Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 38, Issue 10, Pages 1833-1838Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2012.05.012
Keywords
High frequency ultrasound; Human skin; Three-dimensional; Sebaceous gland
Funding
- Japan Society for the Promotion of Science [22300175, 21650125]
- Sendai Advanced Preventive Health Care Services Cluster from the Ministry of Education, Culture, Sports, Science, and Technology
- Ministry of Economy, Trade and Industry
- Grants-in-Aid for Scientific Research [21650125, 23650300, 22300175] Funding Source: KAKEN
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Observing the morphology of human skin is important in the diagnosis of skin cancer and inflammation and in the assessment of skin aging. High-frequency ultrasound imaging provides high spatial resolution of the deep layers of the skin, which cannot be visualized by optical methods. The objectives of the present study were to develop a three-dimensional (3-D) ultrasound microscope and to observe the morphology of normal human skin in vivo. A concave polyvinylidene fluoride transducer with a central frequency of 120 MHz was excited using an electric pulse generated by semiconductor switching. The transducer was scanned two-dimensionally by using two linear motors on the region-of-interest and the ultrasonic reflection was digitized with 2-GHz sampling. Consecutive B-mode images perpendicular to the skin surface were reconstructed to generate multiplanar reconstructed images and 3-D volume-rendering images clearly showing microstructures such as sebaceous glands and hair follicles. The 3-D ultrasound microscope could be used to successfully image the morphology of human skin noninvasively and may provide important information on skin structure. (E-mail: saijo@idac.tohoku.ac.jp) (C) 2012 World Federation for Ultrasound in Medicine & Biology.
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