Article
Medicine, General & Internal
Felix Rafael De Bie, Christopher Gates Halline, Travis Kotzur, Kevin Hayes, Christopher Copeland Rouse, Jonathan Chang, Abby Christine Larson, Sameer Ahmad Khan, Ashley Spina, Samantha Tilden, Francesca Maria Russo, Holly Lee Hedrick, Jan Deprest, Emily Anne Partridge
Summary: In a nitrofen rat model, prenatal administration of treprostinil significantly reduces pulmonary arteriole muscularization. These results suggest that prophylactic treatment may be a potential approach for managing CDH-related PH.
Article
Obstetrics & Gynecology
Emily J. J. Horn-Oudshoorn, Francesca M. Russo, Jan A. Deprest, Florian Kipfmueller, Annegret Geipel, Thomas Schaible, Neysan Rafat, Anne-Gael Cordier, Alexandra Benachi, Nimrah Abbasi, Priscilla P. L. Chiu, Willem P. de Boode, Esther Sikkel, Nina C. J. Peters, Bettina E. Hansen, Irwin K. M. Reiss, Philip L. J. DeKoninck
Summary: This retrospective cohort study aimed to describe the outcomes of preterm born infants with congenital diaphragmatic hernia (CDH) and investigate the associations between prenatal imaging markers and survival. The results showed that prenatal imaging markers, including lung-to-head ratio, stomach position, and total fetal lung volume, were associated with postnatal survival in infants with CDH born at or before 32 weeks of gestation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ana Idelson, Kinneret Tenenbaum-Gavish, David Danon, Nir-Ram Duvdevani, Ruben Bromiker, Gil Klinger, Sharon Orbach-Zinger, Anastasia Almog, Adi Sharabi-Nov, Hamutal Meiri, Kypros H. Nicolaides, Arnon Wiznitzer, Yuval Gielchinsky
Summary: This study provides a comprehensive report on the experience gained in prenatal treatment of congenital diaphragmatic hernia (CDH) using fetoscopic endoluminal tracheal occlusion (FETO) at a newly established specialized fetal medicine center. The survival rate was found to be 50%.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Pediatrics
Katherine C. Ott, Michael Bi, Federico Scorletti, Saad A. Ranginwala, William S. Marriott, Jose L. Peiro, Beth M. Kline-Fath, Amir M. Alhajjat, Aimen F. Shaaban
Summary: Liver herniation affects lung development and can lead to clinically significant pulmonary hypoplasia and pulmonary hypertension. It has been found that the liver grows faster in right-sided fetuses compared to left-sided fetuses, and there is a positive correlation between liver growth and lung growth when the liver remains entirely within the abdomen. However, this positive correlation is lost when the liver is herniated above the diaphragm.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Ben Van Calster, Alexandra Benachi, Kypros H. Nicolaides, Eduard Gratacos, Christoph Berg, Nicola Persico, Glenn J. Gardener, Michael Belfort, Yves Ville, Greg Ryan, Anthony Johnson, Haruhiko Sago, Przemyslaw Kosinski, Pietro Bagolan, Tim Van Mieghem, Philip L. J. DeKoninck, Francesca M. Russo, Stuart B. Hooper, Jan A. Deprest
Summary: This analysis suggests that fetoscopic endoluminal tracheal occlusion improves survival in cases of moderate and severe lung hypoplasia. The timing of balloon insertion may impact the treatment effect, but further research is needed to determine its precise influence due to the limited sample size and confounding factors. In particular, early insertion of the balloon greatly increases the risk of preterm delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Flaminia Pugnaloni, Irma Capolupo, Neil Patel, Paola Giliberti, Andrea Dotta, Pietro Bagolan, Florian Kipfmueller
Summary: This review highlights the importance of miRNAs in CDH-related PH and summarizes the findings from animal and human CDH studies. The focus on epigenetic modulators of CDH-PH offers potential for developing innovative diagnostic tools and treatment approaches, and enhances researchers' understanding of CDH pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Judith Leyens, Lukas Schroeder, Annegret Geipel, Christoph Berg, Bartolomeo Bo, Lotte Lemloh, Neil Patel, Andreas Mueller, Florian Kipfmueller
Summary: This study aims to describe the early course of pulmonary hypertension (PH) in infants with congenital diaphragmatic hernia (CDH) and its relation to prognostic markers and outcome measures. The severity of PH varied significantly in the first 48 hours of life. Patients with mild/no PH had a better prognosis, while patients with severe PH had a higher risk of mortality and ECMO. Assessing PH within 2-6 hours is crucial in the care for CDH neonates.
FRONTIERS IN PEDIATRICS
(2023)
Article
Anatomy & Morphology
Mar Janna Dahl, Anna Lavizzari, Jonathan W. Davis, Peter B. Noble, Raffaele Dellaca, J. Jane Pillow
Summary: The extent of lung hypoplasia affects the outcomes of infants with congenital diaphragmatic hernia. Current treatments aim to balance the need for increased gas exchange surface area with the restoration of pulmonary epithelial cells and consideration of long-term effects of prematurity. Sufficient lung development in utero requires intra-thoracic space, appropriate composition of fetal lung fluid, regular fetal breathing movements, adequate gas exchange area, and surfactant production.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alecsander F. Bressan, Victoria Oliveira Maia, Beatriz de Souza Rodrigues, Giuliana Bertozi, Sabrina S. Batah, Alexandre T. Fabro, Gloria Pelizzo, Ugo Maria Pierucci, Rita C. Tostes, Lourenco Sbragia, Fernando S. Carneiro
Summary: Congenital diaphragmatic hernia (CDH) can cause abnormalities in the pulmonary arteries of both the contralateral and ipsilateral sides of the diaphragm. Nitric oxide (NO) is commonly used to treat CDH but may not always be effective. This study investigated the different responses of the left and right pulmonary arteries to a NO donor in a rabbit model of left CDH. The results showed that newborns with CDH had increased vasorelaxant responses to the NO donor compared to the control group, possibly due to increased cGMP mobilization.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mayo Miura, Kenji Imai, Hiroyuki Tsuda, Rika Miki, Sho Tano, Yumiko Ito, Shima Hirako-Takamura, Yoshinori Moriyama, Takafumi Ushida, Yukako Iitani, Tomoko Nakano-Kobayashi, Shinya Toyokuni, Hiroaki Kajiyama, Tomomi Kotani
Summary: The study demonstrated that molecular hydrogen (H-2) as an antioxidant can improve respiratory function in CDH rat models by attenuating lung morphology and pulmonary artery thickening, enhancing alveolarization and pulmonary artery remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Kasra Khalaj, Rebeca Lopes Figueira, Lina Antounians, Sree Gandhi, Matthew Wales, Louise Montalva, George Biouss, Augusto Zani
Summary: This study demonstrates that extracellular vesicles derived from rat amniotic fluid stem cells (AFSC-EVs) can rescue impaired lung development in a rodent model of pulmonary hypoplasia. AFSC-EVs restore key factors responsible for branching morphogenesis and significantly improve the expression of cell markers associated with lung development at different stages. The findings suggest that AFSC-EV-based therapies hold potential for treating pulmonary hypoplasia secondary to congenital diaphragmatic hernia (CDH).
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Acoustics
R. A. Didier, E. R. Oliver, P. Rungsiprakarn, S. E. Debari, S. E. Adams, H. L. Hedrick, N. S. Adzick, N. Khalek, L. J. Howell, B. G. Coleman
Summary: In infants with left CDH without liver herniation, those with stomach-down CDH have lower neonatal morbidity compared to those with stomach herniation, despite similar observed-to-expected lung-area-to-head-circumference ratio and total lung volume. Accurate prenatal ultrasound characterization of CDH is crucial for appropriate prenatal counseling and patient management.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Letter
Medicine, General & Internal
Charles J. H. Stolar, Alan W. Flake, Paul D. Losty, Jan A. Deprest, Kypros H. Nicolaides, Alexandra Benachi
Summary: The lower mortality rates reported in the study should not be generalized outside of well-designed trials at experienced centers. Despite a standardized protocol, the study lacks information on adherence to standardized care over a 10-year trial period at multiple centers with varying experience. The low use of extracorporeal life support mentioned in the study appears inconsistent.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Giuliana Orlandi, Paolo Toscano, Olimpia Gabrielli, Enrica Di Lella, Antonia Lettieri, Luigi Manzo, Laura Letizia Mazzarelli, Carmine Sica, Letizia Di Meglio, Lavinia Di Meglio, Ferdinando Antonio Gulino, Giosue Giordano Incognito, Attilio Tuscano, Stefano Cianci, Aniello Di Meglio
Summary: This study reports a case of prenatal-diagnosed congenital diaphragmatic hernia (CDH) and intrathoracic kidney (ITK), and conducts a systematic review of all cases with this association. The rarity of this association is highlighted, but no significant complications were found associated with it. Accurate prenatal diagnosis and counseling are crucial in planning adequate prenatal and postnatal management to improve neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anatomy & Morphology
Andrew V. V. Stainsby, Philip L. J. DeKoninck, Kelly J. J. Crossley, Alison Thiel, Megan J. J. Wallace, James T. T. Pearson, Aidan J. J. Kashyap, Michelle K. K. Croughan, Beth A. A. Allison, Ryan Hodges, Marta Thio, Andreas W. W. Flemmer, Erin V. V. McGillick, Arjan B. B. te Pas, Stuart B. B. Hooper, Marcus J. J. Kitchen
Summary: Congenital diaphragmatic hernia (CDH) is a major cause of severe lung hypoplasia and pulmonary hypertension in newborns. This study examined the 3D structure of the pulmonary arterial tree in rabbits with surgically induced diaphragmatic hernia (DH), and found that DH significantly reduced the number and branching of pulmonary arteries, leading to a decrease in arterial cross-sectional area, which may be a major contributor to pulmonary hypertension in infants with CDH.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Pediatrics
Gabriel F. Ramos, Vanessa P. Ribeiro, Mariana P. Mercadante, Maira P. Ribeiro, Artur F. Delgado, Sylvia C. L. Farhat, Marta M. Leal, Heloisa H. Marques, Vicente Odone-Filho, Uenis Tannuri, Werther B. Carvalho, Sandra J. Grisi, Magda Carneiro-Sampaio, Clovis A. Silva
JORNAL DE PEDIATRIA
(2019)
Article
Gastroenterology & Hepatology
Leonardo Ervolino Corbi, Ana Cristina Aoun Tannuri, Maria Julia de Aro Braz, Vitor Ribeiro Paes, Lourenco Sbragia, Rebeca Lopes Figueira, Karina Miura da Costa, Maria Cecilia Mendonca Coelho, Josiane Oliveira Goncalves, Suellen Serafini, Uenis Tannuri
DIGESTIVE DISEASES AND SCIENCES
(2019)
Article
Immunology
G. de Freitas Paganoti, A. C. A. Tannuri, A. C. Dantas Marques, R. R. Torres, N. E. Mendes Gibelli, U. Tannuri
TRANSPLANTATION PROCEEDINGS
(2019)
Article
Pediatrics
Victor Van Vaisberg, Ana Cristina Aoun Tannuri, Fabiana Roberto Lima, Uenis Tannuri
JOURNAL OF PEDIATRIC SURGERY
(2020)
Review
Medicine, General & Internal
Joice Anaize Tonon do Amaral, Renata Salatini, Claudia Arab, Luiz Carlos Abreu, Vitor E. Valenti, Carlos B. M. Monteiro, Uenis Tannuri, Ana Cristina Aoun Tannuri
MEDICINA-LITHUANIA
(2020)
Article
Pediatrics
Ana Cristina Aoun Tannuri, Simone Santoro Angelo, Priscilla Takyi, Armando Ribeiro da Silva, Uenis Tannuri
Summary: Esophagocoloplasty or total gastric transposition is a good alternative for patients with complex esophageal atresia, as it has shown excellent long-term results with normal deglutition function when compared to esophageal elongation procedures.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Clovis Artur Silva, Vitor Cavalcanti Trindade, Roberta Capretz D'Oliveira Abel, Marcelo Oliveira Silva, Joao Fernando Vecchi Santos, Vera Hermina Kalika Koch, Ana Paula Scoleze Ferrer, Alexandra Brentani, Vicente Odone-Filho, Uenis Tannuri, Werther Brunow Carvalho, Magda Carneiro-Sampaio, Sandra Josefina Ferraz Ellero Grisi
Summary: The study found that early-career pediatricians tend to face higher workload, lower income, and work-related issues, while those who have been in the field for over 5 years are more stable and satisfied in their practice.
REVISTA PAULISTA DE PEDIATRIA
(2021)
Article
Pediatrics
Caroline Gouveia Buff Passone, Sandra Josefina Grisi, Sylvia Costa Farhat, Thais Della Manna, Antonio Carlos Pastorino, Renata Antunes Alveno, Caroline Vasconcelos Sa Miranda, Aurora Rosaria Waetge, Mariana Nutti Cordon, Vicente Odone-Filho, Uenis Tannuri, Werther Brunow Carvalho, Magda Carneiro-Sampaio, Clovis Artur Silva
REVISTA PAULISTA DE PEDIATRIA
(2020)
Article
Medicine, General & Internal
Clovis Artur Silva, Vitor Cavalcanti Trindade, Amanda Monteiro da Cruz, Bruna Paccola Blanco, Joao Fernando Vecchi Santos, Alexandre Archanjo Ferraro, Vicente Odone-Filho, Uenis Tannuri, Werther Brunow Carvalho, Magda Carneiro-Sampaio, Sandra Elisabete Vieira, Sandra Josefina Ferraz Ellero Grisi
Article
Medicine, General & Internal
Ana Cristina Aoun Tannuri, Lucas Arjona de Andrade Hara, Guilherme de Freitas Paganoti, Wagner de Castro Andrade, Uenis Tannuri
Article
Medicine, General & Internal
Isabela K. R. Agra, Adolfo W. Liao, Mara S. Hoshida, Regina Schultz, Marcello P. Toscano, Rossana Pv Francisco, Marcelo Zugaib, Maria L. Brizot
Article
Medicine, General & Internal
Marco Aurelio Knippel Galletta, Roberto Eduardo Bittar, Isabela Agra, Eliane Cerqueira Leite Guerra, Rossana Pulcineli Vieira Francisco, Marcelo Zugaib
Letter
Gastroenterology & Hepatology
Karina Lucio de Medeiros Bastos, Caio Robledo Quaio, Fabiana Roberto Lima, Iana Manuelle Araujo, Candice Alves Tavares Araujo, Flavia Balbo Piazzon, Ismael Dale Cotrim Guerreiro da Silva, Gabriel Nuncio Benevides, Ana Cristina Tannuri, Uenis Tannuri, Ramiro Anthero Azevedo, Chong Ae Kim
CLINICAL AND MOLECULAR HEPATOLOGY
(2019)
Review
Medicine, General & Internal
Michele Luglio, Uenis Tannuri, Werther Brunow de Carvalho, Karina Lucio de Medeiros Bastos, Isadora Souza Rodriguez, Cintia Johnston, Artur Figueiredo Delgado
Article
Medicine, General & Internal
Pedro Augusto Dantas de Moraes, Ana Cristina Aoun Tannuri, Livio Moreira Rios, Vitor Ribeiro Pees, Josiane de Oliveira Goncalves, Suellen Serafini, Uenis Tannuri