Article
Anatomy & Morphology
Xiangjun Lu, Jian Shen, Siyuan Huang, Haitao Wang, Dongdong Liu
Summary: This study demonstrates that the low expression of CLEC3B in LUAD cells leads to decreased cell adhesion capability, enhanced EMT, migration, and invasion, which is associated with the p53 signaling pathway.
Article
Pharmacology & Pharmacy
Nongyao Nonpanya, Kittipong Sanookpan, Nicharat Sriratanasak, Chanida Vinayanuwattikun, Duangdao Wichadakul, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Artocarpin targets FAK to suppress EMT and migratory behaviors of lung cancer cells, without affecting normal lung cells.
Article
Chemistry, Multidisciplinary
Qiu-di Deng, Xue-Ping Lei, Yi-Hang Zhong, Min-Shan Chen, Yuan-Yu Ke, Zhan Li, Jing Chen, Li-Juan Huang, Yu Zhang, Lu Liang, Zhong-Xiao Lin, Qing Liu, Song-Pei Li, Xi-Yong Yu
Summary: Triptolide derived from Tripterygium wilfordii Hook F inhibits NSCLC metastasis by targeting EMT and reducing beta-catenin expression. In animal models, triptolide suppresses tumor growth, decreases lung metastasis, suggesting its potential therapeutic effect on NSCLC metastasis.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Wen-Yueh Hung, Wei-Jiunn Lee, Guo-Zhou Cheng, Ching-Han Tsai, Yi-Chieh Yang, Tsung-Ching Lai, Ji-Qing Chen, Chi-Li Chung, Jer-Hwa Chang, Ming-Hsien Chien
Summary: Our study showed that penfluridol can reduce the migration, invasion, and adhesion of LADC cells, potentially by inhibiting MMP-12 expression and reversing MMP-12-induced EMT. MMP-12 may serve as a useful biomarker for predicting LADC progression and as a promising penfluridol target for treating metastatic LADC.
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Plant Sciences
Gege Xu, Haiping Zhao, Jingdong Xu, Yu Zhang, Xiaoyan Qi, Aiping Shi
Summary: The research indicates that HAE can effectively inhibit self-renewal of stem-like cells, wound healing, and metastasis in breast cancer cells by targeting the NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claudia M. Garcia-Cuellar, Miguel Santibanez-Andrade, Yolanda I. Chirino, Raul Quintana-Belmares, Rocio Morales-Barcenas, Ericka Marel Quezada-Maldonado, Yesennia Sanchez-Perez
Summary: The study demonstrated that PM10 exposure induces EMT in lung cancer cells, leading to an increase in invasive phenotype. TGFB1 plays a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Huaguo Liang, Zexin Chen, Ruihui Yang, Qingsong Huang, Hongmei Chen, Wanting Chen, Li Zou, Peng Wei, Shijie Wei, Yongxia Yang, Yongli Zhang
Summary: The polyphenolic compound Methyl gallate (MG) found in plants can inhibit the proliferation, migration, and invasion of HCC cells both in vitro and in vivo. The therapeutic mechanism of MG potentially involves the regulation of the AMPK/NF-kappa B pathway, which influences the epithelial-mesenchymal transition and MMP expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Pathology
Zhe Cheng, Suwen Li, Jiaqi Yuan, Yongdong Li, Shan Cheng, Shilu Huang, Jun Dong
Summary: In this study, the expression patterns of HDAC1 and its impact on prognosis in glioblastoma (GBM) patients were evaluated based on TCGA and CGGA databases. High expression of HDAC1 was found to be associated with poor prognosis in GBM, and its interaction with the EMT-related protein VIM was explored. Functional enrichment analysis further revealed the enrichment of cancer markers in GBM tissues with high HDAC1 expression. In vitro and in vivo experiments demonstrated that an HDAC1 inhibitor could inhibit the EMT process and affect the invasive ability of GBM cells.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Eun Ju Kim, Jeong Seon Kim, Sieun Lee, Inyoung Cheon, Seo Ree Kim, Yoon Ho Ko, Keunsoo Kang, Xiaochao Tan, Jonathan M. Kurie, Young-Ho Ahn
Summary: The study found that lnc-Nr2f1 is upregulated by ZEB1 and NR2F1 in lung adenocarcinoma cells, and promotes migration and invasion of these cells by regulating TWIST2.
Review
Biochemistry & Molecular Biology
Andrea Abaurrea, Angela M. Araujo, Maria M. Caffarel
Summary: Epithelial-mesenchymal plasticity (EMP) is crucial in cancer development, promoting the acquisition of mesenchymal features in cancer cells through cytokine signal transduction pathways, such as the interleukin 6 (IL-6) family. However, the effect may depend heavily on the context.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qin Yu, Jianzhang Wang, Tiantian Li, Xinyue Guo, Shaojie Ding, Xuan Che, Libo Zhu, Yangying Peng, Xinxin Xu, Gen Zou, Xinmei Zhang
Summary: RON, a receptor tyrosine kinase, promotes endometriosis development by facilitating epithelial-mesenchymal transition (EMT) of endometrial epithelial cells. Inhibition or knockdown of RON expression suppresses the migration and invasion of endometrial epithelial cells. Targeting RON may offer a new therapeutic approach for endometriosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Min Hee Yang, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Sang Hoon Jung, Hyejin Ko, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Summary: Procaine inhibits the EMT process and c-Met-dependent signaling cascades, suggesting its potential as an anti-metastatic agent for HCC.
Article
Oncology
Jin-Xing Zhang, Wei Yang, Jun-Zheng Wu, Chun Zhou, Sheng Liu, Hai-Bin Shi, Wei-Zhong Zhou
Summary: The study found that miR-32-5p is downregulated in NSCLC tissues and inhibits the migration and invasion abilities of tumors by targeting SMAD3. miR-32-5p may be a potential therapeutic target for the treatment of lung adenocarcinoma.
Article
Hematology
Yujie Kong, Chen Cai, Li Ling, Li Zeng, Meihong Wu, Yanyun Wu, Wei Zhang, Zhong Liu
TRANSFUSION AND APHERESIS SCIENCE
(2020)
Article
Oncology
Yongyi Zeng, Wei Zhang, Zhenli Li, Youshi Zheng, Yingchao Wang, Geng Chen, Liman Qiu, Kun Ke, Xiaoping Su, Zhixiong Cai, Jingfeng Liu, Xiaolong Liu
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Medicine, General & Internal
Ling Li, Wei Zhang, Yu Hu, Xunliang Tong, Shangen Zheng, Juntao Yang, Yujie Kong, Lili Ren, Qing Wei, Heng Mei, Caiying Hu, Cuihua Tao, Ru Yang, Jue Wang, Yongpei Yu, Yong Guo, Xiaoxiong Wu, Zhihua Xu, Li Zeng, Nian Xiong, Lifeng Chen, Juan Wang, Ning Man, Yu Liu, Haixia Xu, E. Deng, Xuejun Zhang, Chenyue Li, Conghui Wang, Shisheng Su, Linqi Zhang, Jianwei Wang, Yanyun Wu, Zhong Liu
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, Research & Experimental
Ling Li, Chianru Tan, Jia Zeng, Chen Luo, Shi Hu, Yanke Peng, Wenjuan Li, Zhixiong Xie, Yueming Ling, Xuejun Zhang, E. Deng, Haixia Xu, Jue Wang, Yudi Xie, Yaling Zhou, Wei Zhang, Yong Guo, Zhong Liu
Summary: This study collected nasopharyngeal swabs, anal swabs, saliva, blood, and urine specimens from patients with a course of disease ranging from 7 to 69 days. It was found that the positive detection rate was highest in nasopharyngeal swabs, followed by anal swabs. There was no significant correlation between antibody levels and days after symptom onset or viral load.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Wei Zhang, Qi Yin, Haidong Huang, Jingjing Lu, Hao Qin, Si Chen, Wenjun Zhang, Xiaoping Su, Weihong Sun, Yuchao Dong, Qiang Li
Summary: Strongly immunogenic neoantigens were identified from NSCLC patients through whole-exome sequencing and machine-learning-based predictions. The efficient antitumor responses of NRTs were demonstrated in transgenic mice and tumor-bearing mouse models both in vivo and in vitro. These results suggest the feasibility of developing neoantigen-based personalized immunotherapies for NSCLC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Duan, Jia Zeng, Puyu Deng, Zhong Ni, Rongli Lu, Wenxi Xia, Guoqiang Jing, Xiaoping Su, Stephan Ehrmann, Wei Zhang, Jie Li
Summary: The study identified the ROX index as a predictor of HFNC failure among COVID-19 patients, aiding in avoiding delayed intubation in resource-limited areas and reducing mortality.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pan Li, Zhengmao Lu, Qiang Li, Zhenmeng Wang, Yan Guo, Chen Cai, Shengyun Wang, Peng Liu, Xiaoping Su, Yi Huang, Yuchao Dong, Wenjuan Qiu, Yueming Ling, Lonny Yarmus, Fengming Luo, Li Zeng, Chong Bai, Wei Zhang
Summary: The study indicates that early administration of tocilizumab can effectively improve the clinical prognosis of patients with COVID-19, especially for those with interleukin-6 levels below 100 pg/ml.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Jiaxing Sun, Jing Zhang, Haiyan Hu, Huan Qin, Ximing Liao, Feilong Wang, Wei Zhang, Qi Yin, Xiaoping Su, Yanan He, Wenfeng Li, Kun Wang, Qiang Li
Summary: NRT cells induced by RNA mutanome vaccine exhibit significant anti-tumour effect in mouse lung cancer by promoting active T-cell infiltration into the tumor tissue and delaying tumor progression.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Critical Care Medicine
Ivan Pavlov, Hangyong He, Bairbre McNicholas, Yonatan Perez, Elsa Tavernier, Matthew W. Trump, Julie A. Jackson, Wei Zhang, Daniel S. Rubin, Thomas Spiegel, Anthony Hung, Miguel Angel Ibarra Estrada, Oriol Roca, David L. Vines, David Cosgrave, Sara Mirza, John G. Laffey, Todd W. Rice, Stephan Ehrmann, Jie Li
Summary: Awake prone positioning (APP) can improve oxygenation in patients with acute respiratory failure due to COVID-19, but it does not reduce the intubation rate. Randomized controlled clinical studies are needed to confirm these findings due to the high heterogeneity and observational nature of the included studies.
Article
Cell Biology
Lin Xia, Zhoufeng Wang, Xinyue Wu, Tianfu Zeng, Wenxin Luo, Xinlei Hu, Yinyun Ni, Guowei Che, Lunxu Liu, Wei Zhang, Dan Xie, Weimin Li
Summary: This study highlights the importance of integrating different technologies for detecting somatic structural variations in NSCLC cases and identifying potential oncogenes. The findings lay the groundwork for further exploration of the associations among somatic structural variations, gene expression, and regulatory networks in patients with NSCLC.
Article
Hematology
Rui He, Jue Wang, Zhenmeng Wang, Yu Liu, Haixia Xu, Xuejun Zhang, E. Deng, Yundi Yin, Xin Ji, Xiaoyu Guan, Qi Ren, Caixia Wu, Yongjun Chen, Ling Li, Wei Zhang, Zhong Liu
Summary: This study proposed a potential estimation equation for evaluating the dose of high antibody titer convalescent plasma, which could assist in the rational allocation of plasma with high antibody titers and provide an individualized treatment strategy for convalescent plasma therapy.
TRANSFUSION MEDICINE
(2022)
Article
Oncology
Xinlei Hu, Kai Luo, Hui Shi, Xiaoqin Yan, Ruichen Huang, Bi Zhao, Jun Zhang, Dan Xie, Wei Zhang
Summary: This study successfully constructed a diagnostic model for lung cancer using the 5hmC signal and fragmentation profiles in 5hmC cfDNA data, which can effectively distinguish lung cancer patients from healthy individuals. The models showed good performance in different lung cancer subtypes and stages, and were associated with patient survival rates. The results demonstrate the significant application value of clinical diagnostic models based on cfDNA 5hmC data.
CLINICAL EPIGENETICS
(2022)
Article
Immunology
Qinying Sun, Yang Xia, Hao Qin, Wei Zhang, Jun Wang, Yunye Ning, Yuchao Dong
Summary: This study reveals that MEF2 can promote M2 polarization and inhibit M1 polarization of macrophages. Overexpression of MEF2 can alleviate LPS-induced ALI. Furthermore, MEF2 regulates macrophage phenotypes through the modulation of KLF2. MiR-33 may be involved in macrophage polarization by inhibiting MEF2 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Oncology
Ruichen Huang, Bi Zhao, Shi Hu, Qian Zhang, Xiaoping Su, Wei Zhang
Summary: Neoantigens generated by non-synonymous mutations can activate neoantigen-reactive T cells and effectively inhibit tumor growth. Immunotherapy based on these T cells has shown great success in treating melanoma and other solid tumors. Improvements in the preparation and function evaluation of these T cells, as well as ongoing clinical trials, are discussed in this review.
BIOMARKER RESEARCH
(2023)
Article
Medicine, General & Internal
Chuan Li, Fengming Luo, Chengwu Liu, Nian Xiong, Zhihua Xu, Wei Zhang, Ming Yang, Ye Wang, Dan Liu, Chao Yu, Jia Zeng, Li Zhang, Duo Li, Yanbin Liu, Mei Feng, Ruoyang Liu, Jiandong Mei, Senyi Deng, Zhen Zeng, Yuanhong He, Haiyan Liu, Zhengyu Shi, Meng Duan, Deying Kang, Jiayu Liao, Weimin Li, Lunxu Liu
Summary: There are limited effective therapies available for COVID-19. In a multicenter randomized trial, rSIFN-co therapy combined with baseline antiviral agents showed a faster time to clinical improvement compared to traditional interferon-alpha therapy combined with antiviral agents.
ANNALS OF MEDICINE
(2021)