Article
Pediatrics
Sivan Farladansky-Gershnabel, Hadar Gluska, Nufar Halevi, Neta Kotser, Maya Sharon-Weiner, Hanoch Schreiber, Rivka Sukenik-Halevi, Yaniv Ebner, Shmuel Arnon, Ofer Markovitch
Summary: This retrospective study assessed the efficacy of prenatal sonographic diagnosis of orofacial clefts and the postnatal outcomes of these children. The study found a low accuracy rate for prenatal sonographic diagnosis and highlighted the importance of improving parental counseling and therapeutic plans.
Article
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Ahmed Ali Alfawzan, Fatema Akhter, Haytham Jamil Alswairki, Prabhat Kumar Chaudhari
Summary: This study investigated the variation between non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to lip morphology (LM) and nasolabial angle (NLA). The results showed significant disparities in LM-1 and NLA between NSCLP and NC individuals.
APPLIED SCIENCES-BASEL
(2022)
Editorial Material
Surgery
Eva Rubio, Esperanza Mantilla-Rivas, Monica Manrique, Kenneth L. Fan, Anna Blask, Erin M. Rada, Dorothy Bulas, Marney A. White, Gary F. Rogers, Albert K. Oh
Summary: The objective of this study was to investigate the association between prenatal alveolar cleft width and the likelihood of secondary palate cleft in unilateral cleft lip. The study found that alveolar defects greater than or equal to 4 mm on prenatal ultrasound were highly predictive of the presence of secondary palate cleft in patients with unilateral cleft lip. This finding is clinically significant for prenatal diagnosis of cleft palate.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Robert Frederick, Amy Claire Hogan, Natalie Seabolt, Rose Mary S. Stocks
Summary: This article emphasizes the benefits of a multidisciplinary team approach in the systemic management of patients with cleft lip and cleft palate, and suggests the addition of a registered dietitian to the care team. An ideal cleft palate care team should focus on a comprehensive, collaborative, and family-centered approach. While care teams may vary depending on context and location, there are still some key principles.
Article
Surgery
Daniel C. Sasson, Alex M. Rokni, Nikhil D. Shah, Selcen S. Yuksel, Eugene Park, Arun K. Gosain
Summary: The study suggests that complete CL and associated cleft palate are significantly associated with the accuracy of prenatal diagnosis. Parents are more satisfied with true-positive prenatal diagnosis and perceive knowing their child's diagnosis in advance to be more helpful. Therefore, these results can aid physicians in providing more informed prenatal counseling.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Natalia Kaczorowska, Marcin Mikulewicz
Summary: This paper examines cephalometric parameters in patients with cleft lip and palate and cleft lip, and compares the differences between these patient groups. The results show that cleft palate surgery has an effect on the forward growth of the maxilla.
APPLIED SCIENCES-BASEL
(2022)
Review
Genetics & Heredity
Arwa Babai, Melita Irving
Summary: Orofacial clefting is a common birth defect worldwide, presenting as cleft lip only, isolated cleft palate or cleft lip and palate. It has a diverse genetic background influenced by gene-gene and gene-environment interaction, resulting in syndromic and nonsyndromic orofacial clefts. Orofacial clefts cause significant physiological difficulties, impacting feeding, speech and language development, and other developmental aspects, leading to increased social and financial burden. The management of orofacial clefts requires a multidisciplinary team approach.
Article
Multidisciplinary Sciences
Shanshan Jia, Qiang Zhang, Yu Wang, Xiaowei Wei, Hui Gu, Dan Liu, Wei Ma, Yiwen He, Wenting Luo, Zhengwei Yuan
Summary: This study found that miRNAs in the plasma of pregnant women can serve as potential biomarkers for diagnosing nonsyndromic cleft lip with palate (nsCLP). Compared to plasma, eight let-7 cluster miRNAs in plasma-derived exosomes showed higher sensitivity and specificity in diagnosing fetal nsCLP. Among them, hsa-let-7a-3p was identified as a better diagnostic indicator and was downregulated in nsCLP fetal lip tissues.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Obstetrics & Gynecology
Kathleen Minor, Jane Chueh
Summary: Orofacial clefts are common congenital anomalies, and prenatal detection of cleft palate without cleft lip is currently low. Improving prenatal diagnosis, counseling, and genetic testing for orofacial clefts is essential. 2D sonographic markers and association with retrognathia/micrognathia can be utilized to optimize prenatal detection of cleft palate.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chihiro Iwaya, Akiko Suzuki, Junichi Iwata
Summary: Cleft lip and palate is a common congenital birth defect with varied causes. Recent studies suggest that non-coding RNAs, specifically microRNAs, may play a role in the development of cleft lip and palate. This review examines the potential of microRNAs as causative mechanisms in humans and mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Chin-Han Chang, Chi-Hua Chang, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: This study investigated the prevalence of tooth agenesis, tooth malformation, and eruption patterns of upper canines/first premolars in Taiwanese children. The results suggest a strong correlation between the patterns of dental anomalies and the cleft sites in cleft lip and cleft palate patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Xiaofeng Li, Yu Tian, Ling Qiu, Shu Lou, Guirong Zhu, Yue Gao, Lan Ma, Yongchu Pan
Summary: This study utilized an expression quantitative trait locus (eQTL) dataset to identify multiple associations with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). Functional annotation analysis showed that these risk loci were significantly enriched in transcription regulation and chromatin open regions on the genome. Additionally, these susceptible genes were closely related to cell fate determination, the pluripotency of stem cells, and Wnt signaling pathways.
Article
Pharmacology & Pharmacy
O. Y. Celik, M. Bucak, E. Saglam, N. C. Kahraman, A. O. Kaymak, O. Arat, M. Ibanoglu, T. T. Ilhan, E. Ergun, S. Celen, C. Iskender
Summary: This study aimed to compare the diagnostic accuracy of two ultrasound techniques (ATV and ESV) in detecting cleft palate without cleft lip. The results showed that ATV has higher sensitivity and specificity.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Otorhinolaryngology
David O'Neil Danis, Kevin Bachrach, Jacquelyn Piraquive, Alexander P. Marston, Jessica R. Levi
Summary: The study found an association between neonatal abstinence syndrome (NAS) and cleft lip and/or cleft palate (CLP), specifically isolated cleft palate, suggesting that prenatal exposure to opioids may be an environmental risk factor in the development of CLP.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Genetics & Heredity
Benjamin L. Green, Grace-Ann Fasaye, Sarah G. Samaranayake, Anna Duemler, Lauren A. Gamble, Jeremy L. Davis
Summary: Pathogenic and likely pathogenic variants in the CDH1 gene are associated with increased risk of gastric and breast cancers, as well as hereditary cleft lip and palate (CLP). This study aimed to determine the prevalence of CLP in families with these variants. The results showed a high prevalence of CLP in families carrying CDH1 variants, with no clear genotype-phenotype pattern. Genetic testing for CDH1 should be considered in families with CLP and a history of gastric or lobular breast cancer.
FRONTIERS IN GENETICS
(2022)