Review
Cell Biology
Julian M. Rozenberg, Olga S. Rogovaya, Gerry Melino, Nickolai A. Barlev, Alexander Kagansky
Summary: p63 and p73 cooperate in genome stability surveillance, with specific interactors contributing to transcriptional repression and spindle assembly checkpoint for p73, and mRNA processing and splicing regulation for p63. This analysis reveals the diversification of RNA and DNA specific functions within the p53 family.
Review
Cell Biology
Kyra Laubach, Jin Zhang, Xinbin Chen
Summary: The p53 family of tumor suppressors, including p53, p63, and p73, play critical roles in various biological processes such as cell cycle arrest, apoptosis, differentiation, development, multiciliogenesis, and fertility. This review focuses on the roles of p53, p63, and p73 in lipid and iron metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Rui Qiao, Mengmeng Wei, Hui Chen, Xianhong Zhang, Jie Zhang, Liyang Gao, Haijun Ma, Yujiong Wang, Le Li
Summary: Cancer cells alter their metabolism to support biogenesis, proliferation, and survival. The glucose-associated pentose phosphate pathway (PPP) plays a crucial role in cancer cell proliferation. TAp73 activates 6-phosphogluconate dehydrogenase (6PGD) to produce ribulose 5-phosphate (Ru5P) and NADPH, which counteracts reactive oxygen species and protects cells from apoptosis. Additionally, overexpression of 6PGD rescues the proliferation and tumorigenic ability of TAp73-deficient cells.
MOLECULAR CANCER RESEARCH
(2023)
Review
Cell Biology
Kiyohiro Ando, Akira Nakagawara
Summary: The RUNX family plays a crucial role in neural crest cell differentiation and may also be involved in neuroblastoma tumorigenesis. Its function in tumor development can vary depending on the specific context, including the response to chemotherapy. In primary neuroblastomas, RUNX3 acts as a tumor suppressor, while RUNX1 regulates cell proliferation in a dual manner influenced by genetic and epigenetic factors, including MYCN. This review focuses on the mechanism through which the RUNX family regulates neurotrophin receptors (Trk family) associated with neuroblastoma aggressiveness, as well as their potential involvement in functional alterations of the p53 family members in neuroblastoma tumorigenesis. Understanding the contribution of the RUNX family to neuroblastoma tumorigenesis is crucial for future molecular-based therapies.
Article
Genetics & Heredity
Julia Wallmeier, Diana Bracht, Hessa S. Alsaif, Gerard W. Dougherty, Heike Olbrich, Sandra Cindric, Mark Dzietko, Christoph Heyer, Norbert Teig, Charlotte Thiels, Eissa Faqeih, Aqeela Al-Hashim, Sameena Khan, Ibrahim Mogarri, Mohammed Almannai, Wadha Al Otaibi, Fowzan S. Alkuraya, Cordula Koerner-Rettberg, Heymut Omran
Summary: TP73, a member of the TP53 family of transcription factors, has been found to cause mucociliary clearance disorder, possibly due to a defect in multiciliated cell differentiation.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Medicine, General & Internal
Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan
Summary: This study identified potential biomarkers for bladder cancer diagnosis and disease progression using aptamer screening and systems biology analysis. Urine d-dimer showed high sensitivity (97%) for bladder cancer diagnosis, while urine IL-8 and IgA were associated with disease progression. These biomarkers could be used for initial triage and patient follow-up, reducing the need for invasive cystoscopy-based diagnostic methods.
Article
Oncology
Yuanzheng Yang, Zhanglong Peng, Elsa R. Flores, Eugenie S. Kleinerman
Summary: Outcomes for patients with osteosarcoma have remained stagnant for more than 3 decades, and the search for novel therapeutic agents is crucial. This study shows that Pramlintide, an FDA-approved drug for type 2 diabetes, may have potential efficacy against osteosarcoma by interfering with tumor glycolysis and leading to decreased cell growth and increased cell death. Injection of Pramlintide into osteosarcoma tumor nodules resulted in significantly smaller tumors, indicating its potential as a novel therapeutic approach for relapsed osteosarcoma patients.
Article
Oncology
Eugene Shkolyar, Qian Zhao, Kathleen E. Mach, Nikola C. Teslovich, Timothy J. Lee, Susanne Cox, Eila C. Skinner, Ying Lu, Joseph C. Liao
Summary: The study aimed to develop a urinary mRNA biomarker panel for risk stratification in patients undergoing bladder cancer screening and surveillance. Results showed that the expression of ROBOT, CRH, and IGF2 correlated with increased-risk disease, with a sensitivity of 92.5% and specificity of 73.5%. The overall calculated standardized net benefit of the model was 0.81.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Multidisciplinary Sciences
Katsunori Yanai, Shohei Kaneko, Hiroki Ishii, Akinori Aomatsu, Kenichi Ishibashi, Yoshiyuki Morishita
Summary: This study established an effective method for extracting and evaluating miRNA expression in the kidney and serum of mice. Using qRT-PCR analysis, it was found that the expression of miRNA-7218-5p and miRNA-7219-5p significantly changed in the kidney and serum of mice with age-dependent renal impairment, and the relationship between the kidney and serum was clarified.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Review
Biochemistry & Molecular Biology
Gabriela Vanessa Flores Monar, Thomas Reynolds, Maxie Gordon, David Moon, Chulso Moon
Summary: Bladder cancer is a financially burdensome cancer with significant impact on patients and the medical community. Current detection methods have limitations and there is a need to explore new screening assays. This article provides a comprehensive overview of bladder cancer and analyzes FDA-approved assays for diagnosis and monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Bong Kyun Kim, Sang-A Lee, Minju Park, Eui Ju Jeon, Mi Jung Kim, Jung Min Kim, Heesuk Kim, Seungwon Jung, Sang Kyung Kim
Summary: This article introduces a photonic PCR platform using hydrogel microparticles, which utilizes photothermal nanomaterials as heating elements for rapid and portable POCT. The researchers successfully demonstrate the ability to perform multiplex assays by loading multiple encoded pPIN microparticles in a single reaction.
Review
Cell Biology
Nourin Shakeeb, Prashanth Varkey, Amita Ajit
Summary: Saliva is increasingly studied as a non-invasive and stress-free diagnostic material, with RNA extracted from saliva being used for early disease detection through real-time reverse transcriptase polymerase chain reaction (RT-PCR). Assessing the host inflammatory response and its resolution at early stages can serve as a prognostic and predictive method for determining therapeutic response or disease progression. The potential of saliva as a specimen for diagnosing early inflammatory biomarkers using RT-PCR is fascinating and useful.
Article
Genetics & Heredity
Navdeep Malik, Hualong Yan, Howard H. Yang, Gamze Ayaz, Wendy DuBois, Yu-Chou Tseng, Young-Im Kim, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Jing Huang
Summary: CBFB is a tumor suppressor gene frequently mutated in solid tumors, especially in breast cancer. It cooperates with TP53 to maintain the expression of TAp73, which acts as a mediator for the tumor suppressive function of p53. Loss of TAp73 expression enhances the tumorigenic effect of CBFB and is a common event in human breast cancer. This study provides insights into the functional association between CBFB and p53 in breast cancer and has implications for precision medicine.
Review
Biochemistry & Molecular Biology
Ignacija Vlasic, Andela Horvat, Ana Tadijan, Neda Slade
Summary: Metastatic melanoma, a highly aggressive tumor, is often characterized by mutations in the MAPK pathway, particularly in the protein kinase BRAF. However, resistance to BRAF inhibitors is a major obstacle in melanoma treatment, with the reactivation of MAPK or PI3K/AKT pathways and the involvement of the p53 pathway contributing to acquired resistance. In melanoma, the canonical tumor suppressor p53 is frequently inactivated through various mechanisms. The TP53 gene and its family members TP63 and TP73 encode multiple protein isoforms with diverse functions in tumorigenesis. Some p53 isoforms are expressed in melanoma cells and have been shown to play specific roles in proliferation, survival, metastasis, invasion, migration, and treatment response. Particularly, p53 isoforms involved in acquired resistance to MAPK inhibitors present potential therapeutic targets to overcome resistance in melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Yuan Xiong, Tayla B. Heavican-Foral, Elisa Mandato, Huiyun Liu, Geoffrey M. Nelson, Lu Yang, Renee Chen, Katherine A. Donovan, Marcus K. Jones, Mikhail Roshal, Yanming Zhang, Ran Xu, Ajit J. Nirmal, Salvia Jain, Catharine Leahy, Kristen L. Jones, Kristen E. Stevenson, Natasha Galasso, Nivetha Ganesan, Tiffany Chang, Wen-Chao Wu, Abner Louissaint, Lydie Debaize, Hojong Yoon, Paola Dal Cin, Wing C. Chan, Shannan J. Ho Sui, Samuel Y. Ng, Andrew L. Feldman, Steven M. Horwitz, Karen Adelman, Eric S. Fischer, Chun-Wei Chen, David M. Weinstock, Myles Brown
Summary: Gene fusions involving TP63 play a crucial role in lymphomas and have a significant impact on prognosis. TP63 fusions coordinate the recruitment of two epigenetic modifying complexes, resulting in therapeutic vulnerability to EZH2 inhibition. Targeting EZH2 with valemetostat shows promising results in treating lymphoma harboring TP63 fusions.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Dimitrios Tsoukalas, Athanasios K. Alegakis, Persefoni Fragkiadaki, Evangelos Papakonstantinou, Gerasimos Tsilimidos, Franco Geraci, Evangelia Sarandi, Dragana Nikitovic, Demetrios A. Spandidos, Aristides Tsatsakis
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2019)
Review
Oncology
Efthimios Dardiotis, Athina-Maria Aloizou, Sofia Markoula, Vasileios Siokas, Konstantinos Tsarouhas, Georgios Tzanakakis, Massimo Libra, Athanassios P. Kyritsis, Alexandros G. Brotis, Michael Aschner, Illana Gozes, Dimitrios P. Bogdanos, Demetrios A. Spandidos, Panayiotis D. Mitsias, Aristidis Tsatsakis
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Review
Medicine, Research & Experimental
Alexandra Trivli, Ioannis Koliarakis, Chryssa Terzidou, George N. Goulielmos, Charalambos S. Siganos, Demetrios A. Spandidos, Georgios Dalianis, Efstathios T. Detorakis
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Review
Medicine, Research & Experimental
Maria Mamma, Demetrios A. Spandidos
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Review
Medicine, Research & Experimental
Sophie I. Mavrogeni, Konstantinos Tsarouhas, Demetrios A. Spandidos, Christina Kanaka-Gantenbein, Flora Bacopoulou
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Review
Oncology
Mayya Petrovna Razgonova, Valery Vyacheslavovich Veselov, Alexander Mikhailovich Zakharenko, Kirill Sergeyevich Golokhvast, Alexander Evgenyevich Nosyrev, Giancarlo Cravotto, Aristidis Tsatsakis, Demetrios A. Spandidos
MOLECULAR MEDICINE REPORTS
(2019)
Article
Oncology
Mihaela Mitroi, Dana Albulescu, Alina Captianescu, Anca Oana Docea, Gabriela Musat, George Mitroi, Ovidiu Zlatian, Aristidis Tsatsakis, George Tzanakakis, Demetrios A. Spandidos, Daniela Calina
MOLECULAR MEDICINE REPORTS
(2019)
Article
Oncology
Luca Falzone, Giovanni L. Romano, Rossella Salemi, Claudio Bucolo, Barbara Tomasello, Gabriella Lupo, Carmelina D. Anfuso, Demetrios A. Spandidos, Massimo Libra, Saverio Candido
MOLECULAR MEDICINE REPORTS
(2019)
Article
Medicine, Research & Experimental
Erifili Hatziagelaki, Anastasia Tsiavou, Charilaos Gerasimou, George D. Vavougios, Aris Spathis, Efstathios Laskos, Charalabos Papageorgiou, Athanasios Douzenis, Nikos Christodoulou, Nicolaos Stefanis, Demetrios A. Spandidos, Nikolaos Nikolakakis, Konstantinos Tsamakis, Emmanouil Rizos
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Medicine, Research & Experimental
Daniela Cristea, Marius Trandafir, Violeta Claudia Bojinca, Adriana Simona Ciontea, Melania Mihaela Andrei, Andrei Popa, Brandusa Elena Lixandru, Cornelia Madalina Militaru, Alexandra Maria Nascutiu, Denisa Predeteanu, Ruxandra Ionescu, Claudiu Popescu, Ani Ioana Cotar, Mircea Ioan Popa, Demetrios A. Spandidos, Irina Codita
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Review
Medicine, Research & Experimental
Loukia Vassilopoulou, Michail Matalliotakis, Maria I. Zervou, Charoula Matalliotaki, Konstantinos Krithinakis, Ioannis Matalliotakis, Demetrios A. Spandidos, George N. Goulielmos
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Editorial Material
Medicine, Research & Experimental
Ioannis Mammas, Demetrios Spandidos
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Medicine, Research & Experimental
Ioannis Mammas, Tina Dalianis, Sotiros Doukas, Apostolos Zaravinos, Vassilis Achtsidis, Prakash Thiagarajan, Maria Theodoridou, Demetrios Spandidos
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Medicine, Research & Experimental
Ioannis Mammas, Maria Theodoridou, Prakash Thiagarajan, Angeliki Melidou, Georgia Papaioannou, Paraskevi Korovessi, Chryssie Koutsaftiki, Alexia Papatheodoropoulou, Marcos Calachanis, Tina Dalianis, Demetrios Spandidos
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Review
Oncology
Artemis Papanastasiou, Theodora Seliniotaki, Emmanouil Rizos, Katerina Kampoli, Anastasios Ntavatzikos, Nikolaos Arkadopoulos, Christina Tsionou, Demetrios A. Spandidos, Anna Koumarianou