Article
Immunology
Mohammed J. S. Al-Ghabban, Nagham Y. Al-Bayati, Qasim S. Al-Mayah, Hisham Y. Al-Matubsi
Summary: The GG genotype of CTLA-4+49G/A polymorphism was found to be significantly less common in CL patients, with the G allele being more common in controls. Newly diagnosed CL patients had significantly higher serum sCTLA-4 levels, which may serve as an additional diagnostic tool.
MICROBIAL PATHOGENESIS
(2021)
Review
Biochemistry & Molecular Biology
Gil-Ran Kim, Je-Min Choi
Summary: CTLA-4, an immune checkpoint molecule, plays a crucial role in T-cell activation and immune regulation. Its signaling is independent of ligand interaction and relies on tyrosine and lysine motifs. This review summarizes the biology and molecular signaling events of CTLA-4 and discusses strategies to target its signaling for immune modulation and disease therapy.
MOLECULES AND CELLS
(2022)
Article
Medicine, General & Internal
Hao-Yun Chang, Chao-Yu Liu, Yen-Li Lo, Shih-Hwa Chiou, Kai-Hsi Lu, Ming-Cheng Lee, Yuan-Hung Wang
Summary: This meta-analysis investigated the potential effects of five polymorphisms in the CTLA-4 gene on breast cancer susceptibility and found that the +49 A/G polymorphism is significantly associated with breast cancer, especially in non-Asian populations and studies with hospital-based controls.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Oncology
Hongyuan Wan, Hangsheng Zhou, Yanyan Feng, Yongquan Chen, Lijie Zhu, Yuanyuan Mi
Summary: The rs231775 polymorphism of CTLA-4 gene is associated with different cancer types, and this study verified and analyzed the association. The results showed that this polymorphism may reduce cancer risk, and the association varied among different cancer types.
FRONTIERS IN ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jinkui Wang, Chenghao Zhanghuang, Xiaojun Tan, Tao Mi, Jiayan Liu, Liming Jin, Mujie Li, Zhaoxia Zhang, Dawei He
Summary: A new nomogram has been developed to predict the cancer-specific survival (CSS) of childhood osteosarcoma (OSC) and Ewing's sarcoma (EWS). This predictive model shows good accuracy and reliability, and can assist doctors and patients in developing clinical strategies.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Saki Nakane, Kentaro Imamura, Rio Hisanaga, Kazuyuki Ishihara, Atsushi Saito
Summary: The study demonstrated that CTLA-4-Ig can effectively inhibit bone resorption in periodontitis by affecting osteoclast differentiation and activity, potentially through the regulation of the NF-kappa B pathway and PP2A expression.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Immunology
Jiajia Liu, Xiaoyi Tian, Yan Wang, Xixiong Kang, Wenqi Song
Summary: The study aimed to investigate the significance of serum sCTLA-4 levels as a noninvasive biomarker for diagnosis and prognosis evaluation in glioma patients. Results showed that serum sCTLA-4 levels were increased in glioma patients, positively correlated with tumor grade, and could be a valuable predictive biomarker for diagnosis and prognosis evaluation in glioma. The ROC curve analysis and survival analysis demonstrated that sCTLA-4 levels were associated with tumor grade and could be an independent prognostic factor for progression-free survival in glioma patients.
Review
Immunology
Zili Lin, Ziyi Wu, Wei Luo
Summary: Ewing's sarcoma is a malignant tumor that mainly affects children and adolescents, with traditional treatments being ineffective for patients with metastatic disease. CAR-T cell therapy, a novel immune therapy, has been approved for leukemia and lymphoma, and is now being explored for solid tumors like EWS. Further research is needed to optimize the efficacy of this new treatment approach.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Massimo Serra, Claudia Maria Hattinger, Michela Pasello, Chiara Casotti, Leonardo Fantoni, Chiara Riganti, Maria Cristina Manara
Summary: The ATP-binding cassette (ABC) transporter superfamily plays crucial roles in cellular trafficking and drug resistance in cancers. Studies on ABC transporters in osteosarcoma and Ewing's sarcoma have shown their significance in the treatment of these rare bone sarcomas, highlighting the potential for new therapeutic targets. Additionally, efforts to overcome ABC-mediated chemoresistance offer hope for improved treatment options in the future.
Article
Cell Biology
Giorgia Giordano, Alessandra Merlini, Giulio Ferrero, Giulia Mesiano, Erika Fiorino, Silvia Brusco, Maria Laura Centomo, Valeria Leuci, Lorenzo D'Ambrosio, Massimo Aglietta, Dario Sangiolo, Giovanni Grignani, Ymera Pignochino
Summary: The study focused on the expression of tyrosine kinase EphA2 in bone sarcomas and found it to be a potential therapeutic target. EPHA2 was observed to be expressed at higher levels in bone sarcoma cell lines and tumor tissues, correlating with different histological types and clinical outcomes.
Review
Immunology
Ting-Wei Lin, Ya-Chiao Hu, Yao-Hsu Yang, Yin-Hsiu Chien, Ni-Chung Lee, Hsin-Hui Yu, Bor-Luen Chiang, Li-Chieh Wang
Summary: We reported a case of a patient with multiple disorders, including autoimmune disease, immunodeficiency, enteropathy, organomegaly and lymphocytic infiltration. The patient showed excellent response to abatacept treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Multidisciplinary Sciences
Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q. Gabrielski, Lixin Zheng, Tovah E. Markowitz, Waipan Chan, Jian Song, Arun K. Boddapati, Keita Saeki, Bjoern Haupl, Ann Y. Park, Yan H. Cheng, Jing Cui, Thomas Oellerich, Michael J. Lenardo
Summary: Apoptosis is a genetically regulated program of cell death that plays a key role in immune disease processes. The transcription factor EBF4 was identified as a regulator of T cell death and cytotoxic immune function in humans, suggesting its importance in immune responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Viswajit Mulpuru, Nidhi Mishra
Summary: The study aims to identify potential CTL epitopes in the SARS-CoV-2 Indian isolate for Indian population, analyze their immunogenicity and foreignness, and investigate their interactions with HLA system to confirm their candidacy as epitope candidates for vaccine development.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jia-Nan Cheng, Wen Luo, Chengdu Sun, Zheng Jin, Xianghua Zeng, Peter B. Alexander, Zhihua Gong, Xin Xia, Xiaofang Ding, Shouxia Xu, Ping Zou, Yisong Y. Wan, Qingzhu Jia, Qi-Jing Li, Bo Zhu
Summary: Cancer immunotherapy efficacy can be improved by enhancing eosinophil infiltration through radiation, which also boosts the effectiveness of CD8(+) T cells and adoptive T cell therapy. Eosinophil mobilization may serve as a mechanistically relevant biomarker for predicting the effectiveness of pre-immunotherapy radiation and enhancing T cell-mediated immunotherapy against cancers.
Article
Oncology
Wu Wang, Xi Wang, Wenli Yang, Kai Zhong, Na He, Xuexia Li, Yanyang Pang, Zi Lu, Aiqun Liu, Xiaoling Lu
Summary: The study showed that stimulation with the CTLA-4 specific nanobody Nb36 resulted in enhanced anti-tumor effects of DC-CIK cells both in vitro and in vivo, significantly inhibiting tumor growth and extending the survival of tumor-bearing mice.