Article
Cell Biology
Peipei Ding, Yanqing Xu, Luying Li, Xinyue Lv, Ling Li, Jianfeng Chen, Danlei Zhou, Xiaochao Wang, Qi Wang, Wei Zhang, Tian Liao, Qing-Hai Ji, Qun-Ying Lei, Weiguo Hu
Summary: This study uncovers the activation of C5 complement within tumor cells, which affects colorectal tumorigenesis by regulating the stability of beta-catenin. The findings provide a potential target for tumor prevention and treatment.
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Plant Sciences
Shengen Yi, Xiaoxin Jin, Bo Liu, Peidong Wu, Wang Xiao, Weidong Chen
Summary: This study found that Portulaca oleracea extract (POE) inhibited the development of colorectal cancer (CRC) by regulating gut microbiota imbalance, inactivating the Wnt/beta-catenin signaling pathway, and downregulating the expression of c-Myc and cyclin D1.
Article
Oncology
Huiyang Li, Yanfei Qin, Yiran Huang, Jinquan Wang, Biqiong Ren
Summary: Curcumin inhibits the expression of SPAG5, a protein involved in the Wnt signaling pathway, in HCC patients. SPAG5 may function as an upstream regulator of the Wnt/beta-catenin pathway and could be a potential target for HCC treatment.
Article
Oncology
Shenglan Liu, Junhong Wu, Xiaolu Lu, Caiyao Guo, Qisheng Zheng, Yu Wang, Qiao Hu, Shuigen Bian, Li Luo, Qilai Cheng, Zhiping Liu, Wei Dai
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality and has limited effective druggable targets. Targeting cancer stem cells (CSCs) may provide a promising strategy against CRC. Cyclin-dependent kinase 12 (CDK12) is involved in the self-renewal of CSCs and may serve as a potential therapeutic target. In this study, CDK12 was found to be required for CRC survival, and its activation promoted tumor initiation, outgrowth, metastasis, and self-renewal of CRC CSCs through Wnt/beta-catenin signaling. The study suggests that CDK12 is a potential druggable target for CRC treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Chen Li, Boran Cheng, Xiaodong Yang, Gangling Tong, Fen Wang, Mengqing Li, Xiangyu Wang, Shubin Wang
Summary: This study found that SOX8 is upregulated in colorectal carcinoma (CRC) and promotes cell proliferation, migration, and invasion. SOX8 acts as an oncogene in CRC through the activation of FZD6-dependent Wnt/beta-catenin signaling.
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Biochemistry & Molecular Biology
Pusheng Yang, Panpan Zhang, Shu Zhang
Summary: Disease recurrence and metastasis have a negative impact on the prognosis of advanced endometrial carcinoma (EC) patients. RNA-binding proteins (RBPs), although their exact role in EC is unknown, have been associated with tumor development and metastasis. This study used various databases to identify RBPs and focused on MEX3A, which was found to be upregulated and associated with poor prognosis in EC patients. Experimental evidence showed that MEX3A promotes the growth, migration, and invasion of EC cells. Mechanistically, MEX3A interacts with DVL3 to stabilize beta-catenin, leading to enhanced epithelial-mesenchymal transition (EMT) and activation of the Wnt/beta-catenin pathway. Therefore, MEX3A may be a potential therapeutic target for EC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sha Zeng, Li Chen, Qiang Sun, Hui Zhao, Han Yang, Shan Ren, Maolun Liu, Xianli Meng, Haibo Xu
Summary: The study shows that Scutellarin can suppress colitis-associated cancer in mice by inhibiting the Wnt/β-catenin signaling pathway, leading to alleviation of pathological symptoms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays. RapMIF is a rapid multiplexed immunofluorescence method that can measure the spatial protein maps of up to 25 proteins, providing combinatorial signaling states and enabling precision therapy design.
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Morgan K. K. Penny, Antonio M. M. Lerario, Kaitlin J. J. Basham, Sahiti Chukkapalli, Dipika R. R. Mohan, Chris LaPensee, Kimber Converso-Baran, Mark J. J. Hoenerhoff, Laura Suarez-Fernandez, Carmen Gonzalez del Rey, Thomas J. J. Giordano, Ruolan Han, Erika A. A. Newman, Gary D. D. Hammer
Summary: Adrenocortical carcinoma (ACC) is a rare and aggressive cancer with limited treatment options. This study identified a novel Wnt/β-catenin-associated signature enriched in ECM, which was predictive of poor survival in ACC patients. Inhibition of Wnt/β-catenin signaling reduced ECM expression and cancer cell viability, suggesting it as a potential therapeutic strategy for ACC.
Review
Surgery
Osman Nuri Dilek, Feyyaz Gungor, Turan Acar, Arif Atay, Sebnem Karasu, Halis Bag, Fatma Husniye Dilek
Summary: Hepaticojejunostomy is a challenging and complex procedure that requires confidence in conditions with a large number of segmental bile ducts. Portoenterostomy involves the joining of multiple bile ducts into a single cavity using various techniques. This study discusses the successful application of portoenterostomy in patients undergoing aggressive resection for bile duct tumors and hilar cholangiocarcinomas.
INDIAN JOURNAL OF SURGERY
(2021)
Review
Surgery
Feyyaz Gungor, Yigit Atalay, Nihan Acar, Emine Ozlem Gur, Ibrahim Kokulu, Turan Acar, Sebnem Karasu, Osman Nuri Dilek
Summary: Gallstone ileus is a rare disease and our study aims to share clinical approaches and long-term outcomes, drawing attention to this rare condition. Through a retrospective evaluation of 11 patients, we found vomiting and abdominal pain to be the most common symptoms, and Rigler triad was detected in all cases on abdominal CT scans. We concluded that enterolithotomy is the preferred treatment, but one-step procedure is more advantageous in low-risk patients.
ACTA CHIRURGICA BELGICA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebnem Karasu, Feyyaz Gungor, Coskun Onak, Osman Nuri Dilek
Summary: Preoperative CT findings, including measuring pancreatic density, PI index, and WD, can be used as a noninvasive quantitative method to predict the possibility of postoperative PF development.
Article
Gastroenterology & Hepatology
Nihan Acar, Turan Acar, Yunus Sur, Halis Bag, Haldun Kar, Yeliz Yilmaz Bozok, Osman Nuri Dilek
Summary: This study retrospectively analyzed the medical records of 57 patients who underwent subtotal cholecystectomy. The study found that leaving the remnant tissue pouch open, presence of comorbidity and emergency operative condition increased the risk of bile leak.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Surgery
Oguzhan Ozsay, Mehmet Can Aydin, Kagan Karabulut, Mahmut Basoglu, Osman Nuri Dilek
Summary: Superior mesenteric/portal vein reconstruction (SMPVR) thrombosis is a challenging complication following pancreaticoduodenectomy with venous resection. This study found that the use of Dacron grafts and splenic vein division are associated with SMPVR thrombosis.
ACTA CHIRURGICA BELGICA
(2023)
Review
Emergency Medicine
Arif Atay, Feyyaz Gungor, Yunus Sur, Orgun Gunes, Fatma Husniye Dilek, Sebnem Karasu, Osman Nuri Dilek
Summary: The study aimed to evaluate HA traumas in HPB surgery, showing a high risk of complications in patients with HA injuries, but risks can be reduced through appropriate treatment plans.
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
(2022)
Article
Pathology
Gozde Topel, Ebru Cakir, Ilgin Aydin, Fatma Husniye Dilek, Aysegul Akder Sari
Summary: This study analyzed clinicopathological parameters of microscopic colitis cases in the Turkish population. The findings suggest that there are differences in clinical and pathological features among the different subtypes of microscopic colitis, and that susceptibility to microscopic colitis may vary between ethnic groups.
TURKISH JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, General & Internal
Arif Atay, Feyyaz Gungor, Nihan Acar, Yunus Sur, Fatma Husniye Dilek, Osman Nuri Dilek
Summary: This descriptive study evaluated the clinical, laboratory, and imaging data of patients who underwent pancreatoduodenectomy (PD) for proven benign pathologies. The study found that patients with benign pathology had better CRP and total bilirubin parameters, and recommended PD for patients with pancreatic mass and unruled cancer risk. It also suggested evaluating undiagnosed lesions with a multidisciplinary approach and crosschecking diagnostic tools to reduce PD due to benign causes.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Letter
Medicine, General & Internal
Arif Atay, Furkan Karahan, Sadi Bener, Bulent Turgut, Fatma Husniye Dilek, Osman Nuri Dilek
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Meeting Abstract
Pathology
M. Konur, B. Bolat Kucukzeybek, A. Avci, F. H. Dilek, F. S. Pehlivan, F. Dag, I. Aydin, I. Cakir, N. Ekinci, S. Karaarslan, A. Akder Sari
Review
Surgery
Osman Nuri Dilek, Ahmet Atasever, Nihan Acar, Sebnem Karasu, Emine Ozlem Gur, Oguzhan Ozsay, Hakan Camyar, Fatma Husniye Dilek
TURKISH JOURNAL OF SURGERY
(2020)
Meeting Abstract
Pathology
S. Demir, D. Unal Kocabey, F. H. Dilek, Y. Yilmaz, A. Akder Sari