with significant decrease in QUV and cQUV in early FGR, and lower maternal CO in both early and late FGR.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Francesco Galanti, Ilaria Pisani, Serena Riccio, Daniele Farsetti, Barbara Vasapollo, Gian Paolo Novelli, Donatella Miriello, Rocco Rago, Herbert Valensise
Summary: This study evaluated the hemodynamic parameters in women undergoing in vitro fertilization (IVF) and found a possible correlation between hemodynamics and embryo implantation. Specifically, lower systemic vascular resistance (SVR) before the beginning of IVF techniques and during the window of implantation may positively influence embryo implantation.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Barbara Vasapollo, Gian Paolo Novelli, Daniele Farsetti, Herbert Valensise
Summary: This study found a strong relationship between maternal hemodynamics as expressed by PVR at mid gestation and fetal growth at delivery in chronic hypertension. PVR at mid gestation was strongly correlated with birthweight at delivery and the diagnosis of fetal growth restriction. This finding highlights the importance of maternal hemodynamics for identifying chronic hypertensive patients at risk for developing fetal growth restriction.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Herbert Valensise, Daniele Farsetti, Francesca Pometti, Barbara Vasapollo, Gian Paolo Novelli, Christoph Lees
Summary: This study investigated the relationships between maternal and fetal hemodynamics in a population with suspected fetal growth restriction. The results showed that maternal and fetal hemodynamic parameters were different in the three groups of fetuses: fetal growth restriction, small for gestational age, and adequate for gestational age. Maternal hemodynamic parameters were closely and continuously correlated with fetal hemodynamic features. Assessing maternal and fetal hemodynamic parameters is important for the diagnosis and monitoring of fetal growth restriction.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Endocrinology & Metabolism
Costanzo Moretti, Natalia Lazzarin, Elena Vaquero, Alessandro Dal Lago, Luisa Campagnolo, Herbert Valensise
Summary: Pregnancy can cause changes in thyroid function, which requires complex hormonal and metabolic adaptations. Thyroid function is crucial for successful implantation and progression of pregnancy. Abnormal thyroid function is common among women of childbearing age, leading to a high incidence of thyroid diseases during pregnancy. This study aims to analyze the adaptive events and mechanisms that occur in thyroid function during pregnancy, as well as interpret laboratory data for monitoring thyroid function during normal pregnancy or in the presence of thyroid abnormalities.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Urology & Nephrology
Federica Sala, Melania Loggia, Giorgia Cardella, Claudia Morgani, Giovanni Grossi, Marzio Angelo Zullo, Herbert Carmelo Carlo Valensise, Pier Luigi Palazzetti, Michele Carlo Schiavi
Summary: The objective of this study was to compare the efficacy of the transobturator tape (TOT) procedure combined with solifenacin (TOT-S) or prasterone (TOT-P) in postmenopausal women affected by mixed urinary incontinence (MUI). The study found that after 12 weeks of follow-up, TOT-P demonstrated the same effectiveness as TOT-S in reducing urinary symptoms, and TOT-P also improved vaginal health index (VHI) and sexual function scores compared with TOT-S.
LUTS-LOWER URINARY TRACT SYMPTOMS
(2023)
Article
Obstetrics & Gynecology
Barbara Vasapollo, Gian Paolo Novelli, Daniele Farsetti, Francesca Pometti, Roberta Frantellizzi, Filomena Maellaro, Marco Silvestrini, Marcello Pais, Herbert Valensise
Summary: Tailored treatment with NO donors and oral fluids for hypodynamic chronic hypertensive patients may reduce or mitigate adverse outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)