Serum Total Antioxidant Status, Lipid Profile, Malondialdehyde and Erythrocyte Superoxide Dismutase Levels in Hashimoto Thyroiditis Patients Treated with Levothyroxine

Objective: To Compare the serum level of total antioxidant status (TAS), malondialdehyde (MDA) and erythrocyte superoxide dismutase (SOD) levels in Hashimoto thyroiditis patients treated with levothyroxine and healthy control subjects and to assess possible correlations of these parameters with biochemical parameters such as glucose and lipid profile. Material and Methods: SOD, TAS, MDA, fasting glucose, lipid profile, thyroid hormones and body mass index (BMI) were measured in 30 Hashimoto thyroiditis patients treated with levothyroxine and 30 healthy control subjects. Results: Body Mass Index was increased in Hashimoto thyroiditis patients compared to control subjects. The biochemical parameters such as glucose, triglycerides, total cholesterol and low-density lipoprotein cholesterol (LDL-C) were higher and high-density lipoprotein cholesterol (HDL-C) was lower in the patient group than in control patients. TAS and MDA levels were significantly higher and erythrocyte SOD levels were lower in the patient group compared to the control group. Conclusion: Our study showed that lipid peroxidation was increased In hypothyroid patients compared to healthy controls, even though they were treated with levothyroxine. Erytrocyte SOD levels were lower and TAS was higher in the patient group compared to the control group. Thyroiditis patients treated with levothyroxine had normal thyroid control group. Thyroiditis patients treated with levothyroxine had normal thyroid control group. Thyroiditis patients treated with levothyroxine had normal thyroid homone ranges but treatment did not seem to improve dyslipidemia and oxidative sties. In conclusion, although the hypothyroid patients had normal thyroid hormone levels due to levothyroxine treatment, oxidative stress parameters seemed to contiue to increase. Thus, we suggest that antioxidant treatment may be continued even after the achievement of euthyroidism.