Article
Surgery
Tommaso Simoncini, Andrea Panattoni, Mustafa Aktas, Jozef Ampe, Cornelia Betschart, Alexander L. A. Bloemendaal, Stephan Buse, Giuseppe Campagna, Marta Caretto, Mauro Cervigni, Esther C. J. Consten, Hugo H. Davila, Jean Dubuisson, Eloy Espin-Basany, Bernardina Fabiani, Jean-Luc Faucheron, Andrea Giannini, Brooke Gurland, Dieter Hahnloser, Ralf Joukhadar, Paolo Mannella, Liliana Mereu, Jacopo Martellucci, Guillaume Meurette, Maria Magdalena Montt Guevara, Carlo Ratto, Barry A. O'Reilly, Christl Reisenauer, Eleonora Russo, Steven Schraffordt Koops, Shahab Siddiqi, Alessandro Sturiale, Gabriele Naldini
Summary: This study aimed to address the role of robotic pelvic floor reconstructive procedures through expert opinion. The results showed that robotic surgery has significant technical advantages over standard laparoscopy and is particularly important for complex reconstructive procedures, although benefits can be found in less challenging cases as well. However, more research is needed to objectively assess the specific settings where robotic surgery would provide the most benefit.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Immunology
Florence Kauffmann, Catherine Heffernan, Francois Meurice, Martin O. C. Ota, Volker Vetter, Giacomo Casabona
Summary: The article reviews the challenges in controlling measles, mumps and rubella infections, mainly related to low immunization coverage and vaccine characteristics. Strategies to address these challenges include raising awareness of disease severity and vaccines impact, targeting high-risk population, improving vaccination access, setting up outbreak preparedness plans, and strengthening surveillance systems.
EXPERT REVIEW OF VACCINES
(2021)
Review
Endocrinology & Metabolism
Bianca de Oliveira Horvath-Pereira, Gustavo Henrique Dona Rodrigues Almeida, Leandro Norberto da Silva Junior, Pedro Gabriel do Nascimento, Barbara de Oliveira Horvath Pereira, Joao Victor Barbosa Tenorio Fireman, Maria Laura dos Reis Ferre Pereira, Ana Claudia Oliveira Carreira, Maria Angelica Miglino
Summary: Traditional therapies for male infertility focus on restoring fertility or preserving sperm in severe cases, but have limitations that impact their effectiveness. Reproductive medicine has turned to biotechnological alternatives, such as tissue-engineered testicular tissue reconstruction, to improve infertility treatment and gamete preservation. This approach mimics the testicular microenvironment to maintain male gametes in culture or produce viable grafts for transplantation. The use of biomaterials plays a crucial role in these artificial biological systems, but each material has advantages and disadvantages. This review discusses the progress and challenges in testicular regenerative medicine and the reconstruction of the testicular microenvironment using tissue bioengineering approaches.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Multidisciplinary
Eyal Klang, Shelly Soffer, Abraham Tsur, Eyal Shachar, Adi Lahat
Summary: The health system can benefit greatly from adopting innovative measures, as demonstrated during the COVID-19 pandemic. In this article, the authors provide an overview of how gastroenterology has embraced innovative technologies through text-mining analysis. The fields of the microbiome and advanced endoscopy were found to be the most innovative, with increasing interest in artificial intelligence, virtual reality, and telemedicine. The implementation of VR and telemedicine has the potential to improve physician and patient training, increase access to care, reduce costs, and improve patient outcomes.
Article
Medicine, General & Internal
Anne-Cecile Pizzoferrato, Stephanie Ragot, Louis Verite, Nicolas Naiditch, Xavier Fritel
Summary: The study aimed to assess women's perception of postoperative pelvic floor repair complications and compare it to the Clavien-Dindo classification. The results showed that women's perception of surgical complications differed from the Clavien-Dindo classification, with lack of repair and long-term disability being two major factors contributing to the perception of seriousness.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Entomology
Natalie E. Duffus, Craig R. Christie, Juliano Morimoto
Summary: Insects, like many other organisms, provide essential services for our societies, such as pollination. However, there is often a general misunderstanding about the benefits of insects to our cultures, leading to avoidance or attempts to exterminate them. By better understanding and appreciating the role of insects in cultural services, it is possible to change people's attitudes and promote more appropriate conservation efforts.
Article
Polymer Science
Anja R. A. Palmans, E. W. Meijer, Scott E. Denmark
Summary: Stereochemical nomenclature is a point of attention as different fields in chemistry become more entwined. Amplification of asymmetry is recommended as an alternative to amplification of chirality, referring to the increase of asymmetry in enantiomeric composition at the molecular or supramolecular level. This covers the nonproportional increase in optical activity in helical polymers and high enantiomeric excesses found in asymmetric catalysis with nonlinear effects.
JOURNAL OF POLYMER SCIENCE
(2021)
Editorial Material
Geriatrics & Gerontology
Kenneth Rockwood
Summary: The proposal to use frailty as a rationing criterion in the face of capacity shortages and as an alternative to age in risk stratification is defensible. Future research should focus on generating better COVID-19-specific prognostic information to determine which lives are most likely to be saved in the event of resource scarcity.
Editorial Material
Environmental Sciences
Geert Jan Van Oldenborgh, Michael F. Wehner, Robert Vautard, Friederike E. L. Otto, Sonia I. Seneviratne, Peter A. Stott, Gabriele C. Hegerl, Sjoukje Y. Philip, Sarah F. Kew
Summary: As global warming continues, heatwaves become more frequent and intense. However, regional and local factors play a significant role in determining heatwave trends. While climate models can simulate heatwaves reasonably well, temperature variability in some regions does not align with global warming. This poses a major scientific challenge in reliably attributing and projecting heatwave changes, particularly in areas where the simulation of moisture budget, land surface changes, short-lived forcers, and soil moisture interactions is inadequate.
Article
Environmental Sciences
Debora Maia-Silva, Rohini Kumar, Roshanak Nateghi
Summary: The higher frequency and intensity of sustained heat events have increased the demand for cooling energy across the globe. Current estimates of summer-time energy demand based on Cooling Degree Days (CDD) fall significantly short of capturing regional thermal comfort levels. Accounting for humidity in the calculation of thermal comfort is crucial in accurately estimating cooling energy demand.
Review
Gastroenterology & Hepatology
Sandra Strainiene, Milda Peciulyte, Tomas Strainys, Ieva Stundiene, Ilona Savlan, Valentina Liakina, Jonas Valantinas
Summary: Approximately 20% of cirrhotic patients with ascites develop umbilical herniation, which can lead to life-threatening complications such as the rupture of an umbilical hernia. Flood syndrome, resulting from large-volume ascites and end-stage liver disease, remains a challenging condition for clinicians due to the lack of clear guidelines for management. Key questions regarding the treatment and prevention of Flood syndrome include the best treatment approach, determining individual risk factors, preventing hernia ruptures, and managing patients during the COVID-19 pandemic.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Clinical Neurology
Ece Bayram, Lucia Batzu, Bension Tilley, Rhea Gandhi, Priya Jagota, Roberta Biundo, Michela Garon, Tittaya Prasertpan, Claudia Lazcano-Ocampo, K. Ray Chaudhuri, Rimona S. Weil
Summary: Cognitive impairment is common in Parkinson's disease (PD) and effective treatments beyond cholinesterase inhibitors are lacking. This study examined recent clinical trials for cognitive outcomes in PD and found that only a small proportion of trials were completed and few showed significant improvement. Factors contributing to the lack of detectable benefit include trial design, lack of enrichment for at-risk groups, short follow-up duration, and insensitive outcome measures.
PARKINSONISM & RELATED DISORDERS
(2023)
Editorial Material
Infectious Diseases
Els Torreele, Yap Boum II, Ismael Adjaho, Franck Guy Biaou Ale, Sal Ha Issoufou, Geza Harczi, Chibuzo Okonta, Piero Olliaro
Summary: Two breakthrough treatments for Ebola virus disease have been registered and stockpiled in the USA, but are still not available in the most affected countries. The fragmented research and development process and the lack of public health-focused leadership are the main reasons behind this issue. Current financial incentives prioritize registration and stockpiling in the USA, neglecting the responsibility to provide access where it is needed. Stronger leadership in African countries is necessary to drive drug development efforts and ensure equitable access to treatments.
LANCET INFECTIOUS DISEASES
(2023)
Article
Economics
Chris Skedgel, Nadine Henderson, Adrian Towse, David Mott, Colin Green
Summary: There is strong evidence suggesting that individuals and the public place higher value on health improvements in more severe health conditions. This preference is now being taken into account in health technology assessment in some countries, such as the Netherlands, England and Wales, Norway, Sweden, and the United States. To ensure fairness and consistency in the consideration of societal severity preferences, a more explicit and quantitative approach is needed. However, challenges such as discontinuities between severity categories and the complexity of calculating a continuous severity adjustment need to be addressed.
Article
Psychology, Clinical
Louise C. P. Fennell, Shannon A. Johnson
Summary: This paper critically examines six common assumptions/biases about autism that may influence neuropsychologists in their clinical work, aiming to encourage reflection on these biases to improve neuropsychological service delivery for individuals on the autism spectrum.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Correction
Urology & Nephrology
Christopher R. Chapple, Emma Mironska, Adrian Wagg, Ian Milsom, David Castro Diaz, Heinz Koelbl, Dmitry Pushkar, Andrea Tubaro, Dirk De Ridder, Emmanuel Chartier-Kastler, Lawrence D. Phillips
EUROPEAN UROLOGY FOCUS
(2022)
Article
Urology & Nephrology
Loes Oomen, Erik Leijte, Darren E. Shilhan, Michelle Battye, Wout F. J. Feitz
Summary: This study examined the patient population with rare urorectogenital diseases or complex conditions within the ERN eUROGEN network from 2013 to 2019. The results showed an increase in clinical activity, but there were differences in patient numbers among healthcare providers. Improved definitions of diagnostic codes and a better understanding of the data-gathering process are needed to obtain valid patient numbers.
Review
Urology & Nephrology
Francesco Esperto, Wesley Verla, Achilles Ploumidis, Rachel Barratt, Roberto La Rocca, Nicolaas Lumen, Yuhong Yuan, Felix Campos-Juanatey, Tamsin Greenwell, Francisco Martins, Nadir Osman, Silke Riechardt, Marjan Waterloos, Konstantinos Dimitropoulos
Summary: This study systematically assessed the efficacy of single-stage OMGU in treating LS strictures, demonstrating low complication rates and beneficial impact, suggesting justified application in patients with LS strictures.
WORLD JOURNAL OF UROLOGY
(2022)
Review
Urology & Nephrology
Karl H. Pang, Riccardo Campi, Salvador Arlandis, Kari Bo, Christopher R. Chapple, Elisabetta Costantini, Fawzy Farag, Jan Groen, Markos Karavitakis, Marie Carmela Lapitan, Margarida Manso, Serenella Monagas Arteaga, Arjun K. Nambiar, Aisling U. Nic An Riogh, Eabhann M. O'Connor, Nadir I. Osman, Benoit Peyronnet, Veronique Phe, Vasileios I. Sakalis, Neha Sihra, Lazaros Tzelves, Huub van der Vaart, Yuhong Yuan, Muhammad Imran Omar, Christopher K. Harding
Summary: The evidence on diagnostic tests for female bladder outlet obstruction is limited and heterogeneous. The current standard for diagnosing bladder outlet obstruction in women is pressure-flow studies +/- fluoroscopy.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Urology & Nephrology
Oluwaseun Akinjise-Ferdinand, Rachel Hubbard, Nadir Osman, Christopher R. Chapple
Summary: This study describes two cases of previous injections of Bulkamid referred for management of a presumed periurethral diverticulum based on MRI findings. We found that a limited noncontrast CT pelvis followed by a VCMG and repeat CT pelvis effectively differentiated between Bulkamid and these presumed periurethral diverticulae.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Obstetrics & Gynecology
Elizabeth R. R. Mueller, Jeffrey P. P. Weiss, J. L. H. Ruud Bosch, Bilal Chughtai, Matt T. T. Rosenberg, Elizabeth D. D. Bacci, Jason C. C. Simeone, Fredrik L. L. Andersson, Kristian Juul, Karin S. S. Coyne, Christopher R. R. Chapple
Summary: This study used data from a large US population-based, cross-sectional, epidemiological study to evaluate the symptoms and bother experienced by women with nocturnal polyuria (NP). The results showed that NP is prevalent in women with significant bother and is often associated with other urinary symptoms. Therefore, multifactorial causes and potential treatments of NP should be considered, particularly at a later age.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Review
Urology & Nephrology
Thomas F. Monaghan, Jeffrey P. Weiss, Alan J. Wein, Syed N. Rahman, Jason M. Lazar, Donald L. Bliwise, Karel Everaert, Gary E. Lemack, Jean-Nicolas Cornu, Marcus J. Drake, Christopher R. Chapple, Hashim Hashim, Jerry G. Blaivas, Roger R. Dmochowski
Summary: This article introduces a novel system, Sleep CALM, for organizing the complex differential diagnosis for nocturia, which includes sleep disorders, comorbidities, patient actions/lifestyle factors, lower urinary tract dysfunction, and medications. Nocturia and sleep disorders are closely intertwined and should not be used as grounds for exclusion from nocturia treatment, but rather leveraged to broaden therapeutic options. Nocturia may be a potential harbinger of serious medical conditions beyond the genitourinary tract, and urologists should have a low threshold for referral to improve health status.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Christopher R. R. Chapple, Matt T. T. Rosenberg, Elizabeth R. R. Mueller, Bilal Chughtai, Jeffrey P. P. Weiss, Kristian Juul, Anne B. B. Brooks, Elizabeth D. D. Bacci, Fredrik L. L. Andersson, Karin S. S. Coyne, J. L. H. Ruud Bosch
Summary: This large-scale epidemiologic study aimed to explore the impact of nocturnal polyuria (NP) on health-related quality of life (HRQoL). The study found that patients with frequent nocturia had greater burden on daily life, lower urinary tract symptoms bother, prostate symptoms (men only), work productivity, physical and mental health, depression, fatigue, and daytime sleepiness compared to those without nocturia. NP associated with other urologic or comorbid conditions had greater patient burden than idiopathic NP, especially for women.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Cell & Tissue Engineering
Sarah Shafaat, Sabiniano Roman Regueros, Christopher Chapple, Sheila MacNeil, Vanessa Hearnden
Summary: Childbirth can lead to common pelvic floor problems in postmenopausal women, necessitating reconstructive surgery. In this study, a tissue-engineered vaginal wound model was developed to investigate wound healing and the role of estradiol in pelvic tissue repair. The results showed that estradiol significantly improved wound healing and epithelial maturation, as well as promoted collagen reorganization and downregulated α-SMA expression. This model provides a valuable tool for studying vaginal wound healing and developing therapies for improved tissue healing after reconstructive pelvic floor surgery.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Urology & Nephrology
Kunlin Yang, Karl H. Pang, Shubo Fan, Xinfei Li, Nadir I. Osman, Christopher R. Chapple, Liqun Zhou, Xuesong Li
Summary: Robotic ureteral reconstruction (RUR) has a success rate of over 90% in treating ureteral diseases and is associated with lower estimated blood loss and shorter length of stay compared to the open and laparoscopic approaches. However, more studies and evidence are needed to determine the superiority of RUR.
Article
Urology & Nephrology
Christopher Chapple, Paul Abrams, Thomas Lam, Altaf Mangera, Mohammed Belal, Carmel Curtis, Jacqueline Emkes, Sarah Hillery, Karen Irwin, Karen Logan, Polly Weston, Ann Yates
Summary: This article provides a multidisciplinary consensus view on clean intermittent self-catheterisation (CISC) as a method for emptying the bladder. It emphasizes the importance of considering each patient individually and the term Bladder Voiding Efficiency (BVE). It also discusses the potential benefits of CISC for patients with neurological disorders.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Roger Dmochowski, Christopher Chapple, Jennifer Gruenenfelder, Jun Yu, Anand Patel, Mariana Nelson, Eric Rovner
Summary: This study aimed to evaluate the safety of onabotulinumtoxinA treatment for adults with overactive bladder (OAB) and urinary incontinence (UI) and its effect on clean intermittent catheterization (CIC) initiation. The results showed that the incidence of CIC was low overall and less frequent for women. It was rare with PVRmax <= 200 ml and did not appear to correlate with baseline PVR.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Meeting Abstract
Pharmacology & Pharmacy
V. Nitti, D. A. Ginsberg, A. Kohan, K. McCammond, B. Jenkins, I. Yushmanova, A. Boroujerdi, C. Chapple
Article
Urology & Nephrology
Emmanuel Chartier-Kastler, Christopher Chapple, Brigitte Schurch, Mehdi Saad
Summary: This study describes the incidence and frequency of symptoms suggestive of urinary tract infection in people using different types of intermittent urinary catheters. When the same type of prelubricated catheter was used throughout the study period, the incidence of these symptoms was lower than for hydrophilic catheters.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
