Article
Oncology
Sophie Bartsch, Kimia Mirzakhani, Laura Neubert, Alexander Stenzel, Marzieh Ehsani, Mohsen Esmaeili, Thanakorn Pungsrinont, Merve Kacal, Seyed Mohammad Mahdi Rasa, Julia Kallenbach, Divya Damodaran, Federico Ribaudo, Marc-Oliver Grimm, Francesco Neri, Aria Baniahmad
Summary: The expression of human telomerase reverse transcriptase subunit (hTERT) is hormonally controlled, with androgen treatment suppressing hTERT expression in prostate cancer cells. This inhibition and activation of hTERT by androgens is mediated by androgen receptor (AR) co-repressors ING1 and ING2. This reveals a dual role of AR in controlling hTERT expression during prostate cancer tumorigenesis.
Article
Pharmacology & Pharmacy
Rehab M. Elgharabawy, Ibrahim El Tantawy El Sayed, Nada Abd-Allah Rezk, Ehab Tousson
Summary: The study found that costus root had protective effects against EST-induced cardiac toxicity, improving cardiac toxicity, lipid profiles, electrolytes, and apoptosis, and providing protection against EST. This suggests the potential benefits of costus as an adjuvant in the prevention and treatment of cardiac toxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Matthias Ilmer, Markus Otto Guba
Summary: Liver transplantation is now being considered for non-resectable colorectal liver metastases, with good oncologic outcomes; however, due to organ shortage, strict selection of suitable candidates is necessary. Dynamic criteria based on tumor biology provide a better prediction of individual oncological outcomes.
Article
Biochemistry & Molecular Biology
Yufan Qiu, Yi Yang, Riyao Yang, Chunxiao Liu, Jung-Mao Hsu, Zhou Jiang, Linlin Sun, Yongkun Wei, Chia-Wei Li, Dihua Yu, Jin Zhang, Mien-Chie Hung
Summary: The study reveals that PD-1 can be secreted in an exosomal form by activated T cells and interact remotely with PD-L1. This interaction can attenuate the suppression of tumor-specific cytotoxic T cell activity by PD-L1, restoring tumor surveillance.
Article
Oncology
Michele Simbolo, Mirna Bilotta, Andrea Mafficini, Claudio Luchini, Daniela Furlan, Frediano Inzani, Gianluigi Petrone, Davide Bonvissuto, Stefano La Rosa, Giovanni Schinzari, Antonio Bianchi, Ernesto Rossi, Roberta Menghi, Felice Giuliante, Stefania Boccia, Aldo Scarpa, Guido Rindi
Summary: The study investigated the gene expression profiles and mutations of pancreatic neuroendocrine tumors with different grades, revealing significant differences in gene expression and LINE-1 DNA methylation between grades, while mutations did not correlate with specific expression profiles. The role of Ki67 in defining specific expression profiles, independently from lesion location or patient, was confirmed.
Article
Oncology
Nathan D. Lee, Kamran Kaveh, Ivana Bozic
Summary: Tumors are composed of genetically distinct subclones of cells that can interact with each other, influencing tumor initiation, progression, and metastasis. Previous research has mainly focused on the self-effect of driver mutations in cancer cells. However, recent studies have highlighted the significance of clonal interactions, such as cooperation and competition, in tumor biology. Mathematical and computational models have played a crucial role in understanding the nature of these interactions. Integrating quantitative methods with experimental and clinical data can further unveil the roles of clonal interactions in human cancers.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Cell Biology
Dong Wang, Xiaohui Wang, Yujia Song, Mahan Si, Yuqi Sun, Xiaohui Liu, Shuxiang Cui, Xianjun Qu, Xinfeng Yu
Summary: This study found a significant positive correlation between CXCR7 expression and CAF activation markers in colonic tissues and transgenic mice. RNA sequencing revealed an increase in miR-146a-5p and miR-155-5p levels in CXCR7-overexpressing CRC cells and their exosomes. Furthermore, these CRC cell-derived miRNAs could be uptaken by CAFs via exosomes and promote their activation, leading to enhanced invasive capacity of CRC cells and pro-metastatic switch. The activation of CAFs by miR-146a-5p and miR-155-5p also facilitated tumor formation and lung metastasis of CRC in vivo. Therefore, these findings provide new insights into CXCR7-mediated CRC metastasis and suggest potential biomarkers and therapeutic targets for inhibiting CRC metastasis.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Erik S. Blomain, Everett J. Moding
Summary: Analysis of circulating nucleic acids has emerged as a non-invasive approach to leverage tumor molecular abnormalities as biomarkers of prognosis and treatment response. This approach holds promise for advancing precision radiotherapy by investigating tumor clonal evolution and acquired resistance through liquid biopsies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yinxi Wang, Kimmo Kartasalo, Philippe Weitz, Balazs Acs, Masi Valkonen, Christer Larsson, Pekka Ruusuvuori, Johan Hartman, Mattias Rantalainen
Summary: The study demonstrated that deep learning analysis of transcriptome-wide expression morphology enables the prediction of mRNA expression and proliferation markers from routine histopathology whole slide images in breast cancer. This approach represents a significant advancement in predicting tumor molecular characteristics.
Article
Oncology
Ania Alay, David Cordero, Sara Hijazo-Pechero, Elisabet Aliagas, Adriana Lopez-Doriga, Raul Marin, Ramon Palmero, Roger Llatjos, Ignacio Escobar, Ricard Ramos, Susana Padrones, Victor Moreno, Ernest Nadal, Xavier Sole
Summary: This study identifies T-helper 2 (T-H2) and cytotoxic T (T-C) cells as key factors associated with overall survival in malignant pleural mesothelioma (MPM). Three immune clusters were defined based on the levels of T-H2 and T-C immune infiltration, with the IG1 and IG3 groups showing associations with worse and better overall survival, respectively. Integration of gene expression with functional signatures of drug response showed that IG3 patients might be more likely to respond to immune-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Aleksandr Ianevski, Anil K. Giri, Tero Aittokallio
Summary: We developed a computational platform, ScType, for automated and fast cell-type identification using scRNA-seq data and a comprehensive cell marker database. ScType provides unbiased and accurate cell type annotations by ensuring the specificity of marker genes across cell clusters and types. It can also distinguish between healthy and malignant cell populations based on single-nucleotide variant calling.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Katarzyna Iwanczyk, Bartosz Czachowski, Patrycja Sosnowska-Sienkiewicz, Gabriela Telman, Paulina Ciazynska, Przemyslaw Mankowski, Danuta Januszkiewicz-Lewandowska
Summary: Wilms tumor, a rare childhood cancer, may have both genetic and environmental factors involved in its occurrence. This study presents a case of monozygotic twin girls with Wilms tumor and provides detailed clinical, histological, and molecular analysis. The study suggests that environmental factors, such as pesticide exposure by the twins' parents, may contribute to the development of Wilms tumor.
Article
Biochemistry & Molecular Biology
Yulin Li, Liang Yue, Yanqing Li, Qinxiu Zhang, Xin Liang
Summary: Meta-analysis revealed that high Ki-67 expression was associated with poorer overall survival, disease-free survival, and local recurrence-free survival in nasopharyngeal carcinoma patients, but not with distant metastasis-free survival.
BIOSCIENCE REPORTS
(2021)
Review
Immunology
Espen Basmo Ellingsen, Sara M. Mangsbo, Eivind Hovig, Gustav Gaudernack
Summary: Telomerase-based therapeutic cancer vaccines have shown potential in clinical research and may enhance the efficacy of checkpoint inhibition. With its almost universal presence in cancer and essential role in tumor growth, telomerase is an attractive therapeutic target. Rational treatment combinations, such as checkpoint inhibitors, are likely necessary to fully unlock the clinical potential of telomerase-based cancer vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hongde Yu, Bolun Zhang, Lin Qi, Jian Han, Mingyang Guan, Jiaze Li, Qingtao Meng
Summary: Our study reveals the regulatory role of AP003352.1/miR-141-3p/LPAR3 axis in the development of osteosarcoma, and suggests that this axis could serve as a multi-gene diagnostic marker for osteosarcoma.
Article
Obstetrics & Gynecology
Ruya Colak, Asli Celik, Gulden Diniz, Senem Alkan Ozdemir, Osman Yilmaz, Sebnem Calkavur
Summary: This study evaluates the efficacy of Pycnogenol in an experimental hypoxic-ischemic rat model and finds that PYC reduces apoptosis and neuronal injury, potentially providing protection against hypoxic-ischemic encephalopathy.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aysenur Akkulak, Duriye Nur Dagdelen, Abdullah Yalcin, Esin Oktay, Gulden Diniz, Dudu Solakoglu Kahraman, Mehmet Senoglu, Gizem Donmez Yalcin
Summary: The study found that intracranial tumors exhibit excitotoxicity caused by glutamate metabolism disorders, analyzed the expression levels of glutamate dehydrogenase, glutamine synthetase and sirtuin 4 in intracranial tumor cells, and found that SIRT4 and GS are expressed at higher levels in U87 cells while GDH is expressed at lower levels, suggesting that understanding the mechanisms of glutamate metabolism and excitotoxicity in intracranial tumors may help in the development of therapies.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Genetics & Heredity
Berk Ozyilmaz, Ozgur Kirbiyik, Taha R. Ozdemir, Ozge Kaya Ozer, Yasar B. Kutbay, Kadri M. Erdogan, Merve Saka Guvenc, Sener Arikan, Tuba Sozen Turk, Murat Yildirim Kale, Irem Fatma Uludag, Figen Baydan, Filiz Sertpoyraz, Pinar Gencpinar, Gulden Diniz
Summary: Calpainopathy is characterized by symmetric and progressive weakness of proximal muscles. More than 500 likely pathogenic variants in the CAPN3 gene have been reported, but a clear genotype-phenotype association has not yet been established. This study aims to add new data to the literature by evaluating patients with likely pathogenic/pathogenic variants and suggesting novel genotype-phenotype associations.
Article
Gastroenterology & Hepatology
A. K. Kayapinar, D. Solakoglu, K. Bas, E. Oymaci, B. Isbilen, B. Calik, G. Diniz, G. Akbulut
Summary: This study investigated the relationship between H. pylori and prognostic factors in gastric cancer. The results showed that age, tumor diameter, TNM stage, lymph node capsule invasion, perineural and lymphovascular invasion, diffuse p53, PLR, and NLR were important prognostic factors in gastric cancer, and their effectiveness was not affected by the presence of H. pylori.
ACTA GASTRO-ENTEROLOGICA BELGICA
(2022)
Article
Cell Biology
Gonul Catli, Wen Gao, Corinne Foley, Berk Ozyilmaz, Neslihan Edeer, Gulden Diniz, Monique Losekoot, Jaap van Doorn, Andrew Dauber, Bumin N. Dundar, Jan M. Wit, Vivian Hwa
Summary: STAT5B deficiency is a rare autosomal recessive disorder characterized by severe growth hormone insensitivity and immunodeficiency. However, we report an atypical case of STAT5B deficiency in a young female subject with growth impairment, hypergammaglobulinemia, and elevated B lymphocytes, but no pulmonary disease. The subject had a novel homozygous frame-shift STAT5B variant that resulted in reduced expression and loss-of-function. This suggests that an intact, functional STAT5B is necessary for normal growth and immune function.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aysen Turedi Yildirim, Huseyin Gulen, Hulya Turkmen, Gulcihan Ozek, Yesim Oymak, Burak Durmaz, Emin Karaca
Summary: Hb Hammersmith is a rare and unstable variant of hemoglobin with limited treatment options. In this case, a seven-month-old girl with anemia and splenomegaly was diagnosed with Hb Hammersmith through DNA sequencing and successfully treated with hematopoietic stem cell transplantation.
Article
Oncology
Husnu Tore Yavuzsen, Zekiye Sultan Altun, Gulden Diniz, Duygu Ayaz, Sevil Sayhan, Ilker Cakir, Bahadir Saatli, Tugba Yavuzsen, Safiye Aktas
Summary: This study evaluated the relationship between miRNA expressions and clinical and histopathological data in ovarian cancer. The results suggest that the expressions of miR200a and 200c may be useful for the evaluation of histopathological subtypes of ovarian cancer.
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY
(2022)
Article
Oncology
Gulden Diniz, Ayse Gul Pulular, Dudu Solakoglu Kahraman, Umut Varol, Sevil Sayhan, Duygu Ayaz, Cem Karaali
Summary: This study examined the expression and prognostic value of NGAL and KIM-1 in breast cancer. The results showed positive expression of NGAL and KIM-1 in breast cancer cells, indicating that KIM-1 may be a new treatment option for breast cancer. Further studies in larger populations are needed to confirm these findings.
EUROPEAN JOURNAL OF BREAST HEALTH
(2022)
Meeting Abstract
Oncology
Rejin Kebudi, Dilek Kacar, Derya Ozyoruk, Deniz Tugcu, Nese Yarali, Inci Ilhan, Aysenur Bahadir, Zeynep Ozdemir, Aykan Ozguven, Mehmet Fatih Orhan, Aysen Turedi Yildirim, Canan Albayrak, Ibrahim Kartal, Namik Yasar Ozbek, Neriman Sari, Huseyin Tokgoz, Meryem Albayrak, Aylin Canbolat Aydin, Nilgun Eroglu, Sultan Aydin, Hulya Uzel, Bulent Zulfikar, Mustafa Buyukavci, Huseyin Gulen, Ersin Toret, Ozcan Bor
PEDIATRIC BLOOD & CANCER
(2022)
Letter
Pathology
Gulden Diniz, Berk Ozyilmaz, Sarenur Gokben
TURKISH JOURNAL OF PATHOLOGY
(2022)
Meeting Abstract
Immunology
Sukran Kose, Tuba Tatli Kis, Gulden Diniz, Ilkay Akbulut, Basak Gol Serin, Canberk Yilmaz, Mine Ozyazici, Mesut Arici, Aysu Yurdasiper, Osman Yilmaz
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Sukran Kose, Tuba Tatli Kis, Gulden Diniz, Ilkay Akbulut, Basak Gol Serin, Canberk Yilmaz, Mine Ozyazici, Mesut Arici, Aysu Yurdasiper, Osman Yilmaz
Summary: This study established a new mouse model for allergic rhinitis and asthma, showing histopathological characteristics of AR, and demonstrated the potential of this model in investigating the coexistence of allergic rhinitis and asthma.
IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI
(2021)
Article
Health Care Sciences & Services
Sukran Kose, Tuba Tatli Kis, Canberk Yilmaz, Mehmet Kis, Mustafa Baris, Gulden Diniz, Osman Yilmaz
Summary: This study introduced a new rat model of infective endocarditis induced by S. aureus using a 20 G catheter. The mortality rate was 28.5% with two rats dying. The practical application of the surgical procedure using the 20 G catheter is believed to be convenient for researchers in experimental research on IE diagnosis and treatment.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2021)
Article
Medicine, General & Internal
Gulden Diniz, Neslihan Guney, Emel Tekin, Senem Ersavas, Hulya Colak
Summary: The study found that KIM-1 expression is higher in patients with IgAN compared to normal controls, and the number of NGAL-positive interstitial inflammatory cells is associated with the severity of tubular atrophy/interstitial fibrosis. Higher levels of serum cholesterol are correlated with increased neutrophil infiltration in the glomeruli.
ACTA MEDICA MEDITERRANEA
(2021)
Article
Oncology
Sevil Sayhan, Gulden Diniz, Duygu Ayaz, Dudu Solakoglu Kahraman
Summary: The study revealed differences in the expression of tumoral PD-L1 and FOXP3-positive cells in different types of cervical neoplasms, with significantly higher expression in invasive tumors compared to intraepithelial lesions. This suggests that PD-L1 may play an important role in the pathogenesis of cervical neoplasms.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2021)