Article
Endocrinology & Metabolism
Chun Zhou, Panpan He, Ziliang Ye, Yuanyuan Zhang, Yanjun Zhang, Sisi Yang, Qimeng Wu, Mengyi Liu, Jing Nie, Xianhui Qin
Summary: The study found an inverse association between serum vitamin D levels and new-onset chronic kidney disease in participants with diabetes. However, this association was not observed in participants without diabetes.
Review
Biochemistry & Molecular Biology
Tudor Lucian Pop, Claudia Sirbe, Gabriel Benta, Alexandra Mititelu, Alina Grama
Summary: Vitamin D plays a crucial role in phospho-calcium metabolism, maintaining calcium levels, and bone health development. Deficiency in vitamin D has been linked to fibrosis progression in chronic liver disease. Vitamin D binding protein, synthesized by the liver, is involved in vitamin D transportation and inflammatory response. A better understanding of the involvement of vitamin D, vitamin D receptors, and vitamin D binding protein in liver inflammation and fibrogenesis could lead to new strategies for diagnosis, prognosis, and treatment of liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Abdur Rahman, Mohamed Abu-Farha, Arshad Channanath, Maha M. Hammad, Emil Anoop, Betty Chandy, Motasem Melhem, Fahd Al-Mulla, Thangavel Alphonse Thanaraj, Jehad Abubaker
Summary: This study investigated the association between SNPs in the GC and CYP2R1 genes with vitamin D levels and deficiency in Kuwaiti adolescents. The results showed significant associations between the SNPs and plasma 25(OH)D levels, with some variants leading to a decrease in vitamin D levels and others associated with higher levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: The study found that vitamin D deficiency rates among young African children were 0.6% and 7.8%, with factors such as country, age, season, inflammation, and malaria influencing the levels. In addition, variations in the GC gene were associated with vitamin D levels.
Article
Gastroenterology & Hepatology
Cai-Zhi Huang, Jie Zhang, Lin Zhang, Cui-Hua Yu, Yi Mo, Li-Ya Mo
Summary: Children with CHB have lower serum levels of 25(OH)D and VDBP than healthy controls. VDBP levels are negatively correlated with HBV replication, while low 25(OH)D levels are independently associated with hepatic fibrosis in children with CHB. There is no significant correlation between serum levels of 25(OH)D and VDBP.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
David Palmer, Steven Soule, Ravinder R. Gaddam, Peter Elder, Stephen Chambers, Matthew Doogue
Summary: In critically ill patients, total 25(OH)D concentration is decreased, but calculated free 25(OH)D concentration remains unchanged.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Nutrition & Dietetics
Rajiv Erasmus, Setjie Maepa, Ian Machingura, Saarah Davids, Shanel Raghubeer, Tandi Matsha
Summary: This study investigated the association between 25(OH) vitamin D, vitamin D-binding proteins, and vitamin D receptor (VDR) polymorphisms in a South African population. The results showed a high prevalence of vitamin D deficiency/insufficiency in this population, with decreased vitamin D levels observed in hyperglycaemic individuals. These findings can contribute to further research on the diagnosis and treatment of hyperglycaemia.
Review
Nutrition & Dietetics
Romina P. Martinelli, Sandra Rayego-Mateos, Matilde Alique, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Alberto Ortiz, Emilio Gonzalez-Parra, Marta Ruiz-Ortega
Summary: With the increase in life expectancy, age-related diseases such as chronic kidney disease are becoming more prevalent, posing a significant health issue in some countries. The lack of biomarkers for early detection of kidney damage and prediction of renal failure progression is a major problem, as current treatments only slow down disease progression. Preclinical research has highlighted the involvement of cellular senescence-related mechanisms in kidney injury and natural aging. In this context, vitamin D or its analogs have shown potential in protecting against kidney injury, with vitamin D deficiency being observed in patients with kidney diseases. This review provides recent evidence on the relationship between vitamin D and kidney diseases, focusing on the underlying mechanisms and the modulation of cellular senescence mechanisms.
Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Valentina Aristarco, Harriet Johansson, Sara Gandini, Debora Macis, Cristina Zanzottera, Gianluca Tolva, Irene Feroce, Chiara Accornero, Bernardo Bonanni, Aliana Guerrieri-Gonzaga, Davide Serrano
Summary: This study found that SNPs of VDR and GC genes may influence breast cancer recurrence and survival in patients, particularly with major alleles of BsmI and TaqI showing lower risk of relapse.
Article
Pediatrics
Shahid Nadeem, Vin Tangpricha, Thomas R. Ziegler, James E. Rhodes, Traci Leong, Yijin Xiang, Larry A. Greenbaum
Summary: In children with chronic kidney disease, daily supplementation of 1000 IU of vitamin D-3 is unlikely to achieve or maintain a plasma 25(OH)D level >= 30 ng/mL. However, a daily dose of 4000 IU of vitamin D-3 was effective in achieving or maintaining vitamin D sufficiency in children with CKD stages 3-5.
PEDIATRIC NEPHROLOGY
(2022)
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Article
Biochemistry & Molecular Biology
Nicola Alessio, Carmela Belardo, Maria Consiglia Trotta, Salvatore Paino, Serena Boccella, Francesca Gargano, Gorizio Pieretti, Flavia Ricciardi, Ida Marabese, Livio Luongo, Umberto Galderisi, Michele D'Amico, Sabatino Maione, Francesca Guida
Summary: Vitamin D deficiency leads to significant changes in microglia cells, suggesting a potential role of these cells in sensory dysfunctions associated with hypovitaminosis D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ting-An Yang, Jau-Yuan Chen, Chieh-An Lin, Yi-Chuan Chen, Wei Yu, Hsiung Ying Huang, Xue-Jie Xiong, Wen-Cheng Li
Summary: This cross-sectional study in China found that vitamin D deficiency is associated with early-stage chronic kidney disease, especially in males.
NUTRITION RESEARCH
(2023)
Review
Nutrition & Dietetics
Marta Zieminska, Beata Sieklucka, Krystyna Pawlak
Summary: Vitamin K and vitamin D deficiency in chronic kidney disease can lead to impaired bone health and increased risk of fractures. Currently, there is no consensus on the optimal supplementation approach for these vitamins in CKD patients.
Article
Transplantation
Hans-Joachim Anders, Jerome Loutan, Annette Bruchfeld, Gema M. Fernandez-Juarez, Juergen Floege, Dimitrios Goumenos, Kultigin Turkmen, Cees van Kooten, Eleni Frangou, Kate Stevens, Andreas Kronbichler, Marten Segelmark, Vladimir Tesar
Summary: This article presents the updated guidelines on the management of lupus nephritis (LN) released by the European League for Rheumatism (EULAR) and other organizations. The article compares the differences between these guidelines and highlights their significance in LN management.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Jonathan Barratt, Richard Lafayette, Jens Kristensen, Andrew Stone, Daniel Cattran, Jurgen Floege, Vladimir Tesar, Hernan Trimarchi, Hong Zhang, Necmi Eren, Alexander Paliege, Brad H. Rovin
Summary: The clinical trial (NefIgArd) of a novel targeted-release formulation of oral budesonide (Nefecon) for the treatment of IgA nephropathy (IgAN) demonstrated significant improvements in proteinuria and glomerular filtration rate, with good tolerability.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Clementina Sitzia, Elena Vianello, Elena Dozio, Marta Kalousova, Tomas Zima, Stefano Brizzola, Paola Roccabianca, Gabriella Tedeschi, John Lamont, Lorenza Tacchini, Massimiliano Marco Corsi-Romanelli
Summary: Obesity is associated with cardiovascular disease and mortality, and adipose-derived IL-33 plays a role in cardiac remodeling. The dysregulation of IL-33/ST2 signaling affects Epac proteins and myocardial gene expression, leading to pro-fibrotic effects. Ghrelin-induced IL-33 secretion counteracts fibrosis and influences transcription factor expression. The effect of IL-33 signaling depends on cell types' origin and the balancing of ST2 isoforms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michaela Neprasova, Dita Maixnerova, Nadja Sparding, Federica Genovese, Morten Asser Karsdal, Helena Koprivova, Marek Kollar, Miloslav Suchanek, Zdenka Hruskova, Vladimir Tesar
Summary: By evaluating biomarkers related to kidney fibrosis, we can predict the outcome of patients with IgA nephropathy (IgAN). Clinical parameters and histological findings can be used to predict the kidney outcome. Biomarkers of collagen and laminin turnover in serum and urine can significantly differentiate IgAN patients with a worse prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Lauren Floyd, Sebastian Bate, Abdul Hadi Kafagi, Nina Brown, Jennifer Scott, Mukunthan Srikantharajah, Marek Myslivecek, Graeme Reid, Faten Aqeel, Doubravka Frausova, Marek Kollar, Phuong Le Kieu, Bilal Khurshid, Charles D. Pusey, Ajay Dhaygude, Vladimir Tesar, Stephen McAdoo, Mark A. Little, Duvuru Geetha, Silke R. Brix
Summary: This study investigated clinical and histologic parameters in patients with anti-glomerular basement membrane (anti-GBM) disease to predict kidney outcomes and identify patients who may benefit from rescue immunosuppressive therapy. Stratifying patients based on the need for renal replacement therapy at diagnosis and renal histology improved prediction accuracy, emphasizing the importance of normal glomeruli.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Rheumatology
Manuel Alfredo Podesta, Federica Mescia, Anna Ricchiuto, Rona Smith, Martina Tedesco, Matthias Arnaldo Cassia, Julia Holle, Renato Alberto Sinico, Annette Bruchfeld, Iva Gunnarsson, Sophie Ohlsson, Bo Baslund, Zdenka Hruskova, Vladimir Tesar, Gianmarco Sabiu, Maurizio Gallieni, Maria C. Cid, Augusto Vaglio, Lorraine Harper, Mario Cozzolino, Francesco Scolari, David Jayne, Federico Alberici
Summary: This study aims to assess factors associated with hypogammaglobulinemia in AAV patients treated with rituximab, and the results showed that hypogammaglobulinemia is common in AAV patients treated with rituximab, and lower IgG levels are associated with severe infections. Age and higher glucocorticoid doses increase the risk of hypogammaglobulinemia in these patients.
Article
Multidisciplinary Sciences
David L. Hoelscher, Nassim Bouteldja, Mehdi Joodaki, Maria L. Russo, Yu-Chia Lan, Alireza Vafaei Sadr, Mingbo Cheng, Vladimir Tesar, Saskia V. Stillfried, Barbara M. Klinkhammer, Jonathan Barratt, Juergen Floege, Ian S. D. Roberts, Rosanna Coppo, Ivan G. Costa, Roman D. Buelow, Peter Boor
Summary: Pathology diagnostics still rely on tissue morphology assessment by trained experts. Here, the authors perform deep-learning-based segmentation followed by large-scale feature extraction of histological images, i.e., next-generation morphometry, to enable outcome-relevant and disease-specific pathomics analysis of non-tumor kidney pathology.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Klara Horackova, Sona Frankova, Petra Zemankova, Petr Nehasil, Marta Cerna, Magdalena Neroldova, Barbora Otahalova, Jan Kral, Milena Hovhannisyan, Viktor Stranecky, Tomas Zima, Marketa Safarikova, Marta Kalousova, C. Z. E. C. A. N. C. A. CZECANCA Consortium, Jan Novotny, Jan Sperl, Marianna Borecka, Sandra Jelinkova, Michal Vocka, Marketa Janatova, Petra Kleiblova, Zdenek Kleibl, Milan Jirsa, Jana Soukupova
Summary: Hepatocellular carcinoma (HCC) mainly results from liver cirrhosis and its genetic predisposition is believed to be rare. In 334 HCC patients considered for liver transplantation, we found only 7 carriers of pathogenic variants in established cancer-predisposition genes. However, two MRN complex genes (NBN and RAD50) were significantly more frequent among patients. Therefore, HCC's genetic predisposition is rare, but germline testing could be considered in liver transplant recipients for tailored follow-up or targeted therapy.
Article
Immunology
Veronika Satrapova, Nadja Sparding, Federica Genovese, Morten Asser Karsdal, Lenka Bartonova, Doubravka Frausova, Eva Honsova, Marek Kollar, Miloslav Suchanek, Helena Koprivova, Romana Rysava, Vladimira Bednarova, Vladimir Tesar, Zdenka Hruskova
Summary: This study found that certain urinary biomarkers can reflect histopathological parameters in kidney biopsy and predict prognosis in patients with ANCA-associated vasculitis (AAV).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jan Miroslav Hartinger, Danica Michalickova, Eliska Dvorackova, Karolina Hronova, Elke H. J. Krekels, Barbora Szonowska, Vladimira Bednarova, Hana Benakova, Gabriela Kroneislova, Jan Zavora, Vladimir Tesar, Ondrej Slanar
Summary: Peritonitis, a complication of peritoneal dialysis, can be treated with intraperitoneal administration of antibiotics. However, there are significant differences in dosing strategies for vancomycin, leading to potential underdosing in a large proportion of patients. Continuous dosing with a loading dose and dose adjustment based on plasma levels can improve intraperitoneal exposure and prevent toxicity.
Article
Cardiac & Cardiovascular Systems
Jan Malik, Anna Valerianova, Satu Sinikka Pesickova, Kristyna Michalickova, Zuzana Hladinova, Zdenka Hruskova, Vladimira Bednarova, Katarina Rocinova, Monika Tothova, Marketa Kratochvilova, Lucie Kaiserova, Kristina Buryskova Salajova, Vaclav Lejsek, Martin Sevcik, Vladimir Tesar
Summary: This study aimed to analyze the prevalence of heart failure and its phenotypes in patients on chronic hemodialysis. The most common phenotype of heart failure in these patients was heart failure with preserved ejection fraction (HFpEF), followed by high-output heart failure. Patients with HFpEF were older and had increased hydration and higher filling pressures in both ventricles.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Chee Kay Cheung, Jonathan Barratt, Kevin Carroll, Richard A. Lafayette, Adrian Liew, Yusuke Suzuki, Vladimir Tesar, Hernan Trimarchi, Muh Geot Wong, Hong Zhang, Vlado Perkovic, Dana V. Rizk
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nadja Sparding, Michaela Neprasova, Dita Maixnerova, Federica Genovese, Morten Asser Karsdal, Marek Kollar, Helena Koprivova, Zdenka Hruskova, Vladimir Tesar
Summary: Kidney fibrosis, a characteristic of chronic kidney disease, can be assessed by measuring different biomarkers of collagen type III. In this study, three collagen type III biomarkers were measured in serum and urine samples of IgA nephropathy patients. The results showed that these biomarkers provided different information about fibrotic burden and had different correlations with the degree of fibrosis in kidney biopsies. Measuring different fragments of the same ECM protein in different matrices can provide valuable insights into pathological kidney tissue alterations in patients with IgA nephropathy.
Meeting Abstract
Urology & Nephrology
Howard Trachtman, Tarak Srivastava, Vladimir Tesar, Kirk N. Campbell, Michelle N. Rheault, Radko Komers, Edward Murphy, Andy Prasad, Loreto Gesualdo
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Review
Urology & Nephrology
Kultigin Turkmen, Hakan Ozer, Vladimir Tesar
Summary: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a group of diseases characterized by necrotizing inflammation of small vessels. Different subgroups of AAV, including GPA, MPA, and EGPA, are defined based on clinical features. Renal involvement is common in AAV, especially in MPA. The prognosis of untreated AAV is poor, but with appropriate immunosuppressive therapy, the 5-year renal survival rate can reach 70-75%. Challenges in the management of AAV include improving disease activity measures, determining optimal therapy duration, and exploring targeted therapies with fewer adverse effects.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
