Article
Cell Biology
Zhen Guo, Mei-Hua Bao, Yun-Xia Fan, Yan Zhang, Hai-Yan Liu, Xiao-Long Zhou, Ben Wu, Qing-Qing Lu, Bin-Sheng He, Xu-Ying Nan, Jiao-Yang Lu
Summary: The genetic polymorphisms of linc00312 may serve as potential biomarkers for NPC carcinogenesis and prognosis, as they can influence the expression and secondary structure of linc00312, thus affecting the sensitivity and survival of NPC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Pasquale Piccolo, Rosa Ferriero, Anna Barbato, Sergio Attanasio, Marcello Monti, Claudia Perna, Florie Borel, Patrizia Annunziata, Annamaria Carissimo, Rossella De Cegli, Luca Quagliata, Luigi M. Terracciano, Chantal Housset, Jeffrey H. Teckman, Christian Mueller, Nicola Brunetti-Pierri
Summary: AAT deficiency is caused by pathogenic variants in the SERPINA1 gene, with the Z allele encoding for Z alpha 1-antitrypsin leading to hepatotoxic polymers. The up-regulation of miR-34b/c in PiZ mouse livers is correlated to intrahepatic ATZ, and its expression is dependent on JNK phosphorylation on Ser574. Deletion of miR-34b/c in PiZ mice results in early liver fibrosis and increased signaling of platelet-derived growth factor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Hao-Yun Tao, Ze-Jiang Zhan, Wen-Ze Qiu, Kai Liao, Ya-Wei Yuan, Tai-Ze Yuan, Rong-Hui Zheng
Summary: The study demonstrated that in patients with locoregionally advanced nasopharyngeal carcinoma, the TP+TP regimen can reduce distant metastasis and improve overall survival compared to TP+DDP, with a similar effect to TPF+DDP and clinical feasibility.
Article
Medicine, Research & Experimental
Youngmi Choi, Seung-Ho Hong
Summary: This study aimed to investigate the potential association between miR-200bT>C and miR-495A>C polymorphisms and susceptibility to hypertension. The results showed significant differences in the miR-495A>C genotype distributions between the hypertension and control groups, while no differences were found for the miR-200bT>C polymorphism. The combined genotypes of TC/CC and CC/CC for miR-200bT>C and miR-495A>C were associated with hypertension susceptibility. The study suggests that the miR-495A>C polymorphism and allelic combinations of miR-200bT>C/miR-495A>C may increase the risk of hypertension in a Korean population.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Cell Biology
Rong Liu, Jie Liu, Ping Wu, Hong Yi, Bin Zhang, Wei Huang
Summary: The study found that FLOT2 can upregulate BCAT1 transcription by maintaining c-Myc expression levels, thereby promoting NPC cell proliferation. FLOT2 and BCAT1 expression in NPC tissues are positively correlated and associated with patient prognosis.
Article
Biochemistry & Molecular Biology
Ikjun Lee, Shuyu Piao, Seonhee Kim, Harsha Nagar, Su-jeong Choi, Minsoo Kim, Giang-Huong Vu, Byeong-Hwa Jeon, Cuk-Seong Kim
Summary: Endothelial senescence impairs vascular function and is a major factor in age-related vasculature diseases. IDH2 is involved in the production of alpha-ketoglutarate and preservation of mitochondrial function. However, the mechanism and regulation of IDH2 in endothelial senescence have not been fully understood.
Article
Cell Biology
Xinping Chen, Weihua Xu, Zhichao Ma, Juan Zhu, Junjie Hu, Xiaojuan Li, Shengmiao Fu
Summary: This study revealed that circ_0000215 is overexpressed in NPC and exerts oncogenic effects by regulating the miR-512-5p/PIK3R1 axis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Nguyen Hoang Viet, Nguyen Quang Trung, Le Thanh Dong, Ly Quoc Trung, J. Luis Espinoza
Summary: Functional polymorphisms in NKG2D and MICA genes are associated with susceptibility to EBV-induced NPC. Specific genotypes, such as LNK/LNK in NKG2D and AA in MICA, show significant associations with increased risk of NPC. Moreover, higher MICA protein expression and EBV titers were observed in NPC patients with specific genotypes, suggesting a potential role of NKG2D axis components in NPC susceptibility to EBV.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Wen-Ling Liao, Fu-Chun Chan, Kai-Ping Chang, Ya-Wen Chang, Che-Hong Chen, Wen-Hui Su, Hen-Hong Chang
Summary: In East Asian population, genetic variants in ALDH isoforms are associated with NPC susceptibility and exhibit a synergistic effect with alcohol consumption, resulting in a cumulative risk effect for NPC among both drinkers and non-drinkers.
Article
Andrology
M. Kemal Ozbilgin, Serdag Demiroren, Meltem Ucoz, Mustafa Oztatlici
Summary: Cyclophosphamide-induced testicular toxicity is associated with alterations in the expression levels of GDNF, occludin, and TGF-beta 3. The decrease in miR-34b and miR-34c expression in tissue samples may serve as an important marker for detecting testicular damage.
Article
Biochemistry & Molecular Biology
Peiying Huang, Mengmeng Li, Qinglai Tang, Kang Jiang, Yuchao Luo
Summary: This study investigated the biological functions and mechanisms of circular RNA_0000523 (circ_0000523) in nasopharyngeal carcinoma (NPC). The results showed that circ_0000523 facilitates NPC progression through regulating the miR-1184/COL1A1 axis.
Article
Biochemistry & Molecular Biology
Hui-Jeong An, Sung-Hwan Cho, Han-Sung Park, Ji-Hyang Kim, Young-Ran Kim, Woo-Sik Lee, Jung-Ryeol Lee, Seong-Soo Joo, Eun-Hee Ahn, Nam-Keun Kim
Summary: This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. The study identified specific genotypes of miR-10a and miR-499 that are associated with increased RPL risk.
Article
Pathology
Lisha Peng, Yong Wang, Jie Luo, Yan Liu, Feng Wang
Summary: This study aims to investigate the role of miR-128-3p in the radiosensitivity of nasopharyngeal carcinoma (NPC) and its underlying mechanism. It was found that miR-128-3p can affect cell proliferation, DNA damage, and cell apoptosis by regulating the expression of VEGFC, thereby enhancing the radiosensitivity of nasopharyngeal carcinoma cells. This finding provides a novel therapeutic target for overcoming radiation resistance.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Yaxuan Wang, Zhan Yang, Junfei Gu, Yanping Zhang, Xin Wang, Zhihai Teng, Dandan Wang, Lei Gao, Wei Li, Shuyuan Yeh, Zhenwei Han
Summary: This study found that ERβ may increase the population of CSCs in ccRCC by altering the ERβ/circPHACTR4/miR-34b-5p/c-Myc signaling pathway. Mechanistically, ERβ suppresses the expression of circPHACTR4 by directly binding to EREs on the promoter region of the PHACTR4 gene, leading to decreased miR-34b-5p expression. Decreased miR-34b-5p then increases c-Myc mRNA translation by targeting its 3' UTR.
Article
Psychology, Clinical
Xiaojing Li, Wei Deng, Rui Xue, Qiang Wang, Hongyan Ren, Wei Wei, Yamin Zhang, Mingli Li, Liansheng Zhao, Xiangdong Du, Yajing Meng, Xiaohong Ma, Mei-Hua Hall, Tao Li
Summary: This study found deficits in event-related potential, including duration mismatch negativity and P3a, in drug naive patients with chronic schizophrenia and bipolar disorder. These deficits appeared to be related to levels of higher-order cognition and functioning.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Mingli Li, Wei Deng, Yinfei Li, Liansheng Zhao, Xiaohong Ma, Hua Yu, Xiaojing Li, Yajing Meng, Qiang Wang, Xiangdong Du, Pak Chung Sham, Lena Palaniyappan, Tao Li
Summary: In the untreated early stages of schizophrenia, patients display both an increase and a decrease in grey matter distribution. The higher grey matter distribution is associated with reduced illness burden and better cognitive performance, suggesting a compensatory role in the early stages of schizophrenia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Bochao Cheng, Yushan Zhou, Veronica P. Y. Kwok, Yuanyuan Li, Song Wang, Yajun Zhao, Yajing Meng, Wei Deng, Jiaojian Wang
Summary: This study identified specific neural circuit disruptions in postpartum depression and postpartum depression comorbid with anxiety, which could enhance the diagnosis and treatment of these disorders.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Psychiatry
Bochao Cheng, Neil Roberts, Yushan Zhou, Xiuli Wang, Yuanyuan Li, Yiming Chen, Yajun Zhao, Pengcheng Deng, Yajing Meng, Wei Deng, Jiaojian Wang
Summary: Post-Partum Depression (PPD) is a common health issue affecting women's emotional well-being and often co-occurs with anxiety (PPD-A). Adequate social support has been shown to protect against PPD and PPD-A, with specific changes in brain functional connectivity strength in different neural circuits associated with these disorders. Perceived social support mediates the relationship between brain connectivity strength in specific regions and symptoms of PPD and PPD-A, highlighting the potential role of social support as a biomarker for these conditions.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Rong Liang, Wei Deng, Wanjun Guo, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo, Tao Li
Summary: This study identified TYW5 as a risk gene for schizophrenia (SCZ) through a comprehensive analysis of genetic associations and brain expression data. TYW5 mRNA expression was significantly associated with SCZ risk, and TYW5 protein abundance in the brain was also linked to SCZ. Further analysis revealed elevated TYW5 expression in the brain tissues and neurons of SCZ cases compared to controls. Additionally, a genetic variant associated with higher TYW5 expression was found to be associated with specific brain structural changes. These findings provide valuable insights into the genetic mechanism of TYW5 in SCZ risk.
Article
Clinical Neurology
Bochao Cheng, Xiao Hu, Neil Roberts, Yajun Zhao, Xin Xu, Yushan Zhou, Xi Tan, Shanhui Chen, Yajing Meng, Song Wang, Haoyang Xing, Wei Deng
Summary: This structural MRI study analyzed the differences in neural structures between postpartum depression (PPD) patients and healthy postnatal women (HPW), as well as the relationship with a range of factors. The results showed significant differences in regional gray matter volume (rGMV) and prolactin levels between PPD patients and HPW. Prolactin level was found to mediate the relationship between brain structure and PPD symptoms in the anterior insular region.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Xiaojing Li, Jia Cai, Ling Yang, Xiao Zhang, Wei Deng, Peiyan Ni, Liansheng Zhao, Xiang-dong Du, Tao Li
Summary: This study found that being left behind during childhood has negative effects on mental health, including shorter telomere length, lower self-esteem, and increased behavioral and emotional problems.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Psychiatry
Yingzhe Zhang, Jeremy Coid, Xiang Liu, Yamin Zhang, Huan Sun, Xiaojing Li, Wanjie Tang, Qiang Wang, Wei Deng, Liansheng Zhao, Xiaohong Ma, Yajing Meng, Mingli Li, Huiyao Wang, Ting Chen, Qiuyue Lv, Wanjun Guo, Tao Li
Summary: University students often experience high levels of stress, and the prevalence of depression is higher than in the general population. The stress from adapting to university life and the pressures from academic study have a greater impact on psychiatric morbidity among students than childhood traumatic experiences and current family problems, although these factors are closely related.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Jia Cai, Wei Wei, Liansheng Zhao, Mingli Li, Xiaojing Li, Sugai Liang, Wei Deng, Xiang Dong Du, Qiang Wang, Wan-jun Guo, Xiaohong Ma, Pak C. Sham, Tao Li
Summary: Individuals with early-onset schizophrenia (EOS), who have less exposure to environmental and medication influences, provide valuable evidence for studying the pathogenesis and phenotypic pattern of schizophrenia. This study found that EOS patients exhibit abnormal brain structure morphology, particularly in the temporal and frontal lobes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Xue Tian, Yuan-hong Li, Lan-zhi Deng, Wen-ze Han, Dan Pu, Xiang-long Han, Shu-fang Du, Wei Deng
Summary: Anxiety and depression play a mediating role in the relationship between gastrointestinal conditions and oral health in orthodontic patients. In particular, anxiety has a significant mediating effect. Future clinical practices and monitoring should pay more attention to the psychological status of patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xueli Yu, Xueyu Qi, Long Wei, Liansheng Zhao, Wei Deng, Wanjun Guo, Qiang Wang, Xiaohong Ma, Xun Hu, Peiyan Ni, Tao Li
Summary: Fingolimod shows potential in ameliorating cognitive deficits in a rat model of schizophrenia by inhibiting inflammation and promoting neurogenesis. This study provides new insights into the use of immunomodulatory strategies to improve cognitive function in schizophrenia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Letter
Psychiatry
Kun Li, Jiang Long, Minne Cao, Rui Xue, Jianning Chen, Bochao Cheng, Jiaojian Wang, Wanjun Guo, Wei Deng, Tao Li
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Jia Cai, Min Xie, Liansheng Zhao, Xiaojing Li, Sugai Liang, Wei Deng, Wanjun Guo, Xiaohong Ma, Pak C. Sham, Qiang Wang, Tao Li
Summary: This study examined white matter abnormalities in adolescent early onset schizophrenia patients and found differences in several neural fiber tracts compared to healthy controls. Specifically, decreased mean diffusivity was found in the right hemisphere of schizophrenia patients. Furthermore, the fractional anisotropy values of certain neural fiber tracts were suggested to be associated with the severity of clinical symptoms in these patients.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
De-Quan Wang, Jing-Jing Zhang, Jian-Ning Chen, Ren-Yu Li, Yi-Xiang Luo, Wei Deng
Summary: This study aims to investigate the effects of exergames on cognitive functions in adolescents with depression and compare the effectiveness of exergames with traditional exercise. The study is a single-center randomized controlled trial that enrolls eligible patients with depression and assigns them to different treatment groups. The findings provide a theoretical basis for the use of exergames as an adjunctive intervention for depression.
Article
Neurosciences
Haiteng Jiang, Peiyin Chen, Zhaohong Sun, Chengqian Liang, Rui Xue, Liansheng Zhao, Qiang Wang, Xiaojing Li, Wei Deng, Zhongke Gao, Fei Huang, Songfang Huang, Yaoyun Zhang, Tao Li
Summary: Schizophrenia is a serious mental disorder, and there is a lack of effective and widely available diagnostic tools. Clinical electroencephalogram (EEG) has shown potential in capturing abnormal schizophrenia neuropathology. This study developed an interpretable deep learning model using multimodal clinical EEG features and demographic information as inputs, and proposed different transfer learning strategies to adapt to different clinical scenarios.
NEUROPSYCHOPHARMACOLOGY
(2023)
