Article
Gastroenterology & Hepatology
Fangwan Yang, Yujuan Liu, Baimei Zeng, Jun Chu, Han Hu, Yanqing Yang, Huan Chen, Caiyun Tian, Ying Li, Shide Lin
Summary: The Lok index has strong predictive accuracy for progression to ACLF in patients with acute exacerbation and severe exacerbation of chronic HBV infection, requiring different thresholds of liver fibrosis based on severity of liver injury.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Immunology
Xuebing Yao, Haiping Yu, Guoyin Fan, Haihong Xiang, Lin Long, Huili Xu, Zhiguo Wu, Mingfa Chen, Wenna Xi, Zhen Gao, Cuiyun Liu, Wenlan Gong, Aoyu Yang, Ke Sun, Rongyan Yu, Junrong Liang, Baogang Xie, Shuilin Sun
Summary: This study found that the diversity and abundance of the gut microbiome significantly decreased as hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) progressed, with potentially pathogenic bacteria showing increased abundance in HBV-ACLF patients compared to healthy controls. The abundance of Bacteroidetes was negatively correlated with serum alpha fetoprotein, while the abundance of Veilonella was positively correlated with serum total bilirubin levels. These findings suggest that the gut microbiota plays an important role in the development of HBV-ACLF.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yun-Hui Liu, Lin Zhu, Zhong-Wei Zhang, Ting-Ting Liu, Qiu-Yu Cheng, Meng Zhang, Yu-Xin Niu, Lin Ding, Wei-Ming Yan, Xiao-Ping Luo, Qin Ning, Tao Chen
Summary: The CCR5-MIP-1β/RANTES axis plays a critical role in the recruitment of cNK cells to the liver during virus-induced acute liver injury. Targeted inhibition of CCR5 provides a therapeutic approach to ameliorate liver damage.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Wenting Peng, Huimin Gu, Da Cheng, Keyu Chen, Cichun Wu, Chuan Jiang, Jinqing Liu, Shifang Peng, Lei Fu
Summary: This study found that TAF is more effective than ETV in reducing viral load and improving survival rate in HBV-ACLF patients, and it also has a lower risk of renal function decline.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Juan Li, Chun-Hua Hu, Yi Chen, Mi-Mi Zhou, Zhi-Jie Gao, Meng-Jun Fu, Jing Wang, Jian-Zhou Li, Tian-Yan Chen, Ying-Ren Zhao, Ying-Li He
Summary: This study found that peripheral lymphocyte count and percentage were significantly reduced in HBV-ACLF patients, as well as decreased CD8(+) T cell, CD4(+) T cell, and NK cell counts. A lower CD8(+) T cell count was associated with a higher mortality rate in HBV-ACLF patients, suggesting a potential prognostic indicator.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Wei Wu, Shanshan Sun, Yijie Wang, Ruihong Zhao, Haotang Ren, Zhiwei Li, Hong Zhao, Yi Zhang, Jifang Sheng, Zhi Chen, Yu Shi
Summary: Patients with ACLF exhibit significant alterations in circulating neutrophils, including increased absolute neutrophil count and changes in phenotype, gene expression, and function. These alterations are associated with poor outcomes and influenced by the circulatory environment in ACLF. Inhibiting glycolysis can reverse neutrophil dysfunction in ACLF patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Xiaoting Tang, Tingting Qi, Beiling Li, Hai Li, Zuxiong Huang, Zhibin Zhu, Minghan Tu, Jie Gao, Congyan Zhu, Xiuhua Jiang, Xutong Yu, Guanting Lu, Ming Xiong, Qinjun He, Fuyuan Zhou, Weiqun Wen, Jinjun Chen, Jinlin Hou
Summary: The study compared the three clinical types of ACLF patients and found that type-A patients were younger with higher platelet counts, aminotransferase levels, and more active HBV replications compared to type-B and type-C. Different types of ACLF patients showed significant differences in liver, kidney, and coagulation failure, as well as short-term mortality rates.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rocio Sedano, Lorena Castro, Mauricio Venegas, Julio Miranda, Carmen Hurtado, Jaime Poniachik, Javier Brahm
Summary: This article reports two cases of young men who have sex with men (MSM) with HBV-related acute liver failure (ALF), both of whom underwent liver transplantation and received antiviral treatment with entecavir post-transplantation without HBIG. Serologic follow-up showed early HBsAg seroconversion and gradual decrease of Anti-HBs titers with normal liver function.
ANNALS OF HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu Liu, Wei Yuan, Miao Fang, Hongying Guo, Xin Zhang, Xue Mei, Yuyi Zhang, Longshan Ji, Yating Gao, Jiefei Wang, Zhiping Qian, Man Li, Yueqiu Gao
Summary: This study aimed to estimate the serum levels of high mobility group protein 1 (HMGB1) in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and analyze its clinical value in the development and outcomes of acute kidney injury (AKI). The results showed that the incidence of AKI in HBV-ACLF patients was 61.0%, and HMGB1 levels were associated with the severity and prognosis of AKI. Therefore, HMGB1 may be a potential predictive factor for the development and prognosis of AKI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Bo Peng, Hao Li, Kai Liu, Pengpeng Zhang, Quan Zhuang, Junhui Li, Min Yang, Ke Cheng, Yingzi Ming
Summary: Acute-on-chronic liver failure (ACLF) is a severe syndrome with high short-term mortality, and the pathophysiology still remains largely unknown. This study aims to depict the immune microenvironment in the liver during ACLF, and explore the role of lipid metabolic disorder on immunity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Xueyun Zhang, Yue Ying, Pu Zhou, Xiaoqin Liu, Ruidong Li, Yifeng Tao, Minhui Dong, Beidi Zhu, Xun Qi, Qianqian Wang, Xiaofei Zhang, Jingwen Wu, Jianming Zheng, Weifeng Zhao, Wenhong Zhang, Zhengxin Wang, Jiming Zhang, Yuxian Huang
Summary: The study found a relationship between the COSSH-ACLF grades of HBV-ACLF patients at 3-7 days after diagnosis and the final confirmation. For patients with poor prognosis, urgent liver transplantation may improve survival rates; however, the necessity of liver transplantation for patients with good prognosis remains unclear.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Infectious Diseases
Xiao-Qin Liu, Xue-Yun Zhang, Yue Ying, Jian-Ming Zheng, Jian Sun, Wen-Hong Zhang, Ji-Ming Zhang, Yu-Xian Huang
Summary: This study focused on comparing ACLF patients with and without BIs, finding that BIs were associated with worse clinical characteristics and prognosis. The use of prophylactic antibiotics was shown to reduce the incidence of BIs and improve transplant-free survival in HBV-ACLF patients. Third-generation cephalosporins were found to be effective in antibiotic prophylaxis.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Microbiology
Xia Yu, Hai Li, Wenting Tan, Xianbo Wang, Xin Zheng, Yan Huang, Beiling Li, Zhongji Meng, Yanhang Gao, Zhiping Qian, Feng Liu, Xiaobo Lu, Jia Shang, Huadong Yan, Yubao Zheng, Weituo Zhang, Shan Yin, Wenyi Gu, Guohong Deng, Xiaomei Xiang, Yi Zhou, Yixin Hou, Qun Zhang, Shue Xiong, Jing Liu, Ruochan Chen, Liyuan Long, Jinjun Chen, Xiuhua Jiang, Sen Luo, Yuanyuan Chen, Chang Jiang, Jinming Zhao, Liujuan Ji, Xue Mei, Jing Li, Tao Li, Rongjiong Zheng, Xinyi Zhou, Haotang Ren, Jifang Sheng, Yu Shi
Summary: The presence of underlying cirrhosis has a significant impact on the performance of clinical prediction models for predicting the outcome of HBV-ACLF. These models are more accurate in patients without cirrhosis, but are limited in patients with cirrhosis, possibly due to complications such as ascites or infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Shuai Gao, Li-Yan Han, Yu-Chen Fan, Kai Wang
Summary: This study aimed to establish a noninvasive model for predicting the 90-day mortality in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) who received glucocorticoid therapy. The HITAS score, based on hepatic encephalopathy grade, INR, total bilirubin, age, and SIRS status, showed better predictive value for 90-day mortality of HBV-ACLF compared to other scoring systems. The HITAS score can help identify HBV-ACLF patients with favorable responses to glucocorticoid treatment.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Xia Yu, Yi Lu, Shanshan Sun, Huilan Tu, Xianbin Xu, Kai Gong, Junjie Yao, Yu Shi, Jifang Sheng
Summary: This study systematically summarized and evaluated 52 clinical prediction models for predicting the prognosis of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). The study found substantial limitations in the quality of HBV-ACLF-specific CPMs, and suggested that disease severity of study populations may impact model performance.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)