Aurora-A: a potential DNA repair modulator

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

(2013) Markus Brockmann et al.   CANCER CELL

RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis

(2013) Gong Yang et al.   INTERNATIONAL JOURNAL OF CANCER

p53 Ser15phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

(2012) Esha Madan et al.   BIOCHEMICAL JOURNAL

Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53

(2012) Lorna Jane Warnock et al.   CANCER BIOLOGY & THERAPY

Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73

(2012) Hiroshi Katayama et al.   CANCER CELL

The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent

(2012) Jayasree S. Nair et al.   CELL CYCLE

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

The Aurora Kinase A Inhibitor MLN8237 Enhances Cisplatin-Induced Cell Death in Esophageal Adenocarcinoma Cells

(2012) V. Sehdev et al.   MOLECULAR CANCER THERAPEUTICS

Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence

(2011) Zhigang Tu et al.   DEVELOPMENTAL CELL

MLN8054, A Small Molecule Inhibitor of Aurora Kinase A, Sensitizes Androgen-Resistant Prostate Cancer to Radiation

(2011) Luigi Moretti et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

AURKA and BRCA2 expression highly correlate with prognosis of endometrioid ovarian carcinoma

(2011) Fan Yang et al.   MODERN PATHOLOGY

Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities

(2011) Florian Jantscher et al.   Molecular Cancer

Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair

(2011) Libing Song et al.   Journal of Molecular Cell Biology

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

(2010) G. Gorgun et al.   BLOOD

Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells

(2010) Patrizia Cammareri et al.   CANCER RESEARCH

Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cellsin vitro

(2010) Mariko Tomita et al.   CANCER SCIENCE

Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2

(2010) G. Yang et al.   CLINICAL CANCER RESEARCH

Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

(2010) Tony Sourisseau et al.   EMBO Molecular Medicine

Suppression of Aurora-A oncogenic potential by c-Myc downregulation

(2010) Shangbin Yang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Human papillomavirus 16 E6 increases the radiosensitivity of p53-mutated cervical cancer cells, associated with up-regulation of aurora A

(2010) Hye-Jin Shin et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Solution Structure of Human Growth Arrest and DNA Damage 45α (Gadd45α) and Its Interactions with Proliferating Cell Nuclear Antigen (PCNA) and Aurora A Kinase

(2010) Ricardo Sánchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo

(2010) J. J. Huck et al.   MOLECULAR CANCER RESEARCH

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage

(2010) Lina Guerra et al.   PLoS One

Aurora-A overexpression enhances cell-aggregation of Ha-rastransformants through the MEK/ERK signaling pathway

(2009) Ya-Shih Tseng et al.   BMC CANCER

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Aurora-A Overexpression in Mouse Liver Causes p53-Dependent Premitotic Arrest during Liver Regeneration

(2009) C.-C. Li et al.   MOLECULAR CANCER RESEARCH

Aurora-A interacts with Cyclin B1 and enhances its stability

(2008) Lili Qin et al.   CANCER LETTERS

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice

(2008) D Zhang et al.   ONCOGENE

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE