Article
Medicine, General & Internal
Felix Rafael De Bie, Christopher Gates Halline, Travis Kotzur, Kevin Hayes, Christopher Copeland Rouse, Jonathan Chang, Abby Christine Larson, Sameer Ahmad Khan, Ashley Spina, Samantha Tilden, Francesca Maria Russo, Holly Lee Hedrick, Jan Deprest, Emily Anne Partridge
Summary: In a nitrofen rat model, prenatal administration of treprostinil significantly reduces pulmonary arteriole muscularization. These results suggest that prophylactic treatment may be a potential approach for managing CDH-related PH.
Article
Pediatrics
Jiyoon Jeong, Byong Sop Lee, Teahyen Cha, Euiseok Jung, Ellen Ai-Rhan Kim, Ki-Soo Kim, Dae Yeon Kim, Jung-Man Namgoong, Seong Chul Kim, Mi-Young Lee, Hye-Sung Won
Summary: This study presented treatment outcomes of patients with antenatally diagnosed RCDH and found that O/E LHR could be a useful predictor for perinatal outcomes in isolated RCDH cases. Further large cohort studies are needed to confirm the association between O/E LHR values and the severity of RCDH.
Article
Biochemistry & Molecular Biology
Mayo Miura, Kenji Imai, Hiroyuki Tsuda, Rika Miki, Sho Tano, Yumiko Ito, Shima Hirako-Takamura, Yoshinori Moriyama, Takafumi Ushida, Yukako Iitani, Tomoko Nakano-Kobayashi, Shinya Toyokuni, Hiroaki Kajiyama, Tomomi Kotani
Summary: The study demonstrated that molecular hydrogen (H-2) as an antioxidant can improve respiratory function in CDH rat models by attenuating lung morphology and pulmonary artery thickening, enhancing alveolarization and pulmonary artery remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Katherine C. Ott, Michael Bi, Federico Scorletti, Saad A. Ranginwala, William S. Marriott, Jose L. Peiro, Beth M. Kline-Fath, Amir M. Alhajjat, Aimen F. Shaaban
Summary: Liver herniation affects lung development and can lead to clinically significant pulmonary hypoplasia and pulmonary hypertension. It has been found that the liver grows faster in right-sided fetuses compared to left-sided fetuses, and there is a positive correlation between liver growth and lung growth when the liver remains entirely within the abdomen. However, this positive correlation is lost when the liver is herniated above the diaphragm.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
R. Gregorio-Hernandez, C. Ramos-Navarro, S. Vigil-Vazquez, E. Rodriguez-Corrales, A. Perez-Perez, M. Arriaga-Redondo, M. Sanchez-Luna
Summary: Lung ultrasound is a valuable tool for assessing pulmonary aeration in neonates, including those with congenital diaphragmatic hernia (CDH). In this study, lung ultrasound examinations were performed on 8 CDH patients before and after surgical correction, and compared between two groups based on mechanical ventilation duration. Lung ultrasound showed potential for diagnosing postoperative complications without radiation exposure and offered quick and serial assessments. These findings highlight the importance of lung ultrasound as an effective alternative to conventional imaging methods in managing CDH.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Medicine, General & Internal
Giuliana Orlandi, Paolo Toscano, Olimpia Gabrielli, Enrica Di Lella, Antonia Lettieri, Luigi Manzo, Laura Letizia Mazzarelli, Carmine Sica, Letizia Di Meglio, Lavinia Di Meglio, Ferdinando Antonio Gulino, Giosue Giordano Incognito, Attilio Tuscano, Stefano Cianci, Aniello Di Meglio
Summary: This study reports a case of prenatal-diagnosed congenital diaphragmatic hernia (CDH) and intrathoracic kidney (ITK), and conducts a systematic review of all cases with this association. The rarity of this association is highlighted, but no significant complications were found associated with it. Accurate prenatal diagnosis and counseling are crucial in planning adequate prenatal and postnatal management to improve neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Shiho Yoshida, Alexander M. Kreger, George K. Gittes
Summary: We propose that intra-amniotic sildenafil administration is an effective prenatal therapy for CDH-induced pulmonary hypertension. Intra-amniotic sildenafil treatment attenuated peripheral vascular muscularization, enhanced pulmonary blood flow, and improved lung architecture in CDH fetuses. Early intervention with intra-amniotic sildenafil treatment may be preferable to accelerate lung development and improve prognosis in CDH cases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Alecsander F. Bressan, Victoria Oliveira Maia, Beatriz de Souza Rodrigues, Giuliana Bertozi, Sabrina S. Batah, Alexandre T. Fabro, Gloria Pelizzo, Ugo Maria Pierucci, Rita C. Tostes, Lourenco Sbragia, Fernando S. Carneiro
Summary: Congenital diaphragmatic hernia (CDH) can cause abnormalities in the pulmonary arteries of both the contralateral and ipsilateral sides of the diaphragm. Nitric oxide (NO) is commonly used to treat CDH but may not always be effective. This study investigated the different responses of the left and right pulmonary arteries to a NO donor in a rabbit model of left CDH. The results showed that newborns with CDH had increased vasorelaxant responses to the NO donor compared to the control group, possibly due to increased cGMP mobilization.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Physiology
Krithika Lingappan, Oluyinka O. Olutoye, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J. D. Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P. Gleghorn, Sundeep G. Keswani
Summary: This is the first application of spatial transcriptomics in patients with CDH, revealing the contribution of different lung cellular subpopulations in CDH pathophysiology and highlighting sex-specific differences.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Valentine Cerbelle, Kevin Le Duc, Stephanie Lejeune, Sebastien Mur, Heloise Lerisson, Elodie Drumez, Rony Sfeir, Julien Bigot, Pauline Verpillat, Riadh Boukhris, Pascal Vaast, Clemence Mordacq, Caroline Thumerelle, Laurent Storme, Antoine Deschildre
Summary: Measurement of fetal lung volume can help identify infants with lower respiratory risk and provide better prediction and personalized follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Genetics & Heredity
Przemyslaw Kosinski, Milena Greczan, Aleksandra Jezela-Stanek
Summary: Fryns syndrome is an autosomal recessive multiple congenital anomaly syndrome characterized by diaphragmatic defects and secondary lung hypoplasia. Despite being first reported in 1979, the exact etiology of the syndrome remains uncertain, and prenatal presentation of these anomalies may require consideration of defects in glycosylphosphatidylinositol anchor synthesis.
FRONTIERS IN GENETICS
(2021)
Article
Pediatrics
Fahad M. S. Arattu Thodika, Svilena Dimitrova, Mahesh Nanjundappa, Mark Davenport, Kypros Nicolaides, Theodore Dassios, Anne Greenough
Summary: This study examined the survival rate of CDH infants treated with iNO and its impact on their response to treatment. The results showed that the highest OI on day 1 could predict survival, and iNO treatment could improve oxygenation in certain CDH infants, with a higher likelihood of a positive response in those who survived.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Acoustics
A. G. Cordier, L. Laup, A. Letourneau, N. Le Sache, V. Fouquet, M. V. Senat, F. Perrotin, J. Rosenblatt, N. Sananes, J. M. Jouannic, G. Benoist, J. C. Jani, A. Benachi
Summary: In patients with isolated left-sided CDH, fetal stomach position is predictive of GIM at 2 years of age, with stomach position grade being associated with the duration of parenteral nutrition and persistence of oral aversion. O/E-LHR was predictive of the need for prosthetic patch repair, but not for GIM, and FETO did not seem to impact the risk of GIM at 2 years.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Celeste R. S. De Groot, Esther J. C. Konings, Willem P. de Boode, Anke J. M. Oerlemans, Esther Sikkel, Sanne M. B. I. Botden, Peter J. Merkus, Robin van der Lee, Rosa Geurtzen
Summary: This study aimed to explore professionals' views regarding prenatal counselling in congenital diaphragmatic hernia (CDH). The professionals agreed that the first counselling session should be soon after diagnosis and additional sessions should be offered. Concerning counselling content, explanation of the diagnosis, prognosis, consequences, treatment options and practical aspects were considered important.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Emily J. J. Horn-Oudshoorn, Francesca M. Russo, Jan A. Deprest, Florian Kipfmueller, Annegret Geipel, Thomas Schaible, Neysan Rafat, Anne-Gael Cordier, Alexandra Benachi, Nimrah Abbasi, Priscilla P. L. Chiu, Willem P. de Boode, Esther Sikkel, Nina C. J. Peters, Bettina E. Hansen, Irwin K. M. Reiss, Philip L. J. DeKoninck
Summary: This retrospective cohort study aimed to describe the outcomes of preterm born infants with congenital diaphragmatic hernia (CDH) and investigate the associations between prenatal imaging markers and survival. The results showed that prenatal imaging markers, including lung-to-head ratio, stomach position, and total fetal lung volume, were associated with postnatal survival in infants with CDH born at or before 32 weeks of gestation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)