Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Physiology
Chunyan Wang, Shucheng Hua, Lei Song
Summary: In recent years, the role of ferroptosis in pulmonary fibrosis has gained interest as a potential therapeutic target. Ferroptosis is a regulated form of cell death that has been implicated in pulmonary fibrosis. The accumulation of lipid peroxides during ferroptosis causes damage to cell membranes and leads to cell death. This review provides an overview of the emerging role of ferroptosis in pulmonary fibrosis and highlights potential therapeutic targets in this pathway.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Hongfeng Ruan, Huihao Zhang, Jing Feng, Huan Luo, Fangda Fu, Sai Yao, Chengcong Zhou, Zhiguo Zhang, Yishan Bian, Hongting Jin, Yuliang Zhang, Chengliang Wu, Peijian Tong
Summary: This study found that the levels of pyroptosis-related proteins were significantly increased in patients with osteoporosis and a mouse model, while osteogenic capacity was compromised. Bioinformatics analysis confirmed shared gene expression patterns between pyroptosis and osteoporosis pathology. In vitro experiments revealed that inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Parina Asgharian, Cristina Quispe, Jesus Herrera-Bravo, Mahsa Sabernavaei, Kamran Hosseini, Haleh Forouhandeh, Tahereh Ebrahimi, Paria Sharafi-Badr, Vahideh Tarhriz, Saiedeh Razi Soofiyani, Pawel Helon, Jovana Rajkovic, Sevgi Durna Dastan, Anca Oana Docea, Javad Sharifi-Rad, Daniela Calina, Wojciech Koch, William C. Cho
Summary: This article discusses five of the most important and common psychiatric illnesses along with conventional therapies and pharmacological therapies. Medicinal plants are being considered as alternative medication due to their biological safety, but clinical studies are needed to confirm their efficacy compared to FDA-approved medicines.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Anil Ahsan, Mengru Liu, Yanrong Zheng, Wenping Yan, Lin Pan, Yue Li, Shijia Ma, Xingxian Zhang, Ming Cao, Zhanxun Wu, Weiwei Hu, Zhong Chen, Xiangnan Zhang
Summary: Stroke is a major cause of death and disability, with its complex pathological mechanisms posing challenges to effective therapy. Autophagy plays a critical role in cellular homeostasis and survival, with both protective and harmful effects on neuronal cells during ischemic injury. Naturally derived compounds have been found to modulate autophagy and provide neuroprotection against stroke, suggesting potential applications in treatment strategies.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Chemistry, Medicinal
Liang Huo, Chunfeng Liu, Yujun Yuan, Xueyan Liu, Qingjun Cao
Summary: Sepsis is a complex clinical syndrome caused by dysfunctional host response to infection, which leads to excess mortality and morbidity globally. Ferroptosis, an iron-dependent non-apoptotic form of cell death characterized by lipid peroxidation, is involved in sepsis and sepsis-related organ damage. Inhibiting ferroptosis has potential therapeutic effects for sepsis-related organ damage.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Rohan Chakraborty, Heena Tabassum, Suhel Parvez
Summary: Traumatic brain injury (TBI) caused by head trauma has significant consequences in terms of disability and healthcare cost. Neuroinflammation, particularly through the NLRP3 inflammasome, plays a crucial role in TBI. Inhibitors of the NLRP3 inflammasome show potential in reducing neuroinflammation and improving cognitive and motor function in TBI. However, clinical trials are needed to evaluate the efficacy of these promising therapeutic candidates.
Review
Immunology
Ruixiang Chen, Chengyu Yin, Jianqiao Fang, Boyi Liu
Summary: Chronic pain negatively affects patients' quality of life, and the dysregulation of NLRP3 inflammasome may contribute to the pathogenesis of chronic pain. Successful therapeutic approaches targeting NLRP3 inflammasome have been developed for chronic pain treatment.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Oncology
Luiz F. S. Oliveira, Danilo Predes, Helena L. Borges, Jose G. Abreu
Summary: Colorectal cancer (CRC) is the second leading cause of death worldwide, and its treatment is limited due to late diagnoses and resistance to available treatments. The use of naturally occurring small molecules that inhibit the Wnt/beta-catenin pathway in experimental CRC models has shown promise in overcoming these challenges. However, moving these small molecules from the laboratory to the clinical platform presents its own set of progress and challenges. This review discusses the importance of understanding the role of the Wnt/beta-catenin pathway in CRC and highlights the potential of naturally occurring small molecules as therapeutic agents.
Review
Pharmacology & Pharmacy
Alerie G. de la Fuente, Silvia Pelucchi, Jerome Mertens, Monica Di Luca, Daniela Mauceri, Elena Marcello
Summary: Ageing is the main risk factor for most primary neurodegenerative disorders, and protein misfolding and toxic protein accumulation are considered causative events. However, other biological pathways affected by brain ageing also contribute to pathogenesis. This article discusses the involvement of mechanisms controlling neuronal structure, gene expression, autophagy, cell metabolism, and neuroinflammation in the onset and progression of neurodegenerative disorders, and reviews therapeutic strategies aiming to normalize these pathways for increased brain resilience.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shahid Ali, Khurshid Ahmad, Sibhghatulla Shaikh, Hee Jin Chun, Inho Choi, Eun Ju Lee
Summary: Myostatin is an inhibitory factor that influences muscle development and metabolism. Inhibition of myostatin improves insulin sensitivity, increases glucose uptake, and reduces body fat. The downregulation of Mss51 in response to myostatin inhibition suggests it as a potential target for the treatment of obesity and type 2 diabetes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biology
Sanna Huda, Bethany Chau, Chuanqi Chen, Herman Somal, Neiloy Chowdhury, Nicola Cirillo
Summary: The study indicates that caspase activation plays a significant role in the pathogenesis of pemphigus vulgaris, but most in vivo studies assessing caspase inhibition in PV models have a high risk of bias. Further research is needed to confirm the efficacy of caspase inhibitors in preventing PV-induced blistering in vivo.
Review
Endocrinology & Metabolism
Huizhen Chen, Chunguang Xie, Qiu Chen, Shougang Zhuang
Summary: Recent studies have shown that HDAC11 plays an important role in metabolic disorders, including adipogenesis, lipid metabolism, metabolic inflammation, glucose tolerance, immune responses, and energy consumption.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jinhua Wang, Dangdang Li, Bo Zhao, Juhyok Kim, Guangchao Sui, Jinming Shi
Summary: Receptors play key roles in oncogenic processes and are correlated with cancer patients' prognoses. Targeting receptors using natural compounds has gained interest for cancer therapy. This review summarizes the classification of receptors, natural compounds targeting these receptors, and the mechanisms of their anti-cancer activities. The aim is to provide primary knowledge for mechanistic regulation and clinical applications of cancer therapies through targeting deregulated receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Jianwen Sheng, Shanjin Zhang, Lule Wu, Gajendra Kumar, Yuanhang Liao, G. K. Pratap, Huizhen Fan
Summary: Alzheimer's disease is the most common form of dementia and a leading cause of death in the US. The disease prevalence is increasing and expected to reach 14.8 million cases by 2050. Current medications have limitations in treating disease progression. Phosphodiesterases play a crucial role in cell functioning and regulating cAMP and cGMP levels. Abnormal cAMP signaling is linked to cognitive problems in neurodegenerative diseases. Natural compounds with PDE inhibitory activity show potential for the treatment of Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Infectious Diseases
Mohd Adnan, Arif Jamal Siddiqui, Emira Noumi, Sami Hannachi, Syed Amir Ashraf, Amir Mahgoub Awadelkareem, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Manojkumar Sachidanandan, Mirav Patel, Mitesh Patel
Summary: This study used a network pharmacology approach to investigate the anti-listeriosis properties of biosurfactants and their mechanisms of action. It identified certain biosurfactants with potential therapeutic effects against L. monocytogenes infection and explored their pharmacological mechanisms, providing a foundation for further research and development.
Article
Biology
Emira Noumi, Iqrar Ahmad, Nouha Bouali, Harun Patel, Siwar Ghannay, Ayshah Aysh ALrashidi, Mohammad A. A. Abdulhakeem, Mitesh Patel, Ozgur Ceylan, Riadh Badraoui, Afnan Elayyan Mousa Elayyan, Mohd Adnan, Adel Kadri, Mejdi Snoussi
Summary: In this study, the phytochemical composition, antimicrobial, antioxidant, anti-quorum sensing, and anticancer activities of Thymus musilii methanolic extract were investigated. The results showed that the extract exhibited high antifungal and antibacterial activity, as well as strong antioxidant properties. The in silico docking study suggested that the constituent compounds of T. musilii may have potential antimicrobial, antioxidant, and anticancer activities.
Review
Biology
Mitesh Patel, Mohd Adnan, Abdu Aldarhami, Abdulrahman S. Bazaid, Nizar H. Saeedi, Almohanad A. Alkayyal, Fayez M. Saleh, Ibrahim B. Awadh, Amir Saeed, Khalid Alshaghdali
Summary: Monkeypox (Mpox), a viral infection, has become a serious global health threat as it spreads beyond its endemic area in Africa to countries like UK, USA, and Australia. This review provides updated information on the epidemiology, clinical features, diagnosis, prevention, and treatment of Mpox, highlighting the challenges in diagnosis and the need for comprehensive measures to combat this emerging disease.
Article
Biochemistry & Molecular Biology
Nouha Bouali, Iqrar Ahmad, Harun Patel, Elham Bader Alhejaili, Walid Sabri Hamadou, Riadh Badraoui, Ramzi Hadj Lajimi, Mousa Alreshidi, Arif Jamal Siddiqui, Mohd Adnan, Mohammad A. Abdulhakeem, Abdulrahman S. Bazaid, Mitesh Patel, Mohd Saeed, Mejdi Snoussi, Emira Noumi
Summary: This study aimed to investigate the antimicrobial potential of Ziziphus honey (ZH) against clinical bacterial strains and yeasts and molds. The results showed that ZH was able to inhibit the growth of both Gram-positive and Gram-negative bacteria. Computational simulations revealed that certain compounds in ZH had good affinity for targeted receptors. These findings highlight the potential pharmacological applications of ZH and its identified compounds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Mitesh Patel, Abdulrahman S. Bazaid, Esam I. Azhar, Hattan S. Gattan, Naif K. Binsaleh, Mirav Patel, Malvi Surti, Mohd Adnan
Summary: Given the rapid spread of the monkeypox virus and the increasing number of cases, it is urgent to develop effective drugs to combat the infection. This study focused on the 3D structure analysis of monkeypox virus Ser/Thr kinase and TK using molecular modeling techniques. Potential anti-viral phytochemicals were screened and selected based on their physicochemical properties and binding affinity towards Ser/Thr kinase and TK through molecular docking. Thalimonine and galanthamine were identified as promising compounds with strong binding affinity towards Ser/Thr kinase and TK.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Abdelbaset Mohamed Elasbali, Waleed Abu Al-Soud, Afnan Elayyan Mousa Elayyan, Ziad H. Al-Oanzi, Hassan H. Alhassan, Bashir M. Mohamed, Hamad H. Alanazi, Mohammad Saquib Ashraf, Shadman Moiz, Mitesh Patel, Mirav Patel, Mohd Adnan
Summary: Traditional cancer treatment faces obstacles such as drug resistance, toxicity, and financial constraints. Phytochemicals that regulate molecular mechanisms are gaining interest as alternative medicine. This study used network pharmacology to explore the regulatory mechanisms of 6-shogaol in cervical cancer treatment. Various databases were screened to identify target genes of 6-shogaol and disease-related targets. Protein-protein interactions and topology analysis identified hub genes. Gene ontology and pathway enrichment analysis were conducted, and molecular docking and survival analysis revealed potential target genes for treatment. The study provides scientific evidence supporting the use of 6-shogaol as a treatment for cervical cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Bandar Alharbi, Salem Hussain Alharethi, Waleed Abu Al-Soud, Lamya Ahmed Al-Keridis, Abdullah A. Aljohani, Deeba Shamim Jairajpuri, Nawaf Alshammari, Mohd Adnan
Summary: PAPSS1 is a critical enzyme that synthesises the biologically active form of sulfate for sulfation reactions. Two phytochemicals, Guggulsterone and Corylin, were found to have significant affinity and specific interaction with the ATP-binding pocket of PAPSS1. Molecular dynamics simulations showed that the binding of Guggulsterone and Corylin stabilizes the structure of PAPSS1, leading to fewer conformational changes. This study highlights the potential of phytochemicals as PAPSS1 inhibitors and the utility of computational approaches in drug discovery.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Reyaz Hassan Mir, Prince Ahad Mir, Jasreen Uppal, Apporva Chawla, Mitesh Patel, Fevzi Bardakci, Mohd Adnan, Roohi Mohi-ud-din
Summary: Homeostasis between protein synthesis and degradation is critical in biological functions. The ubiquitin-proteasome pathway (UPP) plays a major role in cellular protein degradation. UPP inhibition has been used as an anticancer therapy to shift the balance towards cell death. Natural products have been found to be involved in UPP engagement. The discovery of natural compounds targeting UPP pathway could lead to new anticancer medications.
Article
Infectious Diseases
Amir Mahgoub Awadelkareem, Arif Jamal Siddiqui, Emira Noumi, Syed Amir Ashraf, Sibte Hadi, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Mohammad Saquib Ashraf, Corina Danciu, Mitesh Patel, Mohd Adnan
Summary: In recent years, there has been a global threat to human health and environment due to the development of antimicrobial resistance (AMR) in bacterial pathogens. In this study, silver nanoparticles derived from Lactobacillus rhamnosus (AgNPs-LR) were tested against three Gram-negative bacteria to determine their effects on biofilm formation and virulence factors controlled by quorum sensing (QS). The results demonstrated that AgNPs-LR effectively inhibited the development of biofilms and QS-mediated virulent traits of these bacteria.
Article
Infectious Diseases
Valiappan Ranjutha, Yeng Chen, Lamya Ahmed Al-Keridis, Mitesh Patel, Nawaf Alshammari, Mohd Adnan, Sumaira Sahreen, Subash C. B. Gopinath, Sreenivasan Sasidharan
Summary: Polyalthia longifolia is a medicinal plant used in traditional medicine for skin diseases. This study confirms the synergistic antimicrobial activity of Polyalthia longifolia methanol leaf extract (MEPL) and ceftriaxone against methicillin-resistant Staphylococcus aureus (MRSA) bacteria. The combination of MEPL and ceftriaxone significantly reduces the minimum inhibitory concentration of ceftriaxone and inhibits the expression of the resistant mecA gene in MRSA.
Article
Plant Sciences
Emira Noumi, Iqrar Ahmad, Mohd Adnan, Abderrahmen Merghni, Harun Patel, Najla Haddaji, Nouha Bouali, Khulood Fahad Alabbosh, Siwar Ghannay, Kaiss Aouadi, Adel Kadri, Flavio Polito, Mejdi Snoussi, Vincenzo De Feo
Summary: The main purpose of this study was to determine the chemical composition, antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil obtained from Anethum graveolens L. Results showed that the essential oil was effective against eight bacterial strains and limonene was more effective against biofilm formation. The ADME profiling confirmed the important pharmacokinetic and drug-like properties of the identified phytocompounds.
Article
Medicine, Research & Experimental
Mohd Adnan, Arif Jamal Siddiqui, Emira Noumi, Syed Amir Ashraf, Amir Mahgoub Awadelkareem, Sibte Hadi, Mejdi Snoussi, Riadh Badraoui, Fevzi Bardakci, Manojkumar Sachidanandan, Mitesh Patel
Summary: The study demonstrates that a biosurfactant derived from L. acidophilus can effectively inhibit virulence factors, biofilm formation, and quorum sensing in Gram-negative pathogenic bacteria. This provides a promising approach for tackling antimicrobial resistance.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Mousa Alreshidi, Hugh Dunstan, Tim Roberts, Fayez Alreshidi, Ashfaque Hossain, Fevzi Bardakci, Mejdi Snoussi, Riadh Badraoui, Mohd Adnan, Sultan Alouffi, Mohd Saeed
Summary: This study compares the cytoplasmic amino acid levels between clinical and ATCC 29213 strains of Staphylococcus aureus. The results show common features and significant differences in amino acid concentration profiles between the two strains in the mid-exponential phase, and changes in amino acid abundance in the stationary phase.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Yazeed Albulaihed, Mohd Adnan, Arshad Jamal, Mejdi Snoussi, Kartik Patel, Mitesh Patel
Summary: This study aimed to isolate bacteria capable of producing laccase enzymes and optimize laccase production using response surface methodology (RSM) and the one variable at a time approach. The identified bacterium, Stenotrophomonas maltophilia, was able to produce three times more laccase than the unoptimized medium. The laccase exhibited efficient dye decolorization capabilities and enzymatic detoxification of the dye metabolites.
BIORESOURCES AND BIOPROCESSING
(2023)
Article
Biochemistry & Molecular Biology
Bandar Alharbi, Lina I. Alnajjar, Hassan H. Alhassan, Shama Khan, Talha Jawaid, Bekhzod S. Abdullaev, Nawaf Alshammari, Dharmendra Kumar Yadav, Mohd Adnan, Anas Shamsi
Summary: Mitogen-activated protein kinase 7 (MAPK7) plays a vital role in various cellular processes and its elevated expression has been connected to aggressive tumors. This study used virtual screening to identify potential MAPK7 inhibitors from natural products and identified two compounds, ZINC12296700 and ZINC02123081, with strong binding affinity and drug-like properties. Molecular dynamics simulations confirmed the stability of the docked complexes, and molecular mechanics calculations indicated considerable binding affinities. These compounds hold promise as lead candidates for developing novel MAPK7 inhibitors.
JOURNAL OF MOLECULAR RECOGNITION
(2023)