Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes

Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells

(2014) Kristen L. Kozielski et al.   ACS Nano

Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors

(2014) Yusuke Oe et al.   BIOMATERIALS

Effect of biodegradability on CXCR4 antagonism, transfection efficacy and antimetastatic activity of polymeric Plerixafor

(2014) Jing Li et al.   BIOMATERIALS

Quo vadis polyplex?

(2014) Olivia M. Merkel et al.   JOURNAL OF CONTROLLED RELEASE

Polymeric Plerixafor: Effect of PEGylation on CXCR4 Antagonism, Cancer Cell Invasion, and DNA Transfection

(2014) Yan Wang et al.   PHARMACEUTICAL RESEARCH

Development of Functional Poly(amido amine) CXCR4 Antagonists with the Ability to Mobilize Leukocytes and Deliver Nucleic Acids

(2014) Yan Wang et al.   Advanced Healthcare Materials

Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

(2013) Christopher E. Nelson et al.   ACS Nano

Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations

(2013) Chao Wu et al.   BIOMATERIALS

Self-assembly cationic nanoparticles based on cholesterol-grafted bioreducible poly(amidoamine) for siRNA delivery

(2013) Cheng-Jun Chen et al.   BIOMATERIALS

Biomaterials in RNAi therapeutics: quo vadis?

(2013) Ernst Wagner   Biomaterials Science

Targeting the Blind Spot of Polycationic Nanocarrier-Based siRNA Delivery

(2012) Mengyao Zheng et al.   ACS Nano

Dual-Function CXCR4 Antagonist Polyplexes To Deliver Gene Therapy and Inhibit Cancer Cell Invasion

(2012) Jing Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cyclam-Based Polymeric Copper Chelators for Gene Delivery and Potential PET Imaging

(2012) Jing Li et al.   BIOMACROMOLECULES

Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis

(2012) Y.-d. Yao et al.   Science Translational Medicine

CXCL12 (SDF1 )-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

(2011) D. G. Duda et al.   CLINICAL CANCER RESEARCH

PLK1 as an oncology target: current status and future potential

(2011) Campbell McInnes et al.   DRUG DISCOVERY TODAY

The chemokine system and cancer

(2011) Frances R Balkwill   JOURNAL OF PATHOLOGY

RNAi-based Therapeutics Targeting Survivin and PLK1 for Treatment of Bladder Cancer

(2011) Shaguna Seth et al.   MOLECULAR THERAPY

Chemokine receptor CXCR4 level in primary tumors independently predicts outcome for patients with locally advanced breast cancer

(2011) David J. Hiller et al.   SURGERY

Chemokine receptor CXCR4 overexpression predicts recurrence for hormone receptor-positive, node-negative breast cancer patients

(2011) Quyen D. Chu et al.   SURGERY

Targeting Polo-like Kinase in Cancer Therapy

(2010) Y. Degenhardt et al.   CLINICAL CANCER RESEARCH

Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of T-Cell Tropic (X4) HIV-1 Replication

(2010) Gary J. Bridger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of Hydrophobic Interactions on Properties and Stability of DNA−Polyelectrolyte Complexes

(2010) Sergey K. Filippov et al.   LANGMUIR

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Hydrophobic modifications of cationic polymers for gene delivery

(2010) Zonghua Liu et al.   PROGRESS IN POLYMER SCIENCE

Polycation cytotoxicity: a delicate matter for nucleic acid therapy—focus on polyethylenimine

(2010) Ladan Parhamifar et al.   Soft Matter

Aliphatic Lipid Substitution on 2 kDa Polyethylenimine Improves Plasmid Delivery and Transgene Expression

(2009) Artphop Neamnark et al.   MOLECULAR PHARMACEUTICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis and Gene Transfection Efficacies of PEI−Cholesterol-Based Lipopolymers

(2008) Avinash Bajaj et al.   BIOCONJUGATE CHEMISTRY

Poly(amidoamine) Conjugates with Disulfide-Linked Cholesterol Pendants Self-Assembling into Redox-Sensitive Nanoparticles

(2008) Elisabetta Ranucci et al.   BIOMACROMOLECULES