Article
Pathology
Carmen C. van der Pol, Cathy B. Moelans, Quirine F. Manson, Marilot C. T. Batenburg, Elsken van der Wall, Inne Borel Rinkes, Lenny Verkooijen, Venu Raman, Paul J. van Diest
Summary: High cytoplasmic DDX3 expression in male breast cancer is associated with better 10-year survival rates, indicating its potential as a prognostic marker. Low nuclear DDX3 expression is linked to negative lymph node status.
Article
Biochemistry & Molecular Biology
Lin Shen, Jing Zhang, Meng Xu, Ying Zheng, Mo Wang, Suzhen Yang, Bin Qin, Shunle Li, Lei Dong, Fei Dai
Summary: DDX3 functions as a tumor suppressor gene in colorectal cancer. Loss of DDX3 expression promotes cancer progression by regulating E-cadherin and beta-catenin signaling through the MAPK pathway. Targeting the MAPK pathway may be a therapeutic approach for advanced colorectal cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Juan Wang, Fan Yang, Jialang Zhuang, Qin Huo, Jiaying Li, Ni Xie
Summary: This study reveals the role of TRIM58 in the development of chemotherapy resistance in breast cancer and provides potential therapeutic targets through the interaction with DDX3 and the P53/P21 pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Computer Science, Theory & Methods
B. M. S. Bahar Talukder, Farah Ferdaus, Md Tauhidur Rahman
Summary: mPUFs are considered secure due to the unclonable and immutable nature of manufacturer process variations, but attacks are still possible; experiments demonstrate that signatures generated from two memory chips with the same specifications and manufacturing facility may have highly correlated properties, which can be used for non-invasive attacks against memory-based PUFs.
IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY
(2021)
Article
Pharmacology & Pharmacy
Fu-Chun Huo, Zhi-Man Zhu, Wen-Qi Du, Yao-Jie Pan, Xin Jiang, Meng-Jie Kang, Bo-Wen Liu, Jie Mou, Dong-Sheng Pei
Summary: Human papillomavirus (HPV) infection is a causative agent of cervical cancer (CC) and m6A modification plays a role in this process. HPV E6/7 oncoproteins affect global m6A modification and E7 specifically promotes the expression of ALKBH5. ALKBH5 is upregulated in CC and may serve as a prognostic marker. ALKBH5 enhances malignant phenotypes of CC cells and promotes tumorigenesis and metastasis through regulation of PAK5.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Peter 't Hart, Pascal Hommen, Anais Noisier, Adrian Krzyzanowski, Darijan Schueler, Arthur T. Porfetye, Mohammad Akbarzadeh, Ingrid R. Vetter, Helene Adihou, Herbert Waldmann
Summary: Researchers have developed peptide inhibitors targeting RbAp48 protein, successfully inhibiting the interaction between RbAp48 and MTA1 with high stability. Through a structure-based design strategy, the goal of improving affinity was achieved.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Subir Ghosh, Yikai Zheng, Shiva Subbulakshmi Radhakrishnan, Thomas F. Schranghamer, Saptarshi Das
Summary: Researchers have introduced a novel straintronic physically unclonable function (SPUF) by exploiting strain-induced reversible cracking in the contact microstructures of graphene field-effect transistors (GFETs). They found that strain-sensitive GFETs show colossal ON/OFF current ratios, while strain-resilient GFETs exhibit lower ON/OFF current ratios. The SPUFs demonstrated near-ideal performance and resilience to regression-based machine learning attacks, supply voltage variations, and temporal stability.
Article
Multidisciplinary Sciences
Bin Gao, Bohan Lin, Yachuan Pang, Feng Xu, Yuyao Lu, Yen-Cheng Chiu, Zhengwu Liu, Jianshi Tang, Meng-Fan Chang, He Qian, Huaqiang Wu
Summary: Physically unclonable function (PUF) is a solution to address the mistrust in IoT devices. This work demonstrates a concealable PUF using an integrated memristor array and peripherals, achieving efficient concealment and recovery operations. This concealable PUF presents a promising opportunity for building secure memristive hardware systems in the future.
Article
Computer Science, Information Systems
Jianrong Yao, Lihui Pang, Yang Su, Zhi Zhang, Wei Yang, Anmin Fu, Yansong Gao
Summary: Physical Unclonable Function (PUF) is a hardware security primitive divided into weak PUF and strong PUF categories, with PUF recomposition being a method to address the design challenges of reliable and secure lightweight strong PUF.
IEEE TRANSACTIONS ON EMERGING TOPICS IN COMPUTING
(2022)
Article
Computer Science, Information Systems
Amir Ali-Pour, David Hely, Vincent Beroulle, Giorgio Di Natale
Summary: This article discusses how to use Machine Learning to provide an estimated model of physically unclonable functions (PUFs) for faster device enrollment. The key points are ensuring the security of PUFs and efficiently conducting ML-based enrollment. By controlling modeling parameters, the cost of PUF enrollment can be reduced.
Article
Engineering, Electrical & Electronic
Jiahao Liu, Yuanzhe Zhao, Yan Zhu, Chi-Hang Chan, Rui Paulo Martins
Summary: This paper presents a weak PUF-assisted strong PUF that combines the metrics between weak and strong PUFs. The presented strong PUF utilizes unique key streams to encrypt the raw responses, achieving inherent immunity to modeling attacks. Experimental results show that the proposed strong PUF has high energy efficiency and stability, fabricated in 65nm CMOS GP technology.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2022)
Article
Computer Science, Information Systems
Gabriel Torrens, Abdel Alheyasat, Bartomeu Alorda, Sebastia A. Bota
Summary: This work proposes a methodology to estimate the statistical distribution of the probability that a 6T bit-cell starts up to a given logic value in SRAM memories for PUF applications. The distribution is obtained experimentally and an alternative parameter is used to quantify the mismatch of the cell. The resulting distribution is then related to the start-up probability distribution using a two-component logistic function. The proposed imbalance factor is shown to be a good predictor for PUF-related reliability estimation and can be applied at the early design stages.
Article
Computer Science, Information Systems
Jae-Won Nam, Ju-Hyeok Ahn, Jong-Phil Hong
Summary: This paper introduces an ultra-small PUF chip structure for data protection in compact IoT sensor devices. The proposed PUF has fewer transistors and a reduced active area compared to conventional PUFs. By adding the function of a switching transistor to a single main transistor, the proposed structure achieves significant silicon area reduction.
Article
Multidisciplinary Sciences
Minye Yang, Liang Zhu, Qi Zhong, Ramy El-Ganainy, Pai-Yen Chen
Summary: In this work, the authors demonstrate the use of spectral sensitivity near exceptional points (EPs) in electronic circuits to implement physically unclonable functions for security and communication applications. They investigate the spectral sensitivity associated with EPs and propose utilizing it as a resource for hardware security, introducing a physically unclonable function based on analog electronic circuits. This structure provides a perfect entropy source for encryption key generation and may have applications in radio-frequency fingerprinting and wireless communications.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lorenzo Calviello, Srivats Venkataramanan, Karol J. Rogowski, Emanuel Wyler, Kevin Wilkins, Malvika Tejura, Bao Thai, Jacek Krol, Witold Filipowicz, Markus Landthaler, Stephen N. Floor
Summary: DDX3 is an RNA chaperone that regulates translation by affecting a subset of mRNAs. The specific set of mRNAs regulated by DDX3 and its relationship with activity are still unknown. This study defines the subset of the transcriptome responsive to DDX3 inhibition, with implications for basic biology and disease states involving altered DDX3.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Genetics & Heredity
Wen-Pin Su, Sen-Huei Hsu, Li-Chiao Chia, Jui-Yang Lin, Song-Bin Chang, Zong-da Jiang, Yi-Ju Lin, Min-Yu Shih, Yi-Cheng Chen, Mau-Sun Chang, Wen-Bin Yang, Jan-Jong Hung, Po-Cheng Hung, Wei-Sheng Wu, Kyungjae Myung, Hungjiun Liaw
Article
Cell Biology
C-F Chang, P-C Chu, P-Y Wu, M-Y Yu, J-Y Lee, M-D Tsai, M-S Chang
CELL DEATH & DISEASE
(2015)
Article
Multidisciplinary Sciences
Jin-Yu Lee, Li-Jen Lee, Chih-Chen Fan, Ho-Ching Chang, Hsin-An Shih, Ming-Yuan Min, Mau-Sun Chang
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Hao-Yen Chang, Chi-Chen Fan, Po-Chen Chu, Bo-En Hong, Hyeon Jeong Lee, Mau-Sun Chang
Article
Oncology
Wenbin Zhong, You Zhou, Jiwei Li, Raghavendra Mysore, Wei Luo, Shiqian Li, Mau-Sun Chang, Vesa M. Olkkonen, Daoguang Yan
EXPERIMENTAL CELL RESEARCH
(2014)
Article
Fisheries
Chia-Hsiung Cheng, Chih-Ming Chou, Cheng-Ying Chu, Gen-Der Chen, Huang-Wei Lien, Pung-Pung Hwang, Mau-Sun Chang, Chang-Jen Huang
FISH & SHELLFISH IMMUNOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Po-An Yeh, Wen-Hsuan Yang, Pei-Yu Chiang, Shun-Chang Wang, Mau-Sun Chang, Ching-Jin Chang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2012)
Article
Biochemistry & Molecular Biology
Yu-Ling Chen, Yu-Wun Jiang, Yu-Lun Su, Sheng-Chung Lee, Mau-Sun Chang, Ching-Jin Chang
MOLECULAR BIOLOGY REPORTS
(2013)
Article
Multidisciplinary Sciences
Chia-Hsin Chen, Po-Chen Chu, Liekyeow Lee, Huang-Wei Lien, Tse-Ling Lin, Chi-Chen Fan, Peter Chi, Chang-Jen Huang, Mau-Sun Chang
Article
Biochemistry & Molecular Biology
Jhen-Jia Fan, Wen-Hsien Hsu, Kuen-Haur Lee, Ku-Chung Chen, Cheng-Wei Lin, Yu-Lin A. Lee, Tzu-Ping Ko, Lang-Ta Lee, Ming-Ting Lee, Mau-Sun Chang, Chia-Hsiung Cheng
Article
Multidisciplinary Sciences
Jin-Yu Lee, Chih-Chen Fan, Nai-Lin Chou, Hung-Wei Lin, Mau-Sun Chang
Article
Multidisciplinary Sciences
Ting-Wei Shih, Li-Jen Lee, Ho-Ching Chang, Hung-Wei Lin, Mau-Sun Chang
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Hung-Wei Lin, Jin-Yu Lee, Nai-Lin Chou, Ting-Wei Shih, Mau-Sun Chang
Summary: The Y259 phosphorylation of PUF-A plays an important role in tumorigenesis, as its knockout reduces colony formation and invasion capacity in cells, and the unphosphorylated mutant of PUF-A weakens protein stability.
Article
Multidisciplinary Sciences
Jin-Yu Lee, Nai-Lin Chou, Ya-Ru Yu, Hsin-An Shih, Hung-Wei Lin, Chine-Kuo Lee, Mau-Sun Chang
Summary: In this study, the importance of PHRF1 in IgA switching was investigated in CH12F3-2A cells and CD19-Cre mice. The results showed that the loss of PHRF1 decreased IgA production and the levels of PARP1, NELF-A, and NELF-D. Interestingly, IgA switching was not significantly reduced in PHRF1 deficient splenic B lymphocytes.
