Article
Biochemistry & Molecular Biology
Alex Ali Sayour, Mihaly Ruppert, Attila Olah, Kalman Benke, Balint Andras Barta, Eszter Zsary, Haoran Ke, Eszter Maria Horvath, Bela Merkely, Tamas Radovits
Summary: The study revealed that LV SGLT1 protein expression was upregulated regardless of the nature of chronic hemodynamic overload, and significantly correlated with the expression of Nox4 and the level of myocardial nitro-oxidative stress, indicating a pathophysiological role of SGLT1 in HF.
Article
Cardiac & Cardiovascular Systems
Balint Karoly Lakatos, Mihaly Ruppert, Marton Tokodi, Attila Olah, Szilveszter Braun, Christian Karime, Zsuzsanna Ladanyi, Alex Ali Sayour, Balint Andras Barta, Bela Merkely, Tamas Radovits, Attila Kovacs
Summary: The study suggests that in heart failure induced by pressure or volume overload, the global myocardial work index (GMWI) may more accurately reflect left ventricular contractility, while global longitudinal strain (GLS) is influenced by loading conditions and may not be a reliable marker of LV contractility.
Article
Cardiac & Cardiovascular Systems
Yuqing Hu, Debao Li, Chunxia Zhou, Yingying Xiao, Sijuan Sun, Chuan Jiang, Lijun Chen, Jinfen Liu, Hao Zhang, Fen Li, Haifa Hong, Lincai Ye
Summary: In this study, a mouse model of left ventricular volume overload was established, which showed significant impact on cardiac maturation and development, particularly in cardiac conduction. This suggests the importance of early correction of chronic aortic regurgitation in pediatric patients. The underlying mechanism may be associated with the activation of immune responses.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shuhei Toba, Stephen P. Sanders, Kimberlee Gauvreau, John E. Mayer, Chrystalle Katte Carreon
Summary: The study found that patients with ccTGA with IVS or DTGA with IVS after PAB for retraining showed significant cardiomyocyte hypertrophy but lower capillary density, indicating a potential pathological basis for mLV dysfunction after anatomic repair.
ANNALS OF THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Paterek, Marta Okninska, Michal Maczewski, Urszula Mackiewicz
Summary: This study found that right ventricular failure caused by left ventricular failure cannot be solely explained by a decline in cardiomyocyte function. Other factors may play a role, highlighting the need for further research to better understand the biology of right ventricular failure and develop targeted therapies.
Article
Biochemistry & Molecular Biology
Eder Anderson Rodrigues, Aline Regina Ruiz Lima, Mariana Janini Gomes, Lidiane Moreira Souza, Thierres Hernani Dias Pontes, Luana Urbano Pagan, Gilson Masahiro Murata, Felipe Cesar Damatto, Igor Carvalho Depra, Amanda Bergamo Goncalves Castro Rego, David Rafael Abreu Reyes, Leonardo Antonio Mamede Zornoff, Katashi Okoshi, Marina Politi Okoshi
Summary: Exercise plays an important role in preventing and treating cardiac remodeling and heart failure caused by myocardial infarction. This study investigated the effects of resistance exercise on structural, functional, and molecular alterations in infarcted rats. The results showed that resistance exercise improved maximum load-carrying capacity, reduced myocardial oxidative stress, and preserved myocardial metabolism, without changing cardiac structure or left ventricular function in infarcted rats.
Review
Cardiac & Cardiovascular Systems
Katharina Schimmel, Kenzo Ichimura, Sushma Reddy, Francois Haddad, Edda Spiekerkoetter
Summary: Myocardial fibrosis is a process of extracellular matrix remodeling in response to cardiac stress. It can be classified into replacement fibrosis and reactive fibrosis. Reactive fibrosis develops over time in chronic pressure overload and affects the function of the left or right ventricle. Reactive fibrosis in the left ventricle is associated with the development and progression of heart failure, while reactive fibrosis in the right ventricle is common in conditions such as pulmonary arterial hypertension. Understanding the differences and common characteristics of extracellular matrix remodeling in the left and right ventricles under pressure overload is crucial for developing new approaches to treat heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alessia Gimelli, Nicola Riccardo Pugliese, Ronny R. Buechel, Michelangelo Bertasi, Michele Coceani, Paolo Marzullo
Summary: The study demonstrates that evaluating Delta LVMV using CZT-SPECT improves the diagnostic accuracy in predicting the presence of coronary artery disease (CAD), which is significant for diagnosing CAD.
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Biophysics
Yih-Me Lin, Lia Paolino, Lihua Lou, Ariadna Herrera, Erika Pierre, Arvind Agarwal, Sharan Ramaswamy
Summary: Myocardial infarction is a leading cause of death and disability globally. The development of cardiac patches as a cardiovascular regenerative strategy to reduce scar tissue growth and promote cardiac tissue formation is actively pursued. This study found that the tissue microstructure and stress relaxation properties of the porcine left ventricle are directional dependent, which is crucial in designing structurally and bio-mimetic cardiac patches.
JOURNAL OF BIOMECHANICS
(2022)
Article
Engineering, Biomedical
Yuxuan Li, Wenkai Lu, Patrice Monkam, Zhenhui Zhu, Weichun Wu, Mengyi Liu
Summary: In this study, a deep learning model called LVSnake is proposed for accurately extracting left ventricle positions from echocardiography, which can be used for myocardial infarction detection. The model generates initial contours based on key landmarks and then refines them to obtain the final position of the left ventricle. Experimental results demonstrate that the model outperforms previous approaches in terms of localization accuracy and robustness.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Cardiac & Cardiovascular Systems
Ran Xu, Zhiwen Ding, Hao Li, Jing Shi, Leilei Cheng, Huixiong Xu, Jian Wu, Yunzeng Zou
Summary: This study analyzed the cardiac remodeling in aortic stenosis (AS) and aortic regurgitation (AR) using strain imaging. The results showed that global longitudinal strain and strain rate were significantly impaired in AS, while preserved in AR. This suggests that the functional changes in myocardial hypertrophy differ between pressure and volume overload, highlighting the superiority of strain imaging in early detection and differential diagnosis of cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hongyang Shu, Weijian Hang, Yizhong Peng, Jiali Nie, Lujin Wu, Wenjun Zhang, Dao Wen Wang, Ning Zhou
Summary: Trimetazidine attenuates pressure overload-induced heart failure by improving myocardial mitochondrial function and glucose uptake via AMPK, providing significant cardioprotective effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Chunxia Zhou, Debao Li, Qing Cui, Qi Sun, Yuqing Hu, Yingying Xiao, Chuan Jiang, Lisheng Qiu, Haibo Zhang, Lincai Ye, Yanjun Sun
Summary: In children with hypoplastic left heart syndrome (HLHS), the right ventricle (RV) and left ventricle (LV) have different molecular differences and responses to volume overload (VO). This study found that insulin and thyroid hormones play critical roles in these differences, and that inhibiting arrhythmogenic right ventricular cardiomyopathy (ARVC) and exploring insulin, thyroid hormone, and cancer-associated microRNAs as therapeutic targets may improve RV function to match that of the LV.
Article
Cardiac & Cardiovascular Systems
Qing Cui, Sijuan Sun, Hongbin Zhu, Yingying Xiao, Chuan Jiang, Hao Zhang, Jinfen Liu, Lincai Ye, Jie Shen
Summary: A rat model of neonatal cardiac VO was successfully created on P1, showing that VO can induce RV enlargement and increased immune cell presence, suggesting that immune responses may be involved in neonatal RV remodeling under the influence of VO.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Vinay P. Jani, Alexander T. Williams, Vivek P. Jani, Amy G. Tsai, Marcos Intaglietta, Pedro Cabrales
Summary: This study presents a new method for analyzing left ventricular pressure-volume signals using the Prony algorithm, which fits and quantifies the transfer function. The analysis of pressure and volume signals during severe hemorrhagic shock and after resuscitation showed significant differences in the number of poles and the composite transfer function. The implementation of the Prony analysis in this study demonstrates its potential for future applications in various physiological and pathophysiological conditions.
MEDICAL ENGINEERING & PHYSICS
(2023)
Article
Engineering, Biomedical
Emilie Gaudin, Christian Thibaudeau, Louis Arpin, Jean-Daniel Leroux, Maxime Toussaint, Jean-Francois Beaudoin, Jules Cadorette, Maxime Paille, Catherine M. Pepin, Konin Koua, Jonathan Bouchard, Nicolas Viscogliosi, Caroline Paulin, Rejean Fontaine, Roger Lecomte
Summary: LabPET II is a new PET technology platform designed for high-resolution imaging, achieving submillimetric spatial resolution in preclinical and clinical settings. Results show promising capabilities for biomolecular imaging in preclinical research, with submillimetric resolution achieved in hot spot phantoms and exceptional contrast for tiny bone structures in mice.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Biomedical
Francis Loignon-Houle, Stefan Gundacker, Maxime Toussaint, Felix Camirand Lemyre, Etiennette Auffray, Rejean Fontaine, Serge A. Charlebois, Paul Lecoq, Roger Lecomte
Summary: The paper discusses the challenges in achieving 10 ps CTR in TOF-PET globally and presents the concept of time-based DOI estimation. Experimental measurements and simulation studies demonstrate the effectiveness of this concept in improving timing precision of detectors. This two-step approach provides insights into utilizing timing signal features for DOI estimation in order to achieve ultra-fast CTR while maintaining detection efficiency for TOF PET.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narjes Moghadam, Roger Lecomte, Stephane Mercure, Madan M. Rehani, Moulay Ali Nassiri
Summary: The study found that most adult patients undergoing CT examinations fell within the average size range, with the 75th percentile values of CTDIvol and DLP for small patients nearly half of average sized patients, and nearly double for large patients. However, similar findings were not found for chest exams.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Instruments & Instrumentation
Francis Loignon-Houle, Serge A. Charlebois, Rejean Fontaine, Roger Lecomte
Summary: This study investigates the spatial, temporal, and energy evolution of primary electrons generated by 511 keV photons in different scintillators using Monte Carlo simulations. The simulation results show that the electron track is tortuous with a short extent and rapid energy transfer in high-Z or high density materials, while it is longer and less tortuous in lighter materials. These simulations provide insights into the dynamics of energy transfer in different detector concepts.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laurence Convert, Otman Sarrhini, Maxime Paille, Nicolas Salem, Paul G. Charette, Roger Lecomte
Summary: Quantification of physiological parameters in preclinical pharmacokinetic studies based on nuclear imaging requires the monitoring of arterial radioactivity over time, known as the arterial input function (AIF). To address the challenge of limited blood volume available for sampling in rodent models, researchers have developed an Ultra High Sensitivity Blood Counter (UHS-BC) that can accurately measure AIF in small animal models using low detection volumes suitable for PET, SPECT, and PET/MRI investigations. This tool has the potential to reduce the time and number of animals required for pharmacokinetic studies, thus increasing the throughput of new drug development.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2022)
Article
Pharmacology & Pharmacy
Sokhna Keita-Alassane, Colombe Otis, Emilie Bouet, Martin Guillot, Marilyn Frezier, Alienor Delsart, Maxim Moreau, Agathe Bedard, Isabelle Gaumond, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Francis Beaudry, Bertrand Lussier, Roger Lecomte, Serge Marchand, Eric Troncy
Summary: This study investigates the influence of estrogen on pain expression using a rat model of osteoarthritis. The results demonstrate that 17 beta-estradiol has analgesic and anti-allodynic effects, and interferes with the development of central sensitization.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haithem Bouziri, Catherine M. Pepin, Konin Koua, Maher Benhouria, Caroline Paulin, Jinsong Ouyang, Marc Normandin, Jean-Francois Pratte, Georges El Fakhri, Roger Lecomte, Rejean Fontaine
Summary: A more robust crystal identification solution based on dual-threshold time-over-threshold (ToT) technique was proposed and tested in phoswich detectors with various scintillator combinations. The method demonstrated successful crystal identification with high accuracy in broad energy windows, showing potential for application in future detectors.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nikta Zarif Yussefian, Emilie Gaudin, Roger Lecomte, Rejean Fontaine
Summary: This study investigates the method of improving lesion detectability in small animal PET by enhancing coincidence time resolution. The relationship between crystal length, TOF resolution, and CNR performance is derived through simulations, providing a predictive model with a mean-squared error of 0.69.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2022)
Article
Engineering, Electrical & Electronic
Narjes Moghadam, Roger Lecomte, Rejean Fontaine
Summary: Carbon nanotube-based composites with polydimethylsiloxane (PDMS) as a matrix show promising properties in terms of electrical conductivity and electromagnetic interference shielding, effectively eliminating artifacts in PET/MRI scanners caused by low-frequency electromagnetic interferences.
MICROELECTRONIC ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Elisabeth Walsh-Wilkinson, Mohamed Lamine Aidara, Audrey Morin-Grandmont, Sara-Eve Thibodeau, Juliette Gagnon, Mathieu Genest, Marie Arsenault, Jacques Couet
Summary: Age, hypertension, and female sex are risk factors in the development of heart failure with preserved ejection fraction. In this study, the response of the left ventricle (LV) to aging and angiotensin II infusion was investigated using echocardiography in male and female mice. The results showed that LV strain and strain rate levels were higher in young females compared to males. Aging was associated with concentric LV remodeling and a decrease in LV strain and strain rate. Gonadectomy and angiotensin II infusion also had significant effects on LV parameters.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Donald Poirier, Rene Maltais, Jacques A. Rousseau, Jenny Roy, Serge Phoenix, Francisco Cortes-Benitez, Roger Lecomte
Summary: A compound that inhibits 17 beta-HSD3 activity and accumulates in prostate tumor tissues has been discovered. This finding opens up the possibility of targeted molecular radiotherapy or radioimaging diagnosis using radiolabelled versions of the compound.
BIOORGANIC CHEMISTRY
(2022)
Article
Engineering, Biomedical
Otman Sarrhini, Pedro D'Orleans-Juste, Jacques A. A. Rousseau, Jean-Francois Beaudoin, Roger Lecomte
Summary: We proposed an enhanced method for accurately retrieving time-activity curves of blood and tissue from PET cardiac images of mice. The method used a constrained nonnegative matrix factorization algorithm applied to the intensity values of the left ventricle PET image. The method was verified on 32 C57BL/6 mice, showing good agreement with published literature values and significant differences between control and AMI mice. The method outperformed the recently published RUDUR method in signal separation.
INTERNATIONAL JOURNAL OF BIOMEDICAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francis Loignon-Houle, Maxime Toussaint, Emilie Bertrand, Felix Camirand Lemyre, Roger Lecomte
Summary: The production of prompt photons in detectors is crucial for achieving high coincidence time resolution in positron emission tomography. This paper aims to consolidate and extend the foundations for the analytical modeling of prompt generating detectors and investigates different models for lower bound and estimator evaluations. The potential benefits of knowing the proportion of prompt photons within a detection set are also highlighted.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
S. Kuttner, L. T. Luppino, K. K. Wickstrom, N. T. D. Midtbo, E. Dorraji, A. Oteiza, M. Martin-Armas, K. Fenton, L. Convert, O. Sarrhini, R. Lecomte, M. C. Kampffmeyer, R. Jenssen, J. Axelsson, R. Sundset
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Meeting Abstract
Endocrinology & Metabolism
R. Lecomte, L. Arpin, P. Lauzier-Trepanier, C. Thibaudeau, J. Bouchard, R. Espagnet, A. Samson, J. Leroux, R. Fontaine
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
