4.5 Article

INDUCTION OF PULMONARY HEMORRHAGE IN RATS DURING DIAGNOSTIC ULTRASOUND

Journal

ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 38, Issue 8, Pages 1476-1482

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2012.04.004

Keywords

Pulmonary ultrasound; Point of care ultrasound; Comet tail artifact; Bioeffects of ultrasound; Pulmonary hemorrhage

Funding

  1. Department of Radiology, University of Michigan, Ann Arbor, MI, USA

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The induction of pulmonary hemorrhage by pulsed ultrasound was discovered over 20 years ago. This phenomenon may pose a risk of patient lung injury, particularly for point of care pulmonary ultrasound. A diagnostic ultrasound machine (HDI 5000; Philips Healthcare, Andover MA USA) with 7.6 MHz (CL15-7) linear array was used to image the right lung of anesthetized rats in a warmed water bath. The image showed rapid initiation and progression of comet tail artifacts across the lung image for an on-screen mechanical index (MI) of 0.9, which corresponded to a pulmonary hemorrhage in the lung. Groups of rats were scanned at a range of MI settings and a threshold was located at an MI of about 0.44. This finding indicated a greater sensitivity to pulmonary ultrasound than was expected, based on previous results. Further research is needed to understand this phenomenon and to develop safety guidelines for sonographers. (E-mail: douglm@umich.edu) (C) 2012 World Federation for Ultrasound in Medicine & Biology.

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