Article
Multidisciplinary Sciences
Raymond K. H. Yip, Joel S. Rimes, Bianca D. Capaldo, Francois Vaillant, Kellie A. Mouchemore, Bhupinder Pal, Yunshun Chen, Elliot Surgenor, Andrew J. Murphy, Robin L. Anderson, Gordon K. Smyth, Geoffrey J. Lindeman, Edwin D. Hawkins, Jane E. Visvader
Summary: The study demonstrates the preferential homing of mouse mammary tumor cells to specific blood vessels within the bone marrow during the metastasis process, with the tumor cells remodeling the local vasculature by producing granulocyte-colony stimulating factor. This hijacking of the host microenvironment by tumor cells leads to the formation of a pro-tumorigenic niche in the bone marrow, highlighting the importance of targeting this metastatic niche to inhibit blood vessel remodeling and reduce bone metastasis burden.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Bing Chen, Yong Yang, Congwen Yang, Jiaxiang Duan, Lin Chen, Kaizhi Lu, Bin Yi, Yang Chen, Duo Xu, He Huang
Summary: Hepatopulmonary syndrome (HPS) significantly increases mortality of patients, yet its pathogenesis is not fully understood. This study compared CBDL and TAA rat models to investigate the mechanisms of HPS. Neutrophil recruitment in the early stage of rat HPS leads to pulmonary vascular dilatation and hypoxemia, while accumulation of M2 macrophages induced by GM-CSF/GM-CSFR and MCP1/CCR2 promotes pulmonary fibrosis and vascular dilatation, ultimately resulting in HPS development.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Suyeong Seo, Minjeong Jang, Hwieun Kim, Jong Hwan Sung, Nakwon Choi, Kangwon Lee, Hong Nam Kim
Summary: Air pollution-induced neurodegeneration, including cognitive deficits, neuroinflammation, and disrupted blood-brain barrier, is mediated by intercellular interactions. A brain-on-a-chip platform is used to evaluate diesel exhaust particle(DPE)-induced neurodegeneration and reveal the neurodegeneration cascade involving brain endothelial cells(bECs), microglia, and neurons. Inhibition of intercellular interactions, such as neutralizing GM-CSF, suppressing microglial activation, and scavenging ROS, can prevent neurodegeneration in the model.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Critical Care Medicine
Cormac McCarthy, Brenna C. Carey, Bruce C. Trapnell
Summary: Autoimmune pulmonary alveolar proteinosis is a rare disease characterized by dysfunction of myeloid cells, abnormal accumulation of pulmonary surfactant, and innate immune deficiency. Research has brought this disease from obscurity to a paradigm of molecular pathogenesis-based diagnosis and treatment. The low prevalence and nonspecific symptoms make diagnosis challenging and delay accurate treatment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Ophthalmology
Yamei Zhou, Jia Zeng, Yuanyuan Tu, Lele Li, Shu Du, Linling Zhu, Xiaomin Cang, Jiajie Lu, Manhui Zhu, Xiaojuan Liu
Summary: The study revealed the crucial role of CSF1/CSF1R in promoting the formation of CNV, offering potential molecular targets for the treatment of nAMD.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Immunology
Moussa Gouife, Ziqi Ban, Xinyuan Yue, Jianhu Jiang, Jiasong Xie
Summary: This study investigated the immunomodulatory and functional properties of the goldfish MCSF-2 gene, revealing its important role in cell proliferation, differentiation, and survival. Recombinant goldfish MCSF-2 protein was successfully expressed and shown to stimulate proliferation and differentiation of leukocytes. Furthermore, rgMCSF-2 was found to modulate the expression of pro-inflammatory cytokines and transcription factors.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Sherman Chu, Thomas S. McCormick, Hillard M. Lazarus, Luis O. Leal, Mahmoud A. Ghannoum
Summary: Breakthrough fungal infections can be fatal in hosts with impaired immune systems, such as those undergoing hematopoietic cell transplant or intensive chemotherapy. Risk factors include severe neutropenia and corticosteroid use. An individual's level of immunosuppression directly affects infection risk, with early intervention potentially improving outcomes.
CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Sanghoon Lee, Rebekah Karns, Soona Shin
Summary: Hepatic progenitor cells (HPCs) play crucial roles in liver diseases and cancer, but their exact role in disease progression is not well understood. Our study found that HPCs communicate with endothelial cells through paracrine factors, promoting angiogenesis and disease progression. Modulation of HPCs differentiation status and inhibition of CSF1 signaling can suppress the paracrine function of HPCs, inhibiting angiogenesis.
CELLULAR SIGNALLING
(2022)
Article
Medicine, Research & Experimental
Tomoyuki Hioki, Haruhiko Tokuda, Gen Kuroyanagi, Woo Kim, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa
Summary: The study revealed that olive oil polyphenols, hydroxytyrosol and oleuropein, attenuated the synthesis of M-CSF and IL-6 in osteoblasts by inhibiting TNF-α signaling through Akt and p44/p42 MAP kinase pathways. These polyphenols did not significantly affect cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Jianlin Ji, Haitao Xiang, Xu Lu, Pingping Tan, Rongrong Yang, Ting Ye, Zhuo Chen, Dongjian Chen, Haiyan He, Jinliang Chen, Yaoying Ma, Chao Huang
Summary: The study demonstrated that M-CSF preconditioning can alleviate stress-induced depression-like behaviors by modulating neuroinflammatory responses.
Article
Developmental Biology
Giuliano Ferrero, Magali Miserocchi, Elodie Di Ruggiero, Valerie Wittamer
Summary: The study reveals distinct roles of Csf1ra and Csf1rb in hematopoiesis, with Csf1rb identified as a crucial regulator of adult microglia development. It demonstrates that Csf1rb positively regulates HSC-derived myelopoiesis, leading to macrophage deficiency, including microglia, in mutant animals. Overall, this research contributes new insights into evolutionary aspects of Csf1 signaling and offers a unique framework for dissecting embryonic versus adult microglia in vivo.
Article
Immunology
Abhishek Mishra, Vipul K. Singh, Chinnaswamy Jagannath, Selvakumar Subbian, Blanca I. Restrepo, Marie-Claire Gauduin, Arshad Khan
Summary: This study demonstrates the important role of GM-CSF in immunity against tuberculosis infection, showing that GM-CSF levels produced by human macrophages play a critical role in preventing cell death and maintaining a protective state against M. tuberculosis infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Hong-wu Li, Shi-lei Tang
Summary: Gastrointestinal malignant tumors are among the most common types of cancer globally, with poor prognosis for advanced patients. Research on tumor microenvironment and cytokines has become a hotspot, with CSF-1/CSF-1R playing crucial roles in regulating tumor-associated macrophages. Targeted inhibition of the CSF-1/CSF-1R signal axis shows promising prospects in cancer immunotherapy.
Article
Immunology
Clare Pridans, Katharine M. Irvine, Gemma M. Davis, Lucas Lefevre, Stephen J. Bush, David A. Hume
Summary: This study established the methodology for the production of rat ESC-derived macrophages and compared their gene expression profiles with macrophages from different sources, revealing some similarities with mouse macrophages. Unlike mice, rat macrophages were found to express the CSF1R ligand, colony stimulating factor 1 (CSF1).
FRONTIERS IN IMMUNOLOGY
(2021)
Correction
Oncology
Gabriella Cunha Vieira, S. Chockalingam, Zsombor Melegh, Alexander Greenhough, Sally Malik, Marianna Szemes, Ji Hyun Park, Abderrahmane Kaidi, Li Zhou, Daniel Catchpoole, Rhys Morgan, David O. Bates, Peter J. Gabb, Karim Malik
Article
Biochemistry & Molecular Biology
Debashree Saikia, Naba K. Bordoloi, Pronobesh Chattopadhyay, S. Choklingam, Siddhartha S. Ghosh, Ashis K. Mukherjee
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2012)
Article
Chemistry, Multidisciplinary
Navjot Kaur, Nitin Choudhary, Rajendra N. Goyal, S. Viladkar, I. Matai, P. Gopinath, S. Chockalingam, Davinder Kaur
JOURNAL OF NANOPARTICLE RESEARCH
(2013)
Article
Multidisciplinary Sciences
S. Chockalingam, Siddhartha Sankar Ghosh
Article
Multidisciplinary Sciences
Asif Raza, Archita Ghoshal, S. Chockalingam, Siddhartha Sankar Ghosh
SCIENTIFIC REPORTS
(2017)
Article
Engineering, Biomedical
Shilpa Sharma, S. Chockalingam, Pallab Sanpui, Arun Chattopadhyay, Siddhartha Sankar Ghosh
ADVANCED HEALTHCARE MATERIALS
(2014)
Article
Chemistry, Multidisciplinary
Rajkumar Sadasivam, Chockalingam Sankarakuttalam, Packirisamy Gopinath
Article
Biochemistry & Molecular Biology
Sarim Khan, Muskan Garg, S. Chockalingam, P. Gopinath, Patit Paban Kundu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Materials Science, Multidisciplinary
Sarim Khan, Sankarakuttalam Chockalingam, Patit P. Kundu, Gopinath Packirisamy
MATERIALS TODAY COMMUNICATIONS
(2020)
Review
Medical Laboratory Technology
Shlok Jindal, S. Chockalingam, Siddhartha Sankar Ghosh, Gopinath Packirisamy
Summary: The concept of gap junctions and connexins in intercellular communication has been known for around 50 years. While progress has been made in understanding their role in various cellular processes, the lack of advanced therapeutics utilizing gap junction intercellular communication is primarily due to inadequacies in targeting specific connexin proteins in affected tissues with minimal collateral damage. Nanotechnology offers potential solutions to develop more efficient connexin-based therapeutics.
TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Gabriella Cunha Vieira, S. Chockalingam, Zsombor Melegh, Alexander Greenhough, Sally Malik, Marianna Szemes, Ji Hyun Park, Abderrahmane Kaidi, Li Zhou, Daniel Catchpoole, Rhys Morgan, David O. Bates, Peter David Gabb, Karim Malik
