Article
Optics
Ziyu Hua, Kaiyi Zhu, Yifan Wang, Zhaoli Zeng, Yidong Tan
Summary: A contrast-enhanced ultrasound-modulated laser feedback imaging system is proposed, which exhibits high sensitivity and contrast-to-noise ratio. By using laser feedback technique and clinical microbubbles, the system reduces photon consumption in imaging and enhances contrast. Experimental results show that with higher microbubble concentration and thinner depth, the contrast-to-noise ratio increases.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Environmental Sciences
Una Goncin, Ngoc Ton, Ashwin Reddy, Ahmed El Kaffas, Markus Brinkmann, Steven Machtaler
Summary: This study demonstrates the potential of contrast-enhanced ultrasound (CEUS) imaging for measuring organ blood flow in fish, visualizing contrast enhancement in the liver of rainbow trout, and detecting the effects of drugs on blood flow. CEUS shows promise for exploring different organs, fish species, and the impact of chemical contaminants in future research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Acoustics
Mawia Khairalseed, Kenneth Hoyt
Summary: A generalized mathematical framework called pulse inversion spectral deconvolution (PISD) for contrast-enhanced ultrasound (CEUS) imaging is introduced in this article. The PISD approach is based on Gaussian derivative functions (GDFs) and uses PISD pulses to filter backscattered ultrasound (US) data for isolating nonlinear (NL) microbubble (MB) signals. The study evaluates the role of wide-beam transmit aperture size in CEUS imaging and quantifies image enhancement using a contrast-to-noise ratio (CNR). In vivo data collected in rats demonstrates that PISD-based CEUS imaging improves vascular visualization compared to the NL imaging strategy.
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Pharmacology & Pharmacy
Yingying Liu, Xiaoshu Lai, Yao Zhu, Fengjuan Guo, Lili Su, Gulzira Arkin, Tianzhen He, Jinfeng Xu, Haitao Ran
Summary: In this study, a novel cationic magnetic microbubble (MBM) was developed, which could achieve targeted aggregation under a magnetic field and real-time visualization using ultrasound. These microbubbles had good biocompatibility, enhanced ultrasound contrast, and could accumulate in the target site through magnetic targeting.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Marianna E. Horn, Markus Brinkmann, Steven Machtaler
Summary: The intestine is crucial for nutrient uptake and as a defense against pathogens. Inflammation in the intestine can have serious health consequences, and traditional detection methods are invasive. Contrast-enhanced ultrasound (CEUS) imaging presents a non-invasive and cost-effective way to measure inflammation in patients. The use of CEUS has been demonstrated in quantifying vascular perfusion in rainbow trout intestines, showing a potential for broader application in industry and research.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner, Massimo Mischi, Simona Turco
Summary: Investigation of a unique second-wave phenomenon in nanobubble contrast-enhanced ultrasound (CEUS) imaging was conducted. The second wave was observed accompanying the first pass of the contrast agent bolus, which has not been previously observed in CEUS with microbubbles. The study aimed to investigate this phenomenon and its potential clinical applications, and found that the characteristics of the second wave differed between tumor and normal tissue, suggesting its potential for cancer diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Benjamin van Elburg, Joke Deprez, Martin van den Broek, Stefaan C. De Smedt, Michel Versluis, Guillaume Lajoinie, Ine Lentacker, Tim Segers
Summary: Sonoporation is a process facilitated by ultrasound-driven microbubble oscillations that enhances intracellular drug delivery. This study aimed to investigate the role of microbubble size on sonoporation and the relevant mechanism(s). The results showed that sonoporation efficiency strongly depended on the equilibrium bubble size, with bubbles of approximately 4.7 μm radius being the most efficient. Shear stress was unlikely to be the mechanism of action, while normal stress correlated well with sonoporation efficiency.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Agriculture, Dairy & Animal Science
Victor Jose Correia Santos, Priscila Del 'Aguila-Silva, Priscila Silva, Beatriz Gasser, Cristhian Rene Vargas Estrada, Rafael Kretzer Carneiro, Leticia Pavan, Luiz Paulo Nogueira Aires, Igor Cezar Kniphoff da Cruz, Ricardo Andres Ramirez Uscategui, Wilter Ricardo Russiano Vicente, Luciano Andrade Silva, Marcus Antonio Rossi Feliciano
Summary: This study emphasizes the significance of blood circulation between mother and fetus for a healthy pregnancy and lamb development. The use of contrast-enhanced ultrasound technology provides valuable insights into the blood flow patterns and developmental changes during pregnancy.
SMALL RUMINANT RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Stefano Spada, Gary C. W. England, Massimo Vignoli, Augusto Carluccio, Marco Russo
Summary: The diagnosis of prostatic neoplasia in dogs is challenging, and contrast-enhanced ultrasound may play a crucial role in early detection in neutered dogs. Performing contrast-enhanced ultrasound in neutered dogs shows promising vascular patterns of the prostate, indicating its potential as a reliable diagnostic tool.
Review
Chemistry, Physical
Agata A. Exner, Michael C. Kolios
Summary: The field of medical ultrasound has seen significant developments with the use of microbubbles as contrast agents. However, the limitations in their clinical applications due to size have led to the exploration of nanobubbles. This review discusses the potential of nanobubbles as imaging agents and therapeutic vehicles, with the aim of shaping the future of medical ultrasound.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Review
Green & Sustainable Science & Technology
Baorong Duan, Xuefeng Shao, Yan Han, Yi Li, Yuanjun Zhao
Summary: This article details the latest research progress on ultrasound-enhanced bacteriostasis methods, analyzing the mechanisms of each method and pointing out the existing problems and challenges in the development of the technology.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Physics, Multidisciplinary
Hossein Yusefi, Brandon Helfield
Summary: This review article provides an overview of the development and applications of microbubble contrast agents in medical ultrasound imaging, including their basic physics, imaging techniques, and new emerging applications.
FRONTIERS IN PHYSICS
(2022)
Article
Acoustics
Matthew Bruce, Dane DeWees, Jennifer N. Harmon, Lindsay Cates, Zin Z. Khaing, Christoph P. Hofstetter
Summary: Contrast-enhanced ultrasound (CEUS) is a valuable tool for assessing blood flow changes in spinal cord injury. This study utilized new imaging techniques to reveal significant differences in perfusion deficit and delayed microbubble arrival time in the injured tissue. These findings have implications for understanding acute and chronic blood flow changes in spinal cord injury.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Biophysics
Anna Yuan, Yuping Zhang, Guiting Fang, Weijian Chen, Xueyi Zeng, Haibo Zhou, Huaihong Cai, Xing Zhong
Summary: The development of a multifunctional nanotherapeutic agent for high-contrast enhanced dual-modal imaging and photothermal therapy is of great interest. The combination of ultrasound and computed tomography imaging shows great potential in medical imaging. The MoS2-PFH-PLLAs nanotherapeutic agents exhibit good biocompatibility, highly contrast-enhanced US/CT imaging, and combinational enhanced PTT efficacy, demonstrating a promising dual-mode US/CT imaging-guided synergistic therapeutic efficacy for tumor ablation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Benjamin B. Kasten, Patsy G. Oliver, Harrison Kim, Jinda Fan, Soldano Ferrone, Kurt R. Zinn, Donald J. Buchsbaum
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Romone M. Fancy, Harrison Kim, Tiara Napier, Donald J. Buchsbaum, Kurt R. Zinn, Yuhua Song
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin B. Kasten, Abhishek Gangrade, Harrison Kim, Jinda Fan, Soldano Ferrone, Cristina R. Ferrone, Kurt R. Zinn, Donald J. Buchsbaum
NUCLEAR MEDICINE AND BIOLOGY
(2018)
Article
Oncology
Christos Vaklavas, Kurt R. Zinn, Sharon L. Samuel, Zheng Meng, William E. Grizzle, Hyoungsoo Choi, Scott W. Blume
Article
Biochemistry & Molecular Biology
Kiel D. Neumann, Joseph E. Blecha, Thomas R. Hayes, Tony Huynh, Chih-Kai Chao, Nicolas Guilloteau, Kurt R. Zinn, Henry F. VanBrocklin, Charles M. Thompson, John M. Gerdes
ACS CHEMICAL NEUROSCIENCE
(2018)
Review
Biochemistry & Molecular Biology
Benjamin B. Kasten, Soldano Ferrone, Kurt R. Zinn, Donald J. Buchsbaum
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Christopher M. Gentile, Anton V. Borovjagin, Jillian R. Richter, Aditi H. Jani, Hongju Wu, Kurt R. Zinn, Jason M. Warram
Article
Multidisciplinary Sciences
Thomas R. Hayes, Joseph E. Blecha, Chih-Kai Chao, Tony L. Huynh, Henry D. VanBrocklin, Kurt R. Zinn, Palmer W. Taylor, John M. Gerdes, Charles M. Thompson
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacqueline Pei, Georgina Juniper, Nynke S. van den Berg, Naoki Nisho, Trevor Broadt, Anthony R. Welch, Grace S. Yi, Roan C. Raymundo, Stefania U. Chirita, Guolan Lu, Giri Krishnan, Yu-Jin Lee, Shrey Kapoor, Quan Zhou, A. Dimitrios Colevas, Natalie S. Lui, George A. Poultsides, Gordon Li, Kurt R. Zinn, Eben L. Rosenthal
Summary: The study demonstrated that Panitumumab-IRDye800CW was safe and stable to administer over a 54-month window with a low rate of adverse events (7.4%), which is consistent with the rate associated with Panitumumab alone. This data supports re-purposing therapeutic antibodies as diagnostic imaging agents with limited preclinical toxicology studies.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Chemistry, Medicinal
Thomas R. Hayes, Chih-Kai Chao, Joseph E. Blecha, Tony L. Huynh, Kurt R. Zinn, Charles M. Thompson, John M. Gerdes, Henry F. VanBrocklin
Summary: The study focused on developing molecular imaging tools using radiolabeled OP analog tracers to assess reactivated AChE activity in vivo. Carbon-11 and fluorine-18 radiolabeled analog tracers of VX and sarin OP agents were prepared and evaluated in normal rats. The [18F]VX analog tracer showed the most favorable values for various metrics, making it the optimal tracer for future OP exposure and reactivation studies.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Nathan Kauffman, Satyendra Kumar Singh, James Morrison, Kurt R. Zinn
Summary: This study demonstrates the successful inhibition of breast cancer growth (4T1 and EO771) using radiolabeled macroaggregated albumin particles (Bi-212-MAA) as a form of radiation therapy, which showed stable biodistribution in vivo. The potential of this approach can be extended and applied in larger animal models and human clinical trials.
FRONTIERS IN CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Nathan Kauffman, James Morrison, Kevin O'Brien, Jinda Fan, Kurt R. Zinn
Summary: A paradigm shift is occurring in cancer diagnosis and therapy with radiopharmaceuticals. This strategy involves using diagnostic imaging to measure tumor uptake of radioactive agent X to select patients for therapy with radioactive agent Y. X-Y pairs, known as radiotheranostics, are being evaluated for intra-arterial dosing to enhance tumor targeting and improve imaging and therapy. Clinical trials are underway to assess these new therapeutic approaches, including the use of alpha-particle therapy with short-lived radioisotopes.
Article
Chemistry, Analytical
Monica J. Jacobs, Morgan K. Geiger, Suzanne E. Summers, Charles P. DeLuca, Kurt R. Zinn, Dana M. Spence
Summary: The glycation of serum albumin affects the binding of C-peptide and Zn2+ to red blood cells (RBCs), as well as the subsequent release of ATP. This has implications for C-peptide therapy in individuals with type 1 diabetes.
ACS MEASUREMENT SCIENCE AU
(2022)
Article
Biochemical Research Methods
Yueli Liu, Laura E. Hesse, Morgan K. Geiger, Kurt R. Zinn, Timothy J. McMahon, Chengpeng Chen, Dana M. Spence
Summary: A set of 3D-printed analytical devices were developed to investigate the effects of different storage solutions on erythrocytes in transfusion medicine. The results showed that hyperglycemic conditions permanently alter erythrocyte deformability and reduce ATP release. However, normal glycemic storage can mitigate the storage lesion.
Article
Chemistry, Multidisciplinary
Seyedmehdi Hossaini Nasr, Zahra Rashidijahanabad, Sherif Ramadan, Nate Kauffman, Narayanan Parameswaran, Kurt R. Zinn, Chunqi Qian, Ripla Arora, Dalen Agnew, Xuefei Huang
Article
Acoustics
Ting Luo, Zhen Wang, Xiaoling Yu, Zhiyu Han, Zhigang Cheng, Fangyi Liu, Jie Yu, Ping Liang
Summary: This study aimed to investigate the contribution of subtotal ultrasound-guided percutaneous microwave ablation (MWA) to the inhibition of programmed cell death protein-1 (PD-1) in advanced hepatocellular carcinoma (HCC). The results showed that MWA >50% AR could enhance immune-related gene expression, activate CD8+ T cells, and thereby boost the immunomodulatory effect of PD-1 inhibitors.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Letter
Acoustics
Bernard Cosyns, Sharon L. Mulvagh
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Keith Barron, Michael Blaivas, Laura Blaivas, John Sadler, Isadora Deal
Summary: Researchers investigated whether quantitative ultrasound assessment of hyoid bone movement during induced swallowing would predict the failure of traditional assessment methods in stroke patients. They found that manual ultrasound measurement was not accurate in predicting the assessment outcome, but a machine learning algorithm showed substantial agreement with the results, suggesting its potential for improving dysphagia assessment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sheng Chen, Yi-Jie Qiu, Qi Zhang, Xiu-Yun Lu, Yun-Lin Huang, Yi Dong, Wen-Ping Wang
Summary: The impact of hepatocellular carcinoma (HCC) tumor size on Sonazoid contrast-enhanced ultrasound (CEUS) enhancement features was evaluated. The study found that tumor size had a significant impact on the washout features of HCC lesions, with smaller lesions exhibiting a later occurrence of washout.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Ahmed M. Al-Jumaily, Hassan Liaquat, Sharad Paul
Summary: This article presents a comprehensive review on the effect of various operational parameters of focused ultrasound (FUS) on the injury zone produced by ultrasound beams for different dermatological applications. The article highlights the efficient operational parameters of FUS to enhance pain relief during surgery and make skin treatment more affordable. Additionally, a prospective future technique for efficient FUS is discussed.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Celine Porte, Thomas Lisson, Matthias Kohlen, Finn von Maltzahn, Stefanie Dencks, Saskia von Stillfried, Marion Piepenbrock, Anne Rix, Anshuman Dasgupta, Patrick Koczera, Peter Boor, Elmar Stickeler, Georg Schmitz, Fabian Kiessling
Summary: This study aimed to refine ULM for breast cancer patients by optimizing the measurement protocol, identifying translational challenges, and combining ULM with shear wave elastography. The results showed that the settings for microbubble injection strongly influence ULM images, requiring optimized protocols for different indications. Patient and examiner motion were identified as the main translational challenges for ULM.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Jocelyne Rivera, Antonia Digklia, Anna S. Christou, James Anibal, Katherine A. Vallis, Bradford J. Wood, Eleanor Stride
Summary: Immunotherapy is a major modality in cancer medicine, but its efficacy is limited and it has potential side effects. Ultrasound and cavitation agents can enhance the effectiveness of immunotherapy and stimulate immune responses.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Shyamala Guruvare, Shripad Hebbar, Lakshmi Bai, Padmapriya Jaiprakash, Deepa Reddy, Deepa Hc
Summary: This study assessed the accuracy of 3-D surface rendering of 2-D ultrasound images of the uterus using FMRA software for mapping uterine fibroids compared to pathological evaluation. The results showed good correlation between the two methods in terms of fibroid size and location. Inter-observer analysis also demonstrated reproducibility of measurements from two sonologists using the 3-D model.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Yuting Shen, Jiadong Zhang, Daohuai Jiang, Zijian Gao, Yuwei Zheng, Feng Gao, Fei Gao
Summary: This study proposes a straightforward simulation approach based on superposed Wave (s-Wave) to accelerate photoacoustic simulation. By manipulating the phase and amplitude of sensor data, the computation time is significantly reduced. The results show that s-Wave exhibits a speed improvement >2000 times compared with k-Wave in a sparse system configuration, and in terms of optimization-based image reconstruction, the reconstruction time is reduced by approximately 50 times.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jason Voorneveld, Johan G. Bosch
Summary: This study assesses the effect of spatial velocity gradients (SVGs) on block matching, and finds that the sinusoidal flow wavelength and SVG angle have significant impact on the bias and precision of block matching.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Kartini Rahmat, Nazimah Ab Mumin, Wei Lin Ng, Nur Aishah Mohd Taib, Wai Yee Chan, Marlina Tanty Ramli Hamid
Summary: This study demonstrates the value of ABUS as an adjunct to DBT in breast screening and diagnosis, with improved cancer detection rates.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jieyu Hu, Sindre Hellum Olaisen, Erik Smistad, Havard Dalen, Lasse Lovstakken
Summary: This study introduces a fully automated, real-time method for measuring left atrial volume in echocardiography using a neural network to identify key time points and segmentation techniques. The results show that this method provides comparable accuracy to manual measurements while saving time and reducing operator variability, with an average volume difference of 2.9 mL for 2-D and 7.8 mL for 3-D imaging. The application of pseudo-labeling improves the stability of volume curves and the accuracy of end-systole measurement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Anam Bhatti, Takuro Ishii, Yoshifumi Saijo
Summary: A new protocol for fabricating a microflow phantom with bifurcated geometry at a superficial region was proposed in this study. Ultrasound imaging confirmed the successful creation of the desired flow tract with bifurcation at a depth of 2-5 mm. The experiments demonstrated the validity of the proposed protocol for creating a microscale intricate flow tract with desired dimensions and depth. This new phantom will facilitate further improvement in ultrasound technologies for precise visualization of superficial complex vasculatures.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Nima Mobadersany, Pengcheng Liang, Paul Kemper, Elisa E. Konofagou
Summary: This study describes a technique for manufacturing arterial phantoms using polyvinyl alcohol and evaluates the use of pulse wave imaging (PWI) to assess plaque stiffness. The results show that PWI can distinguish between plaques of different stiffness and composition.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)