4.2 Review

Splicing Regulators and Their Roles in Cancer Biology and Therapy

Journal

BIOMED RESEARCH INTERNATIONAL
Volume 2015, Issue -, Pages -

Publisher

HINDAWI LTD
DOI: 10.1155/2015/150514

Keywords

-

Funding

  1. Brazilian agency: Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
  2. Brazilian agency: Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
  3. Brazilian agency: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
  4. Brazilian agency: Fundacao Arthur Bernardes (FUNARBE)

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Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.

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