4.2 Article

High transmissibility of the modern Beijing Mycobacterium tuberculosis in homeless patients of Japan

Journal

TUBERCULOSIS
Volume 89, Issue 4, Pages 252-255

Publisher

CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2009.05.007

Keywords

Mycobacterium tuberculosis; Beijing family; VNTR; Japan; Homeless

Funding

  1. Ministry of Health, Labour and Welfare
  2. US-Japan Cooperative Medical Science Program

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A population-based study of Mycobacterium tuberculosis isolated from homeless tuberculosis patients was performed during 2002-2004 in Osaka City, Japan. The data show that the ancient Beijing subfamily was predominant, whereas clustered isolates based on refined variable number of tandem repeats genotyping (19 loci) mainly belonged to the modern Beijing subfamily, suggesting its increased transmissibility. (C) 2009 Elsevier Ltd. All rights reserved.

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