Article
Geosciences, Multidisciplinary
Eduardo Utrabo-Carazo, Cesar Azorin-Molina, Enric Aguilar, Manola Brunet
Summary: This study analyzes the observed surface mean wind speed (SWS) and gusts over the Iberian Peninsula (IP) in the frequency domain for 1961-2019, aiming to explore sources of predictability in the interannual and decadal scales. The main finding is the strong correlation between surface winds and the stratospheric polar vortex, with a time lag of 2-3 months, indicating that the polar vortex modulates winds in the region. Additionally, the study reveals a decoupling of SWS and gusts on a 9-11 year timescale, showing a marked seasonal dependence in intensity. There are also discrepancies between observed data and simulated data, suggesting inaccuracies in reproducing the variability of surface wind speeds.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Computer Science, Information Systems
Ganghui Lin, Ahmed Elzanaty, Mohamed-Slim Alouini
Summary: This article comprehensively analyzes LB modulation from temporal, spectral, and error performance characteristics. The analysis shows that out-of-band emissions for LB satisfy regulations only when considering a relatively large number of loads. The ML decoder can achieve performance similar to conventional LoRa with a moderate number of loads.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Guy Cloutier, Francois Destrempes, Francois Yu, An Tang
Summary: Quantitative ultrasound (QUS) is a technique that quantifies interactions between ultrasound and biological tissues, extracting fundamental physical properties of tissues for tissue characterization and imaging. Clinical applications are limited but promising, with potential for liver fibrosis, steatosis grading, and breast cancer characterization.
INSIGHTS INTO IMAGING
(2021)
Article
Acoustics
Weiya Xie, Ting Feng, Mengjiao Zhang, Jiayan Li, Dean Ta, Liming Cheng, Qian Cheng
Summary: This study investigated the feasibility of using photoacoustic time-frequency spectral analysis for evaluating bone mineral density and structure. Results showed that parameters such as midband-it and slope were sensitive to BMD and could distinguish between osteoporotic and normal bones.
Article
Engineering, Biomedical
Sangnam Kim, Siyuan Zhang, Sangpil Yoon
Summary: This study investigates the use of mid-band fit (MBF) spectral imaging to achieve multiplexed ultrasound imaging and visualize the locations of different types of stationary gas vesicles (GVs). The technique is successfully applied to agarose gel phantoms and ex vivo mouse liver specimens, effectively localizing and distinguishing clustered GVs from unclustered GVs. Mouse macrophages are used as carriers of GVs and act as beacons to report cell locations. The study demonstrates a novel approach for visualizing biological tissues and offers potential applications in biomedical research.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Acoustics
Jing Gao, Ashley Rosander, Jonathan M. Rubin
Summary: In this study, we used ultrasound scans to examine the anisotropy (directional dependence) of human tendons. By comparing the backscatter of normal tendons with tendons affected by tendinopathy and the adjacent subcutaneous tissues, we found significant differences in tissue anisotropy. These findings suggest that changes in anisotropic backscatter could be used to detect tendon abnormalities and assess the effectiveness of therapy.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Acoustics
Noushin Jafarpisheh, Timothy J. Hall, Hassan Rivaz, Ivan M. Rosado-Mendez
Summary: This paper introduces two novel techniques for estimating QUS parameters, named 1-D- and 2-D-ALGEBRA, which optimize the cost function and are much faster than the dynamic programming method. The proposed ALGEBRA methods outperform least-square and DP methods in phantom experiments.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Chemistry, Analytical
Xiangyun Ma, Kaidi Wang, Keng C. Chou, Qifeng Li, Xiaonan Lu
Summary: Raman spectroscopy is a powerful tool for studying cellular heterogeneity, but its application in single-cell analysis is limited by low signal-to-noise ratio. In this study, a simple and reliable spectral recovery conditional generative adversarial network (SRGAN) is developed to improve the SNR and reduce data acquisition time. The performance of SRGAN is tested on the classification of five major foodborne bacteria based on single-cell Raman spectra, achieving a significantly higher identification accuracy compared to unprocessed spectra. SRGAN has the potential to enhance the throughput of Raman spectroscopy and enable real-time monitoring of single living cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shuangquan Li, Shangyi Ma, Shaoqing Wang
Summary: In this paper, the authors investigate the selection of optimal bandwidth and center frequency for the complex Morlet function (CMOR) as a wavelet basis. They propose a method to select the optimal CMOR wavelet parameters and apply it to analyze the vibration of water molecules. The results show that the CMOR wavelet parameters obtained by their method can meet the requirement of frequency resolution and the limit of edge effect, and the vibration of water molecules exhibits an uphill energy relaxation, consistent with experimental results.
APPLIED SCIENCES-BASEL
(2023)
Article
Computer Science, Artificial Intelligence
Farah Deeba, Caitlin Schneider, Shahed Mohammed, Mohammad Honarvar, Julio Lobo, Edward Tam, Septimiu Salcudean, Robert Rohling
Summary: The study introduces a multiparametric 3D weighted ultrasound method that accurately reconstructs tissue parameters with improved diagnostic utility.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Geosciences, Multidisciplinary
Yubin Li, Yujie Wu, Jie Tang, Ping Zhu, Zhiqiu Gao, Yuanjian Yang
Summary: This study evaluates the uncertainties of turbulent flux calculation using eddy covariance (EC) and wavelet analysis (WA) methods. The results show that the Mexhat-wavelet method has high accuracy in calculating turbulent fluxes under non-stationary conditions.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Multidisciplinary Sciences
Michael Chapman, Marc De Graef, Richard D. James, Xian Chen
Summary: The article introduces a scheme for assigning martensite variant in martensite materials undergoing solid-solid phase transformation using electron backscatter diffraction. It offers an algorithm to assign martensite variants to specific microscopic regions and to check the elastic compatibility of microstructures in shape memory alloys with low hysteresis and high reversibility. This study is part of the theme issue on mathematical design of complex materials.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2021)
Article
Acoustics
Cheng Liu, Yaoheng Yang, Weibao Qiu, Yan Chen, Jiyan Dai, Lei Sun
Summary: High-frequency endoscopic QUS technique shows potential as a complementary method to distinguish colorectal malignancies by leveraging its morphological and micro-structural ultrasound information. The study found significant differences in mean Midband Fit (M) and intercept (I) between malignant and normal tissue regions, as well as in all mean FLD values of spectral parameter combinations.
Article
Environmental Sciences
Matthew Wolfe, Iliyana D. Dobreva, Henry A. Ruiz-Guzman, Da Huo, Brody L. Teare, Tyler Adams, Mark E. Everett, Michael Bishop, Russell Jessup, Dirk B. Hays
Summary: Increasing carbon storage in soils is important for reducing carbon emissions in the next 30 years. Ground-penetrating radar (GPR) can be used as an efficient phenotyping tool to accurately measure and select the root and rhizome mass of crops. The study shows that GPR can be a practical tool for breeding efforts, providing a non-destructive and reliable method for high-throughput breeding programs.
Article
Acoustics
Masaaki Omura, Wakana Saito, Shinsuke Akita, Kenji Yoshida, Tadashi Yamaguchi
Summary: This study investigated the ability of in vivo quantitative ultrasound (QUS) assessment to evaluate lymphedema severity. The results suggest that QUS parameters can be valuable for non-invasively classifying and tracking the progression of lymphedema.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemical Research Methods
Muhannad N. Fadhel, Sila Appak Baskoy, Yanjie Wang, Eno Hysi, Michael C. Kolios
Summary: Vascular disrupting agents can disrupt tumor vessels and inhibit the growth of tumors. Spectroscopic photoacoustic imaging can be used to monitor the effectiveness of these agents in disrupting tumor vessels and assessing the efficacy of cancer treatments.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Biochemical Research Methods
Dana Wegierak, Grace Fishbein, Eric Abenojar, Al De Leon, Jinle Zhu, Yanjie Wang, Charlotte Ferworn, Agata A. Exner, Michael C. Kolios
Summary: This study reports the development of dual-modal photoacoustic (PA) and ultrasound (US) contrast agents by integrating a dye into the lipid shell of gas core nanobubbles (NBs). The results showed that the addition of the dye did not significantly affect the size of the bubbles but increased the gas exchange across the bubble shell. This has important implications for their use as multimodal imaging contrast agents.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Acoustics
Hossein Haghi, Michael C. Kolios
Summary: This study examines the effect of bubble-bubble interactions on the resonance frequency of MB suspensions. It is found that primary delays cause spreading the resonance frequency of identical MBs within a range, where the closest MB to the acoustic source exhibits the lowest resonance frequency and the furthest MB resonates at the highest frequency. The inclusion of secondary delays also significantly affects the resonance frequency, resulting in an increase when the MBs are situated close to each other.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner, Massimo Mischi, Simona Turco
Summary: Investigation of a unique second-wave phenomenon in nanobubble contrast-enhanced ultrasound (CEUS) imaging was conducted. The second wave was observed accompanying the first pass of the contrast agent bolus, which has not been previously observed in CEUS with microbubbles. The study aimed to investigate this phenomenon and its potential clinical applications, and found that the characteristics of the second wave differed between tumor and normal tissue, suggesting its potential for cancer diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Joseph A. Sebastian, Eric M. Strohm, Emmanuel Cherin, Bahram Mirani, Christine E. M. Demore, Michael C. Kolios, Craig A. Simmons
Summary: High-frequency ultrasound can non-invasively characterize and monitor the acoustic properties of biomaterials and engineered tissues. A new method is proposed to accurately measure the speed of sound, acoustic impedance, and acoustic attenuation of cell-laden hydrogels, taking into account the frequency-dependent effects of attenuation in coupling media, hydrogel thickness, and interfacial transmission/reflection coefficients of ultrasound waves. The acoustic attenuation coefficients were found to increase with increasing cell concentration, reflecting the cellularity of the hydrogel independent of its thickness.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Chuan Chen, Reshani Perera, Michael C. C. Kolios, Hessel Wijkstra, Agata A. A. Exner, Massimo Mischi, Simona Turco
Summary: Nanobubbles, with their unique physical properties, have shown potential as a new generation ultrasound contrast agent for various applications. The appearance of a second bolus (wave) following the first pass of nanobubbles has been observed, which is not seen with conventional microbubbles and molecular contrast agents. This study aims to develop a new compartmental pharmacokinetic model to analyze the roles of physiological factors in the characteristics of the second-wave phenomenon.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Tyler K. Hornsby, Farshad Moradi Kashkooli, Anshuman Jakhmola, Michael C. Kolios, Jahangir (Jahan) Tavakkoli
Summary: Ultrasound can induce the release of anticancer drugs from nanoparticle drug carriers, as observed in previous studies. This study applies the DLVO theory to predict the release of doxorubicin from gold nanoparticle drug carriers under low-intensity pulsed ultrasound exposure. The findings contribute to understanding the mechanism of ultrasound-induced drug release from nanoparticles.
Article
Engineering, Biomedical
Michaela B. Cooley, Eric C. Abenojar, Dana Wegierak, Anirban Sen Gupta, Michael C. Kolios, Agata A. Exner
Summary: This study examined the effects of blood components on the acoustic response of nanobubbles. The results showed that nanobubbles in human whole blood had a gradual increase in signal enhancement and attached to the surface of red blood cells, indicating that direct interaction between nanobubbles and red blood cells may be key to extending their circulation time.
BIOACTIVE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Farshad Moradi Kashkooli, Mohammad Souri, Jahangir (Jahan) Tavakkoli, Michael C. Kolios
Summary: Through computational investigation, it is found that focused ultrasound-triggered nano-sized drug delivery can enhance localized treatment efficacy for solid tumors. Integrating thermosensitive liposome and focused ultrasound provides a promising drug delivery system.
Article
Thermodynamics
Eric M. M. Strohm, Krishnan Sathiyamoorthy, Taehoon Bok, Omar Nusrat, Michael C. C. Kolios
Summary: In this study, a novel method utilizing air-coupled photoacoustics was proposed to detect airborne particulates, specifically viral content in respiratory droplets. Measurements were conducted to determine the optimum detection frequency, with a range of 350 kHz to 500 kHz providing the highest amplitude signal with minimal attenuation in air. Atomizer devices were used to simulate the expulsion of respiratory droplets containing water, water with acridine orange dye, and water with gold nanoparticles. Results showed that the photoacoustic signal decreased with the presence of dye or nanoparticles, contrary to expectations. Monte Carlo simulations demonstrated the influence of droplet dimensions on the localized fluence elevation and the trade-off in signal amplitude depending on absorber concentration.
INTERNATIONAL JOURNAL OF THERMOPHYSICS
(2023)
Review
Chemistry, Multidisciplinary
Farshad Moradi Kashkooli, Anshuman Jakhmola, Tyler K. Hornsby, Jahangir (Jahan) Tavakkoli, Michael C. Kolios
Summary: The application of biocompatible nanocarriers in medicine has provided several benefits over conventional treatment methods. Therapeutic ultrasound (TUS) has shown potential in both standalone anticancer treatment and targeted drug release. By combining nanomedicine and ultrasound as a smart drug delivery system (DDS), it is possible to enhance in situ drug delivery, improve access to impermeable tissues, and achieve targeted drug release. However, further research and clinical trials are needed to understand the physical mechanisms and interactions involved and to overcome the challenges in advancing TUS as an efficient and safe cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
K. Sathiyamoorthy, Michael C. Kolios
Summary: We investigated the application of gold nanoshell particles as optical sensors and contrast agents to study the blood functional parameters. Gold nanoshell particles with a core size of 1 mu m that exhibit two prominent plasmonic peaks at 750 and 830 nm were developed. The optical properties of blood samples mixed with gold nanoshells were measured, showing enhanced optical absorption and suggesting their effectiveness as optical sensors/contrast agents for multimodal optical and photoacoustic sensing and imaging.
MATERIALS RESEARCH EXPRESS
(2023)
Review
Nanoscience & Nanotechnology
Farshad Moradi Kashkooli, Tyler K. K. Hornsby, Michael C. C. Kolios, Jahangir (Jahan) Tavakkoli
Summary: Computational modeling is a powerful tool to study and understand complex biological phenomena in anticancer drug delivery systems, especially nano-sized DDSs. The combination of NSDDSs and therapeutic ultrasound has shown great potential for cancer treatment. Mathematical modeling plays a crucial role in developing effective DDSs, as it involves multiple parameters and complex equations governing different phenomena. This study provides an in-depth review of recent advances in the mathematical modeling of TUS-mediated DDSs and discusses their potential for improving cancer treatment through clinical translation.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Ali A. Paknahad, Intesar O. Zalloum, Raffi Karshafian, Michael C. Kolios, Scott S. H. Tsai
Summary: Microfluidic devices are used to create uniform microbubbles. By controlling lipid concentration and microfluidic geometry, monodisperse bulk nanobubbles can be produced. An interesting observation is that microbubbles above and below a critical diameter experience different shrinkage behaviors.
Meeting Abstract
Cell & Tissue Engineering
J. A. Sebastian, E. M. Strohm, E. Cherin, B. Mirani, Z. Mirzaei, C. Demore, M. C. Kolios, C. A. Simmons
TISSUE ENGINEERING PART A
(2022)
Article
Acoustics
Ting Luo, Zhen Wang, Xiaoling Yu, Zhiyu Han, Zhigang Cheng, Fangyi Liu, Jie Yu, Ping Liang
Summary: This study aimed to investigate the contribution of subtotal ultrasound-guided percutaneous microwave ablation (MWA) to the inhibition of programmed cell death protein-1 (PD-1) in advanced hepatocellular carcinoma (HCC). The results showed that MWA >50% AR could enhance immune-related gene expression, activate CD8+ T cells, and thereby boost the immunomodulatory effect of PD-1 inhibitors.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Letter
Acoustics
Bernard Cosyns, Sharon L. Mulvagh
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Keith Barron, Michael Blaivas, Laura Blaivas, John Sadler, Isadora Deal
Summary: Researchers investigated whether quantitative ultrasound assessment of hyoid bone movement during induced swallowing would predict the failure of traditional assessment methods in stroke patients. They found that manual ultrasound measurement was not accurate in predicting the assessment outcome, but a machine learning algorithm showed substantial agreement with the results, suggesting its potential for improving dysphagia assessment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sheng Chen, Yi-Jie Qiu, Qi Zhang, Xiu-Yun Lu, Yun-Lin Huang, Yi Dong, Wen-Ping Wang
Summary: The impact of hepatocellular carcinoma (HCC) tumor size on Sonazoid contrast-enhanced ultrasound (CEUS) enhancement features was evaluated. The study found that tumor size had a significant impact on the washout features of HCC lesions, with smaller lesions exhibiting a later occurrence of washout.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Ahmed M. Al-Jumaily, Hassan Liaquat, Sharad Paul
Summary: This article presents a comprehensive review on the effect of various operational parameters of focused ultrasound (FUS) on the injury zone produced by ultrasound beams for different dermatological applications. The article highlights the efficient operational parameters of FUS to enhance pain relief during surgery and make skin treatment more affordable. Additionally, a prospective future technique for efficient FUS is discussed.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Celine Porte, Thomas Lisson, Matthias Kohlen, Finn von Maltzahn, Stefanie Dencks, Saskia von Stillfried, Marion Piepenbrock, Anne Rix, Anshuman Dasgupta, Patrick Koczera, Peter Boor, Elmar Stickeler, Georg Schmitz, Fabian Kiessling
Summary: This study aimed to refine ULM for breast cancer patients by optimizing the measurement protocol, identifying translational challenges, and combining ULM with shear wave elastography. The results showed that the settings for microbubble injection strongly influence ULM images, requiring optimized protocols for different indications. Patient and examiner motion were identified as the main translational challenges for ULM.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Jocelyne Rivera, Antonia Digklia, Anna S. Christou, James Anibal, Katherine A. Vallis, Bradford J. Wood, Eleanor Stride
Summary: Immunotherapy is a major modality in cancer medicine, but its efficacy is limited and it has potential side effects. Ultrasound and cavitation agents can enhance the effectiveness of immunotherapy and stimulate immune responses.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Shyamala Guruvare, Shripad Hebbar, Lakshmi Bai, Padmapriya Jaiprakash, Deepa Reddy, Deepa Hc
Summary: This study assessed the accuracy of 3-D surface rendering of 2-D ultrasound images of the uterus using FMRA software for mapping uterine fibroids compared to pathological evaluation. The results showed good correlation between the two methods in terms of fibroid size and location. Inter-observer analysis also demonstrated reproducibility of measurements from two sonologists using the 3-D model.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Yuting Shen, Jiadong Zhang, Daohuai Jiang, Zijian Gao, Yuwei Zheng, Feng Gao, Fei Gao
Summary: This study proposes a straightforward simulation approach based on superposed Wave (s-Wave) to accelerate photoacoustic simulation. By manipulating the phase and amplitude of sensor data, the computation time is significantly reduced. The results show that s-Wave exhibits a speed improvement >2000 times compared with k-Wave in a sparse system configuration, and in terms of optimization-based image reconstruction, the reconstruction time is reduced by approximately 50 times.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jason Voorneveld, Johan G. Bosch
Summary: This study assesses the effect of spatial velocity gradients (SVGs) on block matching, and finds that the sinusoidal flow wavelength and SVG angle have significant impact on the bias and precision of block matching.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Kartini Rahmat, Nazimah Ab Mumin, Wei Lin Ng, Nur Aishah Mohd Taib, Wai Yee Chan, Marlina Tanty Ramli Hamid
Summary: This study demonstrates the value of ABUS as an adjunct to DBT in breast screening and diagnosis, with improved cancer detection rates.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jieyu Hu, Sindre Hellum Olaisen, Erik Smistad, Havard Dalen, Lasse Lovstakken
Summary: This study introduces a fully automated, real-time method for measuring left atrial volume in echocardiography using a neural network to identify key time points and segmentation techniques. The results show that this method provides comparable accuracy to manual measurements while saving time and reducing operator variability, with an average volume difference of 2.9 mL for 2-D and 7.8 mL for 3-D imaging. The application of pseudo-labeling improves the stability of volume curves and the accuracy of end-systole measurement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Anam Bhatti, Takuro Ishii, Yoshifumi Saijo
Summary: A new protocol for fabricating a microflow phantom with bifurcated geometry at a superficial region was proposed in this study. Ultrasound imaging confirmed the successful creation of the desired flow tract with bifurcation at a depth of 2-5 mm. The experiments demonstrated the validity of the proposed protocol for creating a microscale intricate flow tract with desired dimensions and depth. This new phantom will facilitate further improvement in ultrasound technologies for precise visualization of superficial complex vasculatures.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Nima Mobadersany, Pengcheng Liang, Paul Kemper, Elisa E. Konofagou
Summary: This study describes a technique for manufacturing arterial phantoms using polyvinyl alcohol and evaluates the use of pulse wave imaging (PWI) to assess plaque stiffness. The results show that PWI can distinguish between plaques of different stiffness and composition.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
