Article
Cardiac & Cardiovascular Systems
Jinjie Xie, Ya Yang, Luya Wang, Yufan Pan, Ruiying Zhang, Yichen Qu, Rongjuan Li, Wenhui Wen, Yue Wu, Jialu Li, Xiaohai Ma
Summary: The study revealed that HoFH patients with CFVR < 2.0 had a significantly higher rate of cardiac events, indicating a correlation between impaired CFVR and prognosis in HoFH patients. CFVR has an independent value in predicting long-term outcomes for HoFH patients.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2021)
Article
Medicine, General & Internal
Carlo Caiati, Arnaldo Scardapane, Fortunato Iacovelli, Paolo Pollice, Teresa Immacolata Achille, Stefano Favale, Mario Erminio Lepera
Summary: E-Doppler TTE assessment is better at predicting coronary stenosis compared to CTA, without exposing patients to harmful radiation and iodinated contrast medium.
Article
Cardiac & Cardiovascular Systems
Laurens F. Reeskamp, Nick S. Nurmohamed, Michiel J. Bom, R. Nils Planken, Roel S. Driessen, Pepijn A. van Diemen, Ilse K. Luirink, Jaap W. Groothoff, Irene M. Kuipers, Paul Knaapen, Erik S. G. Stroes, Albert Wiegman, G. Kees Hovingh
Summary: This study assessed the effectiveness of intensive lipid-lowering therapy in two adolescent patients with homozygous familial hypercholesterolemia (HoFH) through coronary computed tomography angiography (CCTA). The results showed a significant reduction in atherosclerotic plaque volume after 6 months of treatment, indicating the potential for plaque regression in young HoFH patients.
Review
Chemistry, Medicinal
Meral Kayikcioglu, Lale Tokgozoglu
Summary: HoFH is a rare form of familial hypercholesterolemia that causes extremely high levels of LDL-C, leading to early onset of ASCVD if left untreated. Most individuals with HoFH are resistant to conventional lipid lowering therapy due to absent or defective LDL-receptor activity. New agents that provide LDL-receptor independent cholesterol reduction offer promising pharmacotherapies for HoFH patients.
Article
Cardiac & Cardiovascular Systems
Maria Cristina Pasqualetto, Domenico Tuttolomondo, Antonio Cutruzzola, Giampaolo Niccoli, Damini Dey, Alessandro Greco, Chiara Martini, Concetta Irace, Fausto Rigo, Nicola Gaibazzi
Summary: A new imaging metric using CCTA, PCAT CT attenuation, provides information on coronary inflammation; the study found a significant inverse relationship between PCAT CT attenuation and CFVR-lad in subjects without overt or mild CAD.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Peripheral Vascular Disease
Atsushi Nohara, Hayato Tada, Masatsune Ogura, Sachiko Okazaki, Koh Ono, Hitoshi Shimano, Hiroyuki Daida, Kazushige Dobashi, Toshio Hayashi, Mika Hori, Kota Matsuki, Tetsuo Minamino, Shinji Yokoyama, Mariko Harada-Shiba
Summary: Familial hypercholesterolemia (FH) is a genetic disorder with increasing prevalence of HoFH, leading to cardiovascular complications. Treatment involves lipid-lowering therapy and combination drug therapies to manage the condition.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Cardiac & Cardiovascular Systems
W. C. M. Janneke Mulder, W. Leonieke Kranenburg, J. Willemijn Treling, G. Kees Hovingh, H. W. Joost Rutten, J. Jan Busschbach, E. Jeanine Roeters van Lennep
Summary: This study investigates how Dutch patients experience and cope with Homozygous familial hypercholesterolemia (HoFH) in daily life. The study found that Dutch HoFH patients use a variety of effective coping mechanisms, resulting in only a slight impact on their subjective quality of life.
Article
Medicine, General & Internal
Srdjan B. Aleksandric, Ana D. Djordjevic-Dikic, Vojislav L. Giga, Milorad B. Tesic, Ivan A. Soldatovic, Marko D. Banovic, Milan R. Dobric, Vladan Vukcevic, Miloje V. Tomasevic, Dejan N. Orlic, Nikola Boskovic, Ivana Jovanovic, Milan A. Nedeljkovic, Goran Stankovic, Miodrag C. Ostojic, Branko D. Beleslin
Summary: This prospective study aimed to determine the cut-off value of transthoracic Doppler echocardiography (TTDE) coronary flow velocity reserve (CFVR) during dobutamine (DOB) in patients with isolated myocardial bridging (MB), compared with stress-induced wall motion abnormalities (VMA) during exercise stress-echocardiography (SE) as reference.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Peripheral Vascular Disease
Archna Bajaj, Marina Cuchel
Summary: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by extreme elevations of low-density lipoprotein cholesterol (LDL-C), requiring aggressive treatment to prevent premature atherosclerotic cardiovascular disease (ASCVD). The treatment landscape for HoFH has rapidly progressed over the last decade, with the addition of several new therapy options such as PCSK9 inhibitors, lomitapide, and ANGPTL3 inhibitors. Lipoprotein apheresis and gene therapy may also be necessary for some patients.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Pharmacology & Pharmacy
Sandeep Bansal, Andrea Ruzza, Jps Sawhney, Govind Kulkarni, Shammana Iyengar, Vimal Mehta, Andrew Hamer, You Wu, Frederick J. Raal
Summary: The RAMAN study evaluated the safety and tolerability of evolocumab in patients with HoFH in India, showing that the drug was safe and well tolerated in this population with smaller reductions in LDL-C and other lipids than previous studies.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Medicine, General & Internal
Carlo Caiati, Paolo Desario, Giuseppe Tricarico, Fortunato Iacovelli, Paolo Pollice, Stefano Favale, Mario Erminio Lepera
Summary: This case report describes how COVID-19 infection can cause Wellens' syndrome, and introduces the use of enhanced transthoracic coronary echo Doppler for bedside assessment. This method can be pivotal in distinguishing true Wellens' syndrome from pseudo-Wellens' syndrome.
Review
Biochemistry & Molecular Biology
Tycho R. Tromp, Marina Cuchel
Summary: Lowering LDL-C levels to normal in patients with HoFH is challenging, but a combination of multiple lipid-lowering therapies is key. Therapies acting independently of the LDL receptor pathway, such as lomitapide and evinacumab, are considered game changers for many patients with HoFH.
CURRENT OPINION IN LIPIDOLOGY
(2022)
Review
Pharmacology & Pharmacy
Latifah Alothman, Alexandre M. Belanger, Isabelle Ruel, Liam R. Brunham, Lindsay Hales, Jacques Genest, Leo E. Akioyamen
Summary: This systematic review examined the association between Homozygous familial hypercholesterolemia (HoFH) and health-related quality of life (HRQL). The findings suggest that HoFH patients have lower HRQL compared to the general population, particularly in the areas of physical functioning, social functioning, and general health. The review also highlights the high treatment burden and lack of psychological support for patients. However, there is a lack of studies evaluating the association of HoFH with mental health outcomes.
JOURNAL OF CLINICAL LIPIDOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Georg Apfaltrer, Francesco Lavra, Carlo N. De Cecco, Akos Varga-Szemes, Marly van Assen, Domenico Mastrodicasa, Marco Scarabello, Marwen H. Eid, L. Parkwood Griffith, John W. Nance, Sheldon E. Litwin, Luca Saba, U. Joseph Schoepf
Summary: The study found that CCTA, CMRI, and TTE have comparable high specificity and negative predictive value for predicting cardioembolic stroke recurrence. CCTA and CMRI may be valid alternatives to TTE, with CCTA potentially being preferred for better detection of atrial and ventricular thrombus.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Leopoldo Perez de Isla, Jose L. Diaz-Diaz, Manuel J. Romero, Ovidio Muniz-Grijalvo, Juan D. Mediavilla, Rosa F. Argueso, Juan F. Sanchez Munoz-Torrero, Patricia Rubio, Pilar Alvarez-Banos, Paola Ponte, Dolores Manas, Lorena Suarez Gutierrez, Jose Maria Cepeda, Marta Casanas, Francisco Fuentes, Carlos Guijarro, Miguel Angel Barba, Adriana Saltijeral Cerezo, Teresa Padro, Pedro Mata
Summary: This study aimed to assess the effect of alirocumab on coronary plaque burden and its characteristics in patients with familial hypercholesterolemia. The results showed that treatment with alirocumab in addition to high-intensity statin therapy resulted in significant improvement in coronary plaque burden and characteristics after 78 weeks.
Article
Acoustics
Ting Luo, Zhen Wang, Xiaoling Yu, Zhiyu Han, Zhigang Cheng, Fangyi Liu, Jie Yu, Ping Liang
Summary: This study aimed to investigate the contribution of subtotal ultrasound-guided percutaneous microwave ablation (MWA) to the inhibition of programmed cell death protein-1 (PD-1) in advanced hepatocellular carcinoma (HCC). The results showed that MWA >50% AR could enhance immune-related gene expression, activate CD8+ T cells, and thereby boost the immunomodulatory effect of PD-1 inhibitors.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Letter
Acoustics
Bernard Cosyns, Sharon L. Mulvagh
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Keith Barron, Michael Blaivas, Laura Blaivas, John Sadler, Isadora Deal
Summary: Researchers investigated whether quantitative ultrasound assessment of hyoid bone movement during induced swallowing would predict the failure of traditional assessment methods in stroke patients. They found that manual ultrasound measurement was not accurate in predicting the assessment outcome, but a machine learning algorithm showed substantial agreement with the results, suggesting its potential for improving dysphagia assessment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sheng Chen, Yi-Jie Qiu, Qi Zhang, Xiu-Yun Lu, Yun-Lin Huang, Yi Dong, Wen-Ping Wang
Summary: The impact of hepatocellular carcinoma (HCC) tumor size on Sonazoid contrast-enhanced ultrasound (CEUS) enhancement features was evaluated. The study found that tumor size had a significant impact on the washout features of HCC lesions, with smaller lesions exhibiting a later occurrence of washout.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Ahmed M. Al-Jumaily, Hassan Liaquat, Sharad Paul
Summary: This article presents a comprehensive review on the effect of various operational parameters of focused ultrasound (FUS) on the injury zone produced by ultrasound beams for different dermatological applications. The article highlights the efficient operational parameters of FUS to enhance pain relief during surgery and make skin treatment more affordable. Additionally, a prospective future technique for efficient FUS is discussed.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Celine Porte, Thomas Lisson, Matthias Kohlen, Finn von Maltzahn, Stefanie Dencks, Saskia von Stillfried, Marion Piepenbrock, Anne Rix, Anshuman Dasgupta, Patrick Koczera, Peter Boor, Elmar Stickeler, Georg Schmitz, Fabian Kiessling
Summary: This study aimed to refine ULM for breast cancer patients by optimizing the measurement protocol, identifying translational challenges, and combining ULM with shear wave elastography. The results showed that the settings for microbubble injection strongly influence ULM images, requiring optimized protocols for different indications. Patient and examiner motion were identified as the main translational challenges for ULM.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Jocelyne Rivera, Antonia Digklia, Anna S. Christou, James Anibal, Katherine A. Vallis, Bradford J. Wood, Eleanor Stride
Summary: Immunotherapy is a major modality in cancer medicine, but its efficacy is limited and it has potential side effects. Ultrasound and cavitation agents can enhance the effectiveness of immunotherapy and stimulate immune responses.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Shyamala Guruvare, Shripad Hebbar, Lakshmi Bai, Padmapriya Jaiprakash, Deepa Reddy, Deepa Hc
Summary: This study assessed the accuracy of 3-D surface rendering of 2-D ultrasound images of the uterus using FMRA software for mapping uterine fibroids compared to pathological evaluation. The results showed good correlation between the two methods in terms of fibroid size and location. Inter-observer analysis also demonstrated reproducibility of measurements from two sonologists using the 3-D model.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Yuting Shen, Jiadong Zhang, Daohuai Jiang, Zijian Gao, Yuwei Zheng, Feng Gao, Fei Gao
Summary: This study proposes a straightforward simulation approach based on superposed Wave (s-Wave) to accelerate photoacoustic simulation. By manipulating the phase and amplitude of sensor data, the computation time is significantly reduced. The results show that s-Wave exhibits a speed improvement >2000 times compared with k-Wave in a sparse system configuration, and in terms of optimization-based image reconstruction, the reconstruction time is reduced by approximately 50 times.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jason Voorneveld, Johan G. Bosch
Summary: This study assesses the effect of spatial velocity gradients (SVGs) on block matching, and finds that the sinusoidal flow wavelength and SVG angle have significant impact on the bias and precision of block matching.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Kartini Rahmat, Nazimah Ab Mumin, Wei Lin Ng, Nur Aishah Mohd Taib, Wai Yee Chan, Marlina Tanty Ramli Hamid
Summary: This study demonstrates the value of ABUS as an adjunct to DBT in breast screening and diagnosis, with improved cancer detection rates.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jieyu Hu, Sindre Hellum Olaisen, Erik Smistad, Havard Dalen, Lasse Lovstakken
Summary: This study introduces a fully automated, real-time method for measuring left atrial volume in echocardiography using a neural network to identify key time points and segmentation techniques. The results show that this method provides comparable accuracy to manual measurements while saving time and reducing operator variability, with an average volume difference of 2.9 mL for 2-D and 7.8 mL for 3-D imaging. The application of pseudo-labeling improves the stability of volume curves and the accuracy of end-systole measurement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Anam Bhatti, Takuro Ishii, Yoshifumi Saijo
Summary: A new protocol for fabricating a microflow phantom with bifurcated geometry at a superficial region was proposed in this study. Ultrasound imaging confirmed the successful creation of the desired flow tract with bifurcation at a depth of 2-5 mm. The experiments demonstrated the validity of the proposed protocol for creating a microscale intricate flow tract with desired dimensions and depth. This new phantom will facilitate further improvement in ultrasound technologies for precise visualization of superficial complex vasculatures.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Nima Mobadersany, Pengcheng Liang, Paul Kemper, Elisa E. Konofagou
Summary: This study describes a technique for manufacturing arterial phantoms using polyvinyl alcohol and evaluates the use of pulse wave imaging (PWI) to assess plaque stiffness. The results show that PWI can distinguish between plaques of different stiffness and composition.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)