Article
Surgery
Zeynep Gulsum Guc, Hasan Guc, Osman Butun, Ahmet Alacacioglu, Cenk Demirdover
Summary: This study retrospectively analyzed the records of 60 patients with dermatofibrosarcoma protuberans (DFSP) and investigated the effect of surgical margin width (SM) on DFSP recurrence. The study found that the probability of local recurrence was 84% when SM was less than 1.925 cm, but only 2.85% when SM was greater than 1.925 cm. In addition, for metastatic DFSP patients, tyrosine kinase inhibitor imatinib was more effective than cytotoxic chemotherapy. Therefore, SM greater than 2.5 cm can be considered a safe margin width for resection, and imatinib is a more effective treatment for metastatic DFSP patients.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Oncology
Hiba Saifuddin, Maria Yan, James Jakub, Jorys Martinez-Jorge, Randall Roenigk, Aparna Vijayasekaran
Summary: This study reviewed women who underwent surgery for DFSP of the breast at our institution between 1990 and 2019 and found that both Mohs micrographic surgery (MMS) and wide local excision (WLE) are viable surgical options for managing DFSP of the breast. MMS may minimize reconstructive needs and result in fewer complications, but it may also result in asymmetry. Immediate flap reconstruction, especially in larger defects, can achieve excellent aesthetic outcomes for patients with DFSP of the breast without compromising the detection of disease recurrence.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Dylan J. Rust, Bradley D. Kwinta, Larisa J. Geskin, Faramarz H. Samie, Fabrizio Remotti, Sam S. Yoon
Summary: Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin malignancy. The primary treatment is complete resection, but the optimal method is debated. Mohs micrographic surgery is now recommended as the preferred approach according to National Comprehensive Cancer Network guidelines, replacing wide local excision. Medical therapy with imatinib can be used in advanced or unresectable cases. This review focuses on the current management of DFSP, with an emphasis on optimal surgical approach.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Matthew T. Houdek, Kim M. Tsoi, Katherine E. Mallett, Ryan M. Claxton, Peter C. Ferguson, Anthony M. Griffin, Christian L. Baum, Jerry D. Brewer, Peter S. Rose, Jay S. Wunder
Summary: This study reviewed the outcomes of surgical treatment for primary DFSP of the trunk and extremities. The results showed that there was no difference in oncologic outcome between Mohs micrographic surgery (MMS) and wide local excision (WLE) for DFSP outside the head and neck. A 'less is more' approach to follow-up can likely be taken for patients with completely resected DFSP in easy-to-examine anatomical areas.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Dermatology
A. Durack, S. Gran, M. D. Gardiner, A. Jain, E. Craythorne, C. M. Proby, J. Marsden, C. A. Harwood, R. N. Matin
Summary: A retrospective comparative review of surgical management of DFSP in the UK National Health Service showed that wide local excision was the most common surgical modality used and had a low local recurrence rate. Although there were reported deaths during the follow-up analysis period, the study highlights the importance of considering patient preference, clinical expertise, and cost in making treatment decisions when there is no clearly superior surgical modality.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
Yiyin Chen, Guan Jiang
Summary: The size of excision margin in wide local excision surgery for DFSP patients is associated with prognosis, with a significant positive correlation between margins of >= 3 cm and recurrence rate as well as positive margin rate. Excision with <3 cm surgical margin may increase the risk of poor DFSP prognosis, as indicated by the study findings.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Ava G. Chappell, Sydney C. Doe, Brandon Worley, Simon S. Yoo, Pedram Gerami, Murad Alam, Donald W. Buck, John Y. S. Kim, Jeffrey D. Wayne
Summary: A two-step multidisciplinary surgical treatment approach for DFSP minimizes the risk of recurrence, improves patient comfort, and allows for immediate reconstruction after deep margin clearance.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Oncology
Xia Gong, Jia Li, Angang Ding, Jun Chen, Xiaofeng Tao, Ping Xiong, Yamin Rao, Yang Liu, Qilin Sun
Summary: This study aimed to evaluate the characteristics of DFSP through multimodal ultrasound and report the correlation between imaging and tiny extensions. The findings suggest that CEUS may be an effective tool in determining tiny tumor extensions.
Article
Dermatology
Carlos Serra-Guillen, Beatriz Llombart, Eduardo Nagore, Carlos Guillen, Onofre Sanmartin
Summary: This study aimed to calculate the minimum margin required for complete tumor clearance with conventional surgery and analyze the characteristics of DFSP and the effectiveness of Mohs micrographic surgery in treating DFSP. The results showed that tumors on the head and neck required more surgical stages and wider margins. Tumor size was positively correlated with time to diagnosis, age, and number of surgical stages.
DERMATOLOGIC SURGERY
(2022)
Review
Otorhinolaryngology
Arvind K. Badhey, Raisa Tikhtman, Alice L. Tang
Summary: DFSP is an infiltrative cutaneous sarcoma with high risk of local recurrence and low risk of distant metastasis. Surgical management is typically the first line treatment, with lifelong surveillance required due to risk of recurrence. In cases of unresectable disease, systemic therapy such as Imatinib may be successful.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2021)
Review
Dermatology
Nour Kibbi, David Wang, Wei-Lien Wang, Anjela Galan, David J. Leffell, Sean R. Christensen, Gauri Panse
Summary: DFSP in pregnancy is a rare cutaneous sarcoma that may exhibit changes in size or color during pregnancy. Most cases in this series represent conventional DFSP, but there are also unusual clinical and histopathological variants. Treatment can often be safely postponed until after delivery, although recurrent or very large tumors may require prepartum treatment. Monitoring for recurrence or metastasis is recommended.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Oncology
Ling-Ling Ge, Zhi-Chao Wang, Cheng-Jiang Wei, Jing-Xuan Huang, Jun Liu, Yi-Hui Gu, Wei Wang, Qing-Feng Li
Summary: This study utilized single-cell RNA sequencing (scRNA-seq) to comprehensively analyze DFSP, revealing its intratumor heterogeneity and fundamental molecular mechanisms. The study identified different cell subpopulations, functional disparities, and explored the immune microenvironment and intercellular communication.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Surgery
Murat Guner, Sevket Baris Morkavuk, Ali Ekrem Unal
Summary: DFSP is a rare, slow-growing tumor that originates from the skin and subcutaneous tissues. Surgical excision is the treatment of choice with a high local recurrence rate. This study retrospectively analyzed 23 patients with DFSP, where most tumors were located in the body and surgical margins played a crucial role in preventing recurrence.
ANNALI ITALIANI DI CHIRURGIA
(2021)
Article
Oncology
Cuixiang Cao, Zhilong Yi, Mingwei Xie, Yang Xie, Xin Tang, Bin Tu, Yifeng Gao, Miaojian Wan
Summary: This study aimed to investigate whether machine learning-based radiomics models could accurately predict the local recurrence of primary dermatofibrosarcoma protuberans (DFSP) after surgical treatment. The results showed that radiomics models developed using MRI images were helpful for accurate prediction of local recurrence and showed better performance than the Ki67 index.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Dermatology
Emma C. St Martin, Krishna S. Vyas, Sarah Batbold, Patricia J. Erwin, Jerry D. Brewer
Summary: This study evaluated the differences in local recurrence (LR) rates of dermatofibrosarcoma protuberans (DFSP) treated with wide local excision (WLE) versus Mohs micrographic surgery (MMS). The results showed that the LR rate of DFSP in patients treated with MMS is lower than in patients treated with WLE, suggesting that MMS should be considered as a preferred treatment due to high rates of LR after WLE.
DERMATOLOGIC SURGERY
(2022)
Article
Surgery
Byung Jun Kim, Hahn Sol Bae, Yoonho Lee
JOURNAL OF CRANIOFACIAL SURGERY
(2017)
Article
Surgery
Hyeonwoo Kim, Julong Hu, Hak Chang, Byung Jun Kim
PLASTIC AND RECONSTRUCTIVE SURGERY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Byung Jun Kim, Tae Hyun Choi, Sukwha Kim
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2018)
Article
Dentistry, Oral Surgery & Medicine
Byung Jun Kim, Yinglan Piao, Maierdanjiang Wufuer, Woo-Chan Son, Tae Hyun Choi
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2018)
Letter
Surgery
Hyeonwoo Kim, Julong Hu, Hak Chang, Byung Jun Kim
PLASTIC AND RECONSTRUCTIVE SURGERY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Byung Jun Kim, Tae Hyun Choi, Sukwha Kim
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2018)
Article
Biotechnology & Applied Microbiology
Chang Sik Pak, Ji-In Jeon, Yujin Myung, Yung Ki Lee, Byung Jun Kim, Jae Hoon Jeong, Baek-Kyu Kim
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Soo Ick Cho, Jaewon Lee, Gwanghyun Jo, Sang Wha Kim, Kyung Won Minn, Ki Yong Hong, Seong Jin Jo, Kwang Hyun Cho, Byung Jun Kim, Je-Ho Mun
Article
Chemistry, Multidisciplinary
Yun-Jeong Seong, Guang Lin, Byung Jun Kim, Hyoun-Ee Kim, Sukwha Kim, Seol-Ha Jeong
Article
Medicine, General & Internal
Hyeonwoo Kim, Yoon Ha Joo, Na Hee Yu, Sung Tack Kwon, Jung Chan Lee, Byung Jun Kim
Article
Multidisciplinary Sciences
Dongtak Lee, Maierdanjiang Wufuer, Insu Kim, Tae Hyun Choi, Byung Jun Kim, Hyo Gi Jung, Byoungjun Jeon, Gyudo Lee, Ok Hee Jeon, Hak Chang, Dae Sung Yoon
Summary: The study demonstrates the synergistic effect of releasing BMP-2 and ALN in a sequential manner for enhanced bone regeneration. By combining these two bioactive molecules, the collagen-hydroxyapatite composite scaffolds significantly increase osteogenic activity, showing potential for application in cell-free tissue engineering.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Hyokyung Yoo, Hyeonwoo Kim, Sung Tack Kwon, Seong Jin Jo, Je-Ho Mun, Cheol Lee, Yoonjin Kwak, Byung Jun Kim
Summary: This study found that dermal invasion in subungual melanoma mostly occurred in distal areas, with hyponychial invasion being significantly associated with invasion depth, metastatic progression, and disease-free survival.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Immunology
Ju Long Hu, Sung Tack Kwon, Sang Wha Kim, Hee Jin Nam, Byung Jun Kim
Summary: This study compared the effectiveness of local injection and intravenous administration of ADSCs in improving the survival of allogeneic skin grafts in mice. Results showed that both routes of administration significantly increased graft survival, likely through the anti-inflammatory and angiogenic effects of ADSCs.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Surgery
Jun Ho Choi, Hyokyung Yoo, Byung Jun Kim
Summary: This study introduces a novel method of redraping soft tissue along the alar rim to prevent alar retraction in Asian rhinoplasty. Results show that this technique effectively maintains natural contours of the nasal tip, nostrils, and alae in young Asian men, with a significant decrease in the ratio of nostril axes postoperatively.
ARCHIVES OF PLASTIC SURGERY-APS
(2021)
Article
Surgery
Soo Jin Woo, Byung Jun Kim, Sung Tack Kwon
Summary: In patients with short and deviated sixth toes, sparing the fifth toe is an effective method of cosmetic treatment, providing satisfactory surgical results with improved appearance and no residual deformities.
ARCHIVES OF PLASTIC SURGERY-APS
(2021)
