A systemic assessment of the association between tumor necrosis factor alpha 308 G/A polymorphism and risk of cervical cancer

Tumor necrosis factor alpha (TNF-alpha) is a multifunctional cytokine which plays an important role in the human immune response against various pathogens, and there may be a relationship between TNF-alpha 308 G/A polymorphism and cervical cancer risk. We performed a meta-analysis to get a systemic assessment of the association between TNF-alpha 308 G/A polymorphism and cervical cancer risk. Electronic searches of PubMed, Embase, and Web of Science were performed for all publications on the association between TNF-alpha 308 G/A polymorphism and cervical cancer risk through October 26, 2012. The pooled odds ratios (ORs) with their 95 % confidence interval (95 % CIs) were calculated to assess the association. Fifteen studies with a total of 3,743 cervical cancer cases and 4,096 controls were finally included into the meta-analysis. Overall, TNF-alpha 308 G/A polymorphism was significantly associated with increased risk of cervical cancer under three main genetic comparison models (A vs. G, OR 1.20, 95 % CI 1.02-1.42, P = 0.03; AA vs. GG, OR 1.31, 95 % CI 1.00-1.72, P = 0.048; AA vs. GG/GA, OR 1.30, 95 % CI 1.00-1.71, P = 0.05). Subgroup analysis by ethnicity further showed that there was a significant association between TNF-alpha 308 G/A polymorphism and increased risk of cervical cancer in Asians (AA vs. GG, OR 1.83, 95 % CI 1.05-3.20, P = 0.034; AA vs. GG/GA, OR 1.84, 95 % CI 1.05-3.22, P = 0.032). The meta-analysis suggests that TNF-alpha 308 G/A polymorphism is associated with increased risk of cervical cancer, and TNF-alpha 308 G/A mutant allele A is a risk factor of cervical cancer.